Table 2 Open in new tab Multivariable...

	Unadjusted model	Adjusted Model 1	Adjusted Model 2
LA volume (per 10 mL)	1.251 (1.078–1.450)	0.003	1.248 (1.070–1.456)	0.005	1.242 (1.062–1.452)	0.007
NT-proBNP (per SD)	1.583 (1.099–2.281)	0.014	1.575 (1.071–2.315)	0.021	1.588 (1.075–2.345)	0.020
PAI-1 (per SD)	0.660 (0.472–0.921)	0.015	0.660 (0.472–0.921)	0.015	0.680 (0.487–0.950)	0.024

	Unadjusted model	Adjusted Model 1	Adjusted Model 2
LA volume (per 10 mL)	1.251 (1.078–1.450)	0.003	1.248 (1.070–1.456)	0.005	1.242 (1.062–1.452)	0.007
NT-proBNP (per SD)	1.583 (1.099–2.281)	0.014	1.575 (1.071–2.315)	0.021	1.588 (1.075–2.345)	0.020
PAI-1 (per SD)	0.660 (0.472–0.921)	0.015	0.660 (0.472–0.921)	0.015	0.680 (0.487–0.950)	0.024

Table 2

Multivariable factors associated with AF progression

	Unadjusted model		Adjusted Model 1		Adjusted Model 2
	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
LA volume (per 10 mL)	1.251 (1.078–1.450)	0.003	1.248 (1.070–1.456)	0.005	1.242 (1.062–1.452)	0.007
NT-proBNP (per SD)	1.583 (1.099–2.281)	0.014	1.575 (1.071–2.315)	0.021	1.588 (1.075–2.345)	0.020
PAI-1 (per SD)	0.660 (0.472–0.921)	0.015	0.660 (0.472–0.921)	0.015	0.680 (0.487–0.950)	0.024

	Unadjusted model		Adjusted Model 1		Adjusted Model 2
	OR (95% CI)	P-value	OR (95% CI)	P-value	OR (95% CI)	P-value
LA volume (per 10 mL)	1.251 (1.078–1.450)	0.003	1.248 (1.070–1.456)	0.005	1.242 (1.062–1.452)	0.007
NT-proBNP (per SD)	1.583 (1.099–2.281)	0.014	1.575 (1.071–2.315)	0.021	1.588 (1.075–2.345)	0.020
PAI-1 (per SD)	0.660 (0.472–0.921)	0.015	0.660 (0.472–0.921)	0.015	0.680 (0.487–0.950)	0.024

Model 1 was adjusted for type of AF at baseline (paroxysmal or persistent). Model 2 was adjusted for type of AF at baseline, pulmonary vein isolation during study period, and the use of anti-arrhythmic drugs.

CI, confidence interval; LA, left atrium; NT-proBNP, N-terminal pro-B-type natriuretic peptide; OR, odds ratio; PAI-1, plasminogen activator inhibitor; SD, standard deviation.

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