Table 2.
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MICs (mg/L) of EC958 mutants against cephalosporins

StrainCTXFOXCAZFEPCPT
EC9581232160.756
Δslt12483–40.38–0.53–6
ΔtatB4–632–482–30.19–0.251.5–2
ΔenvC12482–40.56
ΔblaCMY-230.75–180.25–0.380.38–0.50.75–2
ΔampG8–123240.38–0.53–4
ΔdacA6–824–3230.19–0.383
ΔyfiH832–4830.25–0.382–3
ΔftsP6–84820.252
ΔtatC632–482–30.252
ΔuvrA12–16323–40.753–6
ΔmrcB12323–40.53–4
ΔdamX164840.756
StrainCTXFOXCAZFEPCPT
EC9581232160.756
Δslt12483–40.38–0.53–6
ΔtatB4–632–482–30.19–0.251.5–2
ΔenvC12482–40.56
ΔblaCMY-230.75–180.25–0.380.38–0.50.75–2
ΔampG8–123240.38–0.53–4
ΔdacA6–824–3230.19–0.383
ΔyfiH832–4830.25–0.382–3
ΔftsP6–84820.252
ΔtatC632–482–30.252
ΔuvrA12–16323–40.753–6
ΔmrcB12323–40.53–4
ΔdamX164840.756

Bold text indicates a significant change compared with WT EC958.

CTX, cefotaxime; FOX, cefoxitin; CAZ, ceftazidime; FEP, cefepime; CPT, ceftaroline.

Table 2.
Open in new tab

MICs (mg/L) of EC958 mutants against cephalosporins

StrainCTXFOXCAZFEPCPT
EC9581232160.756
Δslt12483–40.38–0.53–6
ΔtatB4–632–482–30.19–0.251.5–2
ΔenvC12482–40.56
ΔblaCMY-230.75–180.25–0.380.38–0.50.75–2
ΔampG8–123240.38–0.53–4
ΔdacA6–824–3230.19–0.383
ΔyfiH832–4830.25–0.382–3
ΔftsP6–84820.252
ΔtatC632–482–30.252
ΔuvrA12–16323–40.753–6
ΔmrcB12323–40.53–4
ΔdamX164840.756
StrainCTXFOXCAZFEPCPT
EC9581232160.756
Δslt12483–40.38–0.53–6
ΔtatB4–632–482–30.19–0.251.5–2
ΔenvC12482–40.56
ΔblaCMY-230.75–180.25–0.380.38–0.50.75–2
ΔampG8–123240.38–0.53–4
ΔdacA6–824–3230.19–0.383
ΔyfiH832–4830.25–0.382–3
ΔftsP6–84820.252
ΔtatC632–482–30.252
ΔuvrA12–16323–40.753–6
ΔmrcB12323–40.53–4
ΔdamX164840.756

Bold text indicates a significant change compared with WT EC958.

CTX, cefotaxime; FOX, cefoxitin; CAZ, ceftazidime; FEP, cefepime; CPT, ceftaroline.

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