Blood TSH at Screening, Serum Hormone Values, and Results of Thyroid US and/or Scintigraphy in the Seven Screening Discordant Twin Pairs Becoming Concordant for CH Within the First Month of Life, and in the 40 Screening Discordant Twin Pairs Remaining Discordant at the First Month of Life
| . | Screening Discordant Twin Couples (N = 7) Becoming Concordant for CH Within the First Month of Life (2 MZ, 2 DZ, 3 UNZ) . | Screening Discordant Twin Couples (N = 40) Remaining Discordant for CH at the First Month of Life (11 MZ, 24 DZ, 5 UNZ) . | ||
|---|---|---|---|---|
| Screening Positive Probands . | Screening Negative Cotwins . | Screening Positive Probands . | Screening Negative Cotwins . | |
| Median blood TSH at screening, mU/L (range) | 16.7 (11.0–200) | 5.1 (1.0–8.2) | 22.3 (2.3–946) | 1.0 (0.4–13.5) |
| Median serum TSH, mU/L (range) | 23.0a (15.3–956) | 13.0a (8.6–113) | 85.5a (10.1–1800) | 2.0b (1.0–6.8) |
| Mean ± SD of sFT4, pg/mL (range) | 9.9 ± 3.7a (3.1–13.0) | 11.4 ± 1.9a (8.4–13.2) | 7.3 ± 5.1a (0.4–18.7) | 9.9 ± 3.3b (7.0–16.1) |
| Thyroid US and/or scintigraphy | 1 Hemiagenesis | 1 Hypoplasia | 5 Agenesis | 40 Normal thyroid |
| 1 Ectopy | 6 Normal thyroid | 2 Hemiagenesis | ||
| 5 Normal thyroid | 8 Ectopy | |||
| 10 Hypoplasia | ||||
| 15 Goiter/normal thyroid | ||||
| No. of preterm pairs (<37 wk gestation) | 4 | 29 | ||
| . | Screening Discordant Twin Couples (N = 7) Becoming Concordant for CH Within the First Month of Life (2 MZ, 2 DZ, 3 UNZ) . | Screening Discordant Twin Couples (N = 40) Remaining Discordant for CH at the First Month of Life (11 MZ, 24 DZ, 5 UNZ) . | ||
|---|---|---|---|---|
| Screening Positive Probands . | Screening Negative Cotwins . | Screening Positive Probands . | Screening Negative Cotwins . | |
| Median blood TSH at screening, mU/L (range) | 16.7 (11.0–200) | 5.1 (1.0–8.2) | 22.3 (2.3–946) | 1.0 (0.4–13.5) |
| Median serum TSH, mU/L (range) | 23.0a (15.3–956) | 13.0a (8.6–113) | 85.5a (10.1–1800) | 2.0b (1.0–6.8) |
| Mean ± SD of sFT4, pg/mL (range) | 9.9 ± 3.7a (3.1–13.0) | 11.4 ± 1.9a (8.4–13.2) | 7.3 ± 5.1a (0.4–18.7) | 9.9 ± 3.3b (7.0–16.1) |
| Thyroid US and/or scintigraphy | 1 Hemiagenesis | 1 Hypoplasia | 5 Agenesis | 40 Normal thyroid |
| 1 Ectopy | 6 Normal thyroid | 2 Hemiagenesis | ||
| 5 Normal thyroid | 8 Ectopy | |||
| 10 Hypoplasia | ||||
| 15 Goiter/normal thyroid | ||||
| No. of preterm pairs (<37 wk gestation) | 4 | 29 | ||
Blood TSH at Screening, Serum Hormone Values, and Results of Thyroid US and/or Scintigraphy in the Seven Screening Discordant Twin Pairs Becoming Concordant for CH Within the First Month of Life, and in the 40 Screening Discordant Twin Pairs Remaining Discordant at the First Month of Life
| . | Screening Discordant Twin Couples (N = 7) Becoming Concordant for CH Within the First Month of Life (2 MZ, 2 DZ, 3 UNZ) . | Screening Discordant Twin Couples (N = 40) Remaining Discordant for CH at the First Month of Life (11 MZ, 24 DZ, 5 UNZ) . | ||
|---|---|---|---|---|
| Screening Positive Probands . | Screening Negative Cotwins . | Screening Positive Probands . | Screening Negative Cotwins . | |
| Median blood TSH at screening, mU/L (range) | 16.7 (11.0–200) | 5.1 (1.0–8.2) | 22.3 (2.3–946) | 1.0 (0.4–13.5) |
| Median serum TSH, mU/L (range) | 23.0a (15.3–956) | 13.0a (8.6–113) | 85.5a (10.1–1800) | 2.0b (1.0–6.8) |
| Mean ± SD of sFT4, pg/mL (range) | 9.9 ± 3.7a (3.1–13.0) | 11.4 ± 1.9a (8.4–13.2) | 7.3 ± 5.1a (0.4–18.7) | 9.9 ± 3.3b (7.0–16.1) |
| Thyroid US and/or scintigraphy | 1 Hemiagenesis | 1 Hypoplasia | 5 Agenesis | 40 Normal thyroid |
| 1 Ectopy | 6 Normal thyroid | 2 Hemiagenesis | ||
| 5 Normal thyroid | 8 Ectopy | |||
| 10 Hypoplasia | ||||
| 15 Goiter/normal thyroid | ||||
| No. of preterm pairs (<37 wk gestation) | 4 | 29 | ||
| . | Screening Discordant Twin Couples (N = 7) Becoming Concordant for CH Within the First Month of Life (2 MZ, 2 DZ, 3 UNZ) . | Screening Discordant Twin Couples (N = 40) Remaining Discordant for CH at the First Month of Life (11 MZ, 24 DZ, 5 UNZ) . | ||
|---|---|---|---|---|
| Screening Positive Probands . | Screening Negative Cotwins . | Screening Positive Probands . | Screening Negative Cotwins . | |
| Median blood TSH at screening, mU/L (range) | 16.7 (11.0–200) | 5.1 (1.0–8.2) | 22.3 (2.3–946) | 1.0 (0.4–13.5) |
| Median serum TSH, mU/L (range) | 23.0a (15.3–956) | 13.0a (8.6–113) | 85.5a (10.1–1800) | 2.0b (1.0–6.8) |
| Mean ± SD of sFT4, pg/mL (range) | 9.9 ± 3.7a (3.1–13.0) | 11.4 ± 1.9a (8.4–13.2) | 7.3 ± 5.1a (0.4–18.7) | 9.9 ± 3.3b (7.0–16.1) |
| Thyroid US and/or scintigraphy | 1 Hemiagenesis | 1 Hypoplasia | 5 Agenesis | 40 Normal thyroid |
| 1 Ectopy | 6 Normal thyroid | 2 Hemiagenesis | ||
| 5 Normal thyroid | 8 Ectopy | |||
| 10 Hypoplasia | ||||
| 15 Goiter/normal thyroid | ||||
| No. of preterm pairs (<37 wk gestation) | 4 | 29 | ||
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