Table 1

Grouping of the 20 standard amino acids to four basic groups (C1–C4) and three combined groups (⁠|${H}_1$|-|${H}_3$|⁠) according to their hydrophobicity and charge characteristics

GroupAmino acids
Hydrophobic (C1)A, F, G, I, L, M, P, V, W
Polar (C2)C, N, Q, S, T, Y
Positively charged (C3)K, H, R
Negatively charged (C4)D, E
Combined |${\boldsymbol{H}}_{\mathbf{1}}$|C1 + C2
Combined |${\boldsymbol{H}}_{\mathbf{2}}$|C1 + C3
Combined |${\boldsymbol{H}}_{\mathbf{3}}$|C1 + C4
GroupAmino acids
Hydrophobic (C1)A, F, G, I, L, M, P, V, W
Polar (C2)C, N, Q, S, T, Y
Positively charged (C3)K, H, R
Negatively charged (C4)D, E
Combined |${\boldsymbol{H}}_{\mathbf{1}}$|C1 + C2
Combined |${\boldsymbol{H}}_{\mathbf{2}}$|C1 + C3
Combined |${\boldsymbol{H}}_{\mathbf{3}}$|C1 + C4
Table 1

Grouping of the 20 standard amino acids to four basic groups (C1–C4) and three combined groups (⁠|${H}_1$|-|${H}_3$|⁠) according to their hydrophobicity and charge characteristics

GroupAmino acids
Hydrophobic (C1)A, F, G, I, L, M, P, V, W
Polar (C2)C, N, Q, S, T, Y
Positively charged (C3)K, H, R
Negatively charged (C4)D, E
Combined |${\boldsymbol{H}}_{\mathbf{1}}$|C1 + C2
Combined |${\boldsymbol{H}}_{\mathbf{2}}$|C1 + C3
Combined |${\boldsymbol{H}}_{\mathbf{3}}$|C1 + C4
GroupAmino acids
Hydrophobic (C1)A, F, G, I, L, M, P, V, W
Polar (C2)C, N, Q, S, T, Y
Positively charged (C3)K, H, R
Negatively charged (C4)D, E
Combined |${\boldsymbol{H}}_{\mathbf{1}}$|C1 + C2
Combined |${\boldsymbol{H}}_{\mathbf{2}}$|C1 + C3
Combined |${\boldsymbol{H}}_{\mathbf{3}}$|C1 + C4
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