Table 4.
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Adherence to QCIs

QCIPre-intervention group (n = 385)Intervention group (n = 263)Median improvement in percentage of adherence to QCI (IQR)Relative risk for adherence to QCI (95% CI)P value
Early appropriate antifungal therapy248 (64.4%)203 (81.5%)6.9 (4.3–33)2.4 (1.7–3.6)<0.001
Initial treatment with echinocandins if septic shock or severely ill patients in ICUa47 (45.6%)64 (71.1%)26.1 (0–52.5)2.5 (1.39–4.51)<0.001
Early source controlb165 (54.8%)168 (85.7%)29.5 (20.2–40.8)4.9 (3.1–7.8)<0.001
Follow-up blood culture293 (76.1%)220 (87.6%)17 (7.4–26.5)2.2 (1.4–3.5)<0.001
Ophthalmoscopic evaluation192 (52.5%)221 (85.7%)38.5 (28.3–62.2)5.4 (3.6–8.1)<0.001
Echocardiography319 (84.8%)232 (91%)9.4 (20.2–40.8)1.8 (1.1–3)0.023
De-escalation254 (69.2%)210 (84.3%)13.1 (1.6–22.2)2.4 (1.6–3.6)<0.001
Adequate length of antifungal treatment248 (65.3%)237 (96.3%)32.1 (23.1–41.9)14.02 (6.9–28.2)<0.001
QCIPre-intervention group (n = 385)Intervention group (n = 263)Median improvement in percentage of adherence to QCI (IQR)Relative risk for adherence to QCI (95% CI)P value
Early appropriate antifungal therapy248 (64.4%)203 (81.5%)6.9 (4.3–33)2.4 (1.7–3.6)<0.001
Initial treatment with echinocandins if septic shock or severely ill patients in ICUa47 (45.6%)64 (71.1%)26.1 (0–52.5)2.5 (1.39–4.51)<0.001
Early source controlb165 (54.8%)168 (85.7%)29.5 (20.2–40.8)4.9 (3.1–7.8)<0.001
Follow-up blood culture293 (76.1%)220 (87.6%)17 (7.4–26.5)2.2 (1.4–3.5)<0.001
Ophthalmoscopic evaluation192 (52.5%)221 (85.7%)38.5 (28.3–62.2)5.4 (3.6–8.1)<0.001
Echocardiography319 (84.8%)232 (91%)9.4 (20.2–40.8)1.8 (1.1–3)0.023
De-escalation254 (69.2%)210 (84.3%)13.1 (1.6–22.2)2.4 (1.6–3.6)<0.001
Adequate length of antifungal treatment248 (65.3%)237 (96.3%)32.1 (23.1–41.9)14.02 (6.9–28.2)<0.001
a

193 patients.

b

477 patients. If we only take into account those with catheter related-candidaemia (253 patients), the early catheter removal rate was 44.2% versus 86.6%, P<0.001.

Table 4.
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Adherence to QCIs

QCIPre-intervention group (n = 385)Intervention group (n = 263)Median improvement in percentage of adherence to QCI (IQR)Relative risk for adherence to QCI (95% CI)P value
Early appropriate antifungal therapy248 (64.4%)203 (81.5%)6.9 (4.3–33)2.4 (1.7–3.6)<0.001
Initial treatment with echinocandins if septic shock or severely ill patients in ICUa47 (45.6%)64 (71.1%)26.1 (0–52.5)2.5 (1.39–4.51)<0.001
Early source controlb165 (54.8%)168 (85.7%)29.5 (20.2–40.8)4.9 (3.1–7.8)<0.001
Follow-up blood culture293 (76.1%)220 (87.6%)17 (7.4–26.5)2.2 (1.4–3.5)<0.001
Ophthalmoscopic evaluation192 (52.5%)221 (85.7%)38.5 (28.3–62.2)5.4 (3.6–8.1)<0.001
Echocardiography319 (84.8%)232 (91%)9.4 (20.2–40.8)1.8 (1.1–3)0.023
De-escalation254 (69.2%)210 (84.3%)13.1 (1.6–22.2)2.4 (1.6–3.6)<0.001
Adequate length of antifungal treatment248 (65.3%)237 (96.3%)32.1 (23.1–41.9)14.02 (6.9–28.2)<0.001
QCIPre-intervention group (n = 385)Intervention group (n = 263)Median improvement in percentage of adherence to QCI (IQR)Relative risk for adherence to QCI (95% CI)P value
Early appropriate antifungal therapy248 (64.4%)203 (81.5%)6.9 (4.3–33)2.4 (1.7–3.6)<0.001
Initial treatment with echinocandins if septic shock or severely ill patients in ICUa47 (45.6%)64 (71.1%)26.1 (0–52.5)2.5 (1.39–4.51)<0.001
Early source controlb165 (54.8%)168 (85.7%)29.5 (20.2–40.8)4.9 (3.1–7.8)<0.001
Follow-up blood culture293 (76.1%)220 (87.6%)17 (7.4–26.5)2.2 (1.4–3.5)<0.001
Ophthalmoscopic evaluation192 (52.5%)221 (85.7%)38.5 (28.3–62.2)5.4 (3.6–8.1)<0.001
Echocardiography319 (84.8%)232 (91%)9.4 (20.2–40.8)1.8 (1.1–3)0.023
De-escalation254 (69.2%)210 (84.3%)13.1 (1.6–22.2)2.4 (1.6–3.6)<0.001
Adequate length of antifungal treatment248 (65.3%)237 (96.3%)32.1 (23.1–41.9)14.02 (6.9–28.2)<0.001
a

193 patients.

b

477 patients. If we only take into account those with catheter related-candidaemia (253 patients), the early catheter removal rate was 44.2% versus 86.6%, P<0.001.

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