Table 1. Open in new tab Antimicrobial...

Organism/organism group (no. of isolates)	Number and cumulative percentage of isolates inhibited at MIC (mg/L) of:	MIC₅₀ (mg/L)	MIC₉₀ (mg/L)
Enterobacterales
randomly selected, non-intrinsically resistant Enterobacterales (272)		0	148	87	32	3	2					0.06	0.25
0.0	54.4	86.4	98.2	99.3	100.0
CRE (53)	0	1	29	16	6	1						0.06	0.25
0.0	1.9	56.6	86.8	98.1	100.0
third-generation-cephalosporin- resistant, carbapenem-susceptible Enterobacterales (52)^a		0	32	17	2	1						0.06	0.12
0.0	61.5	94.2	98.1	100.0
ESBL-producing Enterobacterales (24)		0	16	7	1							0.06	0.12
0.0	66.7	95.8	100.0
KPC-producing Enterobacterales (23)		0	11	9	3							0.12	0.25
0.0	47.8	87.0	100.0
MBL-producing Enterobacterales (12)		0	9	1	1	0	0	0	0	0	1	0.06	0.25
0.0	75.0	83.3	91.7	91.7	91.7	91.7	91.7	91.7	100.0
mcr-positive Enterobacterales (75)		0	6	61	8							0.12	0.25
0.0	8.0	89.3	100.0
colistin-resistant, mcr-negative K. pneumoniae (24)			0	1	7	11	2	2	1			0.5	2
0.0	4.2	33.3	79.2	87.5	95.8	100.0
intrinsically resistant Enterobacterales (23)^b				0	1	1	2	2	1	0	16	>8	>8
0.0	4.3	8.7	17.4	26.1	30.4	30.4	100.0
P. aeruginosa
non-MDR isolates (52)			0	21	30	1						0.25	0.25
0.0	40.4	98.1	100.0
XDR isolates (102)		0	2	40	56	4						0.25	0.25
0.0	2.0	41.2	96.1	100.0
A. baumannii (105)	0	2	59	39	5							0.06	0.12
0.0	1.9	58.1	95.2	100.0
S. maltophilia (51)	0	7	22	11	11							0.06	0.25
0.0	13.7	56.9	78.4	100.0
H. influenzae (12)							0	6	6			2	4
0.0	50.0	100.0
M. catarrhalis (11)			0	4	7							0.25	0.25
0.0	36.4	100.0

Organism/organism group (no. of isolates)

Number and cumulative percentage of isolates inhibited at MIC (mg/L) of:

MIC₅₀ (mg/L)

MIC₉₀ (mg/L)

≤0.015

0.03

0.06

0.12

0.25

0.5

Enterobacterales

randomly selected, non-intrinsically resistant Enterobacterales (272)

148

0.06

0.25

0.0

54.4

86.4

98.2

99.3

100.0

CRE (53)

0.06

0.25

0.0

1.9

56.6

86.8

98.1

100.0

third-generation-cephalosporin- resistant, carbapenem-susceptible Enterobacterales (52)^a

0.06

0.12

0.0

61.5

94.2

98.1

100.0

ESBL-producing Enterobacterales (24)

0.06

0.12

0.0

66.7

95.8

100.0

KPC-producing Enterobacterales (23)

0.12

0.25

0.0

47.8

87.0

100.0

MBL-producing Enterobacterales (12)

0.06

0.25

0.0

75.0

83.3

91.7

100.0

mcr-positive Enterobacterales (75)

0.12

0.25

0.0

8.0

89.3

100.0

colistin-resistant, mcr-negative K. pneumoniae (24)

0.5

0.0

4.2

33.3

79.2

87.5

95.8

100.0

intrinsically resistant Enterobacterales (23)^b

0.0

4.3

8.7

17.4

26.1

30.4

100.0

P. aeruginosa

non-MDR isolates (52)

0.25

0.0

40.4

98.1

100.0

XDR isolates (102)

0.25

0.0

2.0

41.2

96.1

100.0

A. baumannii (105)

0.06

0.12

0.0

1.9

58.1

95.2

100.0

S. maltophilia (51)

0.06

0.25

0.0

13.7

56.9

78.4

100.0

H. influenzae (12)

0.0

50.0

100.0

M. catarrhalis (11)

0.25

0.0

36.4

100.0

Organism/organism group (no. of isolates)	Number and cumulative percentage of isolates inhibited at MIC (mg/L) of:	MIC₅₀ (mg/L)	MIC₉₀ (mg/L)
Enterobacterales
randomly selected, non-intrinsically resistant Enterobacterales (272)		0	148	87	32	3	2					0.06	0.25
0.0	54.4	86.4	98.2	99.3	100.0
CRE (53)	0	1	29	16	6	1						0.06	0.25
0.0	1.9	56.6	86.8	98.1	100.0
third-generation-cephalosporin- resistant, carbapenem-susceptible Enterobacterales (52)^a		0	32	17	2	1						0.06	0.12
0.0	61.5	94.2	98.1	100.0
ESBL-producing Enterobacterales (24)		0	16	7	1							0.06	0.12
0.0	66.7	95.8	100.0
KPC-producing Enterobacterales (23)		0	11	9	3							0.12	0.25
0.0	47.8	87.0	100.0
MBL-producing Enterobacterales (12)		0	9	1	1	0	0	0	0	0	1	0.06	0.25
0.0	75.0	83.3	91.7	91.7	91.7	91.7	91.7	91.7	100.0
mcr-positive Enterobacterales (75)		0	6	61	8							0.12	0.25
0.0	8.0	89.3	100.0
colistin-resistant, mcr-negative K. pneumoniae (24)			0	1	7	11	2	2	1			0.5	2
0.0	4.2	33.3	79.2	87.5	95.8	100.0
intrinsically resistant Enterobacterales (23)^b				0	1	1	2	2	1	0	16	>8	>8
0.0	4.3	8.7	17.4	26.1	30.4	30.4	100.0
P. aeruginosa
non-MDR isolates (52)			0	21	30	1						0.25	0.25
0.0	40.4	98.1	100.0
XDR isolates (102)		0	2	40	56	4						0.25	0.25
0.0	2.0	41.2	96.1	100.0
A. baumannii (105)	0	2	59	39	5							0.06	0.12
0.0	1.9	58.1	95.2	100.0
S. maltophilia (51)	0	7	22	11	11							0.06	0.25
0.0	13.7	56.9	78.4	100.0
H. influenzae (12)							0	6	6			2	4
0.0	50.0	100.0
M. catarrhalis (11)			0	4	7							0.25	0.25
0.0	36.4	100.0

Table 1.

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Antimicrobial activity of POL7306 tested against the main organisms and organism groups

Organism/organism group (no. of isolates)	Number and cumulative percentage of isolates inhibited at MIC (mg/L) of:											MIC₅₀ (mg/L)	MIC₉₀ (mg/L)
Organism/organism group (no. of isolates)	≤0.015	0.03	0.06	0.12	0.25	0.5	1	2	4	8	>8	MIC₅₀ (mg/L)	MIC₉₀ (mg/L)
Enterobacterales
randomly selected, non-intrinsically resistant Enterobacterales (272)		0	148	87	32	3	2					0.06	0.25
		0.0	54.4	86.4	98.2	99.3	100.0					0.06	0.25
CRE (53)	0	1	29	16	6	1						0.06	0.25
CRE (53)	0.0	1.9	56.6	86.8	98.1	100.0						0.06	0.25
third-generation-cephalosporin- resistant, carbapenem-susceptible Enterobacterales (52)^a		0	32	17	2	1						0.06	0.12
		0.0	61.5	94.2	98.1	100.0						0.06	0.12
ESBL-producing Enterobacterales (24)		0	16	7	1							0.06	0.12
ESBL-producing Enterobacterales (24)		0.0	66.7	95.8	100.0							0.06	0.12
KPC-producing Enterobacterales (23)		0	11	9	3							0.12	0.25
KPC-producing Enterobacterales (23)		0.0	47.8	87.0	100.0							0.12	0.25
MBL-producing Enterobacterales (12)		0	9	1	1	0	0	0	0	0	1	0.06	0.25
MBL-producing Enterobacterales (12)		0.0	75.0	83.3	91.7	91.7	91.7	91.7	91.7	91.7	100.0	0.06	0.25
mcr-positive Enterobacterales (75)		0	6	61	8							0.12	0.25
mcr-positive Enterobacterales (75)		0.0	8.0	89.3	100.0							0.12	0.25
colistin-resistant, mcr-negative K. pneumoniae (24)			0	1	7	11	2	2	1			0.5	2
colistin-resistant, mcr-negative K. pneumoniae (24)			0.0	4.2	33.3	79.2	87.5	95.8	100.0			0.5	2
intrinsically resistant Enterobacterales (23)^b				0	1	1	2	2	1	0	16	>8	>8
intrinsically resistant Enterobacterales (23)^b				0.0	4.3	8.7	17.4	26.1	30.4	30.4	100.0	>8	>8
P. aeruginosa
non-MDR isolates (52)			0	21	30	1						0.25	0.25
non-MDR isolates (52)			0.0	40.4	98.1	100.0						0.25	0.25
XDR isolates (102)		0	2	40	56	4						0.25	0.25
XDR isolates (102)		0.0	2.0	41.2	96.1	100.0						0.25	0.25
A. baumannii (105)	0	2	59	39	5							0.06	0.12
A. baumannii (105)	0.0	1.9	58.1	95.2	100.0							0.06	0.12
S. maltophilia (51)	0	7	22	11	11							0.06	0.25
S. maltophilia (51)	0.0	13.7	56.9	78.4	100.0							0.06	0.25
H. influenzae (12)							0	6	6			2	4
H. influenzae (12)							0.0	50.0	100.0			2	4
M. catarrhalis (11)			0	4	7							0.25	0.25
M. catarrhalis (11)			0.0	36.4	100.0							0.25	0.25

Organism/organism group (no. of isolates)	Number and cumulative percentage of isolates inhibited at MIC (mg/L) of:											MIC₅₀ (mg/L)	MIC₉₀ (mg/L)
Organism/organism group (no. of isolates)	≤0.015	0.03	0.06	0.12	0.25	0.5	1	2	4	8	>8	MIC₅₀ (mg/L)	MIC₉₀ (mg/L)
Enterobacterales
randomly selected, non-intrinsically resistant Enterobacterales (272)		0	148	87	32	3	2					0.06	0.25
		0.0	54.4	86.4	98.2	99.3	100.0					0.06	0.25
CRE (53)	0	1	29	16	6	1						0.06	0.25
CRE (53)	0.0	1.9	56.6	86.8	98.1	100.0						0.06	0.25
third-generation-cephalosporin- resistant, carbapenem-susceptible Enterobacterales (52)^a		0	32	17	2	1						0.06	0.12
		0.0	61.5	94.2	98.1	100.0						0.06	0.12
ESBL-producing Enterobacterales (24)		0	16	7	1							0.06	0.12
ESBL-producing Enterobacterales (24)		0.0	66.7	95.8	100.0							0.06	0.12
KPC-producing Enterobacterales (23)		0	11	9	3							0.12	0.25
KPC-producing Enterobacterales (23)		0.0	47.8	87.0	100.0							0.12	0.25
MBL-producing Enterobacterales (12)		0	9	1	1	0	0	0	0	0	1	0.06	0.25
MBL-producing Enterobacterales (12)		0.0	75.0	83.3	91.7	91.7	91.7	91.7	91.7	91.7	100.0	0.06	0.25
mcr-positive Enterobacterales (75)		0	6	61	8							0.12	0.25
mcr-positive Enterobacterales (75)		0.0	8.0	89.3	100.0							0.12	0.25
colistin-resistant, mcr-negative K. pneumoniae (24)			0	1	7	11	2	2	1			0.5	2
colistin-resistant, mcr-negative K. pneumoniae (24)			0.0	4.2	33.3	79.2	87.5	95.8	100.0			0.5	2
intrinsically resistant Enterobacterales (23)^b				0	1	1	2	2	1	0	16	>8	>8
intrinsically resistant Enterobacterales (23)^b				0.0	4.3	8.7	17.4	26.1	30.4	30.4	100.0	>8	>8
P. aeruginosa
non-MDR isolates (52)			0	21	30	1						0.25	0.25
non-MDR isolates (52)			0.0	40.4	98.1	100.0						0.25	0.25
XDR isolates (102)		0	2	40	56	4						0.25	0.25
XDR isolates (102)		0.0	2.0	41.2	96.1	100.0						0.25	0.25
A. baumannii (105)	0	2	59	39	5							0.06	0.12
A. baumannii (105)	0.0	1.9	58.1	95.2	100.0							0.06	0.12
S. maltophilia (51)	0	7	22	11	11							0.06	0.25
S. maltophilia (51)	0.0	13.7	56.9	78.4	100.0							0.06	0.25
H. influenzae (12)							0	6	6			2	4
H. influenzae (12)							0.0	50.0	100.0			2	4
M. catarrhalis (11)			0	4	7							0.25	0.25
M. catarrhalis (11)			0.0	36.4	100.0							0.25	0.25

Isolates resistant to ceftriaxone and ceftazidime, and susceptible to meropenem and imipenem.

Includes M. morganii (5), P. mirabilis (4), P. vulgaris (1), P. vulgaris group (1), P. rettgeri (3), P. stuartii (1), S. liquefaciens (1), S. marcescens (5), S. rubidaea (1) and unspeciated Providencia (1).

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