| Cohort . | Cases, n . | Controls, n . | Frequency (affected) . | Frequency (unaffected) . | P-valuea . | OR (CI) . |
|---|---|---|---|---|---|---|
| LBD GWASb | 556 | 1418 | 0.1061 | 0.1326 | 0.024 | 0.77 (0.623–0.967) |
| MSA GWASb | 896 | 3881 | 0.1384 | 0.1336 | 0.592 | 1.042 (0.897–1.209) |
| RBD GWASb | 1046 | 11 961 | 0.1456 | 0.1292 | 0.030 | 1.16 (1.015–1.335) |
| PD GWASb | 56 306c | 1 417 791 | 0.1334d | 0.1354d | 0.022 | 0.969 (0.943–0.996) |
| Cohort . | Cases, n . | Controls, n . | Frequency (affected) . | Frequency (unaffected) . | P-valuea . | OR (CI) . |
|---|---|---|---|---|---|---|
| LBD GWASb | 556 | 1418 | 0.1061 | 0.1326 | 0.024 | 0.77 (0.623–0.967) |
| MSA GWASb | 896 | 3881 | 0.1384 | 0.1336 | 0.592 | 1.042 (0.897–1.209) |
| RBD GWASb | 1046 | 11 961 | 0.1456 | 0.1292 | 0.030 | 1.16 (1.015–1.335) |
| PD GWASb | 56 306c | 1 417 791 | 0.1334d | 0.1354d | 0.022 | 0.969 (0.943–0.996) |
CI = confidence interval; GWAS = genome-wide association study; LBD = Lewy body dementia; MSA = multiple system atrophy; OR = odds ratio; PD = Parkinson’s disease; RBD = REM sleep behaviour disorder.
Uncorrected P-value, all results were not significant after correction for multiple comparisons.
p.N352S was found in imputed genotyping files with an R2 value of 0.975 for dementia with Lewy bodies GWAS, 0.953 for multiple system atrophy GWAS, 0.997 for RBD GWAS, and >0.96 for Parkinson’s disease GWAS.
Including proxy cases.
Frequency estimates were based on a subset of the data including 21 478 cases and 24 388 controls.
| Cohort . | Cases, n . | Controls, n . | Frequency (affected) . | Frequency (unaffected) . | P-valuea . | OR (CI) . |
|---|---|---|---|---|---|---|
| LBD GWASb | 556 | 1418 | 0.1061 | 0.1326 | 0.024 | 0.77 (0.623–0.967) |
| MSA GWASb | 896 | 3881 | 0.1384 | 0.1336 | 0.592 | 1.042 (0.897–1.209) |
| RBD GWASb | 1046 | 11 961 | 0.1456 | 0.1292 | 0.030 | 1.16 (1.015–1.335) |
| PD GWASb | 56 306c | 1 417 791 | 0.1334d | 0.1354d | 0.022 | 0.969 (0.943–0.996) |
| Cohort . | Cases, n . | Controls, n . | Frequency (affected) . | Frequency (unaffected) . | P-valuea . | OR (CI) . |
|---|---|---|---|---|---|---|
| LBD GWASb | 556 | 1418 | 0.1061 | 0.1326 | 0.024 | 0.77 (0.623–0.967) |
| MSA GWASb | 896 | 3881 | 0.1384 | 0.1336 | 0.592 | 1.042 (0.897–1.209) |
| RBD GWASb | 1046 | 11 961 | 0.1456 | 0.1292 | 0.030 | 1.16 (1.015–1.335) |
| PD GWASb | 56 306c | 1 417 791 | 0.1334d | 0.1354d | 0.022 | 0.969 (0.943–0.996) |
CI = confidence interval; GWAS = genome-wide association study; LBD = Lewy body dementia; MSA = multiple system atrophy; OR = odds ratio; PD = Parkinson’s disease; RBD = REM sleep behaviour disorder.
Uncorrected P-value, all results were not significant after correction for multiple comparisons.
p.N352S was found in imputed genotyping files with an R2 value of 0.975 for dementia with Lewy bodies GWAS, 0.953 for multiple system atrophy GWAS, 0.997 for RBD GWAS, and >0.96 for Parkinson’s disease GWAS.
Including proxy cases.
Frequency estimates were based on a subset of the data including 21 478 cases and 24 388 controls.
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