Table 1: Open in new tab Clinical...

Variables	Overall (n = 281)	With AIS (n = 103)	Without AIS (n = 178)	P-value
Demographics
Age (years)	50 (43–57)	52 (46–58)	49 (42–56)	0.021^a
<40	46 (16.4)	11 (10.7)	35 (19.7)	0.065
>60	48 (17.1)	20 (19.4)	28 (15.7)	0.51
Male	217 (77.2)	73 (70.9)	144 (80.9)	1.00
Medical history
Hypertension	178 (63.3)	71 (68.9)	107 (60.1)	0.16
Smoking	42 (14.9)	14 (13.6)	28 (15.7)	0.63
Marfan syndrome	2 (0.7)	1 (1.0)	1 (0.6)	1.00
Diabetes mellitus	4 (1.4)	2 (1.9)	2 (1.1)	1.00
Coronary artery disease	15 (5.3)	4 (3.9)	11 (6.2)	0.41
Bicuspid aortic valve	7 (2.5)	4 (3.9)	3 (1.7)	0.26
Aortic valve insufficiency (moderate or severe)	53 (18.9)	27 (26.2)	26 (14.6)	0.017^b
Presenting symptoms and signs
Chest pain	55 (19.6)	19 (18.4)	36 (20.2)	0.72
Back pain	39 (13.9)	13 (12.6)	26 (14.6)	0.89
Chest and back pain	98 (34.9)	29 (28.2)	69 (38.8)	0.13
Abdominal pain	58 (20.6)	23 (22.3)	35 (19.7)	0.60
Mean SBP (mmHg)	134.9 ± 32.4	133.5 ± 35.8	135.0 ± 30.3	0.574
Mean DBP (mmHg)	72.7 ± 21.2	72.1 ± 23.1	73.0 ± 20.0	0.745
Syncope	22 (7.8)	6 (5.8)	16 (9.0)	0.34
Hypotension/tamponade/shock	22 (7.8)	12 (11.7)	10 (5.6)	0.070
The interval from symptoms to presentation (h)	10 (5–24)	14 (7–48)	9.5 (5–20)	0.25
The interval from symptoms to diagnosis (h)	12.3 (7–25)	15.9 (8–48)	11 (6–22)	0.19

Variables

Overall (n = 281)

With AIS (n = 103)

Without AIS (n = 178)

P-value

Demographics

Age (years)

50 (43–57)

52 (46–58)

49 (42–56)

0.021^a

<40

46 (16.4)

11 (10.7)

35 (19.7)

0.065

>60

48 (17.1)

20 (19.4)

28 (15.7)

0.51

Male

217 (77.2)

73 (70.9)

144 (80.9)

1.00

Medical history

Hypertension

178 (63.3)

71 (68.9)

107 (60.1)

0.16

Smoking

42 (14.9)

14 (13.6)

28 (15.7)

0.63

Marfan syndrome

2 (0.7)

1 (1.0)

1 (0.6)

1.00

Diabetes mellitus

4 (1.4)

2 (1.9)

2 (1.1)

1.00

Coronary artery disease

15 (5.3)

4 (3.9)

11 (6.2)

0.41

Bicuspid aortic valve

7 (2.5)

4 (3.9)

3 (1.7)

0.26

Aortic valve insufficiency (moderate or severe)

53 (18.9)

27 (26.2)

26 (14.6)

0.017^b

Presenting symptoms and signs

Chest pain

55 (19.6)

19 (18.4)

36 (20.2)

0.72

Back pain

39 (13.9)

13 (12.6)

26 (14.6)

0.89

Chest and back pain

98 (34.9)

29 (28.2)

69 (38.8)

0.13

Abdominal pain

58 (20.6)

23 (22.3)

35 (19.7)

0.60

Mean SBP (mmHg)

134.9 ± 32.4

133.5 ± 35.8

135.0 ± 30.3

0.574

Mean DBP (mmHg)

72.7 ± 21.2

72.1 ± 23.1

73.0 ± 20.0

0.745

Syncope

22 (7.8)

6 (5.8)

16 (9.0)

0.34

Hypotension/tamponade/shock

22 (7.8)

12 (11.7)

10 (5.6)

0.070

The interval from symptoms to presentation (h)

10 (5–24)

14 (7–48)

9.5 (5–20)

0.25

The interval from symptoms to diagnosis (h)

12.3 (7–25)

15.9 (8–48)

11 (6–22)

0.19

Variables	Overall (n = 281)	With AIS (n = 103)	Without AIS (n = 178)	P-value
Demographics
Age (years)	50 (43–57)	52 (46–58)	49 (42–56)	0.021^a
<40	46 (16.4)	11 (10.7)	35 (19.7)	0.065
>60	48 (17.1)	20 (19.4)	28 (15.7)	0.51
Male	217 (77.2)	73 (70.9)	144 (80.9)	1.00
Medical history
Hypertension	178 (63.3)	71 (68.9)	107 (60.1)	0.16
Smoking	42 (14.9)	14 (13.6)	28 (15.7)	0.63
Marfan syndrome	2 (0.7)	1 (1.0)	1 (0.6)	1.00
Diabetes mellitus	4 (1.4)	2 (1.9)	2 (1.1)	1.00
Coronary artery disease	15 (5.3)	4 (3.9)	11 (6.2)	0.41
Bicuspid aortic valve	7 (2.5)	4 (3.9)	3 (1.7)	0.26
Aortic valve insufficiency (moderate or severe)	53 (18.9)	27 (26.2)	26 (14.6)	0.017^b
Presenting symptoms and signs
Chest pain	55 (19.6)	19 (18.4)	36 (20.2)	0.72
Back pain	39 (13.9)	13 (12.6)	26 (14.6)	0.89
Chest and back pain	98 (34.9)	29 (28.2)	69 (38.8)	0.13
Abdominal pain	58 (20.6)	23 (22.3)	35 (19.7)	0.60
Mean SBP (mmHg)	134.9 ± 32.4	133.5 ± 35.8	135.0 ± 30.3	0.574
Mean DBP (mmHg)	72.7 ± 21.2	72.1 ± 23.1	73.0 ± 20.0	0.745
Syncope	22 (7.8)	6 (5.8)	16 (9.0)	0.34
Hypotension/tamponade/shock	22 (7.8)	12 (11.7)	10 (5.6)	0.070
The interval from symptoms to presentation (h)	10 (5–24)	14 (7–48)	9.5 (5–20)	0.25
The interval from symptoms to diagnosis (h)	12.3 (7–25)	15.9 (8–48)	11 (6–22)	0.19

Table 1:

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Clinical characteristics of patients with acute type A aortic dissection with and without AIS

Variables	Overall (n = 281)	With AIS (n = 103)	Without AIS (n = 178)	P-value
Demographics
Age (years)	50 (43–57)	52 (46–58)	49 (42–56)	0.021^a
<40	46 (16.4)	11 (10.7)	35 (19.7)	0.065
>60	48 (17.1)	20 (19.4)	28 (15.7)	0.51
Male	217 (77.2)	73 (70.9)	144 (80.9)	1.00
Medical history
Hypertension	178 (63.3)	71 (68.9)	107 (60.1)	0.16
Smoking	42 (14.9)	14 (13.6)	28 (15.7)	0.63
Marfan syndrome	2 (0.7)	1 (1.0)	1 (0.6)	1.00
Diabetes mellitus	4 (1.4)	2 (1.9)	2 (1.1)	1.00
Coronary artery disease	15 (5.3)	4 (3.9)	11 (6.2)	0.41
Bicuspid aortic valve	7 (2.5)	4 (3.9)	3 (1.7)	0.26
Aortic valve insufficiency (moderate or severe)	53 (18.9)	27 (26.2)	26 (14.6)	0.017^b
Presenting symptoms and signs
Chest pain	55 (19.6)	19 (18.4)	36 (20.2)	0.72
Back pain	39 (13.9)	13 (12.6)	26 (14.6)	0.89
Chest and back pain	98 (34.9)	29 (28.2)	69 (38.8)	0.13
Abdominal pain	58 (20.6)	23 (22.3)	35 (19.7)	0.60
Mean SBP (mmHg)	134.9 ± 32.4	133.5 ± 35.8	135.0 ± 30.3	0.574
Mean DBP (mmHg)	72.7 ± 21.2	72.1 ± 23.1	73.0 ± 20.0	0.745
Syncope	22 (7.8)	6 (5.8)	16 (9.0)	0.34
Hypotension/tamponade/shock	22 (7.8)	12 (11.7)	10 (5.6)	0.070
The interval from symptoms to presentation (h)	10 (5–24)	14 (7–48)	9.5 (5–20)	0.25
The interval from symptoms to diagnosis (h)	12.3 (7–25)	15.9 (8–48)	11 (6–22)	0.19

Variables	Overall (n = 281)	With AIS (n = 103)	Without AIS (n = 178)	P-value
Demographics
Age (years)	50 (43–57)	52 (46–58)	49 (42–56)	0.021^a
<40	46 (16.4)	11 (10.7)	35 (19.7)	0.065
>60	48 (17.1)	20 (19.4)	28 (15.7)	0.51
Male	217 (77.2)	73 (70.9)	144 (80.9)	1.00
Medical history
Hypertension	178 (63.3)	71 (68.9)	107 (60.1)	0.16
Smoking	42 (14.9)	14 (13.6)	28 (15.7)	0.63
Marfan syndrome	2 (0.7)	1 (1.0)	1 (0.6)	1.00
Diabetes mellitus	4 (1.4)	2 (1.9)	2 (1.1)	1.00
Coronary artery disease	15 (5.3)	4 (3.9)	11 (6.2)	0.41
Bicuspid aortic valve	7 (2.5)	4 (3.9)	3 (1.7)	0.26
Aortic valve insufficiency (moderate or severe)	53 (18.9)	27 (26.2)	26 (14.6)	0.017^b
Presenting symptoms and signs
Chest pain	55 (19.6)	19 (18.4)	36 (20.2)	0.72
Back pain	39 (13.9)	13 (12.6)	26 (14.6)	0.89
Chest and back pain	98 (34.9)	29 (28.2)	69 (38.8)	0.13
Abdominal pain	58 (20.6)	23 (22.3)	35 (19.7)	0.60
Mean SBP (mmHg)	134.9 ± 32.4	133.5 ± 35.8	135.0 ± 30.3	0.574
Mean DBP (mmHg)	72.7 ± 21.2	72.1 ± 23.1	73.0 ± 20.0	0.745
Syncope	22 (7.8)	6 (5.8)	16 (9.0)	0.34
Hypotension/tamponade/shock	22 (7.8)	12 (11.7)	10 (5.6)	0.070
The interval from symptoms to presentation (h)	10 (5–24)	14 (7–48)	9.5 (5–20)	0.25
The interval from symptoms to diagnosis (h)	12.3 (7–25)	15.9 (8–48)	11 (6–22)	0.19

Results are represented as n (%), mean ± SD or medians with first and third quartiles.

P-value based on the non-parametric Mann–Whitney test.

P-value based on the Fisher’s exact test.

AIS: acute ischaemic stroke; DBP: diastolic blood pressure; SBP: systolic blood pressure.

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