Table 2. Open in new tab Description of...

Cycle 0

Cycle 1

Cycle 2

Cycle 3

Cycle 4

Cycle 5

Cycle 6

Cycle 7

Cycle 8

Cycle 9

Cycle 10

Cycle 11

Cycle 12

Cycle 13

Protocol

Mild stim.

OC + hMG

hMG

Daily dose of hMG, IU

150

225

150

Duration of simulation, d

Total dose of hMG, IU

900

2925

1500

Hormones on day of trigger

Serum LH level, IU/L

21.89

18.52

18.04

11.87

1.62

33.71

17.91

24.18

23.72

10.71

19.58

16.94

27.41

11.4

Serum E2 level, pg/mL

102

130

101

110

Serum P level, ng/mL

3.19

1.4

0.1

1.2

0.7

1.0

1.1

2.0

0.7

0.9

1.9

0.6

0.7

0.9

Serum T level, ng/mL

—

0.2

0.17

0.28

0.15

0.14

0.17

0.18

0.19

0.18

0.2

0.8

No. of total follicles

No. of leading follicles (≥18 mm) right + left

Ovulation trigger (dose)

1000IU hCG

0.1 mg of T

5000 IU of hCG

0.2 mg of T

5000 IU of hCG

0.1 mg of T + 5000 IU of hCG

Time interval between hCG administration and oocyte retrieval, h

40.5

40.2

No. of oocytes retrieved

No. of embryos developed

Hormones on day after trigger

Serum hCG level, IU/L

—

97.00

—

198.33

113.11

168.94

291.91

140.20

194

Serum LH level, IU/L

—

157.85

62.33

104.44

2.49

122.87

194.24

186.62

18.39

83.54

116.14

150.89

120.24

140.0

Serum E2 level, IU/L

—

199

123

102

115

94.0

Serum P level, ng/mL

—

4.8

0.16

1.2

0.5

1.8

9.9

6.2

0.7

5.5

6.4

4.0

4.2

3.8

Serum T level, ng/mL

—

0.3

0.28

0.29

0.18

0.2

0.22

0.18

0.21

0.13

0.15

0.21

Table 2.

Open in new tab

Description of the Assisted Reproductive Technology Cycles in the Proband of Family 1

	Cycle 0	Cycle 1	Cycle 2	Cycle 3	Cycle 4	Cycle 5	Cycle 6	Cycle 7	Cycle 8	Cycle 9	Cycle 10	Cycle 11	Cycle 12	Cycle 13
Protocol	Mild stim.	NC	NC	NC	OC + hMG	NC	NC	NC	NC	NC	NC	NC	NC	hMG
Daily dose of hMG, IU	150	0	0	0	225	0	0	0	0	0	0	0	0	150
Duration of simulation, d	6	20	6	11	13	15	0	22	10	14	10	18	6	10
Total dose of hMG, IU	900	0	0	0	2925	0	0	0	0	0	0	0	0	1500
Hormones on day of trigger
Serum LH level, IU/L	21.89	18.52	18.04	11.87	1.62	33.71	17.91	24.18	23.72	10.71	19.58	16.94	27.41	11.4
Serum E2 level, pg/mL	33	102	60	82	82	61	130	101	90	91	110	84	78	86
Serum P level, ng/mL	3.19	1.4	0.1	1.2	0.7	1.0	1.1	2.0	0.7	0.9	1.9	0.6	0.7	0.9
Serum T level, ng/mL	—	—	0.2	0.17	0.28	0.15	0.14	0.17	0.18	0.19	0.18	0.2	0.2	0.8
No. of total follicles	4	3	5	6	3	2	6	4	4	3	5	4	6	4
No. of leading follicles (≥18 mm) right + left	1	1	4	5	2	1	6	3	4	3	5	4	4	4
Ovulation trigger (dose)	1000IU hCG	0.1 mg of T	0.1 mg of T	0.1 mg of T	5000 IU of hCG	0.2 mg of T	0.2 mg of T	0.2 mg of T	5000 IU of hCG	0.1 mg of T + 5000 IU of hCG	0.1 mg of T + 5000 IU of hCG	0.1 mg of T + 5000 IU of hCG	0.1 mg of T + 5000 IU of hCG	0.1 mg of T + 5000 IU of hCG
Time interval between hCG administration and oocyte retrieval, h	24	33	35	37	35	37	39	39	39	39	40	40	40.5	40.2
No. of oocytes retrieved	0	1	0	3	0	0	1	0	0	0	1	2	1	2
No. of embryos developed	0	0	0	0	0	0	1	0	0	0	1	1	1	2
Hormones on day after trigger
Serum hCG level, IU/L	—	—	—	—	97.00	—	—	—	198.33	113.11	168.94	291.91	140.20	194
Serum LH level, IU/L	—	157.85	62.33	104.44	2.49	122.87	194.24	186.62	18.39	83.54	116.14	150.89	120.24	140.0
Serum E2 level, IU/L	—	86	66	99	75	77	199	123	79	102	115	86	93	94.0
Serum P level, ng/mL	—	4.8	0.16	1.2	0.5	1.8	9.9	6.2	0.7	5.5	6.4	4.0	4.2	3.8
Serum T level, ng/mL	—	—	0.3	0.28	0.29	0.18	0.2	0.22	0.18	0.21	0.13	0.15	0.21	0.21

	Cycle 0	Cycle 1	Cycle 2	Cycle 3	Cycle 4	Cycle 5	Cycle 6	Cycle 7	Cycle 8	Cycle 9	Cycle 10	Cycle 11	Cycle 12	Cycle 13
Protocol	Mild stim.	NC	NC	NC	OC + hMG	NC	NC	NC	NC	NC	NC	NC	NC	hMG
Daily dose of hMG, IU	150	0	0	0	225	0	0	0	0	0	0	0	0	150
Duration of simulation, d	6	20	6	11	13	15	0	22	10	14	10	18	6	10
Total dose of hMG, IU	900	0	0	0	2925	0	0	0	0	0	0	0	0	1500
Hormones on day of trigger
Serum LH level, IU/L	21.89	18.52	18.04	11.87	1.62	33.71	17.91	24.18	23.72	10.71	19.58	16.94	27.41	11.4
Serum E2 level, pg/mL	33	102	60	82	82	61	130	101	90	91	110	84	78	86
Serum P level, ng/mL	3.19	1.4	0.1	1.2	0.7	1.0	1.1	2.0	0.7	0.9	1.9	0.6	0.7	0.9
Serum T level, ng/mL	—	—	0.2	0.17	0.28	0.15	0.14	0.17	0.18	0.19	0.18	0.2	0.2	0.8
No. of total follicles	4	3	5	6	3	2	6	4	4	3	5	4	6	4
No. of leading follicles (≥18 mm) right + left	1	1	4	5	2	1	6	3	4	3	5	4	4	4
Ovulation trigger (dose)	1000IU hCG	0.1 mg of T	0.1 mg of T	0.1 mg of T	5000 IU of hCG	0.2 mg of T	0.2 mg of T	0.2 mg of T	5000 IU of hCG	0.1 mg of T + 5000 IU of hCG	0.1 mg of T + 5000 IU of hCG	0.1 mg of T + 5000 IU of hCG	0.1 mg of T + 5000 IU of hCG	0.1 mg of T + 5000 IU of hCG
Time interval between hCG administration and oocyte retrieval, h	24	33	35	37	35	37	39	39	39	39	40	40	40.5	40.2
No. of oocytes retrieved	0	1	0	3	0	0	1	0	0	0	1	2	1	2
No. of embryos developed	0	0	0	0	0	0	1	0	0	0	1	1	1	2
Hormones on day after trigger
Serum hCG level, IU/L	—	—	—	—	97.00	—	—	—	198.33	113.11	168.94	291.91	140.20	194
Serum LH level, IU/L	—	157.85	62.33	104.44	2.49	122.87	194.24	186.62	18.39	83.54	116.14	150.89	120.24	140.0
Serum E2 level, IU/L	—	86	66	99	75	77	199	123	79	102	115	86	93	94.0
Serum P level, ng/mL	—	4.8	0.16	1.2	0.5	1.8	9.9	6.2	0.7	5.5	6.4	4.0	4.2	3.8
Serum T level, ng/mL	—	—	0.3	0.28	0.29	0.18	0.2	0.22	0.18	0.21	0.13	0.15	0.21	0.21

Cycle 0 represents the previous IVF cycles in other IVF center.

Abbreviations: OC, oral contraception; NC, natural cycle; stim., stimulation; T, triptorelin.

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