Baseline sleep disturbance scoresa (pooled modified intention-to-treat population)
| Mean (s.d.) . | Placebo +antidepressant (n = 303) . | Quetiapine XR(150 mg/d) +antidepressant (n = 309) . | Quetiapine XR(300 mg/d) +antidepressant (n = 307) . |
|---|---|---|---|
| MADRS Item 4 (reduced sleep) score | 3.4 (1.2) | 3.4 (1.1) | 3.4 (1.3) |
| HAMD Item 4 (insomnia-early) score | 1.4 (0.8) | 1.4 (0.7) | 1.4 (0.8) |
| HAMD Item 5 (insomnia-middle) score | 1.5 (0.6) | 1.6 (0.6) | 1.5 (0.6) |
| HAMD Item 6 (insomnia-late) score | 1.2 (0.8) | 1.3 (0.8) | 1.3 (0.8) |
| HAMD sleep disturbance factor (Items 4+5+6) score | 4.2 (1.5) | 4.3 (1.5) | 4.2 (1.5) |
| PSQI global score | 11.8 (3.8) | 12.3 (3.9) | 12.1 (4.0) |
| Mean (s.d.) . | Placebo +antidepressant (n = 303) . | Quetiapine XR(150 mg/d) +antidepressant (n = 309) . | Quetiapine XR(300 mg/d) +antidepressant (n = 307) . |
|---|---|---|---|
| MADRS Item 4 (reduced sleep) score | 3.4 (1.2) | 3.4 (1.1) | 3.4 (1.3) |
| HAMD Item 4 (insomnia-early) score | 1.4 (0.8) | 1.4 (0.7) | 1.4 (0.8) |
| HAMD Item 5 (insomnia-middle) score | 1.5 (0.6) | 1.6 (0.6) | 1.5 (0.6) |
| HAMD Item 6 (insomnia-late) score | 1.2 (0.8) | 1.3 (0.8) | 1.3 (0.8) |
| HAMD sleep disturbance factor (Items 4+5+6) score | 4.2 (1.5) | 4.3 (1.5) | 4.2 (1.5) |
| PSQI global score | 11.8 (3.8) | 12.3 (3.9) | 12.1 (4.0) |
XR, Extended-release; MADRS, Montgomery-Åsberg Depression Rating Scale; HAMD, Hamilton Depression Rating Scale; PSQI Pittsburgh Sleep Quality Index.
For patients included in the last assessment (week 6) analysis for each variable.
Baseline sleep disturbance scoresa (pooled modified intention-to-treat population)
| Mean (s.d.) . | Placebo +antidepressant (n = 303) . | Quetiapine XR(150 mg/d) +antidepressant (n = 309) . | Quetiapine XR(300 mg/d) +antidepressant (n = 307) . |
|---|---|---|---|
| MADRS Item 4 (reduced sleep) score | 3.4 (1.2) | 3.4 (1.1) | 3.4 (1.3) |
| HAMD Item 4 (insomnia-early) score | 1.4 (0.8) | 1.4 (0.7) | 1.4 (0.8) |
| HAMD Item 5 (insomnia-middle) score | 1.5 (0.6) | 1.6 (0.6) | 1.5 (0.6) |
| HAMD Item 6 (insomnia-late) score | 1.2 (0.8) | 1.3 (0.8) | 1.3 (0.8) |
| HAMD sleep disturbance factor (Items 4+5+6) score | 4.2 (1.5) | 4.3 (1.5) | 4.2 (1.5) |
| PSQI global score | 11.8 (3.8) | 12.3 (3.9) | 12.1 (4.0) |
| Mean (s.d.) . | Placebo +antidepressant (n = 303) . | Quetiapine XR(150 mg/d) +antidepressant (n = 309) . | Quetiapine XR(300 mg/d) +antidepressant (n = 307) . |
|---|---|---|---|
| MADRS Item 4 (reduced sleep) score | 3.4 (1.2) | 3.4 (1.1) | 3.4 (1.3) |
| HAMD Item 4 (insomnia-early) score | 1.4 (0.8) | 1.4 (0.7) | 1.4 (0.8) |
| HAMD Item 5 (insomnia-middle) score | 1.5 (0.6) | 1.6 (0.6) | 1.5 (0.6) |
| HAMD Item 6 (insomnia-late) score | 1.2 (0.8) | 1.3 (0.8) | 1.3 (0.8) |
| HAMD sleep disturbance factor (Items 4+5+6) score | 4.2 (1.5) | 4.3 (1.5) | 4.2 (1.5) |
| PSQI global score | 11.8 (3.8) | 12.3 (3.9) | 12.1 (4.0) |
XR, Extended-release; MADRS, Montgomery-Åsberg Depression Rating Scale; HAMD, Hamilton Depression Rating Scale; PSQI Pittsburgh Sleep Quality Index.
For patients included in the last assessment (week 6) analysis for each variable.
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