Table 3 Open in new tab Univariable and...

Candidate predictor

Rate per 100 person year (95% CI)

Univariable model HR (95% CI)

P-value

Multivariable model^a HR (95% CI)

P-value

Age (years)

0.072

0.032

<16

7.8 (3.7–16.3)

≥16

3.3 (2.5–4.5)

0.45 (0.20–0.99)

0.41 (0.18–0.92)

Sex

0.952

0.861

Female

3.6 (2.4–5.4)

Male

3.6 (2.5–5.2)

0.98 (0.57–1.70)

1.06 (0.57–1.95)

Work-up

0.053

0.173

Incomplete

2.3 (1.5–3.4)

Complete

6.4 (4.1–10.1)

1.92 (0.99–3.70)

1.58 (0.82–3.08)

ICD

0.005

0.054

0.8 (0.2–2.3)

Yes

4.7 (95.6–6.3)

4.19 (1.26–13.00)

3.42 (0.98–11.94)

Family history of SD

0.855

–

5.3 (3.8–7.3)

Yes

4.9 (2.4–10.4)

0.93 (0.41–2.09)

Previous syncope

0.780

–

3.6 (2.6–4.9)

Yes

3.8 (2.2–6.4)

1.09 (0.59–2.01)

Diabetes

0.162^b

–

3.8 (2.9–5.0)

Yes

Hypertension

0.258

–

4.0 (3.0–5.4)

Yes

2.5 (1.3–4.7)

0.67 (0.33–1.38)

Dyslipidaemia

0.196

–

3.8 (2.9–5.0)

Yes

1.7 [0.89 (0.42–1.89) 0.4–6.8]

0.46 (0.11–1.81)

Smoking

0.755

–

3.4 (2.8–5.1)

Yes

2.9 (1.4–5.8)

0.89 (0.42–1.89)

Table 3

Open in new tab

Univariable and multivariable Cox models for arrhythmic events (sustained ventricular arrhythmia, appropriate shock or cardiac death)

Candidate predictor	Rate per 100 person year (95% CI)	Univariable model HR (95% CI)	P-value	Multivariable model^a HR (95% CI)	P-value
Age (years)			0.072		0.032
<16	7.8 (3.7–16.3)	1		1
≥16	3.3 (2.5–4.5)	0.45 (0.20–0.99)		0.41 (0.18–0.92)
Sex			0.952		0.861
Female	3.6 (2.4–5.4)	1		1
Male	3.6 (2.5–5.2)	0.98 (0.57–1.70)		1.06 (0.57–1.95)
Work-up			0.053		0.173
Incomplete	2.3 (1.5–3.4)	1		1
Complete	6.4 (4.1–10.1)	1.92 (0.99–3.70)		1.58 (0.82–3.08)
ICD			0.005		0.054
No	0.8 (0.2–2.3)	1		1
Yes	4.7 (95.6–6.3)	4.19 (1.26–13.00)		3.42 (0.98–11.94)
Family history of SD			0.855	–	–
No	5.3 (3.8–7.3)	1
Yes	4.9 (2.4–10.4)	0.93 (0.41–2.09)
Previous syncope			0.780	–	–
No	3.6 (2.6–4.9)	1
Yes	3.8 (2.2–6.4)	1.09 (0.59–2.01)
Diabetes			0.162^b	–	–
No	3.8 (2.9–5.0)	1
Yes	0	NA
Hypertension			0.258	–	–
No	4.0 (3.0–5.4)	1
Yes	2.5 (1.3–4.7)	0.67 (0.33–1.38)
Dyslipidaemia			0.196	–	–
No	3.8 (2.9–5.0)	1
Yes	1.7 [0.89 (0.42–1.89) 0.4–6.8]	0.46 (0.11–1.81)
Smoking			0.755	–	–
No	3.4 (2.8–5.1)	1
Yes	2.9 (1.4–5.8)	0.89 (0.42–1.89)

Candidate predictor	Rate per 100 person year (95% CI)	Univariable model HR (95% CI)	P-value	Multivariable model^a HR (95% CI)	P-value
Age (years)			0.072		0.032
<16	7.8 (3.7–16.3)	1		1
≥16	3.3 (2.5–4.5)	0.45 (0.20–0.99)		0.41 (0.18–0.92)
Sex			0.952		0.861
Female	3.6 (2.4–5.4)	1		1
Male	3.6 (2.5–5.2)	0.98 (0.57–1.70)		1.06 (0.57–1.95)
Work-up			0.053		0.173
Incomplete	2.3 (1.5–3.4)	1		1
Complete	6.4 (4.1–10.1)	1.92 (0.99–3.70)		1.58 (0.82–3.08)
ICD			0.005		0.054
No	0.8 (0.2–2.3)	1		1
Yes	4.7 (95.6–6.3)	4.19 (1.26–13.00)		3.42 (0.98–11.94)
Family history of SD			0.855	–	–
No	5.3 (3.8–7.3)	1
Yes	4.9 (2.4–10.4)	0.93 (0.41–2.09)
Previous syncope			0.780	–	–
No	3.6 (2.6–4.9)	1
Yes	3.8 (2.2–6.4)	1.09 (0.59–2.01)
Diabetes			0.162^b	–	–
No	3.8 (2.9–5.0)	1
Yes	0	NA
Hypertension			0.258	–	–
No	4.0 (3.0–5.4)	1
Yes	2.5 (1.3–4.7)	0.67 (0.33–1.38)
Dyslipidaemia			0.196	–	–
No	3.8 (2.9–5.0)	1
Yes	1.7 [0.89 (0.42–1.89) 0.4–6.8]	0.46 (0.11–1.81)
Smoking			0.755	–	–
No	3.4 (2.8–5.1)	1
Yes	2.9 (1.4–5.8)	0.89 (0.42–1.89)

CI, confidence interval; ICD, implantable cardioverter-defibrillator; NA, not applicable; SD, standard deviation.

Multivariable model P = 0.013, Harrell’s c = 0.63 (95% CI 0.54–0.72).

Log-rank test.

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