| Knowledge gaps . | Less than 10 case reports . | More than 11 case reports . | Limited knowledge (small trials or registries, but no RCT) . | Resolution of gap (in principle) feasible . | Upcoming trials in the field (Clinical Trial.gov) . |
|---|---|---|---|---|---|
| Impact of modern medical treatment on the utility of ICD therapy | One RCT (DANISH trial) | Conduction of large RCT feasible but with significant difficulties | EU-CERT-ICD (NCT02064192, prospective observational) | ||
| Device therapies for protection of patients with LVEF >35% but high individual risk for SCD | None | Personalized risk prediction needed, but in principle feasible | PRESERVE-EF (NCT02124018) | ||
| SMART-MI (NCT02594488) | |||||
| Role of subcutaneous ICD compared with the transvenous systems | Registries (EFFORTLESS and others) | RCT already being conducted | PRAETORIAN (NCT01296022) |
| Knowledge gaps . | Less than 10 case reports . | More than 11 case reports . | Limited knowledge (small trials or registries, but no RCT) . | Resolution of gap (in principle) feasible . | Upcoming trials in the field (Clinical Trial.gov) . |
|---|---|---|---|---|---|
| Impact of modern medical treatment on the utility of ICD therapy | One RCT (DANISH trial) | Conduction of large RCT feasible but with significant difficulties | EU-CERT-ICD (NCT02064192, prospective observational) | ||
| Device therapies for protection of patients with LVEF >35% but high individual risk for SCD | None | Personalized risk prediction needed, but in principle feasible | PRESERVE-EF (NCT02124018) | ||
| SMART-MI (NCT02594488) | |||||
| Role of subcutaneous ICD compared with the transvenous systems | Registries (EFFORTLESS and others) | RCT already being conducted | PRAETORIAN (NCT01296022) |
ICD, implantable cardioverter-defibrillator; LVEF, left ventricular ejection fraction; RCT, randomized controlled trial; SCD, sudden cardiac death; VT, ventricular tachycardia.
| Knowledge gaps . | Less than 10 case reports . | More than 11 case reports . | Limited knowledge (small trials or registries, but no RCT) . | Resolution of gap (in principle) feasible . | Upcoming trials in the field (Clinical Trial.gov) . |
|---|---|---|---|---|---|
| Impact of modern medical treatment on the utility of ICD therapy | One RCT (DANISH trial) | Conduction of large RCT feasible but with significant difficulties | EU-CERT-ICD (NCT02064192, prospective observational) | ||
| Device therapies for protection of patients with LVEF >35% but high individual risk for SCD | None | Personalized risk prediction needed, but in principle feasible | PRESERVE-EF (NCT02124018) | ||
| SMART-MI (NCT02594488) | |||||
| Role of subcutaneous ICD compared with the transvenous systems | Registries (EFFORTLESS and others) | RCT already being conducted | PRAETORIAN (NCT01296022) |
| Knowledge gaps . | Less than 10 case reports . | More than 11 case reports . | Limited knowledge (small trials or registries, but no RCT) . | Resolution of gap (in principle) feasible . | Upcoming trials in the field (Clinical Trial.gov) . |
|---|---|---|---|---|---|
| Impact of modern medical treatment on the utility of ICD therapy | One RCT (DANISH trial) | Conduction of large RCT feasible but with significant difficulties | EU-CERT-ICD (NCT02064192, prospective observational) | ||
| Device therapies for protection of patients with LVEF >35% but high individual risk for SCD | None | Personalized risk prediction needed, but in principle feasible | PRESERVE-EF (NCT02124018) | ||
| SMART-MI (NCT02594488) | |||||
| Role of subcutaneous ICD compared with the transvenous systems | Registries (EFFORTLESS and others) | RCT already being conducted | PRAETORIAN (NCT01296022) |
ICD, implantable cardioverter-defibrillator; LVEF, left ventricular ejection fraction; RCT, randomized controlled trial; SCD, sudden cardiac death; VT, ventricular tachycardia.
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