Table 3
Open in new tab

Summary of the main differences in EC in schizophrenia

Region 1 (a set of regions)Region 2z value of region 1 to 2 ECz value of region 2 to 1 ECEC of region 1 to 2 in HCEC of region 1 to 2 in SCZEC of region 2 to 1 in HCEC of region 2 to 1 in SCZ
Cingulate_Post_L, ParaHippocampal_L, Fusiform_L, Temporal_Sup_L, Temporal_Mid_L, Temporal_Sup_RCuneus_L−2.6530.5170.04140.03580.01790.0211
Fusiform_L, Temporal_Mid_L, Temporal_Pole_Mid_R, Temporal_Mid_R, Fusiform_R, ParaHippocampal_RCuneus_R−4.3150.7130.04870.03980.01300.0147
Temporal_Inf_R, Temporal_Pole_Mid_R, Thalamus_R, Precuneus_R, Cingulate_Post_RParaHippocampal_R2.720−0.4300.02150.02730.04780.0512
Frontal_Inf_Oper_L, Heschl_L, Temporal_Pole_Mid_LTemporal_Sup_L−4.789−0.8890.04600.03890.04300.0442
ParaHippocampal_L, Heschl_L, Temporal_Pole_Mid_L, Cingulate_Post_RTemporal_Mid_L−2.305−0.7990.03060.02870.03510.0367
Temporal_Pole_Mid_R, Heschl_R, Cingulate_Post_RTemporal_Mid_R−1.2940.7500.03420.03340.04130.0480
Temporal_Pole_Mid_R, Heschl_R, Amygdala_R, ParaHippocampal_R, Hippocampus_RTemporal_Pole_Sup_R−4.297−0.2920.04780.04210.03860.0408
Precuneus_L, Temporal_Pole_Mid_R, Heschl_R, Precuneus_R, Amygdala_RTemporal_Sup_R−0.990−0.7900.02860.02540.04270.0444
Rolandic_Oper_L, Calcarine_L, Precuneus_L, Temporal_Pole_Mid_L, Precuneus_RFusiform_L0.9600.2860.01870.01920.04110.0457
Precuneus_L, Temporal_Pole_Mid_R, ParaHippocampal_RFusiform_R−1.3572.2740.03500.03260.03050.0395
ParaHippocampal_L, Lingual_L, Fusiform_L, Paracentral_Lobule_L, Temporal_Sup_L, Temporal_Pole_Mid_L, Fusiform_R, Lingual_ROccipital_Sup_L−4.3330.3720.04680.03890.02530.0283
Temporal_Pole_Mid_R, Fusiform_R, ParaHippocampal_ROccipital_Sup_R−4.1010.0800.04680.03860.01700.0175
ParaHippocampal_L, Fusiform_L, Precuneus_L, Temporal_Pole_Mid_L, Precuneus_ROccipital_Mid_L−1.2322.2060.02890.02620.02740.0375
Precuneus_L, Temporal_Pole_Mid_R, Precuneus_R, Postcentral_R, ParaHippocampal_R, Precentral_ROccipital_Mid_R−1.3930.1330.03360.03070.02470.0292
ParaHippocampal_L, Fusiform_L, Temporal_Sup_L, Temporal_Pole_Mid_LLingual_L−4.752−0.4260.05690.04740.02460.0258
Fusiform_L, Temporal_Pole_Mid_R, Postcentral_R, Fusiform_R, ParaHippocampal_RLingual_R−4.555−0.3390.06570.05720.02270.0236
Fusiform_L, Temporal_Pole_Mid_R, Temporal_Sup_R, ParaHippocampal_RCalcarine_R−4.3511.4810.04750.03590.01450.0175
OFCmed_L, Temporal_Pole_Mid_R, ParaHippocampal_ROlfactory_R−3.650−1.3410.05440.04550.02600.0259
Supp_Motor_Area_L, Pallidum_R, Putamen_R, Supp_Motor_Area_RFrontal_Inf_Oper_R−4.316−2.0820.04190.03540.03190.0316
Pallidum_R, Putamen_R, SupraMarginal_R, ParaHippocampal_R, Supp_Motor_Area_R, Frontal_Inf_Tri_R, Frontal_Inf_Oper_RInsula_R−4.036−1.6710.04750.04200.03420.0331
Supp_Motor_Area_L, Frontal_Med_Orb_L, Paracentral_Lobule_L, Heschl_L, Paracentral_Lobule_R, Cingulate_Ant_R, Frontal_Sup_Medial_R, Supp_Motor_Area_RCingulate_Mid_L−3.916−0.0020.03860.03270.03800.0418
Cingulate_Mid_L, Putamen_R, Cingulate_Ant_R, Frontal_Sup_Medial_R, Supp_Motor_Area_RCingulate_Mid_R−2.181−0.7150.04420.04400.05800.0614
Precentral_L, Frontal_Sup_2_L, Postcentral_L, Precentral_RSupp_Motor_Area_L4.203−2.2690.05510.07400.03870.0379
Supp_Motor_Area_L, Paracentral_Lobule_L, Paracentral_Lobule_R, Occipital_Mid_R, Supp_Motor_Area_RPrecentral_R−4.8160.6890.04390.03630.07040.0810
Paracentral_Lobule_L, Paracentral_Lobule_R, Supp_Motor_Area_RPostcentral_R−5.0811.9510.05210.04510.05540.0686
Precentral_L, Supp_Motor_Area_L, Amygdala_L, Paracentral_Lobule_L, Heschl_L, Paracentral_Lobule_R, Supp_Motor_Area_RPostcentral_L−4.8301.5450.04840.04100.05220.0619
ParaHippocampal_L, Precuneus_L, Paracentral_Lobule_L, Paracentral_Lobule_R, Precuneus_RParietal_Sup_L−0.3500.7700.03360.03590.03360.0408
Cingulate_Ant_L, Putamen_L, Pallidum_L, Thalamus_R, Pallidum_RThalamus_L−4.402−1.4820.04620.03980.04030.0404
Cingulate_Ant_L, Putamen_L, Thalamus_L, Pallidum_RThalamus_R−4.476−2.4800.04330.03700.04650.0448
Region 1 (a set of regions)Region 2z value of region 1 to 2 ECz value of region 2 to 1 ECEC of region 1 to 2 in HCEC of region 1 to 2 in SCZEC of region 2 to 1 in HCEC of region 2 to 1 in SCZ
Cingulate_Post_L, ParaHippocampal_L, Fusiform_L, Temporal_Sup_L, Temporal_Mid_L, Temporal_Sup_RCuneus_L−2.6530.5170.04140.03580.01790.0211
Fusiform_L, Temporal_Mid_L, Temporal_Pole_Mid_R, Temporal_Mid_R, Fusiform_R, ParaHippocampal_RCuneus_R−4.3150.7130.04870.03980.01300.0147
Temporal_Inf_R, Temporal_Pole_Mid_R, Thalamus_R, Precuneus_R, Cingulate_Post_RParaHippocampal_R2.720−0.4300.02150.02730.04780.0512
Frontal_Inf_Oper_L, Heschl_L, Temporal_Pole_Mid_LTemporal_Sup_L−4.789−0.8890.04600.03890.04300.0442
ParaHippocampal_L, Heschl_L, Temporal_Pole_Mid_L, Cingulate_Post_RTemporal_Mid_L−2.305−0.7990.03060.02870.03510.0367
Temporal_Pole_Mid_R, Heschl_R, Cingulate_Post_RTemporal_Mid_R−1.2940.7500.03420.03340.04130.0480
Temporal_Pole_Mid_R, Heschl_R, Amygdala_R, ParaHippocampal_R, Hippocampus_RTemporal_Pole_Sup_R−4.297−0.2920.04780.04210.03860.0408
Precuneus_L, Temporal_Pole_Mid_R, Heschl_R, Precuneus_R, Amygdala_RTemporal_Sup_R−0.990−0.7900.02860.02540.04270.0444
Rolandic_Oper_L, Calcarine_L, Precuneus_L, Temporal_Pole_Mid_L, Precuneus_RFusiform_L0.9600.2860.01870.01920.04110.0457
Precuneus_L, Temporal_Pole_Mid_R, ParaHippocampal_RFusiform_R−1.3572.2740.03500.03260.03050.0395
ParaHippocampal_L, Lingual_L, Fusiform_L, Paracentral_Lobule_L, Temporal_Sup_L, Temporal_Pole_Mid_L, Fusiform_R, Lingual_ROccipital_Sup_L−4.3330.3720.04680.03890.02530.0283
Temporal_Pole_Mid_R, Fusiform_R, ParaHippocampal_ROccipital_Sup_R−4.1010.0800.04680.03860.01700.0175
ParaHippocampal_L, Fusiform_L, Precuneus_L, Temporal_Pole_Mid_L, Precuneus_ROccipital_Mid_L−1.2322.2060.02890.02620.02740.0375
Precuneus_L, Temporal_Pole_Mid_R, Precuneus_R, Postcentral_R, ParaHippocampal_R, Precentral_ROccipital_Mid_R−1.3930.1330.03360.03070.02470.0292
ParaHippocampal_L, Fusiform_L, Temporal_Sup_L, Temporal_Pole_Mid_LLingual_L−4.752−0.4260.05690.04740.02460.0258
Fusiform_L, Temporal_Pole_Mid_R, Postcentral_R, Fusiform_R, ParaHippocampal_RLingual_R−4.555−0.3390.06570.05720.02270.0236
Fusiform_L, Temporal_Pole_Mid_R, Temporal_Sup_R, ParaHippocampal_RCalcarine_R−4.3511.4810.04750.03590.01450.0175
OFCmed_L, Temporal_Pole_Mid_R, ParaHippocampal_ROlfactory_R−3.650−1.3410.05440.04550.02600.0259
Supp_Motor_Area_L, Pallidum_R, Putamen_R, Supp_Motor_Area_RFrontal_Inf_Oper_R−4.316−2.0820.04190.03540.03190.0316
Pallidum_R, Putamen_R, SupraMarginal_R, ParaHippocampal_R, Supp_Motor_Area_R, Frontal_Inf_Tri_R, Frontal_Inf_Oper_RInsula_R−4.036−1.6710.04750.04200.03420.0331
Supp_Motor_Area_L, Frontal_Med_Orb_L, Paracentral_Lobule_L, Heschl_L, Paracentral_Lobule_R, Cingulate_Ant_R, Frontal_Sup_Medial_R, Supp_Motor_Area_RCingulate_Mid_L−3.916−0.0020.03860.03270.03800.0418
Cingulate_Mid_L, Putamen_R, Cingulate_Ant_R, Frontal_Sup_Medial_R, Supp_Motor_Area_RCingulate_Mid_R−2.181−0.7150.04420.04400.05800.0614
Precentral_L, Frontal_Sup_2_L, Postcentral_L, Precentral_RSupp_Motor_Area_L4.203−2.2690.05510.07400.03870.0379
Supp_Motor_Area_L, Paracentral_Lobule_L, Paracentral_Lobule_R, Occipital_Mid_R, Supp_Motor_Area_RPrecentral_R−4.8160.6890.04390.03630.07040.0810
Paracentral_Lobule_L, Paracentral_Lobule_R, Supp_Motor_Area_RPostcentral_R−5.0811.9510.05210.04510.05540.0686
Precentral_L, Supp_Motor_Area_L, Amygdala_L, Paracentral_Lobule_L, Heschl_L, Paracentral_Lobule_R, Supp_Motor_Area_RPostcentral_L−4.8301.5450.04840.04100.05220.0619
ParaHippocampal_L, Precuneus_L, Paracentral_Lobule_L, Paracentral_Lobule_R, Precuneus_RParietal_Sup_L−0.3500.7700.03360.03590.03360.0408
Cingulate_Ant_L, Putamen_L, Pallidum_L, Thalamus_R, Pallidum_RThalamus_L−4.402−1.4820.04620.03980.04030.0404
Cingulate_Ant_L, Putamen_L, Thalamus_L, Pallidum_RThalamus_R−4.476−2.4800.04330.03700.04650.0448

A positive value for z indicates a higher EC in SCZ.

Table 3
Open in new tab

Summary of the main differences in EC in schizophrenia

Region 1 (a set of regions)Region 2z value of region 1 to 2 ECz value of region 2 to 1 ECEC of region 1 to 2 in HCEC of region 1 to 2 in SCZEC of region 2 to 1 in HCEC of region 2 to 1 in SCZ
Cingulate_Post_L, ParaHippocampal_L, Fusiform_L, Temporal_Sup_L, Temporal_Mid_L, Temporal_Sup_RCuneus_L−2.6530.5170.04140.03580.01790.0211
Fusiform_L, Temporal_Mid_L, Temporal_Pole_Mid_R, Temporal_Mid_R, Fusiform_R, ParaHippocampal_RCuneus_R−4.3150.7130.04870.03980.01300.0147
Temporal_Inf_R, Temporal_Pole_Mid_R, Thalamus_R, Precuneus_R, Cingulate_Post_RParaHippocampal_R2.720−0.4300.02150.02730.04780.0512
Frontal_Inf_Oper_L, Heschl_L, Temporal_Pole_Mid_LTemporal_Sup_L−4.789−0.8890.04600.03890.04300.0442
ParaHippocampal_L, Heschl_L, Temporal_Pole_Mid_L, Cingulate_Post_RTemporal_Mid_L−2.305−0.7990.03060.02870.03510.0367
Temporal_Pole_Mid_R, Heschl_R, Cingulate_Post_RTemporal_Mid_R−1.2940.7500.03420.03340.04130.0480
Temporal_Pole_Mid_R, Heschl_R, Amygdala_R, ParaHippocampal_R, Hippocampus_RTemporal_Pole_Sup_R−4.297−0.2920.04780.04210.03860.0408
Precuneus_L, Temporal_Pole_Mid_R, Heschl_R, Precuneus_R, Amygdala_RTemporal_Sup_R−0.990−0.7900.02860.02540.04270.0444
Rolandic_Oper_L, Calcarine_L, Precuneus_L, Temporal_Pole_Mid_L, Precuneus_RFusiform_L0.9600.2860.01870.01920.04110.0457
Precuneus_L, Temporal_Pole_Mid_R, ParaHippocampal_RFusiform_R−1.3572.2740.03500.03260.03050.0395
ParaHippocampal_L, Lingual_L, Fusiform_L, Paracentral_Lobule_L, Temporal_Sup_L, Temporal_Pole_Mid_L, Fusiform_R, Lingual_ROccipital_Sup_L−4.3330.3720.04680.03890.02530.0283
Temporal_Pole_Mid_R, Fusiform_R, ParaHippocampal_ROccipital_Sup_R−4.1010.0800.04680.03860.01700.0175
ParaHippocampal_L, Fusiform_L, Precuneus_L, Temporal_Pole_Mid_L, Precuneus_ROccipital_Mid_L−1.2322.2060.02890.02620.02740.0375
Precuneus_L, Temporal_Pole_Mid_R, Precuneus_R, Postcentral_R, ParaHippocampal_R, Precentral_ROccipital_Mid_R−1.3930.1330.03360.03070.02470.0292
ParaHippocampal_L, Fusiform_L, Temporal_Sup_L, Temporal_Pole_Mid_LLingual_L−4.752−0.4260.05690.04740.02460.0258
Fusiform_L, Temporal_Pole_Mid_R, Postcentral_R, Fusiform_R, ParaHippocampal_RLingual_R−4.555−0.3390.06570.05720.02270.0236
Fusiform_L, Temporal_Pole_Mid_R, Temporal_Sup_R, ParaHippocampal_RCalcarine_R−4.3511.4810.04750.03590.01450.0175
OFCmed_L, Temporal_Pole_Mid_R, ParaHippocampal_ROlfactory_R−3.650−1.3410.05440.04550.02600.0259
Supp_Motor_Area_L, Pallidum_R, Putamen_R, Supp_Motor_Area_RFrontal_Inf_Oper_R−4.316−2.0820.04190.03540.03190.0316
Pallidum_R, Putamen_R, SupraMarginal_R, ParaHippocampal_R, Supp_Motor_Area_R, Frontal_Inf_Tri_R, Frontal_Inf_Oper_RInsula_R−4.036−1.6710.04750.04200.03420.0331
Supp_Motor_Area_L, Frontal_Med_Orb_L, Paracentral_Lobule_L, Heschl_L, Paracentral_Lobule_R, Cingulate_Ant_R, Frontal_Sup_Medial_R, Supp_Motor_Area_RCingulate_Mid_L−3.916−0.0020.03860.03270.03800.0418
Cingulate_Mid_L, Putamen_R, Cingulate_Ant_R, Frontal_Sup_Medial_R, Supp_Motor_Area_RCingulate_Mid_R−2.181−0.7150.04420.04400.05800.0614
Precentral_L, Frontal_Sup_2_L, Postcentral_L, Precentral_RSupp_Motor_Area_L4.203−2.2690.05510.07400.03870.0379
Supp_Motor_Area_L, Paracentral_Lobule_L, Paracentral_Lobule_R, Occipital_Mid_R, Supp_Motor_Area_RPrecentral_R−4.8160.6890.04390.03630.07040.0810
Paracentral_Lobule_L, Paracentral_Lobule_R, Supp_Motor_Area_RPostcentral_R−5.0811.9510.05210.04510.05540.0686
Precentral_L, Supp_Motor_Area_L, Amygdala_L, Paracentral_Lobule_L, Heschl_L, Paracentral_Lobule_R, Supp_Motor_Area_RPostcentral_L−4.8301.5450.04840.04100.05220.0619
ParaHippocampal_L, Precuneus_L, Paracentral_Lobule_L, Paracentral_Lobule_R, Precuneus_RParietal_Sup_L−0.3500.7700.03360.03590.03360.0408
Cingulate_Ant_L, Putamen_L, Pallidum_L, Thalamus_R, Pallidum_RThalamus_L−4.402−1.4820.04620.03980.04030.0404
Cingulate_Ant_L, Putamen_L, Thalamus_L, Pallidum_RThalamus_R−4.476−2.4800.04330.03700.04650.0448
Region 1 (a set of regions)Region 2z value of region 1 to 2 ECz value of region 2 to 1 ECEC of region 1 to 2 in HCEC of region 1 to 2 in SCZEC of region 2 to 1 in HCEC of region 2 to 1 in SCZ
Cingulate_Post_L, ParaHippocampal_L, Fusiform_L, Temporal_Sup_L, Temporal_Mid_L, Temporal_Sup_RCuneus_L−2.6530.5170.04140.03580.01790.0211
Fusiform_L, Temporal_Mid_L, Temporal_Pole_Mid_R, Temporal_Mid_R, Fusiform_R, ParaHippocampal_RCuneus_R−4.3150.7130.04870.03980.01300.0147
Temporal_Inf_R, Temporal_Pole_Mid_R, Thalamus_R, Precuneus_R, Cingulate_Post_RParaHippocampal_R2.720−0.4300.02150.02730.04780.0512
Frontal_Inf_Oper_L, Heschl_L, Temporal_Pole_Mid_LTemporal_Sup_L−4.789−0.8890.04600.03890.04300.0442
ParaHippocampal_L, Heschl_L, Temporal_Pole_Mid_L, Cingulate_Post_RTemporal_Mid_L−2.305−0.7990.03060.02870.03510.0367
Temporal_Pole_Mid_R, Heschl_R, Cingulate_Post_RTemporal_Mid_R−1.2940.7500.03420.03340.04130.0480
Temporal_Pole_Mid_R, Heschl_R, Amygdala_R, ParaHippocampal_R, Hippocampus_RTemporal_Pole_Sup_R−4.297−0.2920.04780.04210.03860.0408
Precuneus_L, Temporal_Pole_Mid_R, Heschl_R, Precuneus_R, Amygdala_RTemporal_Sup_R−0.990−0.7900.02860.02540.04270.0444
Rolandic_Oper_L, Calcarine_L, Precuneus_L, Temporal_Pole_Mid_L, Precuneus_RFusiform_L0.9600.2860.01870.01920.04110.0457
Precuneus_L, Temporal_Pole_Mid_R, ParaHippocampal_RFusiform_R−1.3572.2740.03500.03260.03050.0395
ParaHippocampal_L, Lingual_L, Fusiform_L, Paracentral_Lobule_L, Temporal_Sup_L, Temporal_Pole_Mid_L, Fusiform_R, Lingual_ROccipital_Sup_L−4.3330.3720.04680.03890.02530.0283
Temporal_Pole_Mid_R, Fusiform_R, ParaHippocampal_ROccipital_Sup_R−4.1010.0800.04680.03860.01700.0175
ParaHippocampal_L, Fusiform_L, Precuneus_L, Temporal_Pole_Mid_L, Precuneus_ROccipital_Mid_L−1.2322.2060.02890.02620.02740.0375
Precuneus_L, Temporal_Pole_Mid_R, Precuneus_R, Postcentral_R, ParaHippocampal_R, Precentral_ROccipital_Mid_R−1.3930.1330.03360.03070.02470.0292
ParaHippocampal_L, Fusiform_L, Temporal_Sup_L, Temporal_Pole_Mid_LLingual_L−4.752−0.4260.05690.04740.02460.0258
Fusiform_L, Temporal_Pole_Mid_R, Postcentral_R, Fusiform_R, ParaHippocampal_RLingual_R−4.555−0.3390.06570.05720.02270.0236
Fusiform_L, Temporal_Pole_Mid_R, Temporal_Sup_R, ParaHippocampal_RCalcarine_R−4.3511.4810.04750.03590.01450.0175
OFCmed_L, Temporal_Pole_Mid_R, ParaHippocampal_ROlfactory_R−3.650−1.3410.05440.04550.02600.0259
Supp_Motor_Area_L, Pallidum_R, Putamen_R, Supp_Motor_Area_RFrontal_Inf_Oper_R−4.316−2.0820.04190.03540.03190.0316
Pallidum_R, Putamen_R, SupraMarginal_R, ParaHippocampal_R, Supp_Motor_Area_R, Frontal_Inf_Tri_R, Frontal_Inf_Oper_RInsula_R−4.036−1.6710.04750.04200.03420.0331
Supp_Motor_Area_L, Frontal_Med_Orb_L, Paracentral_Lobule_L, Heschl_L, Paracentral_Lobule_R, Cingulate_Ant_R, Frontal_Sup_Medial_R, Supp_Motor_Area_RCingulate_Mid_L−3.916−0.0020.03860.03270.03800.0418
Cingulate_Mid_L, Putamen_R, Cingulate_Ant_R, Frontal_Sup_Medial_R, Supp_Motor_Area_RCingulate_Mid_R−2.181−0.7150.04420.04400.05800.0614
Precentral_L, Frontal_Sup_2_L, Postcentral_L, Precentral_RSupp_Motor_Area_L4.203−2.2690.05510.07400.03870.0379
Supp_Motor_Area_L, Paracentral_Lobule_L, Paracentral_Lobule_R, Occipital_Mid_R, Supp_Motor_Area_RPrecentral_R−4.8160.6890.04390.03630.07040.0810
Paracentral_Lobule_L, Paracentral_Lobule_R, Supp_Motor_Area_RPostcentral_R−5.0811.9510.05210.04510.05540.0686
Precentral_L, Supp_Motor_Area_L, Amygdala_L, Paracentral_Lobule_L, Heschl_L, Paracentral_Lobule_R, Supp_Motor_Area_RPostcentral_L−4.8301.5450.04840.04100.05220.0619
ParaHippocampal_L, Precuneus_L, Paracentral_Lobule_L, Paracentral_Lobule_R, Precuneus_RParietal_Sup_L−0.3500.7700.03360.03590.03360.0408
Cingulate_Ant_L, Putamen_L, Pallidum_L, Thalamus_R, Pallidum_RThalamus_L−4.402−1.4820.04620.03980.04030.0404
Cingulate_Ant_L, Putamen_L, Thalamus_L, Pallidum_RThalamus_R−4.476−2.4800.04330.03700.04650.0448

A positive value for z indicates a higher EC in SCZ.

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