| Characteristics . | INSTI-Based Regimen (n = 54) . | Non-INSTI–Based Regimen (n = 165) . | P value . |
|---|---|---|---|
| Agea | 42.7 (11.1) | 46.8 (11.2) | .020 |
| Sex | |||
| Male, n (%) | 42 (77.8) | 131 (79.4) | .800 |
| Female, n (%) | 12 (22.2) | 34 (20.6) | |
| HIV acquisition mode | |||
| IDU, n (%) | 5 (9.3) | 29 (17.6) | .143 |
| Other, n (%) | 49 (90.7) | 136 (82.4) | |
| History of hypertension, n (%) | 9 (16.7) | 48 (29.1) | .071 |
| History of diabetes, n (%) | 3 (5.7) | 14 (8.5) | .505 |
| Heighta | 1.7 (0.1) | 1.7 (0.1) | .282 |
| Weight(kg)a | 70.1 (12.0) | 70.5(14.3) | .733 |
| BMI (kg/mt2)a | 23.5 (3.0) | 24.1 (4.5) | .865 |
| CD4+ T cell count (cells/μL)a | 276.8 (162.3) | 263.7 (173.3) | .408 |
| CD8+ T cell count (cells/μL)a | 789.2 (395.9) | 766.7 (441.4) | .441 |
| Log10 HIV-1 RNA (copies/mL)a | 4.9 (0.6) | 4.9 (0.8) | .875 |
| Fasting blood glucose (mg/dL)a | 88.1 (8.6) | 91.1 (26.9) | .111 |
| Triglycerides (mg/dL)a | 116.5 (57.6) | 133.6 (87.8) | .410 |
| HDL cholesterol (mg/dL)a | 40.5 (10.7) | 40.7 (14.1) | .472 |
| LDL cholesterol (mg/dL)a | 96.5 (23.9) | 102.0 (36.1) | .811 |
| ALT (UI/L)a | 29.1 (16.9) | 42.5 (38.8) | .007 |
| AST (UI/L)a | 29.4 (14.5) | 36.3 (29.8) | .097 |
| TyGa | 4.6 (0.2) | 4.6 (0.3) | .504 |
| HSIa | 32.1 (4.6) | 33.7 (5.7) | .157 |
| Systolic blood pressurea | 131.5 (19.7) | 135.2 (19.9) | .216 |
| Diastolic blood pressurea | 78.4 (12.3) | 82.4 (12.7) | .068 |
| Characteristics . | INSTI-Based Regimen (n = 54) . | Non-INSTI–Based Regimen (n = 165) . | P value . |
|---|---|---|---|
| Agea | 42.7 (11.1) | 46.8 (11.2) | .020 |
| Sex | |||
| Male, n (%) | 42 (77.8) | 131 (79.4) | .800 |
| Female, n (%) | 12 (22.2) | 34 (20.6) | |
| HIV acquisition mode | |||
| IDU, n (%) | 5 (9.3) | 29 (17.6) | .143 |
| Other, n (%) | 49 (90.7) | 136 (82.4) | |
| History of hypertension, n (%) | 9 (16.7) | 48 (29.1) | .071 |
| History of diabetes, n (%) | 3 (5.7) | 14 (8.5) | .505 |
| Heighta | 1.7 (0.1) | 1.7 (0.1) | .282 |
| Weight(kg)a | 70.1 (12.0) | 70.5(14.3) | .733 |
| BMI (kg/mt2)a | 23.5 (3.0) | 24.1 (4.5) | .865 |
| CD4+ T cell count (cells/μL)a | 276.8 (162.3) | 263.7 (173.3) | .408 |
| CD8+ T cell count (cells/μL)a | 789.2 (395.9) | 766.7 (441.4) | .441 |
| Log10 HIV-1 RNA (copies/mL)a | 4.9 (0.6) | 4.9 (0.8) | .875 |
| Fasting blood glucose (mg/dL)a | 88.1 (8.6) | 91.1 (26.9) | .111 |
| Triglycerides (mg/dL)a | 116.5 (57.6) | 133.6 (87.8) | .410 |
| HDL cholesterol (mg/dL)a | 40.5 (10.7) | 40.7 (14.1) | .472 |
| LDL cholesterol (mg/dL)a | 96.5 (23.9) | 102.0 (36.1) | .811 |
| ALT (UI/L)a | 29.1 (16.9) | 42.5 (38.8) | .007 |
| AST (UI/L)a | 29.4 (14.5) | 36.3 (29.8) | .097 |
| TyGa | 4.6 (0.2) | 4.6 (0.3) | .504 |
| HSIa | 32.1 (4.6) | 33.7 (5.7) | .157 |
| Systolic blood pressurea | 131.5 (19.7) | 135.2 (19.9) | .216 |
| Diastolic blood pressurea | 78.4 (12.3) | 82.4 (12.7) | .068 |
Abbreviaitons: ALT, serum alanine aminotransferase; AST, serum aspartate aminotransferase; HIS, hepatic steatosis index calculated using the formula (8 × [ALT/AST ratio] + BMI [+2, if female; +2, if diabetes mellitus]); IDU, injection drug use; INSTI, integrase strand transfer inhibitors; TyG, triglyceride and glucose index calculated using the formula Ln (fasting triglyceride [mg/dl] × fasting plasma glucose [mg/dl]/2).
aMean (standard deviation).
| Characteristics . | INSTI-Based Regimen (n = 54) . | Non-INSTI–Based Regimen (n = 165) . | P value . |
|---|---|---|---|
| Agea | 42.7 (11.1) | 46.8 (11.2) | .020 |
| Sex | |||
| Male, n (%) | 42 (77.8) | 131 (79.4) | .800 |
| Female, n (%) | 12 (22.2) | 34 (20.6) | |
| HIV acquisition mode | |||
| IDU, n (%) | 5 (9.3) | 29 (17.6) | .143 |
| Other, n (%) | 49 (90.7) | 136 (82.4) | |
| History of hypertension, n (%) | 9 (16.7) | 48 (29.1) | .071 |
| History of diabetes, n (%) | 3 (5.7) | 14 (8.5) | .505 |
| Heighta | 1.7 (0.1) | 1.7 (0.1) | .282 |
| Weight(kg)a | 70.1 (12.0) | 70.5(14.3) | .733 |
| BMI (kg/mt2)a | 23.5 (3.0) | 24.1 (4.5) | .865 |
| CD4+ T cell count (cells/μL)a | 276.8 (162.3) | 263.7 (173.3) | .408 |
| CD8+ T cell count (cells/μL)a | 789.2 (395.9) | 766.7 (441.4) | .441 |
| Log10 HIV-1 RNA (copies/mL)a | 4.9 (0.6) | 4.9 (0.8) | .875 |
| Fasting blood glucose (mg/dL)a | 88.1 (8.6) | 91.1 (26.9) | .111 |
| Triglycerides (mg/dL)a | 116.5 (57.6) | 133.6 (87.8) | .410 |
| HDL cholesterol (mg/dL)a | 40.5 (10.7) | 40.7 (14.1) | .472 |
| LDL cholesterol (mg/dL)a | 96.5 (23.9) | 102.0 (36.1) | .811 |
| ALT (UI/L)a | 29.1 (16.9) | 42.5 (38.8) | .007 |
| AST (UI/L)a | 29.4 (14.5) | 36.3 (29.8) | .097 |
| TyGa | 4.6 (0.2) | 4.6 (0.3) | .504 |
| HSIa | 32.1 (4.6) | 33.7 (5.7) | .157 |
| Systolic blood pressurea | 131.5 (19.7) | 135.2 (19.9) | .216 |
| Diastolic blood pressurea | 78.4 (12.3) | 82.4 (12.7) | .068 |
| Characteristics . | INSTI-Based Regimen (n = 54) . | Non-INSTI–Based Regimen (n = 165) . | P value . |
|---|---|---|---|
| Agea | 42.7 (11.1) | 46.8 (11.2) | .020 |
| Sex | |||
| Male, n (%) | 42 (77.8) | 131 (79.4) | .800 |
| Female, n (%) | 12 (22.2) | 34 (20.6) | |
| HIV acquisition mode | |||
| IDU, n (%) | 5 (9.3) | 29 (17.6) | .143 |
| Other, n (%) | 49 (90.7) | 136 (82.4) | |
| History of hypertension, n (%) | 9 (16.7) | 48 (29.1) | .071 |
| History of diabetes, n (%) | 3 (5.7) | 14 (8.5) | .505 |
| Heighta | 1.7 (0.1) | 1.7 (0.1) | .282 |
| Weight(kg)a | 70.1 (12.0) | 70.5(14.3) | .733 |
| BMI (kg/mt2)a | 23.5 (3.0) | 24.1 (4.5) | .865 |
| CD4+ T cell count (cells/μL)a | 276.8 (162.3) | 263.7 (173.3) | .408 |
| CD8+ T cell count (cells/μL)a | 789.2 (395.9) | 766.7 (441.4) | .441 |
| Log10 HIV-1 RNA (copies/mL)a | 4.9 (0.6) | 4.9 (0.8) | .875 |
| Fasting blood glucose (mg/dL)a | 88.1 (8.6) | 91.1 (26.9) | .111 |
| Triglycerides (mg/dL)a | 116.5 (57.6) | 133.6 (87.8) | .410 |
| HDL cholesterol (mg/dL)a | 40.5 (10.7) | 40.7 (14.1) | .472 |
| LDL cholesterol (mg/dL)a | 96.5 (23.9) | 102.0 (36.1) | .811 |
| ALT (UI/L)a | 29.1 (16.9) | 42.5 (38.8) | .007 |
| AST (UI/L)a | 29.4 (14.5) | 36.3 (29.8) | .097 |
| TyGa | 4.6 (0.2) | 4.6 (0.3) | .504 |
| HSIa | 32.1 (4.6) | 33.7 (5.7) | .157 |
| Systolic blood pressurea | 131.5 (19.7) | 135.2 (19.9) | .216 |
| Diastolic blood pressurea | 78.4 (12.3) | 82.4 (12.7) | .068 |
Abbreviaitons: ALT, serum alanine aminotransferase; AST, serum aspartate aminotransferase; HIS, hepatic steatosis index calculated using the formula (8 × [ALT/AST ratio] + BMI [+2, if female; +2, if diabetes mellitus]); IDU, injection drug use; INSTI, integrase strand transfer inhibitors; TyG, triglyceride and glucose index calculated using the formula Ln (fasting triglyceride [mg/dl] × fasting plasma glucose [mg/dl]/2).
aMean (standard deviation).
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