Table 1.
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General Information of Hepatotoxicity Datasets

DatasetSizeOriginal CategoriesSpeciesRules of HarmonizationReference
15341 or 0 (hepatotoxic or not)HumansSameEkins et al. (2010)
29511 or 0 (hepatotoxic or not)Humans, rodents, nonrodentsOnly human data were usedFourches et al. (2010)
36051, −1, or 0 (hepatotoxic or not, and inconclusive)HumansExcluding inconclusivesLiu et al. (2015b)
4627HH, NE, WE, AHHumans, animalsHH, WE as 1; NE as 0 (AH were excluded)Greene et al. (2010)
5287Most, less and no concern for DILIHumansMost and less concern as 1; no concern as 0Chen et al. (2011)
613141 or 0 (hepatotoxic or not)HumansSameKim et al. (2016)
737121 or 0 (hepatotoxic or not)Humans, animalsOnly human data were usedMulliner et al. (2016)
812741 or 0 (hepatotoxic or not)HumansSameLiew et al. (2011)
DatasetSizeOriginal CategoriesSpeciesRules of HarmonizationReference
15341 or 0 (hepatotoxic or not)HumansSameEkins et al. (2010)
29511 or 0 (hepatotoxic or not)Humans, rodents, nonrodentsOnly human data were usedFourches et al. (2010)
36051, −1, or 0 (hepatotoxic or not, and inconclusive)HumansExcluding inconclusivesLiu et al. (2015b)
4627HH, NE, WE, AHHumans, animalsHH, WE as 1; NE as 0 (AH were excluded)Greene et al. (2010)
5287Most, less and no concern for DILIHumansMost and less concern as 1; no concern as 0Chen et al. (2011)
613141 or 0 (hepatotoxic or not)HumansSameKim et al. (2016)
737121 or 0 (hepatotoxic or not)Humans, animalsOnly human data were usedMulliner et al. (2016)
812741 or 0 (hepatotoxic or not)HumansSameLiew et al. (2011)

Abbreviations: HH, evidence for human hepatotoxicity; NE, no evidence for hepatotoxicity in any species; WE, weak evidence (<10 case reports) for human hepatotoxicity; AH, evidence for animal hepatotoxicity but not tested in humans.

Table 1.
Open in new tab

General Information of Hepatotoxicity Datasets

DatasetSizeOriginal CategoriesSpeciesRules of HarmonizationReference
15341 or 0 (hepatotoxic or not)HumansSameEkins et al. (2010)
29511 or 0 (hepatotoxic or not)Humans, rodents, nonrodentsOnly human data were usedFourches et al. (2010)
36051, −1, or 0 (hepatotoxic or not, and inconclusive)HumansExcluding inconclusivesLiu et al. (2015b)
4627HH, NE, WE, AHHumans, animalsHH, WE as 1; NE as 0 (AH were excluded)Greene et al. (2010)
5287Most, less and no concern for DILIHumansMost and less concern as 1; no concern as 0Chen et al. (2011)
613141 or 0 (hepatotoxic or not)HumansSameKim et al. (2016)
737121 or 0 (hepatotoxic or not)Humans, animalsOnly human data were usedMulliner et al. (2016)
812741 or 0 (hepatotoxic or not)HumansSameLiew et al. (2011)
DatasetSizeOriginal CategoriesSpeciesRules of HarmonizationReference
15341 or 0 (hepatotoxic or not)HumansSameEkins et al. (2010)
29511 or 0 (hepatotoxic or not)Humans, rodents, nonrodentsOnly human data were usedFourches et al. (2010)
36051, −1, or 0 (hepatotoxic or not, and inconclusive)HumansExcluding inconclusivesLiu et al. (2015b)
4627HH, NE, WE, AHHumans, animalsHH, WE as 1; NE as 0 (AH were excluded)Greene et al. (2010)
5287Most, less and no concern for DILIHumansMost and less concern as 1; no concern as 0Chen et al. (2011)
613141 or 0 (hepatotoxic or not)HumansSameKim et al. (2016)
737121 or 0 (hepatotoxic or not)Humans, animalsOnly human data were usedMulliner et al. (2016)
812741 or 0 (hepatotoxic or not)HumansSameLiew et al. (2011)

Abbreviations: HH, evidence for human hepatotoxicity; NE, no evidence for hepatotoxicity in any species; WE, weak evidence (<10 case reports) for human hepatotoxicity; AH, evidence for animal hepatotoxicity but not tested in humans.

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