Characteristics of 757 patients with known AF and pre-stroke CHA2DS2-VASc ≥1 with regard to prescription of OAC (including VKA or NOAC) or no prescription of OAC at the time of the index stroke
| . | . | Univariable analysis . | Multivariable analysis with backward selection . | |||
|---|---|---|---|---|---|---|
| . | OAC . | No OAC . | OR (CI) . | P-value . | OR (CI) . | P-value . |
| n = 470 . | n = 287 . | |||||
| Age categories, years, % (n) | <0.001b | 0.002 | ||||
| 18–64 | 6.2 (29) | 14.6 (42) | 1 | 1 | ||
| 65–74 | 21.9 (103) | 25.8 (74) | 2.02 (1.15–3.53) | 0.014 | 2.00 (1.13–3.54) | 0.017 |
| 75–84 | 51.7 (243) | 40.4 (116) | 3.03 (1.80–5.12) | <0.001 | 2.81 (1.65–4.78) | <0.001 |
| ≥ 85 | 20.2 (95) | 19.2 (55) | 2.50 (1.40–4.46) | 0.002 | 2.13 (1.28–4.17) | 0.005 |
| Sex, female, % (n) | 50.0 (235) | 44.9 (129) | 0.82 (0.61–1.10) | 0.177 | – | – |
| Known AF before index stroke, % (n) | ||||||
| Paroxysmal AF | 42.3 (199) | 50.2 (144) | 1 | 1 | ||
| Non-paroxysmal or unknown type of AFa | 57.7 (271) | 49.8 (143) | 1.37 (1.02–1.84) | 0.036 | 1.31 (0.96–1.78) | 0.086 |
| Cardiovascular risk factors, % (n) | ||||||
| Prior stroke or transient ischaemic attack | 36.6 (172) | 22.0 (63) | 2.05 (1.47–2.87) | <0.001 | 1.97 (1.40–2.78) | <0.001 |
| Hypertension | 91.3 (429) | 87.5 (251) | 1.50 (0.93–2.41) | 0.093 | 1.32 (0.77–2.26) | 0.307 |
| Heart failure | 16.0 (75) | 20.6 (59) | 0.73 (0.50–1.07) | 0.108 | – | – |
| Diabetes | 36.0 (169) | 24.7 (71) | 1.71 (1.23–2.37) | 0.001 | 1.64 (1.17–2.28) | 0.004 |
| Vascular disease | 31.1 (146) | 34.8 (100) | 0.84 (0.62–1.15) | 0.282 | – | – |
| Renal impairment (eGFR <90 mL/min) | 92.1 (433) | 91.6 (263) | 0.94 (0.55–1.60) | 0.810 | – | – |
| CHA2DS2-VASc pre-stroke, median [IQR] | 5 [4–6] | 4 [3–5] | ||||
| CHA2DS2-VASc pre-stroke, categories, % (n) | <0.001b | 0.168 | ||||
| 1 | 2.1 (10) | 9.1 (26) | 1 | 1 | ||
| 2–3 | 21.1 (99) | 26.6 (76) | 3.39 (1.54–7.45) | 0.002 | 2.12 (0.89–5.03) | 0.088 |
| ≥ 4 | 76.8 (361) | 64.5 (185) | 5.07 (2.40–10.75) | <0.001 | 1.70 (0.67–4.32) | 0.269 |
| HAS-BLED pre-stroke, median [IQR] | 3 [2–3] | 3 [2–3] | ||||
| HAS-BLED pre-stroke, categories, % (n) | ||||||
| 0–2 | 48.9 (230) | 47.0 (135) | 1 | – | – | |
| 3–6 | 51.1 (240) | 53.0 (152) | 0.93 (0.69–1.24) | 0.612 | – | – |
| . | . | Univariable analysis . | Multivariable analysis with backward selection . | |||
|---|---|---|---|---|---|---|
| . | OAC . | No OAC . | OR (CI) . | P-value . | OR (CI) . | P-value . |
| n = 470 . | n = 287 . | |||||
| Age categories, years, % (n) | <0.001b | 0.002 | ||||
| 18–64 | 6.2 (29) | 14.6 (42) | 1 | 1 | ||
| 65–74 | 21.9 (103) | 25.8 (74) | 2.02 (1.15–3.53) | 0.014 | 2.00 (1.13–3.54) | 0.017 |
| 75–84 | 51.7 (243) | 40.4 (116) | 3.03 (1.80–5.12) | <0.001 | 2.81 (1.65–4.78) | <0.001 |
| ≥ 85 | 20.2 (95) | 19.2 (55) | 2.50 (1.40–4.46) | 0.002 | 2.13 (1.28–4.17) | 0.005 |
| Sex, female, % (n) | 50.0 (235) | 44.9 (129) | 0.82 (0.61–1.10) | 0.177 | – | – |
| Known AF before index stroke, % (n) | ||||||
| Paroxysmal AF | 42.3 (199) | 50.2 (144) | 1 | 1 | ||
| Non-paroxysmal or unknown type of AFa | 57.7 (271) | 49.8 (143) | 1.37 (1.02–1.84) | 0.036 | 1.31 (0.96–1.78) | 0.086 |
| Cardiovascular risk factors, % (n) | ||||||
| Prior stroke or transient ischaemic attack | 36.6 (172) | 22.0 (63) | 2.05 (1.47–2.87) | <0.001 | 1.97 (1.40–2.78) | <0.001 |
| Hypertension | 91.3 (429) | 87.5 (251) | 1.50 (0.93–2.41) | 0.093 | 1.32 (0.77–2.26) | 0.307 |
| Heart failure | 16.0 (75) | 20.6 (59) | 0.73 (0.50–1.07) | 0.108 | – | – |
| Diabetes | 36.0 (169) | 24.7 (71) | 1.71 (1.23–2.37) | 0.001 | 1.64 (1.17–2.28) | 0.004 |
| Vascular disease | 31.1 (146) | 34.8 (100) | 0.84 (0.62–1.15) | 0.282 | – | – |
| Renal impairment (eGFR <90 mL/min) | 92.1 (433) | 91.6 (263) | 0.94 (0.55–1.60) | 0.810 | – | – |
| CHA2DS2-VASc pre-stroke, median [IQR] | 5 [4–6] | 4 [3–5] | ||||
| CHA2DS2-VASc pre-stroke, categories, % (n) | <0.001b | 0.168 | ||||
| 1 | 2.1 (10) | 9.1 (26) | 1 | 1 | ||
| 2–3 | 21.1 (99) | 26.6 (76) | 3.39 (1.54–7.45) | 0.002 | 2.12 (0.89–5.03) | 0.088 |
| ≥ 4 | 76.8 (361) | 64.5 (185) | 5.07 (2.40–10.75) | <0.001 | 1.70 (0.67–4.32) | 0.269 |
| HAS-BLED pre-stroke, median [IQR] | 3 [2–3] | 3 [2–3] | ||||
| HAS-BLED pre-stroke, categories, % (n) | ||||||
| 0–2 | 48.9 (230) | 47.0 (135) | 1 | – | – | |
| 3–6 | 51.1 (240) | 53.0 (152) | 0.93 (0.69–1.24) | 0.612 | – | – |
AF, atrial fibrillation; CI, confidence interval; eGFR, estimated glomerular filtration rate; IQR, interquartile range; NOAC, non-vitamin K-dependent oral anticoagulant; OAC, oral anticoagulation; OR, odds ratio; VKA, vitamin K antagonist.
397 registry patients were classified to have non-paroxysmal AF (n = 397) and 17 patients were classified to have an unknown type of AF.
These P-values refer to the overall P-value of the respective categorical variable.
Characteristics of 757 patients with known AF and pre-stroke CHA2DS2-VASc ≥1 with regard to prescription of OAC (including VKA or NOAC) or no prescription of OAC at the time of the index stroke
| . | . | Univariable analysis . | Multivariable analysis with backward selection . | |||
|---|---|---|---|---|---|---|
| . | OAC . | No OAC . | OR (CI) . | P-value . | OR (CI) . | P-value . |
| n = 470 . | n = 287 . | |||||
| Age categories, years, % (n) | <0.001b | 0.002 | ||||
| 18–64 | 6.2 (29) | 14.6 (42) | 1 | 1 | ||
| 65–74 | 21.9 (103) | 25.8 (74) | 2.02 (1.15–3.53) | 0.014 | 2.00 (1.13–3.54) | 0.017 |
| 75–84 | 51.7 (243) | 40.4 (116) | 3.03 (1.80–5.12) | <0.001 | 2.81 (1.65–4.78) | <0.001 |
| ≥ 85 | 20.2 (95) | 19.2 (55) | 2.50 (1.40–4.46) | 0.002 | 2.13 (1.28–4.17) | 0.005 |
| Sex, female, % (n) | 50.0 (235) | 44.9 (129) | 0.82 (0.61–1.10) | 0.177 | – | – |
| Known AF before index stroke, % (n) | ||||||
| Paroxysmal AF | 42.3 (199) | 50.2 (144) | 1 | 1 | ||
| Non-paroxysmal or unknown type of AFa | 57.7 (271) | 49.8 (143) | 1.37 (1.02–1.84) | 0.036 | 1.31 (0.96–1.78) | 0.086 |
| Cardiovascular risk factors, % (n) | ||||||
| Prior stroke or transient ischaemic attack | 36.6 (172) | 22.0 (63) | 2.05 (1.47–2.87) | <0.001 | 1.97 (1.40–2.78) | <0.001 |
| Hypertension | 91.3 (429) | 87.5 (251) | 1.50 (0.93–2.41) | 0.093 | 1.32 (0.77–2.26) | 0.307 |
| Heart failure | 16.0 (75) | 20.6 (59) | 0.73 (0.50–1.07) | 0.108 | – | – |
| Diabetes | 36.0 (169) | 24.7 (71) | 1.71 (1.23–2.37) | 0.001 | 1.64 (1.17–2.28) | 0.004 |
| Vascular disease | 31.1 (146) | 34.8 (100) | 0.84 (0.62–1.15) | 0.282 | – | – |
| Renal impairment (eGFR <90 mL/min) | 92.1 (433) | 91.6 (263) | 0.94 (0.55–1.60) | 0.810 | – | – |
| CHA2DS2-VASc pre-stroke, median [IQR] | 5 [4–6] | 4 [3–5] | ||||
| CHA2DS2-VASc pre-stroke, categories, % (n) | <0.001b | 0.168 | ||||
| 1 | 2.1 (10) | 9.1 (26) | 1 | 1 | ||
| 2–3 | 21.1 (99) | 26.6 (76) | 3.39 (1.54–7.45) | 0.002 | 2.12 (0.89–5.03) | 0.088 |
| ≥ 4 | 76.8 (361) | 64.5 (185) | 5.07 (2.40–10.75) | <0.001 | 1.70 (0.67–4.32) | 0.269 |
| HAS-BLED pre-stroke, median [IQR] | 3 [2–3] | 3 [2–3] | ||||
| HAS-BLED pre-stroke, categories, % (n) | ||||||
| 0–2 | 48.9 (230) | 47.0 (135) | 1 | – | – | |
| 3–6 | 51.1 (240) | 53.0 (152) | 0.93 (0.69–1.24) | 0.612 | – | – |
| . | . | Univariable analysis . | Multivariable analysis with backward selection . | |||
|---|---|---|---|---|---|---|
| . | OAC . | No OAC . | OR (CI) . | P-value . | OR (CI) . | P-value . |
| n = 470 . | n = 287 . | |||||
| Age categories, years, % (n) | <0.001b | 0.002 | ||||
| 18–64 | 6.2 (29) | 14.6 (42) | 1 | 1 | ||
| 65–74 | 21.9 (103) | 25.8 (74) | 2.02 (1.15–3.53) | 0.014 | 2.00 (1.13–3.54) | 0.017 |
| 75–84 | 51.7 (243) | 40.4 (116) | 3.03 (1.80–5.12) | <0.001 | 2.81 (1.65–4.78) | <0.001 |
| ≥ 85 | 20.2 (95) | 19.2 (55) | 2.50 (1.40–4.46) | 0.002 | 2.13 (1.28–4.17) | 0.005 |
| Sex, female, % (n) | 50.0 (235) | 44.9 (129) | 0.82 (0.61–1.10) | 0.177 | – | – |
| Known AF before index stroke, % (n) | ||||||
| Paroxysmal AF | 42.3 (199) | 50.2 (144) | 1 | 1 | ||
| Non-paroxysmal or unknown type of AFa | 57.7 (271) | 49.8 (143) | 1.37 (1.02–1.84) | 0.036 | 1.31 (0.96–1.78) | 0.086 |
| Cardiovascular risk factors, % (n) | ||||||
| Prior stroke or transient ischaemic attack | 36.6 (172) | 22.0 (63) | 2.05 (1.47–2.87) | <0.001 | 1.97 (1.40–2.78) | <0.001 |
| Hypertension | 91.3 (429) | 87.5 (251) | 1.50 (0.93–2.41) | 0.093 | 1.32 (0.77–2.26) | 0.307 |
| Heart failure | 16.0 (75) | 20.6 (59) | 0.73 (0.50–1.07) | 0.108 | – | – |
| Diabetes | 36.0 (169) | 24.7 (71) | 1.71 (1.23–2.37) | 0.001 | 1.64 (1.17–2.28) | 0.004 |
| Vascular disease | 31.1 (146) | 34.8 (100) | 0.84 (0.62–1.15) | 0.282 | – | – |
| Renal impairment (eGFR <90 mL/min) | 92.1 (433) | 91.6 (263) | 0.94 (0.55–1.60) | 0.810 | – | – |
| CHA2DS2-VASc pre-stroke, median [IQR] | 5 [4–6] | 4 [3–5] | ||||
| CHA2DS2-VASc pre-stroke, categories, % (n) | <0.001b | 0.168 | ||||
| 1 | 2.1 (10) | 9.1 (26) | 1 | 1 | ||
| 2–3 | 21.1 (99) | 26.6 (76) | 3.39 (1.54–7.45) | 0.002 | 2.12 (0.89–5.03) | 0.088 |
| ≥ 4 | 76.8 (361) | 64.5 (185) | 5.07 (2.40–10.75) | <0.001 | 1.70 (0.67–4.32) | 0.269 |
| HAS-BLED pre-stroke, median [IQR] | 3 [2–3] | 3 [2–3] | ||||
| HAS-BLED pre-stroke, categories, % (n) | ||||||
| 0–2 | 48.9 (230) | 47.0 (135) | 1 | – | – | |
| 3–6 | 51.1 (240) | 53.0 (152) | 0.93 (0.69–1.24) | 0.612 | – | – |
AF, atrial fibrillation; CI, confidence interval; eGFR, estimated glomerular filtration rate; IQR, interquartile range; NOAC, non-vitamin K-dependent oral anticoagulant; OAC, oral anticoagulation; OR, odds ratio; VKA, vitamin K antagonist.
397 registry patients were classified to have non-paroxysmal AF (n = 397) and 17 patients were classified to have an unknown type of AF.
These P-values refer to the overall P-value of the respective categorical variable.
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