Clinical and histological characteristics of NM and SSM in overall cases (N = 20 132)
| Variable . | NM No. (%) . | SSM No. (%) . | P . |
|---|---|---|---|
| Total | 5062 (100.0) | 15 070 (100.0) | |
| Age, median (IQR), y | 62.8 (50.1−73.9) | 55.8 (44.1−67.1) | <.001* |
| Age, y | |||
| ≤50 | 1253 (24.8) | 5656 (37.5) | <.001† |
| >50 | 3809 (75.2) | 9414 (62.5) | |
| Sex | |||
| Male | 3051 (60.3) | 7880 (52.3) | <.001† |
| Female | 2011 (39.7) | 7190 (47.7) | |
| Anatomic site of melanoma | |||
| Head/neck | 1042 (20.8) | 1589 (10.7) | <.001† |
| Trunk | 1842 (36.8) | 6734 (45.2) | |
| Upper extremities | 1038 (20.7) | 2879 (19.3) | |
| Lower extremities | 1082 (21.6) | 3700 (24.8) | |
| Missing | 58 | 168 | |
| Breslow thickness, mm | |||
| ≤1.0 | 297 (5.9) | 9384 (62.3) | <.001† |
| 1.1–2.0 | 1082 (21.4) | 3484 (23.1) | |
| 2.1–4.0 | 1823 (36.0) | 1547 (10.3) | |
| >4.0 | 1860 (36.7) | 655 (4.3) | |
| Breslow thickness, median (IQR), mm | 3.1 (2.0, 5.2) | 0.8 (0.5, 1.4) | <.001* |
| Ulceration | |||
| Present | 2370 (49.0) | 1976 (13.7) | <.001† |
| Absent | 2464 (51.0) | 12 422 (86.3) | |
| Missing | 228 | 672 | |
| Regression | |||
| Present | 420 (9.7) | 3782 (28.1) | <.001† |
| Absent | 3918 (90.3) | 9657 (71.9) | |
| Missing | 724 | 1631 | |
| Nevus remnants | |||
| Present | 627 (17.0) | 4014 (36.0) | <.001† |
| Absent | 3051 (83.0) | 7140 (64.0) | |
| Missing | 1384 | 3916 | |
| Mitoses | |||
| Present | 3616 (94.9) | 6384 (63.9) | <.001† |
| Absent | 193 (5.1) | 3613 (36.1) | |
| Missing | 1253 | 5073 | |
| Tumor spread (initial diagnosis) | |||
| Localized | 3066 (69.8) | 11 802 (87.5) | <.001† |
| Regional metastasis | 1159 (26.4) | 1592 (11.8) | |
| Distant metastasis | 170 (3.9) | 98 (0.7) | |
| Missing | 667 | 1578 |
| Variable . | NM No. (%) . | SSM No. (%) . | P . |
|---|---|---|---|
| Total | 5062 (100.0) | 15 070 (100.0) | |
| Age, median (IQR), y | 62.8 (50.1−73.9) | 55.8 (44.1−67.1) | <.001* |
| Age, y | |||
| ≤50 | 1253 (24.8) | 5656 (37.5) | <.001† |
| >50 | 3809 (75.2) | 9414 (62.5) | |
| Sex | |||
| Male | 3051 (60.3) | 7880 (52.3) | <.001† |
| Female | 2011 (39.7) | 7190 (47.7) | |
| Anatomic site of melanoma | |||
| Head/neck | 1042 (20.8) | 1589 (10.7) | <.001† |
| Trunk | 1842 (36.8) | 6734 (45.2) | |
| Upper extremities | 1038 (20.7) | 2879 (19.3) | |
| Lower extremities | 1082 (21.6) | 3700 (24.8) | |
| Missing | 58 | 168 | |
| Breslow thickness, mm | |||
| ≤1.0 | 297 (5.9) | 9384 (62.3) | <.001† |
| 1.1–2.0 | 1082 (21.4) | 3484 (23.1) | |
| 2.1–4.0 | 1823 (36.0) | 1547 (10.3) | |
| >4.0 | 1860 (36.7) | 655 (4.3) | |
| Breslow thickness, median (IQR), mm | 3.1 (2.0, 5.2) | 0.8 (0.5, 1.4) | <.001* |
| Ulceration | |||
| Present | 2370 (49.0) | 1976 (13.7) | <.001† |
| Absent | 2464 (51.0) | 12 422 (86.3) | |
| Missing | 228 | 672 | |
| Regression | |||
| Present | 420 (9.7) | 3782 (28.1) | <.001† |
| Absent | 3918 (90.3) | 9657 (71.9) | |
| Missing | 724 | 1631 | |
| Nevus remnants | |||
| Present | 627 (17.0) | 4014 (36.0) | <.001† |
| Absent | 3051 (83.0) | 7140 (64.0) | |
| Missing | 1384 | 3916 | |
| Mitoses | |||
| Present | 3616 (94.9) | 6384 (63.9) | <.001† |
| Absent | 193 (5.1) | 3613 (36.1) | |
| Missing | 1253 | 5073 | |
| Tumor spread (initial diagnosis) | |||
| Localized | 3066 (69.8) | 11 802 (87.5) | <.001† |
| Regional metastasis | 1159 (26.4) | 1592 (11.8) | |
| Distant metastasis | 170 (3.9) | 98 (0.7) | |
| Missing | 667 | 1578 |
P value was calculated using a two-sided Mannã Whitney test. IQR = interquartile range; NM = nodular melanoma; SSM = superficial spreading melanoma.
†P value was calculated using a two-sided χ2 test.
Clinical and histological characteristics of NM and SSM in overall cases (N = 20 132)
| Variable . | NM No. (%) . | SSM No. (%) . | P . |
|---|---|---|---|
| Total | 5062 (100.0) | 15 070 (100.0) | |
| Age, median (IQR), y | 62.8 (50.1−73.9) | 55.8 (44.1−67.1) | <.001* |
| Age, y | |||
| ≤50 | 1253 (24.8) | 5656 (37.5) | <.001† |
| >50 | 3809 (75.2) | 9414 (62.5) | |
| Sex | |||
| Male | 3051 (60.3) | 7880 (52.3) | <.001† |
| Female | 2011 (39.7) | 7190 (47.7) | |
| Anatomic site of melanoma | |||
| Head/neck | 1042 (20.8) | 1589 (10.7) | <.001† |
| Trunk | 1842 (36.8) | 6734 (45.2) | |
| Upper extremities | 1038 (20.7) | 2879 (19.3) | |
| Lower extremities | 1082 (21.6) | 3700 (24.8) | |
| Missing | 58 | 168 | |
| Breslow thickness, mm | |||
| ≤1.0 | 297 (5.9) | 9384 (62.3) | <.001† |
| 1.1–2.0 | 1082 (21.4) | 3484 (23.1) | |
| 2.1–4.0 | 1823 (36.0) | 1547 (10.3) | |
| >4.0 | 1860 (36.7) | 655 (4.3) | |
| Breslow thickness, median (IQR), mm | 3.1 (2.0, 5.2) | 0.8 (0.5, 1.4) | <.001* |
| Ulceration | |||
| Present | 2370 (49.0) | 1976 (13.7) | <.001† |
| Absent | 2464 (51.0) | 12 422 (86.3) | |
| Missing | 228 | 672 | |
| Regression | |||
| Present | 420 (9.7) | 3782 (28.1) | <.001† |
| Absent | 3918 (90.3) | 9657 (71.9) | |
| Missing | 724 | 1631 | |
| Nevus remnants | |||
| Present | 627 (17.0) | 4014 (36.0) | <.001† |
| Absent | 3051 (83.0) | 7140 (64.0) | |
| Missing | 1384 | 3916 | |
| Mitoses | |||
| Present | 3616 (94.9) | 6384 (63.9) | <.001† |
| Absent | 193 (5.1) | 3613 (36.1) | |
| Missing | 1253 | 5073 | |
| Tumor spread (initial diagnosis) | |||
| Localized | 3066 (69.8) | 11 802 (87.5) | <.001† |
| Regional metastasis | 1159 (26.4) | 1592 (11.8) | |
| Distant metastasis | 170 (3.9) | 98 (0.7) | |
| Missing | 667 | 1578 |
| Variable . | NM No. (%) . | SSM No. (%) . | P . |
|---|---|---|---|
| Total | 5062 (100.0) | 15 070 (100.0) | |
| Age, median (IQR), y | 62.8 (50.1−73.9) | 55.8 (44.1−67.1) | <.001* |
| Age, y | |||
| ≤50 | 1253 (24.8) | 5656 (37.5) | <.001† |
| >50 | 3809 (75.2) | 9414 (62.5) | |
| Sex | |||
| Male | 3051 (60.3) | 7880 (52.3) | <.001† |
| Female | 2011 (39.7) | 7190 (47.7) | |
| Anatomic site of melanoma | |||
| Head/neck | 1042 (20.8) | 1589 (10.7) | <.001† |
| Trunk | 1842 (36.8) | 6734 (45.2) | |
| Upper extremities | 1038 (20.7) | 2879 (19.3) | |
| Lower extremities | 1082 (21.6) | 3700 (24.8) | |
| Missing | 58 | 168 | |
| Breslow thickness, mm | |||
| ≤1.0 | 297 (5.9) | 9384 (62.3) | <.001† |
| 1.1–2.0 | 1082 (21.4) | 3484 (23.1) | |
| 2.1–4.0 | 1823 (36.0) | 1547 (10.3) | |
| >4.0 | 1860 (36.7) | 655 (4.3) | |
| Breslow thickness, median (IQR), mm | 3.1 (2.0, 5.2) | 0.8 (0.5, 1.4) | <.001* |
| Ulceration | |||
| Present | 2370 (49.0) | 1976 (13.7) | <.001† |
| Absent | 2464 (51.0) | 12 422 (86.3) | |
| Missing | 228 | 672 | |
| Regression | |||
| Present | 420 (9.7) | 3782 (28.1) | <.001† |
| Absent | 3918 (90.3) | 9657 (71.9) | |
| Missing | 724 | 1631 | |
| Nevus remnants | |||
| Present | 627 (17.0) | 4014 (36.0) | <.001† |
| Absent | 3051 (83.0) | 7140 (64.0) | |
| Missing | 1384 | 3916 | |
| Mitoses | |||
| Present | 3616 (94.9) | 6384 (63.9) | <.001† |
| Absent | 193 (5.1) | 3613 (36.1) | |
| Missing | 1253 | 5073 | |
| Tumor spread (initial diagnosis) | |||
| Localized | 3066 (69.8) | 11 802 (87.5) | <.001† |
| Regional metastasis | 1159 (26.4) | 1592 (11.8) | |
| Distant metastasis | 170 (3.9) | 98 (0.7) | |
| Missing | 667 | 1578 |
P value was calculated using a two-sided Mannã Whitney test. IQR = interquartile range; NM = nodular melanoma; SSM = superficial spreading melanoma.
†P value was calculated using a two-sided χ2 test.
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