Table 2. Open in new tab Sequence... | Oxford Academic

Table 2.

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Sequence specificity of WT and K289M fidelity

		Template: incoming	Fidelity (×10⁴)^a	Loss in fidelity relative to WT control^b
WT	Control	C:C	12	1.0
	APC	C:C	2.4	4.8
	Control in APC	C:C	20	0.6
	APC in Control	C:C	7.9	1.5
	AAGAA	G:G	8.7	1.3
	AAAAA	A:G	2.0	5.6
K289M	Control	C:C	5.9	1.9
	APC	C:C	0.4	31.1
	Control in APC	C:C	5.3	2.2
	APC in Control	C:C	1.5	7.5
	AAGAA	G:G	7.9	1.5
	AAAAA	A:G	2.0	5.7

		Template: incoming	Fidelity (×10⁴)^a	Loss in fidelity relative to WT control^b
WT	Control	C:C	12	1.0
	APC	C:C	2.4	4.8
	Control in APC	C:C	20	0.6
	APC in Control	C:C	7.9	1.5
	AAGAA	G:G	8.7	1.3
	AAAAA	A:G	2.0	5.6
K289M	Control	C:C	5.9	1.9
	APC	C:C	0.4	31.1
	Control in APC	C:C	5.3	2.2
	APC in Control	C:C	1.5	7.5
	AAGAA	G:G	7.9	1.5
	AAAAA	A:G	2.0	5.7

^aFidelity is calculated from (k_pol/K_D)_correct/(k_pol/K_D)_incorrect.

^bWT Fidelity with control/fidelity value.

Table 2.

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Sequence specificity of WT and K289M fidelity

		Template: incoming	Fidelity (×10⁴)^a	Loss in fidelity relative to WT control^b
WT	Control	C:C	12	1.0
	APC	C:C	2.4	4.8
	Control in APC	C:C	20	0.6
	APC in Control	C:C	7.9	1.5
	AAGAA	G:G	8.7	1.3
	AAAAA	A:G	2.0	5.6
K289M	Control	C:C	5.9	1.9
	APC	C:C	0.4	31.1
	Control in APC	C:C	5.3	2.2
	APC in Control	C:C	1.5	7.5
	AAGAA	G:G	7.9	1.5
	AAAAA	A:G	2.0	5.7

		Template: incoming	Fidelity (×10⁴)^a	Loss in fidelity relative to WT control^b
WT	Control	C:C	12	1.0
	APC	C:C	2.4	4.8
	Control in APC	C:C	20	0.6
	APC in Control	C:C	7.9	1.5
	AAGAA	G:G	8.7	1.3
	AAAAA	A:G	2.0	5.6
K289M	Control	C:C	5.9	1.9
	APC	C:C	0.4	31.1
	Control in APC	C:C	5.3	2.2
	APC in Control	C:C	1.5	7.5
	AAGAA	G:G	7.9	1.5
	AAAAA	A:G	2.0	5.7

^aFidelity is calculated from (k_pol/K_D)_correct/(k_pol/K_D)_incorrect.

^bWT Fidelity with control/fidelity value.