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Table 1

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The predictive accuracy for every inhibitor on all mutants under four thresholds

Systems	Inhibitors	Mutants no.	Accuracy
Systems	Inhibitors	Mutants no.	No^a	Low^b	Middle^c	High^d
HIV protease	APV	13	1	0.85	0.77	0.85
	NFV	8	1	1	1	1
	SQV	18	1	0.72	0.78	1
	DRV	4	1	1	1	1
	LPV	6	1	1	1	1
HIV reverse transcriptase	EFV	45	0.82	0.76	0.84	0.93
	NVP	34	0.88	0.85	0.94	0.97
	RPV	49	0.84	0.78	0.94	1
	ETR	47	0.79	0.74	0.89	1
Influenza virus neuraminidase	ZMR	7	1	1	1	1
bc1 complex	STI	6	0.83	1	1	1
DHFR-TS	CYC	12	1	1	1	1
DHFR-TS	PYR	12	0.92	0.83	0.83	0.92
Aldose reductase	FID	8	1	0.88	0.88	1
Kinase	GEF	5	1	1	1	1
	DAS	20	0.95	0.8	0.9	1
	NIL	17	1	0.94	1	0.94
Total	17	311	0.89	0.83	0.90	0.97

Systems	Inhibitors	Mutants no.	Accuracy
Systems	Inhibitors	Mutants no.	No^a	Low^b	Middle^c	High^d
HIV protease	APV	13	1	0.85	0.77	0.85
	NFV	8	1	1	1	1
	SQV	18	1	0.72	0.78	1
	DRV	4	1	1	1	1
	LPV	6	1	1	1	1
HIV reverse transcriptase	EFV	45	0.82	0.76	0.84	0.93
	NVP	34	0.88	0.85	0.94	0.97
	RPV	49	0.84	0.78	0.94	1
	ETR	47	0.79	0.74	0.89	1
Influenza virus neuraminidase	ZMR	7	1	1	1	1
bc1 complex	STI	6	0.83	1	1	1
DHFR-TS	CYC	12	1	1	1	1
DHFR-TS	PYR	12	0.92	0.83	0.83	0.92
Aldose reductase	FID	8	1	0.88	0.88	1
Kinase	GEF	5	1	1	1	1
	DAS	20	0.95	0.8	0.9	1
	NIL	17	1	0.94	1	0.94
Total	17	311	0.89	0.83	0.90	0.97

Note: The accuracy is evaluated by categorizing the mutant into ^anon-resistance, ^blow resistance, ^cmiddle resistance, and ^dhigh resistance.

Table 1

Open in new tab

The predictive accuracy for every inhibitor on all mutants under four thresholds

Systems	Inhibitors	Mutants no.	Accuracy
Systems	Inhibitors	Mutants no.	No^a	Low^b	Middle^c	High^d
HIV protease	APV	13	1	0.85	0.77	0.85
	NFV	8	1	1	1	1
	SQV	18	1	0.72	0.78	1
	DRV	4	1	1	1	1
	LPV	6	1	1	1	1
HIV reverse transcriptase	EFV	45	0.82	0.76	0.84	0.93
	NVP	34	0.88	0.85	0.94	0.97
	RPV	49	0.84	0.78	0.94	1
	ETR	47	0.79	0.74	0.89	1
Influenza virus neuraminidase	ZMR	7	1	1	1	1
bc1 complex	STI	6	0.83	1	1	1
DHFR-TS	CYC	12	1	1	1	1
DHFR-TS	PYR	12	0.92	0.83	0.83	0.92
Aldose reductase	FID	8	1	0.88	0.88	1
Kinase	GEF	5	1	1	1	1
	DAS	20	0.95	0.8	0.9	1
	NIL	17	1	0.94	1	0.94
Total	17	311	0.89	0.83	0.90	0.97

Systems	Inhibitors	Mutants no.	Accuracy
Systems	Inhibitors	Mutants no.	No^a	Low^b	Middle^c	High^d
HIV protease	APV	13	1	0.85	0.77	0.85
	NFV	8	1	1	1	1
	SQV	18	1	0.72	0.78	1
	DRV	4	1	1	1	1
	LPV	6	1	1	1	1
HIV reverse transcriptase	EFV	45	0.82	0.76	0.84	0.93
	NVP	34	0.88	0.85	0.94	0.97
	RPV	49	0.84	0.78	0.94	1
	ETR	47	0.79	0.74	0.89	1
Influenza virus neuraminidase	ZMR	7	1	1	1	1
bc1 complex	STI	6	0.83	1	1	1
DHFR-TS	CYC	12	1	1	1	1
DHFR-TS	PYR	12	0.92	0.83	0.83	0.92
Aldose reductase	FID	8	1	0.88	0.88	1
Kinase	GEF	5	1	1	1	1
	DAS	20	0.95	0.8	0.9	1
	NIL	17	1	0.94	1	0.94
Total	17	311	0.89	0.83	0.90	0.97

Note: The accuracy is evaluated by categorizing the mutant into ^anon-resistance, ^blow resistance, ^cmiddle resistance, and ^dhigh resistance.