Response surface analysis results, as well as interaction effect size, by deviation from expected combination effect under Bliss independence in percentage ΔE
| Combination (concentration) . | Effect (log10 cfu/mL × day) . | ||||
|---|---|---|---|---|---|
| tedizolid . | amikacin or ethambutol . | observed, combination . | expected, combinationa . | ΔE (%) . | |
| M. abscessus | |||||
| tedizolid/amikacin (0.5× MIC) | 8.93 | −95.6 | 16.3 | 62.2 | −126 |
| tedizolid/amikacin (1× MIC) | 22.6 | 24.2 | 33.7 | 31.1 | 8.24 |
| tedizolid/amikacin (2× MIC) | 34.8 | 35.6 | 48.8 | 34.9 | 39.7 |
| M. avium | |||||
| tedizolid/ethambutol (0.5× MIC) | 65.8 | 9.39 | 102 | 71.6 | 42.3 |
| tedizolid/ethambutol (1× MIC) | 96.5 | 81.8 | 145 | 133 | 8.81 |
| tedizolid/ethambutol (2× MIC) | 137 | 95.1 | 137 | 159 | −13.4 |
| Combination (concentration) . | Effect (log10 cfu/mL × day) . | ||||
|---|---|---|---|---|---|
| tedizolid . | amikacin or ethambutol . | observed, combination . | expected, combinationa . | ΔE (%) . | |
| M. abscessus | |||||
| tedizolid/amikacin (0.5× MIC) | 8.93 | −95.6 | 16.3 | 62.2 | −126 |
| tedizolid/amikacin (1× MIC) | 22.6 | 24.2 | 33.7 | 31.1 | 8.24 |
| tedizolid/amikacin (2× MIC) | 34.8 | 35.6 | 48.8 | 34.9 | 39.7 |
| M. avium | |||||
| tedizolid/ethambutol (0.5× MIC) | 65.8 | 9.39 | 102 | 71.6 | 42.3 |
| tedizolid/ethambutol (1× MIC) | 96.5 | 81.8 | 145 | 133 | 8.81 |
| tedizolid/ethambutol (2× MIC) | 137 | 95.1 | 137 | 159 | −13.4 |
Under Bliss independence.
Response surface analysis results, as well as interaction effect size, by deviation from expected combination effect under Bliss independence in percentage ΔE
| Combination (concentration) . | Effect (log10 cfu/mL × day) . | ||||
|---|---|---|---|---|---|
| tedizolid . | amikacin or ethambutol . | observed, combination . | expected, combinationa . | ΔE (%) . | |
| M. abscessus | |||||
| tedizolid/amikacin (0.5× MIC) | 8.93 | −95.6 | 16.3 | 62.2 | −126 |
| tedizolid/amikacin (1× MIC) | 22.6 | 24.2 | 33.7 | 31.1 | 8.24 |
| tedizolid/amikacin (2× MIC) | 34.8 | 35.6 | 48.8 | 34.9 | 39.7 |
| M. avium | |||||
| tedizolid/ethambutol (0.5× MIC) | 65.8 | 9.39 | 102 | 71.6 | 42.3 |
| tedizolid/ethambutol (1× MIC) | 96.5 | 81.8 | 145 | 133 | 8.81 |
| tedizolid/ethambutol (2× MIC) | 137 | 95.1 | 137 | 159 | −13.4 |
| Combination (concentration) . | Effect (log10 cfu/mL × day) . | ||||
|---|---|---|---|---|---|
| tedizolid . | amikacin or ethambutol . | observed, combination . | expected, combinationa . | ΔE (%) . | |
| M. abscessus | |||||
| tedizolid/amikacin (0.5× MIC) | 8.93 | −95.6 | 16.3 | 62.2 | −126 |
| tedizolid/amikacin (1× MIC) | 22.6 | 24.2 | 33.7 | 31.1 | 8.24 |
| tedizolid/amikacin (2× MIC) | 34.8 | 35.6 | 48.8 | 34.9 | 39.7 |
| M. avium | |||||
| tedizolid/ethambutol (0.5× MIC) | 65.8 | 9.39 | 102 | 71.6 | 42.3 |
| tedizolid/ethambutol (1× MIC) | 96.5 | 81.8 | 145 | 133 | 8.81 |
| tedizolid/ethambutol (2× MIC) | 137 | 95.1 | 137 | 159 | −13.4 |
Under Bliss independence.
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