| Characteristic . | Caspofungin (2 mg/kg), n=31 . | dAMB (1 mg/kg), n=16 . | Total, N=47 . |
|---|---|---|---|
| Age (days), median (minimum–maximum) | 22.0 (11–88) | 25.0 (7–74) | 22 (7–88) |
| Sex, n (%) | |||
| male | 18 (58.1) | 7 (43.8) | 25 (53.2) |
| female | 13 (41.9) | 9 (56.3) | 22 (46.8) |
| Race, n (%) | |||
| white | 12 (38.7) | 7 (43.8) | 19 (40.4) |
| black or African American | 11 (35.5) | 6 (37.5) | 17 (36.2) |
| multiracial | 5 (16.1) | 2 (12.5) | 7 (14.9) |
| American Indian/Alaskan Native | 3 (9.7) | 1 (6.3) | 4 (8.5) |
| Ethnicity, n (%) | |||
| Hispanic or Latino | 11 (35.5) | 7 (43.8) | 18 (38.3) |
| not Hispanic or Latino | 19 (61.3) | 8 (50.0) | 27 (57.4) |
| unknown/not reported | 1 (3.2) | 1 (6.3) | 2 (4.3) |
| Baseline weight (g) | |||
| median (range) | 1910 (810–4410) | 1684 (425–6540) | 1860 (425–6540) |
| <1000, n (%) | 4 (12.9) | 3 (18.8) | 7 (14.9) |
| 1000 to 1500, n (%) | 9 (29.0) | 4 (25.0) | 13 (27.7) |
| >1500, n (%) | 18 (58.1) | 9 (56.3) | 27 (57.4) |
| Gestational age (weeks), median (minimum–maximum) | 32.0 (26.0–41.0) | 30.0 (26.7–40.0) | 30.4 (26.0–41.0) |
| Birth weight (g) | |||
| median (minimum–maximum) | 1335.0 (850–3985) | 1462.5 (510–4175) | 1445.0 (510–4175) |
| <1000, n (%) | 7 (22.6) | 3 (18.8) | 10 (21.3) |
| 1000 to 1500, n (%) | 11 (35.5) | 6 (37.5) | 17 (36.2) |
| >1500, n (%) | 13 (41.9) | 7 (43.8) | 20 (42.6) |
| Baseline fungal isolates, n (%) | |||
| C. albicans | 27 (87.1) | 12 (75.0) | 39 (83.0) |
| Candida glabrata | 0 | 1 (6.3) | 1 (2.1) |
| Candida intermedia | 1 (3.2) | 0 | 1 (2.1) |
| Candida parapsilosis | 1 (3.2) | 1 (6.3) | 2 (4.3) |
| Candida tropicalis | 1 (3.2) | 0 | 1 (2.1) |
| C. albicans/C. glabrata | 1 (3.2) | 0 | 1 (2.1) |
| Pichia kudriavzevii | 0 | 1 (6.3) | 1 (2.1) |
| unspecified | 0 | 1 (6.3) | 1 (2.1) |
| Associated fungal diagnosis, n/N (%) | |||
| candidaemia | 24/31 (77.4) | 8/16 (50.0) | 32/47 (68.1) |
| urinary tract infection | 3/31 (9.7) | 2/16 (12.5) | 5/47 (10.6) |
| endocarditis | 1/31 (3.2) | 1/16 (6.3) | 2/47 (4.3) |
| lung infection | 1/31 (3.2) | 1/16 (6.3) | 2/47 (4.3) |
| meningoencephalitisa | 1/31 (3.2) | 1/16 (6.3) | 2/47 (4.3) |
| endophthalmitis | 0 | 1/16 (6.3) | 1/47 (2.1) |
| peritonitis | 0 | 1/16 (6.3) | 1/47 (2.1) |
| Characteristic . | Caspofungin (2 mg/kg), n=31 . | dAMB (1 mg/kg), n=16 . | Total, N=47 . |
|---|---|---|---|
| Age (days), median (minimum–maximum) | 22.0 (11–88) | 25.0 (7–74) | 22 (7–88) |
| Sex, n (%) | |||
| male | 18 (58.1) | 7 (43.8) | 25 (53.2) |
| female | 13 (41.9) | 9 (56.3) | 22 (46.8) |
| Race, n (%) | |||
| white | 12 (38.7) | 7 (43.8) | 19 (40.4) |
| black or African American | 11 (35.5) | 6 (37.5) | 17 (36.2) |
| multiracial | 5 (16.1) | 2 (12.5) | 7 (14.9) |
| American Indian/Alaskan Native | 3 (9.7) | 1 (6.3) | 4 (8.5) |
| Ethnicity, n (%) | |||
| Hispanic or Latino | 11 (35.5) | 7 (43.8) | 18 (38.3) |
| not Hispanic or Latino | 19 (61.3) | 8 (50.0) | 27 (57.4) |
| unknown/not reported | 1 (3.2) | 1 (6.3) | 2 (4.3) |
| Baseline weight (g) | |||
| median (range) | 1910 (810–4410) | 1684 (425–6540) | 1860 (425–6540) |
| <1000, n (%) | 4 (12.9) | 3 (18.8) | 7 (14.9) |
| 1000 to 1500, n (%) | 9 (29.0) | 4 (25.0) | 13 (27.7) |
| >1500, n (%) | 18 (58.1) | 9 (56.3) | 27 (57.4) |
| Gestational age (weeks), median (minimum–maximum) | 32.0 (26.0–41.0) | 30.0 (26.7–40.0) | 30.4 (26.0–41.0) |
| Birth weight (g) | |||
| median (minimum–maximum) | 1335.0 (850–3985) | 1462.5 (510–4175) | 1445.0 (510–4175) |
| <1000, n (%) | 7 (22.6) | 3 (18.8) | 10 (21.3) |
| 1000 to 1500, n (%) | 11 (35.5) | 6 (37.5) | 17 (36.2) |
| >1500, n (%) | 13 (41.9) | 7 (43.8) | 20 (42.6) |
| Baseline fungal isolates, n (%) | |||
| C. albicans | 27 (87.1) | 12 (75.0) | 39 (83.0) |
| Candida glabrata | 0 | 1 (6.3) | 1 (2.1) |
| Candida intermedia | 1 (3.2) | 0 | 1 (2.1) |
| Candida parapsilosis | 1 (3.2) | 1 (6.3) | 2 (4.3) |
| Candida tropicalis | 1 (3.2) | 0 | 1 (2.1) |
| C. albicans/C. glabrata | 1 (3.2) | 0 | 1 (2.1) |
| Pichia kudriavzevii | 0 | 1 (6.3) | 1 (2.1) |
| unspecified | 0 | 1 (6.3) | 1 (2.1) |
| Associated fungal diagnosis, n/N (%) | |||
| candidaemia | 24/31 (77.4) | 8/16 (50.0) | 32/47 (68.1) |
| urinary tract infection | 3/31 (9.7) | 2/16 (12.5) | 5/47 (10.6) |
| endocarditis | 1/31 (3.2) | 1/16 (6.3) | 2/47 (4.3) |
| lung infection | 1/31 (3.2) | 1/16 (6.3) | 2/47 (4.3) |
| meningoencephalitisa | 1/31 (3.2) | 1/16 (6.3) | 2/47 (4.3) |
| endophthalmitis | 0 | 1/16 (6.3) | 1/47 (2.1) |
| peritonitis | 0 | 1/16 (6.3) | 1/47 (2.1) |
Meningoencephalitis was confirmed by lumbar puncture.
| Characteristic . | Caspofungin (2 mg/kg), n=31 . | dAMB (1 mg/kg), n=16 . | Total, N=47 . |
|---|---|---|---|
| Age (days), median (minimum–maximum) | 22.0 (11–88) | 25.0 (7–74) | 22 (7–88) |
| Sex, n (%) | |||
| male | 18 (58.1) | 7 (43.8) | 25 (53.2) |
| female | 13 (41.9) | 9 (56.3) | 22 (46.8) |
| Race, n (%) | |||
| white | 12 (38.7) | 7 (43.8) | 19 (40.4) |
| black or African American | 11 (35.5) | 6 (37.5) | 17 (36.2) |
| multiracial | 5 (16.1) | 2 (12.5) | 7 (14.9) |
| American Indian/Alaskan Native | 3 (9.7) | 1 (6.3) | 4 (8.5) |
| Ethnicity, n (%) | |||
| Hispanic or Latino | 11 (35.5) | 7 (43.8) | 18 (38.3) |
| not Hispanic or Latino | 19 (61.3) | 8 (50.0) | 27 (57.4) |
| unknown/not reported | 1 (3.2) | 1 (6.3) | 2 (4.3) |
| Baseline weight (g) | |||
| median (range) | 1910 (810–4410) | 1684 (425–6540) | 1860 (425–6540) |
| <1000, n (%) | 4 (12.9) | 3 (18.8) | 7 (14.9) |
| 1000 to 1500, n (%) | 9 (29.0) | 4 (25.0) | 13 (27.7) |
| >1500, n (%) | 18 (58.1) | 9 (56.3) | 27 (57.4) |
| Gestational age (weeks), median (minimum–maximum) | 32.0 (26.0–41.0) | 30.0 (26.7–40.0) | 30.4 (26.0–41.0) |
| Birth weight (g) | |||
| median (minimum–maximum) | 1335.0 (850–3985) | 1462.5 (510–4175) | 1445.0 (510–4175) |
| <1000, n (%) | 7 (22.6) | 3 (18.8) | 10 (21.3) |
| 1000 to 1500, n (%) | 11 (35.5) | 6 (37.5) | 17 (36.2) |
| >1500, n (%) | 13 (41.9) | 7 (43.8) | 20 (42.6) |
| Baseline fungal isolates, n (%) | |||
| C. albicans | 27 (87.1) | 12 (75.0) | 39 (83.0) |
| Candida glabrata | 0 | 1 (6.3) | 1 (2.1) |
| Candida intermedia | 1 (3.2) | 0 | 1 (2.1) |
| Candida parapsilosis | 1 (3.2) | 1 (6.3) | 2 (4.3) |
| Candida tropicalis | 1 (3.2) | 0 | 1 (2.1) |
| C. albicans/C. glabrata | 1 (3.2) | 0 | 1 (2.1) |
| Pichia kudriavzevii | 0 | 1 (6.3) | 1 (2.1) |
| unspecified | 0 | 1 (6.3) | 1 (2.1) |
| Associated fungal diagnosis, n/N (%) | |||
| candidaemia | 24/31 (77.4) | 8/16 (50.0) | 32/47 (68.1) |
| urinary tract infection | 3/31 (9.7) | 2/16 (12.5) | 5/47 (10.6) |
| endocarditis | 1/31 (3.2) | 1/16 (6.3) | 2/47 (4.3) |
| lung infection | 1/31 (3.2) | 1/16 (6.3) | 2/47 (4.3) |
| meningoencephalitisa | 1/31 (3.2) | 1/16 (6.3) | 2/47 (4.3) |
| endophthalmitis | 0 | 1/16 (6.3) | 1/47 (2.1) |
| peritonitis | 0 | 1/16 (6.3) | 1/47 (2.1) |
| Characteristic . | Caspofungin (2 mg/kg), n=31 . | dAMB (1 mg/kg), n=16 . | Total, N=47 . |
|---|---|---|---|
| Age (days), median (minimum–maximum) | 22.0 (11–88) | 25.0 (7–74) | 22 (7–88) |
| Sex, n (%) | |||
| male | 18 (58.1) | 7 (43.8) | 25 (53.2) |
| female | 13 (41.9) | 9 (56.3) | 22 (46.8) |
| Race, n (%) | |||
| white | 12 (38.7) | 7 (43.8) | 19 (40.4) |
| black or African American | 11 (35.5) | 6 (37.5) | 17 (36.2) |
| multiracial | 5 (16.1) | 2 (12.5) | 7 (14.9) |
| American Indian/Alaskan Native | 3 (9.7) | 1 (6.3) | 4 (8.5) |
| Ethnicity, n (%) | |||
| Hispanic or Latino | 11 (35.5) | 7 (43.8) | 18 (38.3) |
| not Hispanic or Latino | 19 (61.3) | 8 (50.0) | 27 (57.4) |
| unknown/not reported | 1 (3.2) | 1 (6.3) | 2 (4.3) |
| Baseline weight (g) | |||
| median (range) | 1910 (810–4410) | 1684 (425–6540) | 1860 (425–6540) |
| <1000, n (%) | 4 (12.9) | 3 (18.8) | 7 (14.9) |
| 1000 to 1500, n (%) | 9 (29.0) | 4 (25.0) | 13 (27.7) |
| >1500, n (%) | 18 (58.1) | 9 (56.3) | 27 (57.4) |
| Gestational age (weeks), median (minimum–maximum) | 32.0 (26.0–41.0) | 30.0 (26.7–40.0) | 30.4 (26.0–41.0) |
| Birth weight (g) | |||
| median (minimum–maximum) | 1335.0 (850–3985) | 1462.5 (510–4175) | 1445.0 (510–4175) |
| <1000, n (%) | 7 (22.6) | 3 (18.8) | 10 (21.3) |
| 1000 to 1500, n (%) | 11 (35.5) | 6 (37.5) | 17 (36.2) |
| >1500, n (%) | 13 (41.9) | 7 (43.8) | 20 (42.6) |
| Baseline fungal isolates, n (%) | |||
| C. albicans | 27 (87.1) | 12 (75.0) | 39 (83.0) |
| Candida glabrata | 0 | 1 (6.3) | 1 (2.1) |
| Candida intermedia | 1 (3.2) | 0 | 1 (2.1) |
| Candida parapsilosis | 1 (3.2) | 1 (6.3) | 2 (4.3) |
| Candida tropicalis | 1 (3.2) | 0 | 1 (2.1) |
| C. albicans/C. glabrata | 1 (3.2) | 0 | 1 (2.1) |
| Pichia kudriavzevii | 0 | 1 (6.3) | 1 (2.1) |
| unspecified | 0 | 1 (6.3) | 1 (2.1) |
| Associated fungal diagnosis, n/N (%) | |||
| candidaemia | 24/31 (77.4) | 8/16 (50.0) | 32/47 (68.1) |
| urinary tract infection | 3/31 (9.7) | 2/16 (12.5) | 5/47 (10.6) |
| endocarditis | 1/31 (3.2) | 1/16 (6.3) | 2/47 (4.3) |
| lung infection | 1/31 (3.2) | 1/16 (6.3) | 2/47 (4.3) |
| meningoencephalitisa | 1/31 (3.2) | 1/16 (6.3) | 2/47 (4.3) |
| endophthalmitis | 0 | 1/16 (6.3) | 1/47 (2.1) |
| peritonitis | 0 | 1/16 (6.3) | 1/47 (2.1) |
Meningoencephalitis was confirmed by lumbar puncture.
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