Table 2 Open in new tab Dynamic changes...

	Baseline	Mid-term FU	Long-term FU	P-value
Overall population
QT interval (ms)	343 ± 25	345 ± 24^a	346 ± 25^a	<0.0001
QRS duration (ms)	86 ± 9	91 ± 11^a	92 ± 11^a	<0.0001
HR (b.p.m.)	88 ± 13	87 ± 13^a	86 ± 13^a^,b	<0.0001
QTc Bazett (ms)	412 ± 25 (371–449)	411 ± 25 (367–449)	409 ± 25 (367–446)	0.10
QTc Fridericia (ms)	387 ± 21 (355–418)	387 ± 20 (353–419)	387 ± 20 (353–418)	0.59
Males
QT interval (ms)	345 ± 24	347 ± 25^a	348 ± 25^a	0.013
QTc Bazett (ms)	412 ± 24 (372–449)	410 ± 24 (369–448)	408 ± 23 (367–445)	0.06
QTc Fridericia (ms)	388 ± 20 (357–418)	387 ± 20 (355–419)	386 ± 19 (354–418)	0.86
Females
QT interval (ms)	341 ± 25	341 ± 24^a	342 ± 26^a	0.002
QTc Bazett (ms)	414 ± 26 (371–449)	414 ± 25 (375–450)	413 ± 24 (374–449)	0.89
QTc Fridericia (ms)	387 ± 22 (349–412)	388 ± 20 (356–419)	388 ± 20 (355–419)	0.31
Younger (<12 years)
QT interval (ms)	341 ± 25	343 ± 24^a	344 ± 24^a	0.008
QTc Bazett (ms)	411 ± 24	411 ± 25	410 ± 24	0.81
QTc Fridericia (ms)	386 ± 20	387 ± 20	387 ± 20	0.73
Older (≥12 years)
QT interval (ms)	345 ± 24	348 ± 25^a	348 ± 27^a	0.004
QTc Bazett (ms)	413 ± 25	412 ± 23	409 ± 24^a	0.010
QTc Fridericia (ms)	389 ± 21	389 ± 19	387 ± 20	0.58

Baseline

Mid-term FU

Long-term FU

P-value

Overall population

QT interval (ms)

343 ± 25

345 ± 24^a

346 ± 25^a

<0.0001

QRS duration (ms)

86 ± 9

91 ± 11^a

92 ± 11^a

<0.0001

HR (b.p.m.)

88 ± 13

87 ± 13^a

86 ± 13^a^,b

<0.0001

QTc Bazett (ms)

412 ± 25 (371–449)

411 ± 25 (367–449)

409 ± 25 (367–446)

0.10

QTc Fridericia (ms)

387 ± 21 (355–418)

387 ± 20 (353–419)

387 ± 20 (353–418)

0.59

Males

QT interval (ms)

345 ± 24

347 ± 25^a

348 ± 25^a

0.013

QTc Bazett (ms)

412 ± 24 (372–449)

410 ± 24 (369–448)

408 ± 23 (367–445)

0.06

QTc Fridericia (ms)

388 ± 20 (357–418)

387 ± 20 (355–419)

386 ± 19 (354–418)

0.86

Females

QT interval (ms)

341 ± 25

341 ± 24^a

342 ± 26^a

0.002

QTc Bazett (ms)

414 ± 26 (371–449)

414 ± 25 (375–450)

413 ± 24 (374–449)

0.89

QTc Fridericia (ms)

387 ± 22 (349–412)

388 ± 20 (356–419)

388 ± 20 (355–419)

0.31

Younger (<12 years)

QT interval (ms)

341 ± 25

343 ± 24^a

344 ± 24^a

0.008

QTc Bazett (ms)

411 ± 24

411 ± 25

410 ± 24

0.81

QTc Fridericia (ms)

386 ± 20

387 ± 20

0.73

Older (≥12 years)

QT interval (ms)

345 ± 24

348 ± 25^a

348 ± 27^a

0.004

QTc Bazett (ms)

413 ± 25

412 ± 23

409 ± 24^a

0.010

QTc Fridericia (ms)

389 ± 21

389 ± 19

387 ± 20

0.58

	Baseline	Mid-term FU	Long-term FU	P-value
Overall population
QT interval (ms)	343 ± 25	345 ± 24^a	346 ± 25^a	<0.0001
QRS duration (ms)	86 ± 9	91 ± 11^a	92 ± 11^a	<0.0001
HR (b.p.m.)	88 ± 13	87 ± 13^a	86 ± 13^a^,b	<0.0001
QTc Bazett (ms)	412 ± 25 (371–449)	411 ± 25 (367–449)	409 ± 25 (367–446)	0.10
QTc Fridericia (ms)	387 ± 21 (355–418)	387 ± 20 (353–419)	387 ± 20 (353–418)	0.59
Males
QT interval (ms)	345 ± 24	347 ± 25^a	348 ± 25^a	0.013
QTc Bazett (ms)	412 ± 24 (372–449)	410 ± 24 (369–448)	408 ± 23 (367–445)	0.06
QTc Fridericia (ms)	388 ± 20 (357–418)	387 ± 20 (355–419)	386 ± 19 (354–418)	0.86
Females
QT interval (ms)	341 ± 25	341 ± 24^a	342 ± 26^a	0.002
QTc Bazett (ms)	414 ± 26 (371–449)	414 ± 25 (375–450)	413 ± 24 (374–449)	0.89
QTc Fridericia (ms)	387 ± 22 (349–412)	388 ± 20 (356–419)	388 ± 20 (355–419)	0.31
Younger (<12 years)
QT interval (ms)	341 ± 25	343 ± 24^a	344 ± 24^a	0.008
QTc Bazett (ms)	411 ± 24	411 ± 25	410 ± 24	0.81
QTc Fridericia (ms)	386 ± 20	387 ± 20	387 ± 20	0.73
Older (≥12 years)
QT interval (ms)	345 ± 24	348 ± 25^a	348 ± 27^a	0.004
QTc Bazett (ms)	413 ± 25	412 ± 23	409 ± 24^a	0.010
QTc Fridericia (ms)	389 ± 21	389 ± 19	387 ± 20	0.58

Table 2

Open in new tab

Dynamic changes in QT-interval duration found in the study population and in the same population according to gender and age

	Baseline	Mid-term FU	Long-term FU	P-value
Overall population
QT interval (ms)	343 ± 25	345 ± 24^a	346 ± 25^a	<0.0001
QRS duration (ms)	86 ± 9	91 ± 11^a	92 ± 11^a	<0.0001
HR (b.p.m.)	88 ± 13	87 ± 13^a	86 ± 13^a^,b	<0.0001
QTc Bazett (ms)	412 ± 25 (371–449)	411 ± 25 (367–449)	409 ± 25 (367–446)	0.10
QTc Fridericia (ms)	387 ± 21 (355–418)	387 ± 20 (353–419)	387 ± 20 (353–418)	0.59
Males
QT interval (ms)	345 ± 24	347 ± 25^a	348 ± 25^a	0.013
QTc Bazett (ms)	412 ± 24 (372–449)	410 ± 24 (369–448)	408 ± 23 (367–445)	0.06
QTc Fridericia (ms)	388 ± 20 (357–418)	387 ± 20 (355–419)	386 ± 19 (354–418)	0.86
Females
QT interval (ms)	341 ± 25	341 ± 24^a	342 ± 26^a	0.002
QTc Bazett (ms)	414 ± 26 (371–449)	414 ± 25 (375–450)	413 ± 24 (374–449)	0.89
QTc Fridericia (ms)	387 ± 22 (349–412)	388 ± 20 (356–419)	388 ± 20 (355–419)	0.31
Younger (<12 years)
QT interval (ms)	341 ± 25	343 ± 24^a	344 ± 24^a	0.008
QTc Bazett (ms)	411 ± 24	411 ± 25	410 ± 24	0.81
QTc Fridericia (ms)	386 ± 20	387 ± 20	387 ± 20	0.73
Older (≥12 years)
QT interval (ms)	345 ± 24	348 ± 25^a	348 ± 27^a	0.004
QTc Bazett (ms)	413 ± 25	412 ± 23	409 ± 24^a	0.010
QTc Fridericia (ms)	389 ± 21	389 ± 19	387 ± 20	0.58

	Baseline	Mid-term FU	Long-term FU	P-value
Overall population
QT interval (ms)	343 ± 25	345 ± 24^a	346 ± 25^a	<0.0001
QRS duration (ms)	86 ± 9	91 ± 11^a	92 ± 11^a	<0.0001
HR (b.p.m.)	88 ± 13	87 ± 13^a	86 ± 13^a^,b	<0.0001
QTc Bazett (ms)	412 ± 25 (371–449)	411 ± 25 (367–449)	409 ± 25 (367–446)	0.10
QTc Fridericia (ms)	387 ± 21 (355–418)	387 ± 20 (353–419)	387 ± 20 (353–418)	0.59
Males
QT interval (ms)	345 ± 24	347 ± 25^a	348 ± 25^a	0.013
QTc Bazett (ms)	412 ± 24 (372–449)	410 ± 24 (369–448)	408 ± 23 (367–445)	0.06
QTc Fridericia (ms)	388 ± 20 (357–418)	387 ± 20 (355–419)	386 ± 19 (354–418)	0.86
Females
QT interval (ms)	341 ± 25	341 ± 24^a	342 ± 26^a	0.002
QTc Bazett (ms)	414 ± 26 (371–449)	414 ± 25 (375–450)	413 ± 24 (374–449)	0.89
QTc Fridericia (ms)	387 ± 22 (349–412)	388 ± 20 (356–419)	388 ± 20 (355–419)	0.31
Younger (<12 years)
QT interval (ms)	341 ± 25	343 ± 24^a	344 ± 24^a	0.008
QTc Bazett (ms)	411 ± 24	411 ± 25	410 ± 24	0.81
QTc Fridericia (ms)	386 ± 20	387 ± 20	387 ± 20	0.73
Older (≥12 years)
QT interval (ms)	345 ± 24	348 ± 25^a	348 ± 27^a	0.004
QTc Bazett (ms)	413 ± 25	412 ± 23	409 ± 24^a	0.010
QTc Fridericia (ms)	389 ± 21	389 ± 19	387 ± 20	0.58

Data are presented as mean ± SD (5th-95th percentiles). FU, follow-up; HR, heart rate.

P < 0.05 vs. baseline.

P < 0.05 vs. mid-term FU.

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