Meta-analytic findings from placebo-controlled trials in acute bipolar vs. unipolar major depression
| Measures . | Measure (95% CI) . | |
|---|---|---|
| Bipolar . | Unipolar . | |
| Trials | 10 | 142 |
| Antidepressant/control RR | 1.43 (1.11–1.84) | 1.42 (1.38–1.48) |
| Antidepressant/control RD | 0.164 (0.049–0.280) | 0.125 (0.111–0.141) |
| NNT | 6.2 (3.6–6.7) | 8.0 (7.1–9.1) |
| Measures . | Measure (95% CI) . | |
|---|---|---|
| Bipolar . | Unipolar . | |
| Trials | 10 | 142 |
| Antidepressant/control RR | 1.43 (1.11–1.84) | 1.42 (1.38–1.48) |
| Antidepressant/control RD | 0.164 (0.049–0.280) | 0.125 (0.111–0.141) |
| NNT | 6.2 (3.6–6.7) | 8.0 (7.1–9.1) |
CI, Confidence intervals; RR, response-rate ratios; RD, rate differences; NNT, number needed to treat.
Data are derived from Table 1 for bipolar and from Undurraga and Baldessarini (2012) for unipolar trials in acute depression (1980–2010).
Meta-analytic findings from placebo-controlled trials in acute bipolar vs. unipolar major depression
| Measures . | Measure (95% CI) . | |
|---|---|---|
| Bipolar . | Unipolar . | |
| Trials | 10 | 142 |
| Antidepressant/control RR | 1.43 (1.11–1.84) | 1.42 (1.38–1.48) |
| Antidepressant/control RD | 0.164 (0.049–0.280) | 0.125 (0.111–0.141) |
| NNT | 6.2 (3.6–6.7) | 8.0 (7.1–9.1) |
| Measures . | Measure (95% CI) . | |
|---|---|---|
| Bipolar . | Unipolar . | |
| Trials | 10 | 142 |
| Antidepressant/control RR | 1.43 (1.11–1.84) | 1.42 (1.38–1.48) |
| Antidepressant/control RD | 0.164 (0.049–0.280) | 0.125 (0.111–0.141) |
| NNT | 6.2 (3.6–6.7) | 8.0 (7.1–9.1) |
CI, Confidence intervals; RR, response-rate ratios; RD, rate differences; NNT, number needed to treat.
Data are derived from Table 1 for bipolar and from Undurraga and Baldessarini (2012) for unipolar trials in acute depression (1980–2010).
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