Table 2 Open in new tab Brain areas...

Side	Brain area	Cluster size (mm³)	MNI coordinates	T_max
HAMD positive correlations
L	Middle frontal gyrus	80	−30	32	56	5.71
R	Superior temporal gyrus	89	52	−40	18	4.93
R	Middle frontal gyrus	59	34	24	54	4.87
R	Hippocampus	17	40	−36	−6	3.73
R	Precuneus	14	6	−74	42	3.51
R	Posterior cingulate cortex	19	4	−40	38	3.38
L	Superior occipital gyrus	22	−24	−90	34	3.36
HAMD negative correlations
R	Superior frontal gyrus	102	22	−10	72	5.29
R	Superior parietal lobule	170	28	−54	72	4.36
L	Postcentral gyrus	77	−64	−14	20	4.01
R	Precentral gyrus	69	58	2	28	3.94
R	Temporal pole	47	38	12	−22	3.88
R	Lingual gyrus	57	8	−72	8	3.79
L	Superior temporal gyrus	16	−42	−40	24	3.66
L	Superior parietal lobe	12	−26	−52	74	3.13

Side	Brain area	Cluster size (mm³)	MNI coordinates	T_max
HAMD positive correlations
L	Middle frontal gyrus	80	−30	32	56	5.71
R	Superior temporal gyrus	89	52	−40	18	4.93
R	Middle frontal gyrus	59	34	24	54	4.87
R	Hippocampus	17	40	−36	−6	3.73
R	Precuneus	14	6	−74	42	3.51
R	Posterior cingulate cortex	19	4	−40	38	3.38
L	Superior occipital gyrus	22	−24	−90	34	3.36
HAMD negative correlations
R	Superior frontal gyrus	102	22	−10	72	5.29
R	Superior parietal lobule	170	28	−54	72	4.36
L	Postcentral gyrus	77	−64	−14	20	4.01
R	Precentral gyrus	69	58	2	28	3.94
R	Temporal pole	47	38	12	−22	3.88
R	Lingual gyrus	57	8	−72	8	3.79
L	Superior temporal gyrus	16	−42	−40	24	3.66
L	Superior parietal lobe	12	−26	−52	74	3.13

Table 2

Brain areas where neural reactivity to smoking cues vs. neutral cues as measured by BOLD signal during the post-smoking scan was significantly correlated with HAMD scores

Side	Brain area	Cluster size (mm³)	MNI coordinates			T_max
Side	Brain area	Cluster size (mm³)	x	y	z
HAMD positive correlations
L	Middle frontal gyrus	80	−30	32	56	5.71
R	Superior temporal gyrus	89	52	−40	18	4.93
R	Middle frontal gyrus	59	34	24	54	4.87
R	Hippocampus	17	40	−36	−6	3.73
R	Precuneus	14	6	−74	42	3.51
R	Posterior cingulate cortex	19	4	−40	38	3.38
L	Superior occipital gyrus	22	−24	−90	34	3.36
HAMD negative correlations
R	Superior frontal gyrus	102	22	−10	72	5.29
R	Superior parietal lobule	170	28	−54	72	4.36
L	Postcentral gyrus	77	−64	−14	20	4.01
R	Precentral gyrus	69	58	2	28	3.94
R	Temporal pole	47	38	12	−22	3.88
R	Lingual gyrus	57	8	−72	8	3.79
L	Superior temporal gyrus	16	−42	−40	24	3.66
L	Superior parietal lobe	12	−26	−52	74	3.13

Side	Brain area	Cluster size (mm³)	MNI coordinates			T_max
Side	Brain area	Cluster size (mm³)	x	y	z
HAMD positive correlations
L	Middle frontal gyrus	80	−30	32	56	5.71
R	Superior temporal gyrus	89	52	−40	18	4.93
R	Middle frontal gyrus	59	34	24	54	4.87
R	Hippocampus	17	40	−36	−6	3.73
R	Precuneus	14	6	−74	42	3.51
R	Posterior cingulate cortex	19	4	−40	38	3.38
L	Superior occipital gyrus	22	−24	−90	34	3.36
HAMD negative correlations
R	Superior frontal gyrus	102	22	−10	72	5.29
R	Superior parietal lobule	170	28	−54	72	4.36
L	Postcentral gyrus	77	−64	−14	20	4.01
R	Precentral gyrus	69	58	2	28	3.94
R	Temporal pole	47	38	12	−22	3.88
R	Lingual gyrus	57	8	−72	8	3.79
L	Superior temporal gyrus	16	−42	−40	24	3.66
L	Superior parietal lobe	12	−26	−52	74	3.13

BOLD, Blood oxygen level-dependent; HAMD, Hamilton Depression Rating Scale; MNI, Montreal Neurological Institute; R, right; L, left.

p≤0.005 (uncorrected), minimum cluster size ⩾10 voxels.

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