| . | 5 hours . | 6 hours . | 7 hours . | 8 hours . | F test p-value . |
|---|---|---|---|---|---|
| N (%) | 29 (4.7%) | 228 (37.2%) | 278 (45.3%) | 78 (12.7%) | |
| Demographics | |||||
| Age | 69.20 ± 5.38 | 69.36 ± 4.93 | 69.62 ± 4.98 | 70.44 ± 5.40 | 0.404 |
| Gender—N (%) female | 10 (34.48) | 45 (19.74) | 50 (17.99) | 12 (15.38) | 0.142 |
| Education | 2.79 ± 0.86 | 3.46 ± 1.11 | 3.59 ± 1.00 | 3.73 ± 1.09 | <0.001* |
| Tissue types | |||||
| GM (%) | 38.59 ± 2.16 | 38.42 ± 1.87 | 38.43 ± 1.91 | 38.17 ± 1.99 | 0.666 |
| WM (%) | 38.21 ± 2.52 | 37.75 ± 2.35 | 37.87 ± 2.30 | 37.94 ± 2.30 | 0.686 |
| CSF (%) | 23.21 ± 3.45 | 23.83 ± 3.11 | 23.70 ± 3.00 | 23.89 ± 3.26 | 0.865 |
| White matter | |||||
| FA | 0.478 ± 0.018 | 0.479 ± 0.019 | 0.479 ± 0.018 | 0.481 ± 0.021 | 0.625 |
| AD (×103) | 1.084 ± 0.021 | 1.080 ± 0.023 | 1.083 ± 0.026 | 1.082 ± 0.025 | 0.512 |
| RD (×103) | 0.488 ± 0.026 | 0.485 ± 0.027 | 0.487 ± 0.028 | 0.485 ± 0.031 | 0.625 |
| . | 5 hours . | 6 hours . | 7 hours . | 8 hours . | F test p-value . |
|---|---|---|---|---|---|
| N (%) | 29 (4.7%) | 228 (37.2%) | 278 (45.3%) | 78 (12.7%) | |
| Demographics | |||||
| Age | 69.20 ± 5.38 | 69.36 ± 4.93 | 69.62 ± 4.98 | 70.44 ± 5.40 | 0.404 |
| Gender—N (%) female | 10 (34.48) | 45 (19.74) | 50 (17.99) | 12 (15.38) | 0.142 |
| Education | 2.79 ± 0.86 | 3.46 ± 1.11 | 3.59 ± 1.00 | 3.73 ± 1.09 | <0.001* |
| Tissue types | |||||
| GM (%) | 38.59 ± 2.16 | 38.42 ± 1.87 | 38.43 ± 1.91 | 38.17 ± 1.99 | 0.666 |
| WM (%) | 38.21 ± 2.52 | 37.75 ± 2.35 | 37.87 ± 2.30 | 37.94 ± 2.30 | 0.686 |
| CSF (%) | 23.21 ± 3.45 | 23.83 ± 3.11 | 23.70 ± 3.00 | 23.89 ± 3.26 | 0.865 |
| White matter | |||||
| FA | 0.478 ± 0.018 | 0.479 ± 0.019 | 0.479 ± 0.018 | 0.481 ± 0.021 | 0.625 |
| AD (×103) | 1.084 ± 0.021 | 1.080 ± 0.023 | 1.083 ± 0.026 | 1.082 ± 0.025 | 0.512 |
| RD (×103) | 0.488 ± 0.026 | 0.485 ± 0.027 | 0.487 ± 0.028 | 0.485 ± 0.031 | 0.625 |
Figures are means, unless otherwise stated. * 5 < 6, 7, 8 in post hoc t-tests. RD: radial diffusivity. Age, gender, education, and scanner were included as covariates in analyses of MRI outcomes. Education was scored on a five-point scale: (1) no qualifications, (2) O-levels or equivalent, (3) A-levels, college certificate or professional qualification, (4) degree, and (5) higher degree. AD = axial diffusivity, , CSF: cerebrospinal fluid, FA = fractional anisotropy, GM = gray matter, WM = white matter.
| . | 5 hours . | 6 hours . | 7 hours . | 8 hours . | F test p-value . |
|---|---|---|---|---|---|
| N (%) | 29 (4.7%) | 228 (37.2%) | 278 (45.3%) | 78 (12.7%) | |
| Demographics | |||||
| Age | 69.20 ± 5.38 | 69.36 ± 4.93 | 69.62 ± 4.98 | 70.44 ± 5.40 | 0.404 |
| Gender—N (%) female | 10 (34.48) | 45 (19.74) | 50 (17.99) | 12 (15.38) | 0.142 |
| Education | 2.79 ± 0.86 | 3.46 ± 1.11 | 3.59 ± 1.00 | 3.73 ± 1.09 | <0.001* |
| Tissue types | |||||
| GM (%) | 38.59 ± 2.16 | 38.42 ± 1.87 | 38.43 ± 1.91 | 38.17 ± 1.99 | 0.666 |
| WM (%) | 38.21 ± 2.52 | 37.75 ± 2.35 | 37.87 ± 2.30 | 37.94 ± 2.30 | 0.686 |
| CSF (%) | 23.21 ± 3.45 | 23.83 ± 3.11 | 23.70 ± 3.00 | 23.89 ± 3.26 | 0.865 |
| White matter | |||||
| FA | 0.478 ± 0.018 | 0.479 ± 0.019 | 0.479 ± 0.018 | 0.481 ± 0.021 | 0.625 |
| AD (×103) | 1.084 ± 0.021 | 1.080 ± 0.023 | 1.083 ± 0.026 | 1.082 ± 0.025 | 0.512 |
| RD (×103) | 0.488 ± 0.026 | 0.485 ± 0.027 | 0.487 ± 0.028 | 0.485 ± 0.031 | 0.625 |
| . | 5 hours . | 6 hours . | 7 hours . | 8 hours . | F test p-value . |
|---|---|---|---|---|---|
| N (%) | 29 (4.7%) | 228 (37.2%) | 278 (45.3%) | 78 (12.7%) | |
| Demographics | |||||
| Age | 69.20 ± 5.38 | 69.36 ± 4.93 | 69.62 ± 4.98 | 70.44 ± 5.40 | 0.404 |
| Gender—N (%) female | 10 (34.48) | 45 (19.74) | 50 (17.99) | 12 (15.38) | 0.142 |
| Education | 2.79 ± 0.86 | 3.46 ± 1.11 | 3.59 ± 1.00 | 3.73 ± 1.09 | <0.001* |
| Tissue types | |||||
| GM (%) | 38.59 ± 2.16 | 38.42 ± 1.87 | 38.43 ± 1.91 | 38.17 ± 1.99 | 0.666 |
| WM (%) | 38.21 ± 2.52 | 37.75 ± 2.35 | 37.87 ± 2.30 | 37.94 ± 2.30 | 0.686 |
| CSF (%) | 23.21 ± 3.45 | 23.83 ± 3.11 | 23.70 ± 3.00 | 23.89 ± 3.26 | 0.865 |
| White matter | |||||
| FA | 0.478 ± 0.018 | 0.479 ± 0.019 | 0.479 ± 0.018 | 0.481 ± 0.021 | 0.625 |
| AD (×103) | 1.084 ± 0.021 | 1.080 ± 0.023 | 1.083 ± 0.026 | 1.082 ± 0.025 | 0.512 |
| RD (×103) | 0.488 ± 0.026 | 0.485 ± 0.027 | 0.487 ± 0.028 | 0.485 ± 0.031 | 0.625 |
Figures are means, unless otherwise stated. * 5 < 6, 7, 8 in post hoc t-tests. RD: radial diffusivity. Age, gender, education, and scanner were included as covariates in analyses of MRI outcomes. Education was scored on a five-point scale: (1) no qualifications, (2) O-levels or equivalent, (3) A-levels, college certificate or professional qualification, (4) degree, and (5) higher degree. AD = axial diffusivity, , CSF: cerebrospinal fluid, FA = fractional anisotropy, GM = gray matter, WM = white matter.
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