Table 8. Open in new tab Estimates of...

	Frequencies (Pairs)	r_t (95% CI)	Variance Component Under Full Model(95% CI)
Total sample (permanent + transient CH)	Concordant = 2	Concordant = 2	0.72	0.60	P = 0.47	0.24	0.48	0.28
Discordant = 11	Discordant = 24	(0.44–0.90)	(0.34–0.79)		(0.00–0.70)	(0.00–0.78)	(0.10–0.52)
Transient CH	Concordant = 1	Concordant = 0	0.95	0	P = 0.11	0.95	0.00	0.05
Discordant = 1	Discordant = 4	(0.60–0.99)	(0–0.91)		(0.00–0.96)	(0.00–0.91)	(0.001–0.09)
Permanent CH	Concordant = 1	Concordant = 2	0.64	0.64	P = 1.00	0	0.64	0.36
Discordant= 10^b	Discordant = 20	(0.28–0.87)	(0.38–0.82)		(0.00–0.93)	(0.06–0.79)	(0.13–0.57)

	Frequencies (Pairs)	r_t (95% CI)	Variance Component Under Full Model(95% CI)
Total sample (permanent + transient CH)	Concordant = 2	Concordant = 2	0.72	0.60	P = 0.47	0.24	0.48	0.28
Discordant = 11	Discordant = 24	(0.44–0.90)	(0.34–0.79)		(0.00–0.70)	(0.00–0.78)	(0.10–0.52)
Transient CH	Concordant = 1	Concordant = 0	0.95	0	P = 0.11	0.95	0.00	0.05
Discordant = 1	Discordant = 4	(0.60–0.99)	(0–0.91)		(0.00–0.96)	(0.00–0.91)	(0.001–0.09)
Permanent CH	Concordant = 1	Concordant = 2	0.64	0.64	P = 1.00	0	0.64	0.36
Discordant= 10^b	Discordant = 20	(0.28–0.87)	(0.38–0.82)		(0.00–0.93)	(0.06–0.79)	(0.13–0.57)

Table 8.

Estimates of Tetrachoric Correlations by Zygosity and Additive Genetic (A), Common Environmental (C), and Unshared Environmental (E) Variance Components In CH Liability

	Frequencies (Pairs)		r_t (95% CI)			Variance Component Under Full Model(95% CI)
	MZ	DZ	MZ	DZ	Test^a	A	C	E
Total sample (permanent + transient CH)	Concordant = 2	Concordant = 2	0.72	0.60	P = 0.47	0.24	0.48	0.28
Total sample (permanent + transient CH)	Discordant = 11	Discordant = 24	(0.44–0.90)	(0.34–0.79)		(0.00–0.70)	(0.00–0.78)	(0.10–0.52)
Transient CH	Concordant = 1	Concordant = 0	0.95	0	P = 0.11	0.95	0.00	0.05
Transient CH	Discordant = 1	Discordant = 4	(0.60–0.99)	(0–0.91)		(0.00–0.96)	(0.00–0.91)	(0.001–0.09)
Permanent CH	Concordant = 1	Concordant = 2	0.64	0.64	P = 1.00	0	0.64	0.36
Permanent CH	Discordant= 10^b	Discordant = 20	(0.28–0.87)	(0.38–0.82)		(0.00–0.93)	(0.06–0.79)	(0.13–0.57)

	Frequencies (Pairs)		r_t (95% CI)			Variance Component Under Full Model(95% CI)
	MZ	DZ	MZ	DZ	Test^a	A	C	E
Total sample (permanent + transient CH)	Concordant = 2	Concordant = 2	0.72	0.60	P = 0.47	0.24	0.48	0.28
Total sample (permanent + transient CH)	Discordant = 11	Discordant = 24	(0.44–0.90)	(0.34–0.79)		(0.00–0.70)	(0.00–0.78)	(0.10–0.52)
Transient CH	Concordant = 1	Concordant = 0	0.95	0	P = 0.11	0.95	0.00	0.05
Transient CH	Discordant = 1	Discordant = 4	(0.60–0.99)	(0–0.91)		(0.00–0.96)	(0.00–0.91)	(0.001–0.09)
Permanent CH	Concordant = 1	Concordant = 2	0.64	0.64	P = 1.00	0	0.64	0.36
Permanent CH	Discordant= 10^b	Discordant = 20	(0.28–0.87)	(0.38–0.82)		(0.00–0.93)	(0.06–0.79)	(0.13–0.57)

Test for difference between MZ and DZ twins.

The two MZ pairs whose probands had permanent CH and cotwins developed hypothyroidism after the first month of life (at 9 mo and 12 y) were considered discordant for CH.

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