Associations Between Plasma Metabolite Levels and Incidence of T2DM in the MPP (N = 698) and the MDC-CC (N = 3423)
| MPP (N = 698) | MDC-CC (N = 3423) | |||||||
| Model 1 | Model 2 | Model 1 | Model 2 | |||||
| Metabolite | OR | P | OR | P | HR | P | HR | P |
| DMGU | 1.67 (1.31–2.12) | 3.6e-5 | 1.54 (1.20–1.99) | 8.0e-4 | 1.28 (1.05–1.55) | 0.012 | 1.28 (1.05–1.55) | 0.014 |
| 7MG | 1.49 (1.19–1.87) | 5.9e-4 | 1.41 (1.12–1.79) | 4.1e-3 | 1.25 (1.02–1.53) | 0.035 | 1.24 (1.01–1.52) | 0.043 |
| HTML | 1.50 (1.19–1.87) | 5.1e-4 | 1.82 (1.25–2.65) | 1.7e-3 | 1.41 (1.12–1.77) | 3.0e-3 | 1.42 (1.13–1.79) | 2.8e-3 |
| Urea | 1.23 (1.01–1.49) | 0.036 | 1.19 (0.98–1.45) | 0.072 | 1.24 (1.02–1.26) | 0.024 | 1.14 (1.02–1.27) | 0.020 |
| MPP (N = 698) | MDC-CC (N = 3423) | |||||||
| Model 1 | Model 2 | Model 1 | Model 2 | |||||
| Metabolite | OR | P | OR | P | HR | P | HR | P |
| DMGU | 1.67 (1.31–2.12) | 3.6e-5 | 1.54 (1.20–1.99) | 8.0e-4 | 1.28 (1.05–1.55) | 0.012 | 1.28 (1.05–1.55) | 0.014 |
| 7MG | 1.49 (1.19–1.87) | 5.9e-4 | 1.41 (1.12–1.79) | 4.1e-3 | 1.25 (1.02–1.53) | 0.035 | 1.24 (1.01–1.52) | 0.043 |
| HTML | 1.50 (1.19–1.87) | 5.1e-4 | 1.82 (1.25–2.65) | 1.7e-3 | 1.41 (1.12–1.77) | 3.0e-3 | 1.42 (1.13–1.79) | 2.8e-3 |
| Urea | 1.23 (1.01–1.49) | 0.036 | 1.19 (0.98–1.45) | 0.072 | 1.24 (1.02–1.26) | 0.024 | 1.14 (1.02–1.27) | 0.020 |
ORs and HRs are expressed per SD increment of plasma metabolite and calculated from logistic regression models. Regression model 1 is adjusted for age, sex, fasting glucose, and BMI. Model 2 is additionally adjusted for systolic blood pressure and fasting levels of triglycerides, HDL, and LDL cholesterol.
Associations Between Plasma Metabolite Levels and Incidence of T2DM in the MPP (N = 698) and the MDC-CC (N = 3423)
| MPP (N = 698) | MDC-CC (N = 3423) | |||||||
| Model 1 | Model 2 | Model 1 | Model 2 | |||||
| Metabolite | OR | P | OR | P | HR | P | HR | P |
| DMGU | 1.67 (1.31–2.12) | 3.6e-5 | 1.54 (1.20–1.99) | 8.0e-4 | 1.28 (1.05–1.55) | 0.012 | 1.28 (1.05–1.55) | 0.014 |
| 7MG | 1.49 (1.19–1.87) | 5.9e-4 | 1.41 (1.12–1.79) | 4.1e-3 | 1.25 (1.02–1.53) | 0.035 | 1.24 (1.01–1.52) | 0.043 |
| HTML | 1.50 (1.19–1.87) | 5.1e-4 | 1.82 (1.25–2.65) | 1.7e-3 | 1.41 (1.12–1.77) | 3.0e-3 | 1.42 (1.13–1.79) | 2.8e-3 |
| Urea | 1.23 (1.01–1.49) | 0.036 | 1.19 (0.98–1.45) | 0.072 | 1.24 (1.02–1.26) | 0.024 | 1.14 (1.02–1.27) | 0.020 |
| MPP (N = 698) | MDC-CC (N = 3423) | |||||||
| Model 1 | Model 2 | Model 1 | Model 2 | |||||
| Metabolite | OR | P | OR | P | HR | P | HR | P |
| DMGU | 1.67 (1.31–2.12) | 3.6e-5 | 1.54 (1.20–1.99) | 8.0e-4 | 1.28 (1.05–1.55) | 0.012 | 1.28 (1.05–1.55) | 0.014 |
| 7MG | 1.49 (1.19–1.87) | 5.9e-4 | 1.41 (1.12–1.79) | 4.1e-3 | 1.25 (1.02–1.53) | 0.035 | 1.24 (1.01–1.52) | 0.043 |
| HTML | 1.50 (1.19–1.87) | 5.1e-4 | 1.82 (1.25–2.65) | 1.7e-3 | 1.41 (1.12–1.77) | 3.0e-3 | 1.42 (1.13–1.79) | 2.8e-3 |
| Urea | 1.23 (1.01–1.49) | 0.036 | 1.19 (0.98–1.45) | 0.072 | 1.24 (1.02–1.26) | 0.024 | 1.14 (1.02–1.27) | 0.020 |
ORs and HRs are expressed per SD increment of plasma metabolite and calculated from logistic regression models. Regression model 1 is adjusted for age, sex, fasting glucose, and BMI. Model 2 is additionally adjusted for systolic blood pressure and fasting levels of triglycerides, HDL, and LDL cholesterol.
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