| Eurofins panel (304 kinases) | |||
| P33 assays | |||
| IC50 (nM) | IC50 ratioa | ATP (µM) | |
| CaMKIIγ (h) | <3 | ∼1 | 10 |
| CaMKIIδ (h) | <3 | 1 | 10 |
| CaMKIδ (h) | 12 | >4 | 15 |
| CaMKIIβ (h) | 17 | >6 | 15 |
| ACK1 (h) | 26 | >9 | 70 |
| MLK1 (h) | 89 | >30 | 45 |
| SIK (h) | 149 | >50 | 45 |
| PTK5 (h) | 216 | >72 | 155 |
| Pyk2 (h) | 249 | >83 | 90 |
| IRE1 (h) | 254 | >85 | 15 |
| ULK2 (h) | 255 | >85 | 15 |
| CaMKK2 (h) | 294 | >98 | 90 |
| Others | >300 | >100 | Km |
| CEREP panel (107 targets) | |||
| Binding, enzyme, and uptake assays | |||
| I%–10 µM | I%–1 µM | IC50 (nM) | |
| CaMK2α (h) | 101 | NA | NA |
| Sigma (1/2) (h) | 96 | 73 | NA |
| 15-Lipoxygenase-2 (h) | 96 | 73 | 270 |
| M3 (h) | 90 | NA | NA |
| IRK (h) | 74 | NA | NA |
| Others | <50 | NA | NA |
| Ion channels | |||
| Manual patch-clamp | |||
| RA306 IC50 (µM) | KN93 IC50 (µM) | IC50 ratiob | |
| ERG (h) | >30 | 0.08 | >375 |
| Kv4.3 (h) | >30 | 4 | >7.5 |
| Nav1.5 (h) | >30 | 2.7 | >11 |
| Cav1.2 (h) | 14 | 0.9 | 15 |
| Eurofins panel (304 kinases) | |||
| P33 assays | |||
| IC50 (nM) | IC50 ratioa | ATP (µM) | |
| CaMKIIγ (h) | <3 | ∼1 | 10 |
| CaMKIIδ (h) | <3 | 1 | 10 |
| CaMKIδ (h) | 12 | >4 | 15 |
| CaMKIIβ (h) | 17 | >6 | 15 |
| ACK1 (h) | 26 | >9 | 70 |
| MLK1 (h) | 89 | >30 | 45 |
| SIK (h) | 149 | >50 | 45 |
| PTK5 (h) | 216 | >72 | 155 |
| Pyk2 (h) | 249 | >83 | 90 |
| IRE1 (h) | 254 | >85 | 15 |
| ULK2 (h) | 255 | >85 | 15 |
| CaMKK2 (h) | 294 | >98 | 90 |
| Others | >300 | >100 | Km |
| CEREP panel (107 targets) | |||
| Binding, enzyme, and uptake assays | |||
| I%–10 µM | I%–1 µM | IC50 (nM) | |
| CaMK2α (h) | 101 | NA | NA |
| Sigma (1/2) (h) | 96 | 73 | NA |
| 15-Lipoxygenase-2 (h) | 96 | 73 | 270 |
| M3 (h) | 90 | NA | NA |
| IRK (h) | 74 | NA | NA |
| Others | <50 | NA | NA |
| Ion channels | |||
| Manual patch-clamp | |||
| RA306 IC50 (µM) | KN93 IC50 (µM) | IC50 ratiob | |
| ERG (h) | >30 | 0.08 | >375 |
| Kv4.3 (h) | >30 | 4 | >7.5 |
| Nav1.5 (h) | >30 | 2.7 | >11 |
| Cav1.2 (h) | 14 | 0.9 | 15 |
| Eurofins panel (304 kinases) | |||
| P33 assays | |||
| IC50 (nM) | IC50 ratioa | ATP (µM) | |
| CaMKIIγ (h) | <3 | ∼1 | 10 |
| CaMKIIδ (h) | <3 | 1 | 10 |
| CaMKIδ (h) | 12 | >4 | 15 |
| CaMKIIβ (h) | 17 | >6 | 15 |
| ACK1 (h) | 26 | >9 | 70 |
| MLK1 (h) | 89 | >30 | 45 |
| SIK (h) | 149 | >50 | 45 |
| PTK5 (h) | 216 | >72 | 155 |
| Pyk2 (h) | 249 | >83 | 90 |
| IRE1 (h) | 254 | >85 | 15 |
| ULK2 (h) | 255 | >85 | 15 |
| CaMKK2 (h) | 294 | >98 | 90 |
| Others | >300 | >100 | Km |
| CEREP panel (107 targets) | |||
| Binding, enzyme, and uptake assays | |||
| I%–10 µM | I%–1 µM | IC50 (nM) | |
| CaMK2α (h) | 101 | NA | NA |
| Sigma (1/2) (h) | 96 | 73 | NA |
| 15-Lipoxygenase-2 (h) | 96 | 73 | 270 |
| M3 (h) | 90 | NA | NA |
| IRK (h) | 74 | NA | NA |
| Others | <50 | NA | NA |
| Ion channels | |||
| Manual patch-clamp | |||
| RA306 IC50 (µM) | KN93 IC50 (µM) | IC50 ratiob | |
| ERG (h) | >30 | 0.08 | >375 |
| Kv4.3 (h) | >30 | 4 | >7.5 |
| Nav1.5 (h) | >30 | 2.7 | >11 |
| Cav1.2 (h) | 14 | 0.9 | 15 |
| Eurofins panel (304 kinases) | |||
| P33 assays | |||
| IC50 (nM) | IC50 ratioa | ATP (µM) | |
| CaMKIIγ (h) | <3 | ∼1 | 10 |
| CaMKIIδ (h) | <3 | 1 | 10 |
| CaMKIδ (h) | 12 | >4 | 15 |
| CaMKIIβ (h) | 17 | >6 | 15 |
| ACK1 (h) | 26 | >9 | 70 |
| MLK1 (h) | 89 | >30 | 45 |
| SIK (h) | 149 | >50 | 45 |
| PTK5 (h) | 216 | >72 | 155 |
| Pyk2 (h) | 249 | >83 | 90 |
| IRE1 (h) | 254 | >85 | 15 |
| ULK2 (h) | 255 | >85 | 15 |
| CaMKK2 (h) | 294 | >98 | 90 |
| Others | >300 | >100 | Km |
| CEREP panel (107 targets) | |||
| Binding, enzyme, and uptake assays | |||
| I%–10 µM | I%–1 µM | IC50 (nM) | |
| CaMK2α (h) | 101 | NA | NA |
| Sigma (1/2) (h) | 96 | 73 | NA |
| 15-Lipoxygenase-2 (h) | 96 | 73 | 270 |
| M3 (h) | 90 | NA | NA |
| IRK (h) | 74 | NA | NA |
| Others | <50 | NA | NA |
| Ion channels | |||
| Manual patch-clamp | |||
| RA306 IC50 (µM) | KN93 IC50 (µM) | IC50 ratiob | |
| ERG (h) | >30 | 0.08 | >375 |
| Kv4.3 (h) | >30 | 4 | >7.5 |
| Nav1.5 (h) | >30 | 2.7 | >11 |
| Cav1.2 (h) | 14 | 0.9 | 15 |
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