Multivariable Cox hazard analysis of variables predicting mortality within 1-year post-implantation
| Variables . | HR . | 95% CI lower . | 95% CI upper . | P-value . |
|---|---|---|---|---|
| Age (years) | 1.031 | 1.007 | 1.054 | 0.01 |
| Male gender | 1.541 | 0.77 | 3.084 | 0.222 |
| Body mass index (kg/m2) | 1.033 | 1.013 | 1.053 | 0.001 |
| CABG | 0.899 | 0.443 | 1.826 | 0.769 |
| IABP | 0.83 | 0.431 | 1.602 | 0.579 |
| INTERMACS | ||||
| Profile 1 | 4.698 | 1.452 | 15.205 | 0.01 |
| Profile 2 | 2.809 | 1.002 | 7.877 | 0.05 |
| Profile 3 | 1.941 | 0.644 | 5.853 | 0.239 |
| Profile 4 and up | 1 | |||
| Indication | ||||
| Bridge-to-transplant | 1 | |||
| Destination therapy | 2.673 | 1.563 | 4.57 | <0.001 |
| Device type | ||||
| HeartMate II | 4.33 | 0.965 | 19.433 | 0.056 |
| HVAD | 2.453 | 0.451 | 13.343 | 0.299 |
| HeartMate 3 | 1.00 | |||
| Laboratory data (mg/dl) | ||||
| Creatinine (per unit increase) | 1.13 | 0.753 | 1.695 | 0.556 |
| Total bilirubin (per unit increase) | 1.066 | 0.945 | 1.203 | 0.297 |
| Albumin (per unit decrease) | 0.601 | 0.383 | 0.944 | 0.027 |
| INR (per unit increase) | 1.201 | 0.917 | 1.573 | 0.183 |
| MELD (per unit increase) | 0.988 | 0.891 | 1.096 | 0.826 |
| MELD <12.6 | 1 | |||
| MELD ≥12.6 | 3.211 | 1.25 | 8.25 | 0.015 |
| Variables . | HR . | 95% CI lower . | 95% CI upper . | P-value . |
|---|---|---|---|---|
| Age (years) | 1.031 | 1.007 | 1.054 | 0.01 |
| Male gender | 1.541 | 0.77 | 3.084 | 0.222 |
| Body mass index (kg/m2) | 1.033 | 1.013 | 1.053 | 0.001 |
| CABG | 0.899 | 0.443 | 1.826 | 0.769 |
| IABP | 0.83 | 0.431 | 1.602 | 0.579 |
| INTERMACS | ||||
| Profile 1 | 4.698 | 1.452 | 15.205 | 0.01 |
| Profile 2 | 2.809 | 1.002 | 7.877 | 0.05 |
| Profile 3 | 1.941 | 0.644 | 5.853 | 0.239 |
| Profile 4 and up | 1 | |||
| Indication | ||||
| Bridge-to-transplant | 1 | |||
| Destination therapy | 2.673 | 1.563 | 4.57 | <0.001 |
| Device type | ||||
| HeartMate II | 4.33 | 0.965 | 19.433 | 0.056 |
| HVAD | 2.453 | 0.451 | 13.343 | 0.299 |
| HeartMate 3 | 1.00 | |||
| Laboratory data (mg/dl) | ||||
| Creatinine (per unit increase) | 1.13 | 0.753 | 1.695 | 0.556 |
| Total bilirubin (per unit increase) | 1.066 | 0.945 | 1.203 | 0.297 |
| Albumin (per unit decrease) | 0.601 | 0.383 | 0.944 | 0.027 |
| INR (per unit increase) | 1.201 | 0.917 | 1.573 | 0.183 |
| MELD (per unit increase) | 0.988 | 0.891 | 1.096 | 0.826 |
| MELD <12.6 | 1 | |||
| MELD ≥12.6 | 3.211 | 1.25 | 8.25 | 0.015 |
CABG: coronary artery bypass graft; CI: confidence interval; HR: hazard ratio; IABP: intra-aortic balloon pump; INR: international normalized ratio; INTERMACS: interagency registry for mechanically assisted circulatory support; MELD: Model for End-stage Liver Disease.
Multivariable Cox hazard analysis of variables predicting mortality within 1-year post-implantation
| Variables . | HR . | 95% CI lower . | 95% CI upper . | P-value . |
|---|---|---|---|---|
| Age (years) | 1.031 | 1.007 | 1.054 | 0.01 |
| Male gender | 1.541 | 0.77 | 3.084 | 0.222 |
| Body mass index (kg/m2) | 1.033 | 1.013 | 1.053 | 0.001 |
| CABG | 0.899 | 0.443 | 1.826 | 0.769 |
| IABP | 0.83 | 0.431 | 1.602 | 0.579 |
| INTERMACS | ||||
| Profile 1 | 4.698 | 1.452 | 15.205 | 0.01 |
| Profile 2 | 2.809 | 1.002 | 7.877 | 0.05 |
| Profile 3 | 1.941 | 0.644 | 5.853 | 0.239 |
| Profile 4 and up | 1 | |||
| Indication | ||||
| Bridge-to-transplant | 1 | |||
| Destination therapy | 2.673 | 1.563 | 4.57 | <0.001 |
| Device type | ||||
| HeartMate II | 4.33 | 0.965 | 19.433 | 0.056 |
| HVAD | 2.453 | 0.451 | 13.343 | 0.299 |
| HeartMate 3 | 1.00 | |||
| Laboratory data (mg/dl) | ||||
| Creatinine (per unit increase) | 1.13 | 0.753 | 1.695 | 0.556 |
| Total bilirubin (per unit increase) | 1.066 | 0.945 | 1.203 | 0.297 |
| Albumin (per unit decrease) | 0.601 | 0.383 | 0.944 | 0.027 |
| INR (per unit increase) | 1.201 | 0.917 | 1.573 | 0.183 |
| MELD (per unit increase) | 0.988 | 0.891 | 1.096 | 0.826 |
| MELD <12.6 | 1 | |||
| MELD ≥12.6 | 3.211 | 1.25 | 8.25 | 0.015 |
| Variables . | HR . | 95% CI lower . | 95% CI upper . | P-value . |
|---|---|---|---|---|
| Age (years) | 1.031 | 1.007 | 1.054 | 0.01 |
| Male gender | 1.541 | 0.77 | 3.084 | 0.222 |
| Body mass index (kg/m2) | 1.033 | 1.013 | 1.053 | 0.001 |
| CABG | 0.899 | 0.443 | 1.826 | 0.769 |
| IABP | 0.83 | 0.431 | 1.602 | 0.579 |
| INTERMACS | ||||
| Profile 1 | 4.698 | 1.452 | 15.205 | 0.01 |
| Profile 2 | 2.809 | 1.002 | 7.877 | 0.05 |
| Profile 3 | 1.941 | 0.644 | 5.853 | 0.239 |
| Profile 4 and up | 1 | |||
| Indication | ||||
| Bridge-to-transplant | 1 | |||
| Destination therapy | 2.673 | 1.563 | 4.57 | <0.001 |
| Device type | ||||
| HeartMate II | 4.33 | 0.965 | 19.433 | 0.056 |
| HVAD | 2.453 | 0.451 | 13.343 | 0.299 |
| HeartMate 3 | 1.00 | |||
| Laboratory data (mg/dl) | ||||
| Creatinine (per unit increase) | 1.13 | 0.753 | 1.695 | 0.556 |
| Total bilirubin (per unit increase) | 1.066 | 0.945 | 1.203 | 0.297 |
| Albumin (per unit decrease) | 0.601 | 0.383 | 0.944 | 0.027 |
| INR (per unit increase) | 1.201 | 0.917 | 1.573 | 0.183 |
| MELD (per unit increase) | 0.988 | 0.891 | 1.096 | 0.826 |
| MELD <12.6 | 1 | |||
| MELD ≥12.6 | 3.211 | 1.25 | 8.25 | 0.015 |
CABG: coronary artery bypass graft; CI: confidence interval; HR: hazard ratio; IABP: intra-aortic balloon pump; INR: international normalized ratio; INTERMACS: interagency registry for mechanically assisted circulatory support; MELD: Model for End-stage Liver Disease.
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