Murine Strain, Sex-Dependent, and, Age-Dependent Endocannabinoid Receptor Knockout Effects on Bone
| Strain . | Sex . | Age . | Genotype . | Phenotype . |
|---|---|---|---|---|
| CD1 | 3 months | Cnr1−/− | Increased trabecular bone | |
| Decreased bone loss after ovariectomy | ||||
| ABH | 12 months | Cnr1−/− | Decreased trabecular bone | |
| Cnr2−/− | Variable | |||
| CD1 | Male | 3 months | Cnr1−/− | Increased bone mass |
| CD1 | Male | 12 months | Cnr1−/− | Increased bone mass |
| C57BL/6 | Female | 12 months | Cnr1−/− | Decreased peak bone mass |
| Female | 12 months | Increased trabecular bone | ||
| Increased cortical bone | ||||
| Increased bone resorption | ||||
| Decreased sympathetic innervation of bone | ||||
| C57BL/6 | Male and Female | 8‒11, 51 months | Cnr2−/− | Decreased bone mass |
| Age-related trabecular bone loss | ||||
| Cortical expansion | ||||
| C57BL/6 | Male and Female | Birth | Cnr1−/−Cnr2−/− | Increased bone accrual |
| CD1 | ||||
| CD1 | Male and Female | 3 months | Cnr1−/−Cnr2−/− | Increased trabecular bone loss |
| CD1 | Female | 9 months | Cnr1−/−Cnr2−/− | Decreased bone loss after ovariectomy |
| CD1 | Male and Female | 12 months | Cnr1−/−Cnr2−/− | Increased bone strength |
| Strain . | Sex . | Age . | Genotype . | Phenotype . |
|---|---|---|---|---|
| CD1 | 3 months | Cnr1−/− | Increased trabecular bone | |
| Decreased bone loss after ovariectomy | ||||
| ABH | 12 months | Cnr1−/− | Decreased trabecular bone | |
| Cnr2−/− | Variable | |||
| CD1 | Male | 3 months | Cnr1−/− | Increased bone mass |
| CD1 | Male | 12 months | Cnr1−/− | Increased bone mass |
| C57BL/6 | Female | 12 months | Cnr1−/− | Decreased peak bone mass |
| Female | 12 months | Increased trabecular bone | ||
| Increased cortical bone | ||||
| Increased bone resorption | ||||
| Decreased sympathetic innervation of bone | ||||
| C57BL/6 | Male and Female | 8‒11, 51 months | Cnr2−/− | Decreased bone mass |
| Age-related trabecular bone loss | ||||
| Cortical expansion | ||||
| C57BL/6 | Male and Female | Birth | Cnr1−/−Cnr2−/− | Increased bone accrual |
| CD1 | ||||
| CD1 | Male and Female | 3 months | Cnr1−/−Cnr2−/− | Increased trabecular bone loss |
| CD1 | Female | 9 months | Cnr1−/−Cnr2−/− | Decreased bone loss after ovariectomy |
| CD1 | Male and Female | 12 months | Cnr1−/−Cnr2−/− | Increased bone strength |
Murine Strain, Sex-Dependent, and, Age-Dependent Endocannabinoid Receptor Knockout Effects on Bone
| Strain . | Sex . | Age . | Genotype . | Phenotype . |
|---|---|---|---|---|
| CD1 | 3 months | Cnr1−/− | Increased trabecular bone | |
| Decreased bone loss after ovariectomy | ||||
| ABH | 12 months | Cnr1−/− | Decreased trabecular bone | |
| Cnr2−/− | Variable | |||
| CD1 | Male | 3 months | Cnr1−/− | Increased bone mass |
| CD1 | Male | 12 months | Cnr1−/− | Increased bone mass |
| C57BL/6 | Female | 12 months | Cnr1−/− | Decreased peak bone mass |
| Female | 12 months | Increased trabecular bone | ||
| Increased cortical bone | ||||
| Increased bone resorption | ||||
| Decreased sympathetic innervation of bone | ||||
| C57BL/6 | Male and Female | 8‒11, 51 months | Cnr2−/− | Decreased bone mass |
| Age-related trabecular bone loss | ||||
| Cortical expansion | ||||
| C57BL/6 | Male and Female | Birth | Cnr1−/−Cnr2−/− | Increased bone accrual |
| CD1 | ||||
| CD1 | Male and Female | 3 months | Cnr1−/−Cnr2−/− | Increased trabecular bone loss |
| CD1 | Female | 9 months | Cnr1−/−Cnr2−/− | Decreased bone loss after ovariectomy |
| CD1 | Male and Female | 12 months | Cnr1−/−Cnr2−/− | Increased bone strength |
| Strain . | Sex . | Age . | Genotype . | Phenotype . |
|---|---|---|---|---|
| CD1 | 3 months | Cnr1−/− | Increased trabecular bone | |
| Decreased bone loss after ovariectomy | ||||
| ABH | 12 months | Cnr1−/− | Decreased trabecular bone | |
| Cnr2−/− | Variable | |||
| CD1 | Male | 3 months | Cnr1−/− | Increased bone mass |
| CD1 | Male | 12 months | Cnr1−/− | Increased bone mass |
| C57BL/6 | Female | 12 months | Cnr1−/− | Decreased peak bone mass |
| Female | 12 months | Increased trabecular bone | ||
| Increased cortical bone | ||||
| Increased bone resorption | ||||
| Decreased sympathetic innervation of bone | ||||
| C57BL/6 | Male and Female | 8‒11, 51 months | Cnr2−/− | Decreased bone mass |
| Age-related trabecular bone loss | ||||
| Cortical expansion | ||||
| C57BL/6 | Male and Female | Birth | Cnr1−/−Cnr2−/− | Increased bone accrual |
| CD1 | ||||
| CD1 | Male and Female | 3 months | Cnr1−/−Cnr2−/− | Increased trabecular bone loss |
| CD1 | Female | 9 months | Cnr1−/−Cnr2−/− | Decreased bone loss after ovariectomy |
| CD1 | Male and Female | 12 months | Cnr1−/−Cnr2−/− | Increased bone strength |
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