Cox Regression Analysis of Overall Survival and Progression-Free Survival of 102 Primary Glioblastoma MGMT Unmethylated Patients With Substratification by MGMT Values
| . | OS MGMT (<1.11 vs 1.11-1.99) Hazard Ratio (95% CI), P Value . | PFS MGMT (<1.11 vs 1.11-1.99) Hazard Ratio (95% CI), P Value . | OS MGMT (<1 vs 1-1.99) Hazard Ratio (95% CI), P Value . | PFS MGMT (<1 vs 1-1.99) Hazard Ratio (95% CI), P Value . |
|---|---|---|---|---|
| Age at Diagnosis | 1.021 (0.997-1.046), P = .087 | 1.016 (0.995-1.038), P = .145 | 1.026 (1.001-1.052), P = .043 | 1.017 (0.996-1.039), P = .119 |
| KPS | 1.009 (0.982-1.037), P = .510 | 0.996 (0.972-1.021), P = .749 | 1.013 (0.985-1.041), P = .372 | 0.997 (0.973-1.022), P = .835 |
| Gender Male vs female | 1.831 (1.036-3.235), P = .037 | 1.644 (0.995-2.716), P = .052 | 1.925 (1.084-3.416), P = .025 | 1.653 (0.999-2.734), P = .051 |
| Resection STR and Bx vs GTR | 0.983 (0.587-1.645), P = .948 | 1.116 (0.709-1.757), P = .635 | 0.911 (0.540-1.537), P = .727 | 1.109 (0.703-1.750), P = .657 |
| MGMT Lower vs higher | 2.509 (0.891-7.068), P = .082 | 3.132 (1.298-7.558), P = .011 | 2.375 (0.989-5.699), P = .053 | 2.463 (1.133-5.356), P = .023 |
| . | OS MGMT (<1.11 vs 1.11-1.99) Hazard Ratio (95% CI), P Value . | PFS MGMT (<1.11 vs 1.11-1.99) Hazard Ratio (95% CI), P Value . | OS MGMT (<1 vs 1-1.99) Hazard Ratio (95% CI), P Value . | PFS MGMT (<1 vs 1-1.99) Hazard Ratio (95% CI), P Value . |
|---|---|---|---|---|
| Age at Diagnosis | 1.021 (0.997-1.046), P = .087 | 1.016 (0.995-1.038), P = .145 | 1.026 (1.001-1.052), P = .043 | 1.017 (0.996-1.039), P = .119 |
| KPS | 1.009 (0.982-1.037), P = .510 | 0.996 (0.972-1.021), P = .749 | 1.013 (0.985-1.041), P = .372 | 0.997 (0.973-1.022), P = .835 |
| Gender Male vs female | 1.831 (1.036-3.235), P = .037 | 1.644 (0.995-2.716), P = .052 | 1.925 (1.084-3.416), P = .025 | 1.653 (0.999-2.734), P = .051 |
| Resection STR and Bx vs GTR | 0.983 (0.587-1.645), P = .948 | 1.116 (0.709-1.757), P = .635 | 0.911 (0.540-1.537), P = .727 | 1.109 (0.703-1.750), P = .657 |
| MGMT Lower vs higher | 2.509 (0.891-7.068), P = .082 | 3.132 (1.298-7.558), P = .011 | 2.375 (0.989-5.699), P = .053 | 2.463 (1.133-5.356), P = .023 |
Abbreviations: Bx, biopsy; CI, confidence interval; GTR, gross total resection; KPS, Karnofsky Performance Status; MGMT: O6-methylguanine-DNA methyltransferase; OS, overall survival; PFS, progression-free survival; STR, subtotal resection.
Cox Regression Analysis of Overall Survival and Progression-Free Survival of 102 Primary Glioblastoma MGMT Unmethylated Patients With Substratification by MGMT Values
| . | OS MGMT (<1.11 vs 1.11-1.99) Hazard Ratio (95% CI), P Value . | PFS MGMT (<1.11 vs 1.11-1.99) Hazard Ratio (95% CI), P Value . | OS MGMT (<1 vs 1-1.99) Hazard Ratio (95% CI), P Value . | PFS MGMT (<1 vs 1-1.99) Hazard Ratio (95% CI), P Value . |
|---|---|---|---|---|
| Age at Diagnosis | 1.021 (0.997-1.046), P = .087 | 1.016 (0.995-1.038), P = .145 | 1.026 (1.001-1.052), P = .043 | 1.017 (0.996-1.039), P = .119 |
| KPS | 1.009 (0.982-1.037), P = .510 | 0.996 (0.972-1.021), P = .749 | 1.013 (0.985-1.041), P = .372 | 0.997 (0.973-1.022), P = .835 |
| Gender Male vs female | 1.831 (1.036-3.235), P = .037 | 1.644 (0.995-2.716), P = .052 | 1.925 (1.084-3.416), P = .025 | 1.653 (0.999-2.734), P = .051 |
| Resection STR and Bx vs GTR | 0.983 (0.587-1.645), P = .948 | 1.116 (0.709-1.757), P = .635 | 0.911 (0.540-1.537), P = .727 | 1.109 (0.703-1.750), P = .657 |
| MGMT Lower vs higher | 2.509 (0.891-7.068), P = .082 | 3.132 (1.298-7.558), P = .011 | 2.375 (0.989-5.699), P = .053 | 2.463 (1.133-5.356), P = .023 |
| . | OS MGMT (<1.11 vs 1.11-1.99) Hazard Ratio (95% CI), P Value . | PFS MGMT (<1.11 vs 1.11-1.99) Hazard Ratio (95% CI), P Value . | OS MGMT (<1 vs 1-1.99) Hazard Ratio (95% CI), P Value . | PFS MGMT (<1 vs 1-1.99) Hazard Ratio (95% CI), P Value . |
|---|---|---|---|---|
| Age at Diagnosis | 1.021 (0.997-1.046), P = .087 | 1.016 (0.995-1.038), P = .145 | 1.026 (1.001-1.052), P = .043 | 1.017 (0.996-1.039), P = .119 |
| KPS | 1.009 (0.982-1.037), P = .510 | 0.996 (0.972-1.021), P = .749 | 1.013 (0.985-1.041), P = .372 | 0.997 (0.973-1.022), P = .835 |
| Gender Male vs female | 1.831 (1.036-3.235), P = .037 | 1.644 (0.995-2.716), P = .052 | 1.925 (1.084-3.416), P = .025 | 1.653 (0.999-2.734), P = .051 |
| Resection STR and Bx vs GTR | 0.983 (0.587-1.645), P = .948 | 1.116 (0.709-1.757), P = .635 | 0.911 (0.540-1.537), P = .727 | 1.109 (0.703-1.750), P = .657 |
| MGMT Lower vs higher | 2.509 (0.891-7.068), P = .082 | 3.132 (1.298-7.558), P = .011 | 2.375 (0.989-5.699), P = .053 | 2.463 (1.133-5.356), P = .023 |
Abbreviations: Bx, biopsy; CI, confidence interval; GTR, gross total resection; KPS, Karnofsky Performance Status; MGMT: O6-methylguanine-DNA methyltransferase; OS, overall survival; PFS, progression-free survival; STR, subtotal resection.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
