Table 1. Open in new tab Laboratory...

		Patient 1^a			Patient 2^b		Patient 3^c
WBC, 10⁹/L	3.5–9.5	4.22	6.61	8.74	4.74	3.91	3.06^d	3.39^d	4.4
RBC, 10¹²/L	4.3–5.8	4.4	4.26^d	4.02^d	5.21	4.92	4.25	4.34	3.83
Hb, g/L	130–175	144	139	128^d	147	139	127	126	114
PLT, 10⁹/L	120–350	147	210	241	97^d	—	153	274	287
NEUT#, 10⁹/L	1.8–6.3	3.4	5.82	6.51^e	3.11	2.27	1.86	2.46	3.42
LYM#, 10⁹/L	1.1–3.2	0.48^d	0.58^d	1.63	1.2	1.04^d	0.85^d	0.60^d	0.85^d
ESR, mm/h	0–15	49^e	—	31^e	58.8^e	—		40^e	41.5^e
hsCRP, mg/L	0–5	57.8^e	106.2^e	4.3	82.0^e	25.1^e	41.1^e	69.5^e	6.6^e
Mb, ng/mL	0–146.9	96.3	36.5	—	153.8^e	—	16.6	—	—
hsTnI, pg/mL	0–28	1.1	1.3	—	3.6	—	0	—	—
SF, ng/mL	21.8–274.66	459.57^e	—	563.02^e	806.99^e	632.55^e	85.91	—	232.62^e
PCT, ng/mL	<0.05	—	<0.05	<0.05	<0.05	0.05	<0.05	<0.05	<0.05
TBIL, μmol/L	0–26	15.5	15.4	6.5	15	—	8.4	—	5.9
ALT, U/L	9–50	20	14	60^e	52^e	—	15	—	20
AST, U/L	14–40	36	34	40	54^e	—	25	—	11^d
ALB, g/L	40–55	39.3^d	34.2^d	39.6^d	32.4^d	—	33.4^d	—	33.0^d
ALP, U/L	45–125	47	47	46	60	—	47	—	26^d
γ-GT, U/L	10–60	17	19	29	87^e	—	15	—	33
CRE, μmol/L	57–97	88.8	69.2	63	72.7	—	51.6	—	47
UA, μmol/L	208–428	191^d	99^d	195^d	472^e	—	201	—	131^d
CK, U/L	50–310	267	81	51	1081^e	—	46	—	32^d
LDH, U/L	120–250	308^e	315^e	296^e	651^e	—	163	—	222
D-dimer, μg/mL	0–1.5	0.37	—	—	0.43	—	—	—	1.55^e
PT, sec	10.5–13.5	10.6	—	10.2^d	11.3	—	—	—	—
PTA, %	0.8–1.2	129.7^e	—	117.4	95.5	—	—	—	—
FIB, g/L	2–4	4.1^e	—	3.7	4.4^e	—	—	—	—

Patient 1^a

Patient 2^b

Patient 3^c

Reference

Illness Day 4

Illness Day 9

Illness Day 18

Illness Day 12

Illness Day 16

Illness Day 6

Illness Day 11

Illness Day 14

Measure

Range

Hospital Day 1

Hospital Day 6

Hospital Day 15

Hospital Day 2

Hospital Day 6

Hospital Day 1

Hospital Day 6

Hospital Day 9

WBC, 10⁹/L

3.5–9.5

4.22

6.61

8.74

4.74

3.91

3.06^d

3.39^d

4.4

RBC, 10¹²/L

4.3–5.8

4.4

4.26^d

4.02^d

5.21

4.92

4.25

4.34

3.83

Hb, g/L

130–175

144

139

128^d

147

139

127

126

114

PLT, 10⁹/L

120–350

147

210

241

97^d

—

153

274

287

NEUT#, 10⁹/L

1.8–6.3

3.4

5.82

6.51^e

3.11

2.27

1.86

2.46

3.42

LYM#, 10⁹/L

1.1–3.2

0.48^d

0.58^d

1.63

1.2

1.04^d

0.85^d

0.60^d

0.85^d

ESR, mm/h

0–15

49^e

—

31^e

58.8^e

—

40^e

41.5^e

hsCRP, mg/L

0–5

57.8^e

106.2^e

4.3

82.0^e

25.1^e

41.1^e

69.5^e

6.6^e

Mb, ng/mL

0–146.9

96.3

36.5

—

153.8^e

—

16.6

—

hsTnI, pg/mL

0–28

1.1

1.3

—

3.6

—

SF, ng/mL

21.8–274.66

459.57^e

—

563.02^e

806.99^e

632.55^e

85.91

—

232.62^e

PCT, ng/mL

<0.05

—

<0.05

0.05

<0.05

TBIL, μmol/L

0–26

15.5

15.4

6.5

—

8.4

—

5.9

ALT, U/L

9–50

60^e

52^e

—

AST, U/L

14–40

54^e

—

11^d

ALB, g/L

40–55

39.3^d

34.2^d

39.6^d

32.4^d

—

33.4^d

—

33.0^d

ALP, U/L

45–125

—

26^d

γ-GT, U/L

10–60

87^e

—

CRE, μmol/L

57–97

88.8

69.2

72.7

—

51.6

—

UA, μmol/L

208–428

191^d

99^d

195^d

472^e

—

201

—

131^d

CK, U/L

50–310

267

1081^e

—

32^d

LDH, U/L

120–250

308^e

315^e

296^e

651^e

—

163

—

222

D-dimer, μg/mL

0–1.5

0.37

—

0.43

—

1.55^e

PT, sec

10.5–13.5

10.6

—

10.2^d

11.3

—

PTA, %

0.8–1.2

129.7^e

—

117.4

95.5

—

FIB, g/L

2–4

4.1^e

—

3.7

4.4^e

—

		Patient 1^a			Patient 2^b		Patient 3^c
WBC, 10⁹/L	3.5–9.5	4.22	6.61	8.74	4.74	3.91	3.06^d	3.39^d	4.4
RBC, 10¹²/L	4.3–5.8	4.4	4.26^d	4.02^d	5.21	4.92	4.25	4.34	3.83
Hb, g/L	130–175	144	139	128^d	147	139	127	126	114
PLT, 10⁹/L	120–350	147	210	241	97^d	—	153	274	287
NEUT#, 10⁹/L	1.8–6.3	3.4	5.82	6.51^e	3.11	2.27	1.86	2.46	3.42
LYM#, 10⁹/L	1.1–3.2	0.48^d	0.58^d	1.63	1.2	1.04^d	0.85^d	0.60^d	0.85^d
ESR, mm/h	0–15	49^e	—	31^e	58.8^e	—		40^e	41.5^e
hsCRP, mg/L	0–5	57.8^e	106.2^e	4.3	82.0^e	25.1^e	41.1^e	69.5^e	6.6^e
Mb, ng/mL	0–146.9	96.3	36.5	—	153.8^e	—	16.6	—	—
hsTnI, pg/mL	0–28	1.1	1.3	—	3.6	—	0	—	—
SF, ng/mL	21.8–274.66	459.57^e	—	563.02^e	806.99^e	632.55^e	85.91	—	232.62^e
PCT, ng/mL	<0.05	—	<0.05	<0.05	<0.05	0.05	<0.05	<0.05	<0.05
TBIL, μmol/L	0–26	15.5	15.4	6.5	15	—	8.4	—	5.9
ALT, U/L	9–50	20	14	60^e	52^e	—	15	—	20
AST, U/L	14–40	36	34	40	54^e	—	25	—	11^d
ALB, g/L	40–55	39.3^d	34.2^d	39.6^d	32.4^d	—	33.4^d	—	33.0^d
ALP, U/L	45–125	47	47	46	60	—	47	—	26^d
γ-GT, U/L	10–60	17	19	29	87^e	—	15	—	33
CRE, μmol/L	57–97	88.8	69.2	63	72.7	—	51.6	—	47
UA, μmol/L	208–428	191^d	99^d	195^d	472^e	—	201	—	131^d
CK, U/L	50–310	267	81	51	1081^e	—	46	—	32^d
LDH, U/L	120–250	308^e	315^e	296^e	651^e	—	163	—	222
D-dimer, μg/mL	0–1.5	0.37	—	—	0.43	—	—	—	1.55^e
PT, sec	10.5–13.5	10.6	—	10.2^d	11.3	—	—	—	—
PTA, %	0.8–1.2	129.7^e	—	117.4	95.5	—	—	—	—
FIB, g/L	2–4	4.1^e	—	3.7	4.4^e	—	—	—	—

Table 1.

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Laboratory Tests of the 3 Patients Before and After Infusion of High-Dose Intravenous Immunoglobulin

		Patient 1^a			Patient 2^b		Patient 3^c
	Reference	Illness Day 4	Illness Day 9	Illness Day 18	Illness Day 12	Illness Day 16	Illness Day 6	Illness Day 11	Illness Day 14
Measure	Range	Hospital Day 1	Hospital Day 6	Hospital Day 15	Hospital Day 2	Hospital Day 6	Hospital Day 1	Hospital Day 6	Hospital Day 9
WBC, 10⁹/L	3.5–9.5	4.22	6.61	8.74	4.74	3.91	3.06^d	3.39^d	4.4
RBC, 10¹²/L	4.3–5.8	4.4	4.26^d	4.02^d	5.21	4.92	4.25	4.34	3.83
Hb, g/L	130–175	144	139	128^d	147	139	127	126	114
PLT, 10⁹/L	120–350	147	210	241	97^d	—	153	274	287
NEUT#, 10⁹/L	1.8–6.3	3.4	5.82	6.51^e	3.11	2.27	1.86	2.46	3.42
LYM#, 10⁹/L	1.1–3.2	0.48^d	0.58^d	1.63	1.2	1.04^d	0.85^d	0.60^d	0.85^d
ESR, mm/h	0–15	49^e	—	31^e	58.8^e	—		40^e	41.5^e
hsCRP, mg/L	0–5	57.8^e	106.2^e	4.3	82.0^e	25.1^e	41.1^e	69.5^e	6.6^e
Mb, ng/mL	0–146.9	96.3	36.5	—	153.8^e	—	16.6	—	—
hsTnI, pg/mL	0–28	1.1	1.3	—	3.6	—	0	—	—
SF, ng/mL	21.8–274.66	459.57^e	—	563.02^e	806.99^e	632.55^e	85.91	—	232.62^e
PCT, ng/mL	<0.05	—	<0.05	<0.05	<0.05	0.05	<0.05	<0.05	<0.05
TBIL, μmol/L	0–26	15.5	15.4	6.5	15	—	8.4	—	5.9
ALT, U/L	9–50	20	14	60^e	52^e	—	15	—	20
AST, U/L	14–40	36	34	40	54^e	—	25	—	11^d
ALB, g/L	40–55	39.3^d	34.2^d	39.6^d	32.4^d	—	33.4^d	—	33.0^d
ALP, U/L	45–125	47	47	46	60	—	47	—	26^d
γ-GT, U/L	10–60	17	19	29	87^e	—	15	—	33
CRE, μmol/L	57–97	88.8	69.2	63	72.7	—	51.6	—	47
UA, μmol/L	208–428	191^d	99^d	195^d	472^e	—	201	—	131^d
CK, U/L	50–310	267	81	51	1081^e	—	46	—	32^d
LDH, U/L	120–250	308^e	315^e	296^e	651^e	—	163	—	222
D-dimer, μg/mL	0–1.5	0.37	—	—	0.43	—	—	—	1.55^e
PT, sec	10.5–13.5	10.6	—	10.2^d	11.3	—	—	—	—
PTA, %	0.8–1.2	129.7^e	—	117.4	95.5	—	—	—	—
FIB, g/L	2–4	4.1^e	—	3.7	4.4^e	—	—	—	—

		Patient 1^a			Patient 2^b		Patient 3^c
	Reference	Illness Day 4	Illness Day 9	Illness Day 18	Illness Day 12	Illness Day 16	Illness Day 6	Illness Day 11	Illness Day 14
Measure	Range	Hospital Day 1	Hospital Day 6	Hospital Day 15	Hospital Day 2	Hospital Day 6	Hospital Day 1	Hospital Day 6	Hospital Day 9
WBC, 10⁹/L	3.5–9.5	4.22	6.61	8.74	4.74	3.91	3.06^d	3.39^d	4.4
RBC, 10¹²/L	4.3–5.8	4.4	4.26^d	4.02^d	5.21	4.92	4.25	4.34	3.83
Hb, g/L	130–175	144	139	128^d	147	139	127	126	114
PLT, 10⁹/L	120–350	147	210	241	97^d	—	153	274	287
NEUT#, 10⁹/L	1.8–6.3	3.4	5.82	6.51^e	3.11	2.27	1.86	2.46	3.42
LYM#, 10⁹/L	1.1–3.2	0.48^d	0.58^d	1.63	1.2	1.04^d	0.85^d	0.60^d	0.85^d
ESR, mm/h	0–15	49^e	—	31^e	58.8^e	—		40^e	41.5^e
hsCRP, mg/L	0–5	57.8^e	106.2^e	4.3	82.0^e	25.1^e	41.1^e	69.5^e	6.6^e
Mb, ng/mL	0–146.9	96.3	36.5	—	153.8^e	—	16.6	—	—
hsTnI, pg/mL	0–28	1.1	1.3	—	3.6	—	0	—	—
SF, ng/mL	21.8–274.66	459.57^e	—	563.02^e	806.99^e	632.55^e	85.91	—	232.62^e
PCT, ng/mL	<0.05	—	<0.05	<0.05	<0.05	0.05	<0.05	<0.05	<0.05
TBIL, μmol/L	0–26	15.5	15.4	6.5	15	—	8.4	—	5.9
ALT, U/L	9–50	20	14	60^e	52^e	—	15	—	20
AST, U/L	14–40	36	34	40	54^e	—	25	—	11^d
ALB, g/L	40–55	39.3^d	34.2^d	39.6^d	32.4^d	—	33.4^d	—	33.0^d
ALP, U/L	45–125	47	47	46	60	—	47	—	26^d
γ-GT, U/L	10–60	17	19	29	87^e	—	15	—	33
CRE, μmol/L	57–97	88.8	69.2	63	72.7	—	51.6	—	47
UA, μmol/L	208–428	191^d	99^d	195^d	472^e	—	201	—	131^d
CK, U/L	50–310	267	81	51	1081^e	—	46	—	32^d
LDH, U/L	120–250	308^e	315^e	296^e	651^e	—	163	—	222
D-dimer, μg/mL	0–1.5	0.37	—	—	0.43	—	—	—	1.55^e
PT, sec	10.5–13.5	10.6	—	10.2^d	11.3	—	—	—	—
PTA, %	0.8–1.2	129.7^e	—	117.4	95.5	—	—	—	—
FIB, g/L	2–4	4.1^e	—	3.7	4.4^e	—	—	—	—

Abbreviations: γ-GT, γ -glutamyltransferase; ALB, albumin; ALP, alkaline phosphatase; ALT, alanine aminotransferase; AST, aspartase aminotransferase; CK, creatinekinase; CRE, creatinine; ESR, erythrocyte sedimentation rate; FIB, fibrinogen; Hb, hemoglobin; hsCRP, hypersensitive C-reactive protein; hsTn, hypersensitive troponin; IVIg, intravenous immunoglobulin; LDH, lactate dehydrogenase; LYM#, absolute lymphocyte count; Mb, myoglobin; NEUT#, absolute neutrophil count; hsTn, hypersensitive troponin; PLT, platelet count; PT, prothrombin time; PTA, prothrombin activity; RBC, red blood cell count; SF, serum ferritin; TBIL, total bilirubin; UA, urine acid; WBC, white blood cell count.

^aIVIg was initiated on hospital day 7.

^bIVIg was initiated on hospital day 2.

^cIVIg was initiated on hospital day 6.

^dThe value in the patient was below normal.

^eThe value in the patient was above normal.

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