Table 11 Open in new tab Performances of...

Table 11

Performances of seven class-specific classifiers using RF with the selected features

Activity (# features)	Dataset	SN	SP	ACC	MCC	AUC
Anti-parasitic (120)	10-fold CV	0.7526	0.8366	0.8202	0.4955	0.8783
Anti-parasitic (120)	Testing	0.6167	0.7732	0.7685	0.1570	0.7773
Anti-viral (1130)	10-fold CV	0.9109	0.9324	0.9247	0.8382	0.9692
Anti-viral (1130)	Testing	0.9085	0.8406	0.8613	0.7075	0.9404
Anti- cancer (263)	10-fold CV	0.7673	0.7888	0.7855	0.4507	0.8518
Anti- cancer (263)	Testing	0.7766	0.7060	0.7094	0.2208	0.8231
Targeting mammals (362)	10-fold CV	0.8677	0.8893	0.8853	0.6620	0.9392
Targeting mammals (362)	Testing	0.7849	0.8045	0.8035	0.2998	0.8648
Anti- fungal (606)	10-fold CV	0.8573	0.8553	0.8565	0.7050	0.9382
Anti- fungal (606)	Testing	0.8561	0.6675	0.7458	0.5186	0.8578
Targeting Gram-positive bacteria (843)	10-fold CV	0.8852	0.8848	0.8851	0.7687	0.9583
Targeting Gram-positive bacteria (843)	Testing	0.8877	0.6373	0.7423	0.5254	0.8745
Targeting Gram-negative bacteria (839)	10-fold CV	0.8805	0.8815	0.8809	0.7606	0.9560
Targeting Gram-negative bacteria (839)	Testing	0.8575	0.6574	0.7413	0.5116	0.8672

Activity (# features)	Dataset	SN	SP	ACC	MCC	AUC
Anti-parasitic (120)	10-fold CV	0.7526	0.8366	0.8202	0.4955	0.8783
Anti-parasitic (120)	Testing	0.6167	0.7732	0.7685	0.1570	0.7773
Anti-viral (1130)	10-fold CV	0.9109	0.9324	0.9247	0.8382	0.9692
Anti-viral (1130)	Testing	0.9085	0.8406	0.8613	0.7075	0.9404
Anti- cancer (263)	10-fold CV	0.7673	0.7888	0.7855	0.4507	0.8518
Anti- cancer (263)	Testing	0.7766	0.7060	0.7094	0.2208	0.8231
Targeting mammals (362)	10-fold CV	0.8677	0.8893	0.8853	0.6620	0.9392
Targeting mammals (362)	Testing	0.7849	0.8045	0.8035	0.2998	0.8648
Anti- fungal (606)	10-fold CV	0.8573	0.8553	0.8565	0.7050	0.9382
Anti- fungal (606)	Testing	0.8561	0.6675	0.7458	0.5186	0.8578
Targeting Gram-positive bacteria (843)	10-fold CV	0.8852	0.8848	0.8851	0.7687	0.9583
Targeting Gram-positive bacteria (843)	Testing	0.8877	0.6373	0.7423	0.5254	0.8745
Targeting Gram-negative bacteria (839)	10-fold CV	0.8805	0.8815	0.8809	0.7606	0.9560
Targeting Gram-negative bacteria (839)	Testing	0.8575	0.6574	0.7413	0.5116	0.8672

Note: SN, sensitivity; SP, specificity; ACC, accuracy; MCC, Matthews correlation coefficient; AUC, area under the receiver operating characteristic curve.

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