Table 1. Open in new tab Linear...

Macrophage-Mediated Efflux	% Cholesterol Efflux
Lp(a) level	−0.079 (0.028); P = 0.008	−0.022 (0.013); P = 0.106	−0.049 (0.014); P = 0.002	−0.027 (0.008); P = 0.004
PLG level	−1.423 (0.418); P = 0.002	−0.729 (0.298); P = 0.019	−0.179 (0.192); P = 0.362	0.066 (0.151); P = 0.667
HDL-C level	0.095 (0.058); P = 0.110	0.071 (0.060); P = 0.244	0.031 (0.043); P = 0.474	0.039 (0.045); P = 0.396
LDL-C level	0.055 (0.019); P = 0.007	0.037 (0.018); P = 0.049	0.042 (0.009); P = 0.0002	0.035 (0.009); P = 0.001
Male sex	3.004 (2.044); P = 0.150	3.109 (2.140); P = 0.154	−1.709 (0.930); P = 0.072	−1. 582 (0.973); P = 0.119
Age	0.012 (0.070); P = 0.869	−0.041 (0.069); P = 0.552	0.090 (0.031); P = 0.008	0.077 (0.032); P = 0.022
Takes lipid-lowering medication	−4.737 (2.074); P = 0.028	−5.417 (2.149); P = 0.016	0.760 (0.979); P = 0.446	0.359 (1.009); P = 0.725
Lp(a) and PLG interaction	0.008 (0.003); P = 0.029	N/A	0.004 (0.002); P = 0.068	N/A
Constant	14.254 (8.146); P = 0.088	17.646 (8.383); P = 0.042	6.304 (5.573); P = 0.130	6.594 (4.221); P = 0.132
Observations^a	51	51	6.304 (5.573); P = 0.130	6.594 (4.221); P = 0.132
r²	0.55	0.495	0.728	0.685
Adjusted r²	0.465	0.413	0.634	0.593
F statistic	6.427^b (df = 8; 42) (P = 0.00002)	6.032^b (df = 7; 43) (P = 0.0001)	7.700^b (df = 8; 23) (P = 0.0001)	4.015^b (df = 7; 24) (P = 0.0001)

Macrophage-Mediated Efflux

% Cholesterol Efflux

J774

BHK Cells

With Lp(a) and PLG Interaction

Without Lp(a) and PLG Interaction

With Lp(a) and PLG Interaction

Without Lp(a) and PLG Interaction

Lp(a) level

−0.079 (0.028); P = 0.008

−0.022 (0.013); P = 0.106

−0.049 (0.014); P = 0.002

−0.027 (0.008); P = 0.004

PLG level

−1.423 (0.418); P = 0.002

−0.729 (0.298); P = 0.019

−0.179 (0.192); P = 0.362

0.066 (0.151); P = 0.667

HDL-C level

0.095 (0.058); P = 0.110

0.071 (0.060); P = 0.244

0.031 (0.043); P = 0.474

0.039 (0.045); P = 0.396

LDL-C level

0.055 (0.019); P = 0.007

0.037 (0.018); P = 0.049

0.042 (0.009); P = 0.0002

0.035 (0.009); P = 0.001

Male sex

3.004 (2.044); P = 0.150

3.109 (2.140); P = 0.154

−1.709 (0.930); P = 0.072

−1. 582 (0.973); P = 0.119

Age

0.012 (0.070); P = 0.869

−0.041 (0.069); P = 0.552

0.090 (0.031); P = 0.008

0.077 (0.032); P = 0.022

Takes lipid-lowering medication

−4.737 (2.074); P = 0.028

−5.417 (2.149); P = 0.016

0.760 (0.979); P = 0.446

0.359 (1.009); P = 0.725

Lp(a) and PLG interaction

0.008 (0.003); P = 0.029

N/A

0.004 (0.002); P = 0.068

N/A

Constant

14.254 (8.146); P = 0.088

17.646 (8.383); P = 0.042

6.304 (5.573); P = 0.130

6.594 (4.221); P = 0.132

Observations^a

6.304 (5.573); P = 0.130

6.594 (4.221); P = 0.132

r²

0.55

0.495

0.728

0.685

Adjusted r²

0.465

0.413

0.634

0.593

F statistic

6.427^b (df = 8; 42) (P = 0.00002)

6.032^b (df = 7; 43) (P = 0.0001)

7.700^b (df = 8; 23) (P = 0.0001)

4.015^b (df = 7; 24) (P = 0.0001)

Macrophage-Mediated Efflux	% Cholesterol Efflux
Lp(a) level	−0.079 (0.028); P = 0.008	−0.022 (0.013); P = 0.106	−0.049 (0.014); P = 0.002	−0.027 (0.008); P = 0.004
PLG level	−1.423 (0.418); P = 0.002	−0.729 (0.298); P = 0.019	−0.179 (0.192); P = 0.362	0.066 (0.151); P = 0.667
HDL-C level	0.095 (0.058); P = 0.110	0.071 (0.060); P = 0.244	0.031 (0.043); P = 0.474	0.039 (0.045); P = 0.396
LDL-C level	0.055 (0.019); P = 0.007	0.037 (0.018); P = 0.049	0.042 (0.009); P = 0.0002	0.035 (0.009); P = 0.001
Male sex	3.004 (2.044); P = 0.150	3.109 (2.140); P = 0.154	−1.709 (0.930); P = 0.072	−1. 582 (0.973); P = 0.119
Age	0.012 (0.070); P = 0.869	−0.041 (0.069); P = 0.552	0.090 (0.031); P = 0.008	0.077 (0.032); P = 0.022
Takes lipid-lowering medication	−4.737 (2.074); P = 0.028	−5.417 (2.149); P = 0.016	0.760 (0.979); P = 0.446	0.359 (1.009); P = 0.725
Lp(a) and PLG interaction	0.008 (0.003); P = 0.029	N/A	0.004 (0.002); P = 0.068	N/A
Constant	14.254 (8.146); P = 0.088	17.646 (8.383); P = 0.042	6.304 (5.573); P = 0.130	6.594 (4.221); P = 0.132
Observations^a	51	51	6.304 (5.573); P = 0.130	6.594 (4.221); P = 0.132
r²	0.55	0.495	0.728	0.685
Adjusted r²	0.465	0.413	0.634	0.593
F statistic	6.427^b (df = 8; 42) (P = 0.00002)	6.032^b (df = 7; 43) (P = 0.0001)	7.700^b (df = 8; 23) (P = 0.0001)	4.015^b (df = 7; 24) (P = 0.0001)

Table 1.

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Linear Regression Models for Macrophage and BHK Cell–Mediated Efflux

Macrophage-Mediated Efflux	% Cholesterol Efflux
	J774		BHK Cells
	With Lp(a) and PLG Interaction	Without Lp(a) and PLG Interaction	With Lp(a) and PLG Interaction	Without Lp(a) and PLG Interaction
Lp(a) level	−0.079 (0.028); P = 0.008	−0.022 (0.013); P = 0.106	−0.049 (0.014); P = 0.002	−0.027 (0.008); P = 0.004
PLG level	−1.423 (0.418); P = 0.002	−0.729 (0.298); P = 0.019	−0.179 (0.192); P = 0.362	0.066 (0.151); P = 0.667
HDL-C level	0.095 (0.058); P = 0.110	0.071 (0.060); P = 0.244	0.031 (0.043); P = 0.474	0.039 (0.045); P = 0.396
LDL-C level	0.055 (0.019); P = 0.007	0.037 (0.018); P = 0.049	0.042 (0.009); P = 0.0002	0.035 (0.009); P = 0.001
Male sex	3.004 (2.044); P = 0.150	3.109 (2.140); P = 0.154	−1.709 (0.930); P = 0.072	−1. 582 (0.973); P = 0.119
Age	0.012 (0.070); P = 0.869	−0.041 (0.069); P = 0.552	0.090 (0.031); P = 0.008	0.077 (0.032); P = 0.022
Takes lipid-lowering medication	−4.737 (2.074); P = 0.028	−5.417 (2.149); P = 0.016	0.760 (0.979); P = 0.446	0.359 (1.009); P = 0.725
Lp(a) and PLG interaction	0.008 (0.003); P = 0.029	N/A	0.004 (0.002); P = 0.068	N/A
Constant	14.254 (8.146); P = 0.088	17.646 (8.383); P = 0.042	6.304 (5.573); P = 0.130	6.594 (4.221); P = 0.132
Observations^a	51	51	6.304 (5.573); P = 0.130	6.594 (4.221); P = 0.132
r²	0.55	0.495	0.728	0.685
Adjusted r²	0.465	0.413	0.634	0.593
F statistic	6.427^b (df = 8; 42) (P = 0.00002)	6.032^b (df = 7; 43) (P = 0.0001)	7.700^b (df = 8; 23) (P = 0.0001)	4.015^b (df = 7; 24) (P = 0.0001)

Macrophage-Mediated Efflux	% Cholesterol Efflux
	J774		BHK Cells
	With Lp(a) and PLG Interaction	Without Lp(a) and PLG Interaction	With Lp(a) and PLG Interaction	Without Lp(a) and PLG Interaction
Lp(a) level	−0.079 (0.028); P = 0.008	−0.022 (0.013); P = 0.106	−0.049 (0.014); P = 0.002	−0.027 (0.008); P = 0.004
PLG level	−1.423 (0.418); P = 0.002	−0.729 (0.298); P = 0.019	−0.179 (0.192); P = 0.362	0.066 (0.151); P = 0.667
HDL-C level	0.095 (0.058); P = 0.110	0.071 (0.060); P = 0.244	0.031 (0.043); P = 0.474	0.039 (0.045); P = 0.396
LDL-C level	0.055 (0.019); P = 0.007	0.037 (0.018); P = 0.049	0.042 (0.009); P = 0.0002	0.035 (0.009); P = 0.001
Male sex	3.004 (2.044); P = 0.150	3.109 (2.140); P = 0.154	−1.709 (0.930); P = 0.072	−1. 582 (0.973); P = 0.119
Age	0.012 (0.070); P = 0.869	−0.041 (0.069); P = 0.552	0.090 (0.031); P = 0.008	0.077 (0.032); P = 0.022
Takes lipid-lowering medication	−4.737 (2.074); P = 0.028	−5.417 (2.149); P = 0.016	0.760 (0.979); P = 0.446	0.359 (1.009); P = 0.725
Lp(a) and PLG interaction	0.008 (0.003); P = 0.029	N/A	0.004 (0.002); P = 0.068	N/A
Constant	14.254 (8.146); P = 0.088	17.646 (8.383); P = 0.042	6.304 (5.573); P = 0.130	6.594 (4.221); P = 0.132
Observations^a	51	51	6.304 (5.573); P = 0.130	6.594 (4.221); P = 0.132
r²	0.55	0.495	0.728	0.685
Adjusted r²	0.465	0.413	0.634	0.593
F statistic	6.427^b (df = 8; 42) (P = 0.00002)	6.032^b (df = 7; 43) (P = 0.0001)	7.700^b (df = 8; 23) (P = 0.0001)	4.015^b (df = 7; 24) (P = 0.0001)

Data are reported as β coefficient (SE), unless otherwise indicated.

Abbreviations: df, degrees of freedom; N/A, not applicable.

Observations are considered as the number of patients with all parameters mentioned in the table (i.e., 51 of 59 patients for J774 efflux and 32 of 39 patients for BHK efflux).

P < 0.0001.

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