Table 4 Open in new tab Cardiac...

Echosonographic parameters	NaTS group (n = 26)	Saline group (n = 29)	P-value** (NaTS versus saline group)
LVEDD (mm), mean ± SD	47.1 ± 8.5	47.7 ± 7.7	0.512	47.3 ± 6.4	50.0 ± 7.0	0.013	0.583	0.241
LVDES (mm), mean ± SD	32.9 ± 6.9	33.5 ± 6.0	0.476	34.2 ± 6.1	35.6 ± 6.2	0.195	0.466	0.213
IVSD (mm), mean±SD	11.6 ± 2.2	12.0 1.8	0.063	11.4 ± 2.0	11.9 ± 1.6	0.041	0.619	0.662
LPWD (mm), mean ± SD	11.3 ± 2.2	11.6 ± 1.5	0.242	10.8 ± 1.6	11.7 ± 1.4	0.000	0.426	0.973
EF (%), mean ± SD	54.2 ± 7.2	53.1 ± 6.9	0.282	54.8 ± 7.0	53.8 ± 7.8	0.227	0.717	0.571
Overall patients with calcified valves, n	20	20	1.000	20	28	0.008	–
Patients with calcified aortic valves, n	6	4	11	10
Patients with calcified mitral valves, n	5	3	1	3
Patients with calcified aortic plus mitral valves, n	9	13	8	15

Echosonographic parameters

NaTS group (n = 26)

Saline group (n = 29)

P-value** (NaTS versus saline group)

Before

After

P-value*

Before

After

P-value*

Before

After

LVEDD (mm), mean ± SD

47.1 ± 8.5

47.7 ± 7.7

0.512

47.3 ± 6.4

50.0 ± 7.0

0.013

0.583

0.241

LVDES (mm), mean ± SD

32.9 ± 6.9

33.5 ± 6.0

0.476

34.2 ± 6.1

35.6 ± 6.2

0.195

0.466

0.213

IVSD (mm), mean±SD

11.6 ± 2.2

12.0 1.8

0.063

11.4 ± 2.0

11.9 ± 1.6

0.041

0.619

0.662

LPWD (mm), mean ± SD

11.3 ± 2.2

11.6 ± 1.5

0.242

10.8 ± 1.6

11.7 ± 1.4

0.000

0.426

0.973

EF (%), mean ± SD

54.2 ± 7.2

53.1 ± 6.9

0.282

54.8 ± 7.0

53.8 ± 7.8

0.227

0.717

0.571

Overall patients with calcified valves, n

1.000

0.008

–

Patients with calcified aortic valves, n

Patients with calcified mitral valves, n

Patients with calcified aortic plus mitral valves, n

Echosonographic parameters	NaTS group (n = 26)	Saline group (n = 29)	P-value** (NaTS versus saline group)
LVEDD (mm), mean ± SD	47.1 ± 8.5	47.7 ± 7.7	0.512	47.3 ± 6.4	50.0 ± 7.0	0.013	0.583	0.241
LVDES (mm), mean ± SD	32.9 ± 6.9	33.5 ± 6.0	0.476	34.2 ± 6.1	35.6 ± 6.2	0.195	0.466	0.213
IVSD (mm), mean±SD	11.6 ± 2.2	12.0 1.8	0.063	11.4 ± 2.0	11.9 ± 1.6	0.041	0.619	0.662
LPWD (mm), mean ± SD	11.3 ± 2.2	11.6 ± 1.5	0.242	10.8 ± 1.6	11.7 ± 1.4	0.000	0.426	0.973
EF (%), mean ± SD	54.2 ± 7.2	53.1 ± 6.9	0.282	54.8 ± 7.0	53.8 ± 7.8	0.227	0.717	0.571
Overall patients with calcified valves, n	20	20	1.000	20	28	0.008	–
Patients with calcified aortic valves, n	6	4	11	10
Patients with calcified mitral valves, n	5	3	1	3
Patients with calcified aortic plus mitral valves, n	9	13	8	15

Table 4

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Cardiac structure/function and calcification of cardiac valves before and at the end of therapy with NaTS

Echosonographic parameters	NaTS group (n = 26)			Saline group (n = 29)			P-value** (NaTS versus saline group)
Echosonographic parameters	Before	After	P-value*	Before	After	P-value*	Before	After
LVEDD (mm), mean ± SD	47.1 ± 8.5	47.7 ± 7.7	0.512	47.3 ± 6.4	50.0 ± 7.0	0.013	0.583	0.241
LVDES (mm), mean ± SD	32.9 ± 6.9	33.5 ± 6.0	0.476	34.2 ± 6.1	35.6 ± 6.2	0.195	0.466	0.213
IVSD (mm), mean±SD	11.6 ± 2.2	12.0 1.8	0.063	11.4 ± 2.0	11.9 ± 1.6	0.041	0.619	0.662
LPWD (mm), mean ± SD	11.3 ± 2.2	11.6 ± 1.5	0.242	10.8 ± 1.6	11.7 ± 1.4	0.000	0.426	0.973
EF (%), mean ± SD	54.2 ± 7.2	53.1 ± 6.9	0.282	54.8 ± 7.0	53.8 ± 7.8	0.227	0.717	0.571
Overall patients with calcified valves, n	20	20	1.000	20	28	0.008	–
Patients with calcified aortic valves, n	6	4		11	10
Patients with calcified mitral valves, n	5	3		1	3
Patients with calcified aortic plus mitral valves, n	9	13		8	15

Echosonographic parameters	NaTS group (n = 26)			Saline group (n = 29)			P-value** (NaTS versus saline group)
Echosonographic parameters	Before	After	P-value*	Before	After	P-value*	Before	After
LVEDD (mm), mean ± SD	47.1 ± 8.5	47.7 ± 7.7	0.512	47.3 ± 6.4	50.0 ± 7.0	0.013	0.583	0.241
LVDES (mm), mean ± SD	32.9 ± 6.9	33.5 ± 6.0	0.476	34.2 ± 6.1	35.6 ± 6.2	0.195	0.466	0.213
IVSD (mm), mean±SD	11.6 ± 2.2	12.0 1.8	0.063	11.4 ± 2.0	11.9 ± 1.6	0.041	0.619	0.662
LPWD (mm), mean ± SD	11.3 ± 2.2	11.6 ± 1.5	0.242	10.8 ± 1.6	11.7 ± 1.4	0.000	0.426	0.973
EF (%), mean ± SD	54.2 ± 7.2	53.1 ± 6.9	0.282	54.8 ± 7.0	53.8 ± 7.8	0.227	0.717	0.571
Overall patients with calcified valves, n	20	20	1.000	20	28	0.008	–
Patients with calcified aortic valves, n	6	4		11	10
Patients with calcified mitral valves, n	5	3		1	3
Patients with calcified aortic plus mitral valves, n	9	13		8	15

Bold indicates statistical significance and correspond to head P-value (P-value*).

P-values refer to comparisons before and at the end of the study.

P-values refer to comparisons before (NaTS versus saline) and after the study (NaTS versus saline).

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