Table 3. Open in new tab Bacterial kill...

Species	Novartis strain	Piperacillin/IID572^a	Piperacillin/tazobactam^a
E. coli	NB27001	4/4	−1.71 ± 0.29	4/4	−1.3 ± 0.41
NB27235	2/4	−2.20 ± 0.22	4/4	−1.61 ± 0.44
NB27169	4/4	−1.56 ± 0.48	>64/4	1.43 ± 0.50
K. pneumoniae	NB29002	2/4	−0.33 ± 0.55	4/4	0.26 ± 1.01
NB29257	4/4	−0.77 ± 0.34	16/4	−0.81 ± 0.15
NB29001	8/4	−1.09 ± 0.16	8/4	−0.87 ± 0.16
NB29293	8/4	−0.54 ± 0.42	>64/4	2.42 ± 0.10
NB29355	8/4	−0.23 ± 0.35	>64/4	2.90 ± 0.46
NB29084	16/4	−1.64 ± 0.38	16/4	−0.63 ± 0.33
NB29316	16/4	−1.07 ± 0.47	>64/4	0.68 ± 0.60^b
NB29339	16/4	−0.99 ± 1.70	>64/4	3.19 ± 0.19
S. aureus	NB01001	0.5/2	−1.65 ± 0.19	1/4	−2.01 ± 0.55
NB01421	1/2	−2.69 ± 0.68	1/4	−2.78 ± 0.35

Species	Novartis strain	Piperacillin/IID572^a	Piperacillin/tazobactam^a
E. coli	NB27001	4/4	−1.71 ± 0.29	4/4	−1.3 ± 0.41
NB27235	2/4	−2.20 ± 0.22	4/4	−1.61 ± 0.44
NB27169	4/4	−1.56 ± 0.48	>64/4	1.43 ± 0.50
K. pneumoniae	NB29002	2/4	−0.33 ± 0.55	4/4	0.26 ± 1.01
NB29257	4/4	−0.77 ± 0.34	16/4	−0.81 ± 0.15
NB29001	8/4	−1.09 ± 0.16	8/4	−0.87 ± 0.16
NB29293	8/4	−0.54 ± 0.42	>64/4	2.42 ± 0.10
NB29355	8/4	−0.23 ± 0.35	>64/4	2.90 ± 0.46
NB29084	16/4	−1.64 ± 0.38	16/4	−0.63 ± 0.33
NB29316	16/4	−1.07 ± 0.47	>64/4	0.68 ± 0.60^b
NB29339	16/4	−0.99 ± 1.70	>64/4	3.19 ± 0.19
S. aureus	NB01001	0.5/2	−1.65 ± 0.19	1/4	−2.01 ± 0.55
NB01421	1/2	−2.69 ± 0.68	1/4	−2.78 ± 0.35

Table 3.

Bacterial kill from stasis for the piperacillin/IID572 combination and the piperacillin/tazobactam combination in vivo

Species	Novartis strain	Piperacillin/IID572^a		Piperacillin/tazobactam^a
Species	Novartis strain	MIC (mg/L)	Δ log₁₀ cfu/thigh	MIC (mg/L)	Δ log₁₀ cfu/thigh
E. coli	NB27001	4/4	−1.71 ± 0.29	4/4	−1.3 ± 0.41
	NB27235	2/4	−2.20 ± 0.22	4/4	−1.61 ± 0.44
	NB27169	4/4	−1.56 ± 0.48	>64/4	1.43 ± 0.50
K. pneumoniae	NB29002	2/4	−0.33 ± 0.55	4/4	0.26 ± 1.01
	NB29257	4/4	−0.77 ± 0.34	16/4	−0.81 ± 0.15
	NB29001	8/4	−1.09 ± 0.16	8/4	−0.87 ± 0.16
	NB29293	8/4	−0.54 ± 0.42	>64/4	2.42 ± 0.10
	NB29355	8/4	−0.23 ± 0.35	>64/4	2.90 ± 0.46
	NB29084	16/4	−1.64 ± 0.38	16/4	−0.63 ± 0.33
	NB29316	16/4	−1.07 ± 0.47	>64/4	0.68 ± 0.60^b
	NB29339	16/4	−0.99 ± 1.70	>64/4	3.19 ± 0.19
S. aureus	NB01001	0.5/2	−1.65 ± 0.19	1/4	−2.01 ± 0.55
S. aureus	NB01421	1/2	−2.69 ± 0.68	1/4	−2.78 ± 0.35

Species	Novartis strain	Piperacillin/IID572^a		Piperacillin/tazobactam^a
Species	Novartis strain	MIC (mg/L)	Δ log₁₀ cfu/thigh	MIC (mg/L)	Δ log₁₀ cfu/thigh
E. coli	NB27001	4/4	−1.71 ± 0.29	4/4	−1.3 ± 0.41
	NB27235	2/4	−2.20 ± 0.22	4/4	−1.61 ± 0.44
	NB27169	4/4	−1.56 ± 0.48	>64/4	1.43 ± 0.50
K. pneumoniae	NB29002	2/4	−0.33 ± 0.55	4/4	0.26 ± 1.01
	NB29257	4/4	−0.77 ± 0.34	16/4	−0.81 ± 0.15
	NB29001	8/4	−1.09 ± 0.16	8/4	−0.87 ± 0.16
	NB29293	8/4	−0.54 ± 0.42	>64/4	2.42 ± 0.10
	NB29355	8/4	−0.23 ± 0.35	>64/4	2.90 ± 0.46
	NB29084	16/4	−1.64 ± 0.38	16/4	−0.63 ± 0.33
	NB29316	16/4	−1.07 ± 0.47	>64/4	0.68 ± 0.60^b
	NB29339	16/4	−0.99 ± 1.70	>64/4	3.19 ± 0.19
S. aureus	NB01001	0.5/2	−1.65 ± 0.19	1/4	−2.01 ± 0.55
S. aureus	NB01421	1/2	−2.69 ± 0.68	1/4	−2.78 ± 0.35

Experiments were performed using a ratio of 8:1 piperacillin:BLI.

Separate experiment to that where piperacillin/IID572 was tested.