Table 1.
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Possible effects of the CCR5-Δ32 mutation in human diseases

Type of diseaseEffects attributed to the CCR5-Δ32 mutationReference(s)
Rheumatoid arthritisMilder course of disease in CCR5-Δ32 carriers37, 38
Disseminated sclerosisDelayed disease onset and reduced frequency of disease recurrence in CCR5-Δ32 carriers39, 40
Renal transplantationProlonged graft survival in CCR5-Δ32 homozygous recipients; no effect on frequency of rejection episodes41
Atopic asthmaReported data controversial42, 43
SarcoidosisIncreased disease susceptibility and disease severity in CCR5-Δ32 carriers44
Systemic lupus erythematosusIncreased disease severity in CCR5-Δ32 carriers45
Breast cancerShortened disease-free survival in CCR5-Δ32 carriers with p53 wild-type breast tumours46
Type of diseaseEffects attributed to the CCR5-Δ32 mutationReference(s)
Rheumatoid arthritisMilder course of disease in CCR5-Δ32 carriers37, 38
Disseminated sclerosisDelayed disease onset and reduced frequency of disease recurrence in CCR5-Δ32 carriers39, 40
Renal transplantationProlonged graft survival in CCR5-Δ32 homozygous recipients; no effect on frequency of rejection episodes41
Atopic asthmaReported data controversial42, 43
SarcoidosisIncreased disease susceptibility and disease severity in CCR5-Δ32 carriers44
Systemic lupus erythematosusIncreased disease severity in CCR5-Δ32 carriers45
Breast cancerShortened disease-free survival in CCR5-Δ32 carriers with p53 wild-type breast tumours46
Table 1.
Open in new tab

Possible effects of the CCR5-Δ32 mutation in human diseases

Type of diseaseEffects attributed to the CCR5-Δ32 mutationReference(s)
Rheumatoid arthritisMilder course of disease in CCR5-Δ32 carriers37, 38
Disseminated sclerosisDelayed disease onset and reduced frequency of disease recurrence in CCR5-Δ32 carriers39, 40
Renal transplantationProlonged graft survival in CCR5-Δ32 homozygous recipients; no effect on frequency of rejection episodes41
Atopic asthmaReported data controversial42, 43
SarcoidosisIncreased disease susceptibility and disease severity in CCR5-Δ32 carriers44
Systemic lupus erythematosusIncreased disease severity in CCR5-Δ32 carriers45
Breast cancerShortened disease-free survival in CCR5-Δ32 carriers with p53 wild-type breast tumours46
Type of diseaseEffects attributed to the CCR5-Δ32 mutationReference(s)
Rheumatoid arthritisMilder course of disease in CCR5-Δ32 carriers37, 38
Disseminated sclerosisDelayed disease onset and reduced frequency of disease recurrence in CCR5-Δ32 carriers39, 40
Renal transplantationProlonged graft survival in CCR5-Δ32 homozygous recipients; no effect on frequency of rejection episodes41
Atopic asthmaReported data controversial42, 43
SarcoidosisIncreased disease susceptibility and disease severity in CCR5-Δ32 carriers44
Systemic lupus erythematosusIncreased disease severity in CCR5-Δ32 carriers45
Breast cancerShortened disease-free survival in CCR5-Δ32 carriers with p53 wild-type breast tumours46
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