Table 2. Open in new tab Metabolic and...

Clinical Features	Sample Size (n)	Without PCOS [Mean ± SD or Median (IQR)]	With PCOS [Mean ± SD or Median (IQR)]	P
Lipid profile
Cholesterol, mmol/L	30	4.2 ± 0.7	4.4 ± 0.7	0.5
Triglycerides, mmol/L	30	0.6 (0.6, 0.9)	0.8 (0.5, 1.0)	0.6
HDL, mmol/L	30	1.5 ± 0.3	1.5 ± 0.3	1.0
LDL, mmol/L	30	2.5 ± 0.6	2.4 ± 0.7	0.6
OGTT
Fasting glucose, mmol/L	34	4.9 (4.8, 5.4)	4.9 (4.6, 5.3)	0.4
Fasting insulin, pmol/L	34	72.8 (56.2, 89.4)	68.5 (47.2, 102.4)	0.9
2-h Glucose, mmol/L	34	4.75 (4.5, 5.4)	5.5 (4.6, 5.8)	0.2
2-h Insulin, pmol/L	34	278 (207, 399)	309 (165, 737)	0.5
AUC glucose, mmol/L	33	665.8 ± 75.4	783.7 ± 167.8	0.02
AUC insulin, mmol/L	33	48,012 ± 18,367	66,180 ± 40,350	0.11
HOMA	34	2.65 (2.0, 3.2)	2.41 (1.7, 4.4)	0.9
Reproductive markers
fT, pM	34	23.2 (17.7, 31.2)	10.80 (10.3, 14.1)	<0.001
SHBG, nmol/L	34	62.1 ± 21.5	63.4 ± 38.4	0.9
FAI	34	1.42 (1.4, 2.2)	3.17 (2.2, 5.3)	<0.001
AMH, pmol/L	33	18.9 (10.8, 31.1)	48.6 (37.7, 74.6)	<0.001
Systemic methyl substrate/donors
SAM, µg/mL	32	7.7 (5.4, 8.3)	6.9 (6.0, 12.8)	0.7
Folate, nmol/L	33	29.9 (23.2, 37.5)	37.3 (23.4, 45.8)	0.08
Homocysteine	33	9.0 (6.9, 10.1)	7.1 (6.4, 9.7)	0.3
Cytokines
HsCRP, mg/L	30	1.3 (0.5, 3.3)	1.4 (0.6, 4.5)	0.7
IL-6, pg/ml	31	1.8 (1.3, 3.0)	2.1 (1.5, 2.9)	0.3
Cell counts
WBC, µL	31	5335 ± 1229	5750 ± 1497	0.4

Clinical Features

Sample Size (n)

Without PCOS [Mean ± SD or Median (IQR)]

With PCOS [Mean ± SD or Median (IQR)]

Lipid profile

Cholesterol, mmol/L

4.2 ± 0.7

4.4 ± 0.7

0.5

Triglycerides, mmol/L

0.6 (0.6, 0.9)

0.8 (0.5, 1.0)

0.6

HDL, mmol/L

1.5 ± 0.3

1.0

LDL, mmol/L

2.5 ± 0.6

2.4 ± 0.7

0.6

OGTT

Fasting glucose, mmol/L

4.9 (4.8, 5.4)

4.9 (4.6, 5.3)

0.4

Fasting insulin, pmol/L

72.8 (56.2, 89.4)

68.5 (47.2, 102.4)

0.9

2-h Glucose, mmol/L

4.75 (4.5, 5.4)

5.5 (4.6, 5.8)

0.2

2-h Insulin, pmol/L

278 (207, 399)

309 (165, 737)

0.5

AUC glucose, mmol/L

665.8 ± 75.4

783.7 ± 167.8

0.02

AUC insulin, mmol/L

48,012 ± 18,367

66,180 ± 40,350

0.11

HOMA

2.65 (2.0, 3.2)

2.41 (1.7, 4.4)

0.9

Reproductive markers

fT, pM

23.2 (17.7, 31.2)

10.80 (10.3, 14.1)

<0.001

SHBG, nmol/L

62.1 ± 21.5

63.4 ± 38.4

0.9

FAI

1.42 (1.4, 2.2)

3.17 (2.2, 5.3)

<0.001

AMH, pmol/L

18.9 (10.8, 31.1)

48.6 (37.7, 74.6)

<0.001

Systemic methyl substrate/donors

SAM, µg/mL

7.7 (5.4, 8.3)

6.9 (6.0, 12.8)

0.7

Folate, nmol/L

29.9 (23.2, 37.5)

37.3 (23.4, 45.8)

0.08

Homocysteine

9.0 (6.9, 10.1)

7.1 (6.4, 9.7)

0.3

Cytokines

HsCRP, mg/L

1.3 (0.5, 3.3)

1.4 (0.6, 4.5)

0.7

IL-6, pg/ml

1.8 (1.3, 3.0)

2.1 (1.5, 2.9)

0.3

Cell counts

WBC, µL

5335 ± 1229

5750 ± 1497

0.4

Clinical Features	Sample Size (n)	Without PCOS [Mean ± SD or Median (IQR)]	With PCOS [Mean ± SD or Median (IQR)]	P
Lipid profile
Cholesterol, mmol/L	30	4.2 ± 0.7	4.4 ± 0.7	0.5
Triglycerides, mmol/L	30	0.6 (0.6, 0.9)	0.8 (0.5, 1.0)	0.6
HDL, mmol/L	30	1.5 ± 0.3	1.5 ± 0.3	1.0
LDL, mmol/L	30	2.5 ± 0.6	2.4 ± 0.7	0.6
OGTT
Fasting glucose, mmol/L	34	4.9 (4.8, 5.4)	4.9 (4.6, 5.3)	0.4
Fasting insulin, pmol/L	34	72.8 (56.2, 89.4)	68.5 (47.2, 102.4)	0.9
2-h Glucose, mmol/L	34	4.75 (4.5, 5.4)	5.5 (4.6, 5.8)	0.2
2-h Insulin, pmol/L	34	278 (207, 399)	309 (165, 737)	0.5
AUC glucose, mmol/L	33	665.8 ± 75.4	783.7 ± 167.8	0.02
AUC insulin, mmol/L	33	48,012 ± 18,367	66,180 ± 40,350	0.11
HOMA	34	2.65 (2.0, 3.2)	2.41 (1.7, 4.4)	0.9
Reproductive markers
fT, pM	34	23.2 (17.7, 31.2)	10.80 (10.3, 14.1)	<0.001
SHBG, nmol/L	34	62.1 ± 21.5	63.4 ± 38.4	0.9
FAI	34	1.42 (1.4, 2.2)	3.17 (2.2, 5.3)	<0.001
AMH, pmol/L	33	18.9 (10.8, 31.1)	48.6 (37.7, 74.6)	<0.001
Systemic methyl substrate/donors
SAM, µg/mL	32	7.7 (5.4, 8.3)	6.9 (6.0, 12.8)	0.7
Folate, nmol/L	33	29.9 (23.2, 37.5)	37.3 (23.4, 45.8)	0.08
Homocysteine	33	9.0 (6.9, 10.1)	7.1 (6.4, 9.7)	0.3
Cytokines
HsCRP, mg/L	30	1.3 (0.5, 3.3)	1.4 (0.6, 4.5)	0.7
IL-6, pg/ml	31	1.8 (1.3, 3.0)	2.1 (1.5, 2.9)	0.3
Cell counts
WBC, µL	31	5335 ± 1229	5750 ± 1497	0.4

Table 2.

Open in new tab

Metabolic and Reproductive Profile of Participating Women With and Without PCOS

Clinical Features	Sample Size (n)	Without PCOS [Mean ± SD or Median (IQR)]	With PCOS [Mean ± SD or Median (IQR)]	P
Lipid profile
Cholesterol, mmol/L	30	4.2 ± 0.7	4.4 ± 0.7	0.5
Triglycerides, mmol/L	30	0.6 (0.6, 0.9)	0.8 (0.5, 1.0)	0.6
HDL, mmol/L	30	1.5 ± 0.3	1.5 ± 0.3	1.0
LDL, mmol/L	30	2.5 ± 0.6	2.4 ± 0.7	0.6
OGTT
Fasting glucose, mmol/L	34	4.9 (4.8, 5.4)	4.9 (4.6, 5.3)	0.4
Fasting insulin, pmol/L	34	72.8 (56.2, 89.4)	68.5 (47.2, 102.4)	0.9
2-h Glucose, mmol/L	34	4.75 (4.5, 5.4)	5.5 (4.6, 5.8)	0.2
2-h Insulin, pmol/L	34	278 (207, 399)	309 (165, 737)	0.5
AUC glucose, mmol/L	33	665.8 ± 75.4	783.7 ± 167.8	0.02
AUC insulin, mmol/L	33	48,012 ± 18,367	66,180 ± 40,350	0.11
HOMA	34	2.65 (2.0, 3.2)	2.41 (1.7, 4.4)	0.9
Reproductive markers
fT, pM	34	23.2 (17.7, 31.2)	10.80 (10.3, 14.1)	<0.001
SHBG, nmol/L	34	62.1 ± 21.5	63.4 ± 38.4	0.9
FAI	34	1.42 (1.4, 2.2)	3.17 (2.2, 5.3)	<0.001
AMH, pmol/L	33	18.9 (10.8, 31.1)	48.6 (37.7, 74.6)	<0.001
Systemic methyl substrate/donors
SAM, µg/mL	32	7.7 (5.4, 8.3)	6.9 (6.0, 12.8)	0.7
Folate, nmol/L	33	29.9 (23.2, 37.5)	37.3 (23.4, 45.8)	0.08
Homocysteine	33	9.0 (6.9, 10.1)	7.1 (6.4, 9.7)	0.3
Cytokines
HsCRP, mg/L	30	1.3 (0.5, 3.3)	1.4 (0.6, 4.5)	0.7
IL-6, pg/ml	31	1.8 (1.3, 3.0)	2.1 (1.5, 2.9)	0.3
Cell counts
WBC, µL	31	5335 ± 1229	5750 ± 1497	0.4

Clinical Features	Sample Size (n)	Without PCOS [Mean ± SD or Median (IQR)]	With PCOS [Mean ± SD or Median (IQR)]	P
Lipid profile
Cholesterol, mmol/L	30	4.2 ± 0.7	4.4 ± 0.7	0.5
Triglycerides, mmol/L	30	0.6 (0.6, 0.9)	0.8 (0.5, 1.0)	0.6
HDL, mmol/L	30	1.5 ± 0.3	1.5 ± 0.3	1.0
LDL, mmol/L	30	2.5 ± 0.6	2.4 ± 0.7	0.6
OGTT
Fasting glucose, mmol/L	34	4.9 (4.8, 5.4)	4.9 (4.6, 5.3)	0.4
Fasting insulin, pmol/L	34	72.8 (56.2, 89.4)	68.5 (47.2, 102.4)	0.9
2-h Glucose, mmol/L	34	4.75 (4.5, 5.4)	5.5 (4.6, 5.8)	0.2
2-h Insulin, pmol/L	34	278 (207, 399)	309 (165, 737)	0.5
AUC glucose, mmol/L	33	665.8 ± 75.4	783.7 ± 167.8	0.02
AUC insulin, mmol/L	33	48,012 ± 18,367	66,180 ± 40,350	0.11
HOMA	34	2.65 (2.0, 3.2)	2.41 (1.7, 4.4)	0.9
Reproductive markers
fT, pM	34	23.2 (17.7, 31.2)	10.80 (10.3, 14.1)	<0.001
SHBG, nmol/L	34	62.1 ± 21.5	63.4 ± 38.4	0.9
FAI	34	1.42 (1.4, 2.2)	3.17 (2.2, 5.3)	<0.001
AMH, pmol/L	33	18.9 (10.8, 31.1)	48.6 (37.7, 74.6)	<0.001
Systemic methyl substrate/donors
SAM, µg/mL	32	7.7 (5.4, 8.3)	6.9 (6.0, 12.8)	0.7
Folate, nmol/L	33	29.9 (23.2, 37.5)	37.3 (23.4, 45.8)	0.08
Homocysteine	33	9.0 (6.9, 10.1)	7.1 (6.4, 9.7)	0.3
Cytokines
HsCRP, mg/L	30	1.3 (0.5, 3.3)	1.4 (0.6, 4.5)	0.7
IL-6, pg/ml	31	1.8 (1.3, 3.0)	2.1 (1.5, 2.9)	0.3
Cell counts
WBC, µL	31	5335 ± 1229	5750 ± 1497	0.4

Abbreviations: AUC, area under the curve; HDL, high-density lipoprotein; HOMA, homeostatic model assessment; HsCRP, high-sensitivity C-reactive protein; FAI, Free Androgen Index; IQR, interquartile range; LDL, low-density lipoprotein; WBC, white blood cell.

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