Table 4 Open in new tab Cox...

Characteristic	Definition	Multivariable Analysis	Multivariable Analysis
Age	19-59			Ref.			Ref.
	<18	0.79	0.66-0.97	.020	0.80	0.66-0.97	.023
	60+	1.79	1.60-1.99	<.001	1.78	1.59-1.98	<.001
Sex	Female			Ref.			Ref.
	Male	1.15	1.04-1.27	.008	1.16	1.05-1.28	.005
Race	White			Ref.			Ref.
	Black	1.27	1.09-1.46	.002	1.23	1.06-1.42	.006
	Asian and other	0.93	0.77-1.12	.432	0.93	0.77-1.12	.431
	Unknown	0.42	0.14-1.32	.137	0.40	0.13-1.26	.117
Therapy	Sx only
	Rx only
	Sx and Rx
	None
	Unknown
Surgery	GTR						Ref.
	PR				1.10	0.96-1.27	.174
	Biopsy				1.56	1.13-2.14	.007
	No Sx				1.93	1.60-2.32	<.001
	Sx NOS				1.16	1.00-1.35	.055
	Unknown				1.97	1.53-2.52	<.001
Radiation Sequence	No Sx or no Rx			Ref.
	Rx after Sx	0.97	0.86-1.09	.569
	Rx before Sx	0.85	0.67-1.09	.209
	Rx b/a Sx	0.74	0.40-1.39	.355
	Rx intraop	0.72	0.32-1.60	.418
	Unknown	0.98	0.44-2.19	.958
Tumor Location	Limbs			Ref.			Ref.
	Intracranial	0.88	0.66-1.17	.380	0.74	0.55-1.00	.046
	Spinal	1.23	0.91-1.66	.177	1.31	0.97-1.77	.084
	H&N	1.32	1.11-1.58	.002	1.28	1.08-1.53	.005
	Core	1.62	1.44-1.83	<.001	1.57	1.39-1.77	<.001
	NOS and Unknown	1.99	1.61-2.45	<.001	1.73	1.40-2.15	<.001
Tumor Grade	I			Ref.			Ref.
	II	1.33	0.94-1.88	.113	1.35	0.96-1.92	.101
	III	2.83	2.02-3.96	<.001	2.82	2.02-3.95	<.001
	IV	3.40	2.45-4.71	<.001	3.40	2.45-4.71	<.001
	Unknown	2.44	1.79-3.34	<.001	2.32	2.32-1.69	<.001
Tumor Size	≤50 mm			Ref.			Ref.
	>50 mm	2.33	2.00-2.72	<.001	2.33	1.99-2.72	<.001
	Unknown	1.93	1.65-2.25	<.001	1.82	1.55-2.13	<.001

Characteristic

Definition

Multivariable Analysis

95% CI

Age

19-59

Ref.

<18

0.79

0.66-0.97

.020

0.80

0.66-0.97

.023

60+

1.79

1.60-1.99

<.001

1.78

1.59-1.98

<.001

Sex

Female

Ref.

Male

1.15

1.04-1.27

.008

1.16

1.05-1.28

.005

Race

White

Ref.

Black

1.27

1.09-1.46

.002

1.23

1.06-1.42

.006

Asian and other

0.93

0.77-1.12

.432

0.93

0.77-1.12

.431

Unknown

0.42

0.14-1.32

.137

0.40

0.13-1.26

.117

Therapy

Sx only

Rx only

Sx and Rx

None

Unknown

Surgery

GTR

Ref.

1.10

0.96-1.27

.174

Biopsy

1.56

1.13-2.14

.007

No Sx

1.93

1.60-2.32

<.001

Sx NOS

1.16

1.00-1.35

.055

Unknown

1.97

1.53-2.52

<.001

Radiation Sequence

No Sx or no Rx

Ref.

Rx after Sx

0.97

0.86-1.09

.569

Rx before Sx

0.85

0.67-1.09

.209

Rx b/a Sx

0.74

0.40-1.39

.355

Rx intraop

0.72

0.32-1.60

.418

Unknown

0.98

0.44-2.19

.958

Tumor Location

Limbs

Ref.

Intracranial

0.88

0.66-1.17

.380

0.74

0.55-1.00

.046

Spinal

1.23

0.91-1.66

.177

1.31

0.97-1.77

.084

H&N

1.32

1.11-1.58

.002

1.28

1.08-1.53

.005

Core

1.62

1.44-1.83

<.001

1.57

1.39-1.77

<.001

NOS and Unknown

1.99

1.61-2.45

<.001

1.73

1.40-2.15

<.001

Tumor Grade

Ref.

1.33

0.94-1.88

.113

1.35

0.96-1.92

.101

III

2.83

2.02-3.96

<.001

2.82

2.02-3.95

<.001

3.40

2.45-4.71

<.001

3.40

2.45-4.71

<.001

Unknown

2.44

1.79-3.34

<.001

2.32

2.32-1.69

<.001

Tumor Size

≤50 mm

Ref.

>50 mm

2.33

2.00-2.72

<.001

2.33

1.99-2.72

<.001

Unknown

1.93

1.65-2.25

<.001

1.82

1.55-2.13

<.001

Characteristic	Definition	Multivariable Analysis	Multivariable Analysis
Age	19-59			Ref.			Ref.
	<18	0.79	0.66-0.97	.020	0.80	0.66-0.97	.023
	60+	1.79	1.60-1.99	<.001	1.78	1.59-1.98	<.001
Sex	Female			Ref.			Ref.
	Male	1.15	1.04-1.27	.008	1.16	1.05-1.28	.005
Race	White			Ref.			Ref.
	Black	1.27	1.09-1.46	.002	1.23	1.06-1.42	.006
	Asian and other	0.93	0.77-1.12	.432	0.93	0.77-1.12	.431
	Unknown	0.42	0.14-1.32	.137	0.40	0.13-1.26	.117
Therapy	Sx only
	Rx only
	Sx and Rx
	None
	Unknown
Surgery	GTR						Ref.
	PR				1.10	0.96-1.27	.174
	Biopsy				1.56	1.13-2.14	.007
	No Sx				1.93	1.60-2.32	<.001
	Sx NOS				1.16	1.00-1.35	.055
	Unknown				1.97	1.53-2.52	<.001
Radiation Sequence	No Sx or no Rx			Ref.
	Rx after Sx	0.97	0.86-1.09	.569
	Rx before Sx	0.85	0.67-1.09	.209
	Rx b/a Sx	0.74	0.40-1.39	.355
	Rx intraop	0.72	0.32-1.60	.418
	Unknown	0.98	0.44-2.19	.958
Tumor Location	Limbs			Ref.			Ref.
	Intracranial	0.88	0.66-1.17	.380	0.74	0.55-1.00	.046
	Spinal	1.23	0.91-1.66	.177	1.31	0.97-1.77	.084
	H&N	1.32	1.11-1.58	.002	1.28	1.08-1.53	.005
	Core	1.62	1.44-1.83	<.001	1.57	1.39-1.77	<.001
	NOS and Unknown	1.99	1.61-2.45	<.001	1.73	1.40-2.15	<.001
Tumor Grade	I			Ref.			Ref.
	II	1.33	0.94-1.88	.113	1.35	0.96-1.92	.101
	III	2.83	2.02-3.96	<.001	2.82	2.02-3.95	<.001
	IV	3.40	2.45-4.71	<.001	3.40	2.45-4.71	<.001
	Unknown	2.44	1.79-3.34	<.001	2.32	2.32-1.69	<.001
Tumor Size	≤50 mm			Ref.			Ref.
	>50 mm	2.33	2.00-2.72	<.001	2.33	1.99-2.72	<.001
	Unknown	1.93	1.65-2.25	<.001	1.82	1.55-2.13	<.001

Table 4

Open in new tab

Cox Multivariable Analysis of Overall Survival in All Primary Malignant Peripheral Nerve Sheath Tumors: Radiation Sequence and Extent of Surgery

Characteristic	Definition	Multivariable Analysis			Multivariable Analysis
Characteristic	Definition	HR	95% CI	P	HR	95% CI	P
Age	19-59			Ref.			Ref.
	<18	0.79	0.66-0.97	.020	0.80	0.66-0.97	.023
	60+	1.79	1.60-1.99	<.001	1.78	1.59-1.98	<.001
Sex	Female			Ref.			Ref.
	Male	1.15	1.04-1.27	.008	1.16	1.05-1.28	.005
Race	White			Ref.			Ref.
	Black	1.27	1.09-1.46	.002	1.23	1.06-1.42	.006
	Asian and other	0.93	0.77-1.12	.432	0.93	0.77-1.12	.431
	Unknown	0.42	0.14-1.32	.137	0.40	0.13-1.26	.117
Therapy	Sx only
	Rx only
	Sx and Rx
	None
	Unknown
Surgery	GTR						Ref.
	PR				1.10	0.96-1.27	.174
	Biopsy				1.56	1.13-2.14	.007
	No Sx				1.93	1.60-2.32	<.001
	Sx NOS				1.16	1.00-1.35	.055
	Unknown				1.97	1.53-2.52	<.001
Radiation Sequence	No Sx or no Rx			Ref.
	Rx after Sx	0.97	0.86-1.09	.569
	Rx before Sx	0.85	0.67-1.09	.209
	Rx b/a Sx	0.74	0.40-1.39	.355
	Rx intraop	0.72	0.32-1.60	.418
	Unknown	0.98	0.44-2.19	.958
Tumor Location	Limbs			Ref.			Ref.
	Intracranial	0.88	0.66-1.17	.380	0.74	0.55-1.00	.046
	Spinal	1.23	0.91-1.66	.177	1.31	0.97-1.77	.084
	H&N	1.32	1.11-1.58	.002	1.28	1.08-1.53	.005
	Core	1.62	1.44-1.83	<.001	1.57	1.39-1.77	<.001
	NOS and Unknown	1.99	1.61-2.45	<.001	1.73	1.40-2.15	<.001
Tumor Grade	I			Ref.			Ref.
	II	1.33	0.94-1.88	.113	1.35	0.96-1.92	.101
	III	2.83	2.02-3.96	<.001	2.82	2.02-3.95	<.001
	IV	3.40	2.45-4.71	<.001	3.40	2.45-4.71	<.001
	Unknown	2.44	1.79-3.34	<.001	2.32	2.32-1.69	<.001
Tumor Size	≤50 mm			Ref.			Ref.
	>50 mm	2.33	2.00-2.72	<.001	2.33	1.99-2.72	<.001
	Unknown	1.93	1.65-2.25	<.001	1.82	1.55-2.13	<.001

Characteristic	Definition	Multivariable Analysis			Multivariable Analysis
Characteristic	Definition	HR	95% CI	P	HR	95% CI	P
Age	19-59			Ref.			Ref.
	<18	0.79	0.66-0.97	.020	0.80	0.66-0.97	.023
	60+	1.79	1.60-1.99	<.001	1.78	1.59-1.98	<.001
Sex	Female			Ref.			Ref.
	Male	1.15	1.04-1.27	.008	1.16	1.05-1.28	.005
Race	White			Ref.			Ref.
	Black	1.27	1.09-1.46	.002	1.23	1.06-1.42	.006
	Asian and other	0.93	0.77-1.12	.432	0.93	0.77-1.12	.431
	Unknown	0.42	0.14-1.32	.137	0.40	0.13-1.26	.117
Therapy	Sx only
	Rx only
	Sx and Rx
	None
	Unknown
Surgery	GTR						Ref.
	PR				1.10	0.96-1.27	.174
	Biopsy				1.56	1.13-2.14	.007
	No Sx				1.93	1.60-2.32	<.001
	Sx NOS				1.16	1.00-1.35	.055
	Unknown				1.97	1.53-2.52	<.001
Radiation Sequence	No Sx or no Rx			Ref.
	Rx after Sx	0.97	0.86-1.09	.569
	Rx before Sx	0.85	0.67-1.09	.209
	Rx b/a Sx	0.74	0.40-1.39	.355
	Rx intraop	0.72	0.32-1.60	.418
	Unknown	0.98	0.44-2.19	.958
Tumor Location	Limbs			Ref.			Ref.
	Intracranial	0.88	0.66-1.17	.380	0.74	0.55-1.00	.046
	Spinal	1.23	0.91-1.66	.177	1.31	0.97-1.77	.084
	H&N	1.32	1.11-1.58	.002	1.28	1.08-1.53	.005
	Core	1.62	1.44-1.83	<.001	1.57	1.39-1.77	<.001
	NOS and Unknown	1.99	1.61-2.45	<.001	1.73	1.40-2.15	<.001
Tumor Grade	I			Ref.			Ref.
	II	1.33	0.94-1.88	.113	1.35	0.96-1.92	.101
	III	2.83	2.02-3.96	<.001	2.82	2.02-3.95	<.001
	IV	3.40	2.45-4.71	<.001	3.40	2.45-4.71	<.001
	Unknown	2.44	1.79-3.34	<.001	2.32	2.32-1.69	<.001
Tumor Size	≤50 mm			Ref.			Ref.
	>50 mm	2.33	2.00-2.72	<.001	2.33	1.99-2.72	<.001
	Unknown	1.93	1.65-2.25	<.001	1.82	1.55-2.13	<.001

Abbreviations: b/a, before and after; CI, confidence interval; GTR, gross total resection; H&N, head and neck; HR, hazard ratio; intraop, intraoperatively; NOS, not otherwise specified; PR, partial resection; Ref., reference; Rx, radiotherapy; Sx, surgery.

This Feature Is Available To Subscribers Only