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Table 2.

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N-Glycosylation and Glycan Modifications of Circulating TSH Molecules in Euthyroid Children and Adults

Variable	Age Group A 28 Children: 22 F, 6 M Age 0.5–18 mo Mean; CV%	Age Group B 5 Children: 4 F, 1 M Age 2–3 y Mean; CV%	Age Group C 264 Adults: 153 F, 111 M Age 21–87 y Mean; CV%	P Value for A vs B^a	P Value for A vs C^a	P Value for B vs C^a
N-glycosylation
TSHdi, mIU/L	2.61; 54.3	2.25; 47.0	1.09;41.2	NS	^b	^b
TSHtri, mIU/L	0.92; 63.0	1.36; 46.0	1.05; 40.6	NS	NS	NS
Percentage TSHtri	26.1; 10.8	37.7; 4.70	49.2; 8.76	^c	^b	^b
Glycan modifications
SU per TSHdi molecule	2.94; 4.80	2.56; 9.87	2.67; 5.28	^c	^b	NS
SA per TSHdi molecule	0.76; 16.3	1.08; 18.7	1.13; 12.1	^c	^b	NS
SU per TSHtri molecule	3.20; 4.02	2.91; 8.53	2.91; 4.34	^c	^b	NS
SA per TSHtri molecule	1.92; 8.08	2.35; 10.8	2.37; 7.36	^b	^b	NS
Ratio SU/SA on TSHdi	4.01; 22.2	2.47; 27.7	2.40; 17.4	^c	^b	NS
Ratio SU/SA on TSHtri	1.68; 10.2	1.25; 18.4	1.24; 11.4	^c	^b	NS
AMS per glycan on TSHdi	1.85; 2.38	1.82; 1.97	1.90; 1.51	NS	^b	^d
AMS per glycan on TSHtri	1.71; 2.53	1.75; 1.67	1.76; 1.69	^d	^b	NS

Variable	Age Group A 28 Children: 22 F, 6 M Age 0.5–18 mo Mean; CV%	Age Group B 5 Children: 4 F, 1 M Age 2–3 y Mean; CV%	Age Group C 264 Adults: 153 F, 111 M Age 21–87 y Mean; CV%	P Value for A vs B^a	P Value for A vs C^a	P Value for B vs C^a
N-glycosylation
TSHdi, mIU/L	2.61; 54.3	2.25; 47.0	1.09;41.2	NS	^b	^b
TSHtri, mIU/L	0.92; 63.0	1.36; 46.0	1.05; 40.6	NS	NS	NS
Percentage TSHtri	26.1; 10.8	37.7; 4.70	49.2; 8.76	^c	^b	^b
Glycan modifications
SU per TSHdi molecule	2.94; 4.80	2.56; 9.87	2.67; 5.28	^c	^b	NS
SA per TSHdi molecule	0.76; 16.3	1.08; 18.7	1.13; 12.1	^c	^b	NS
SU per TSHtri molecule	3.20; 4.02	2.91; 8.53	2.91; 4.34	^c	^b	NS
SA per TSHtri molecule	1.92; 8.08	2.35; 10.8	2.37; 7.36	^b	^b	NS
Ratio SU/SA on TSHdi	4.01; 22.2	2.47; 27.7	2.40; 17.4	^c	^b	NS
Ratio SU/SA on TSHtri	1.68; 10.2	1.25; 18.4	1.24; 11.4	^c	^b	NS
AMS per glycan on TSHdi	1.85; 2.38	1.82; 1.97	1.90; 1.51	NS	^b	^d
AMS per glycan on TSHtri	1.71; 2.53	1.75; 1.67	1.76; 1.69	^d	^b	NS

Abbreviations: F, female; M, male; NS, not significant (P > 0.05).

^a

Nonparametric Mann-Whitney tests.

^b

P < 0.001.

^c

P < 0.01.

^d

P < 0.05.

Table 2.

Open in new tab

N-Glycosylation and Glycan Modifications of Circulating TSH Molecules in Euthyroid Children and Adults

Variable	Age Group A 28 Children: 22 F, 6 M Age 0.5–18 mo Mean; CV%	Age Group B 5 Children: 4 F, 1 M Age 2–3 y Mean; CV%	Age Group C 264 Adults: 153 F, 111 M Age 21–87 y Mean; CV%	P Value for A vs B^a	P Value for A vs C^a	P Value for B vs C^a
N-glycosylation
TSHdi, mIU/L	2.61; 54.3	2.25; 47.0	1.09;41.2	NS	^b	^b
TSHtri, mIU/L	0.92; 63.0	1.36; 46.0	1.05; 40.6	NS	NS	NS
Percentage TSHtri	26.1; 10.8	37.7; 4.70	49.2; 8.76	^c	^b	^b
Glycan modifications
SU per TSHdi molecule	2.94; 4.80	2.56; 9.87	2.67; 5.28	^c	^b	NS
SA per TSHdi molecule	0.76; 16.3	1.08; 18.7	1.13; 12.1	^c	^b	NS
SU per TSHtri molecule	3.20; 4.02	2.91; 8.53	2.91; 4.34	^c	^b	NS
SA per TSHtri molecule	1.92; 8.08	2.35; 10.8	2.37; 7.36	^b	^b	NS
Ratio SU/SA on TSHdi	4.01; 22.2	2.47; 27.7	2.40; 17.4	^c	^b	NS
Ratio SU/SA on TSHtri	1.68; 10.2	1.25; 18.4	1.24; 11.4	^c	^b	NS
AMS per glycan on TSHdi	1.85; 2.38	1.82; 1.97	1.90; 1.51	NS	^b	^d
AMS per glycan on TSHtri	1.71; 2.53	1.75; 1.67	1.76; 1.69	^d	^b	NS

Variable	Age Group A 28 Children: 22 F, 6 M Age 0.5–18 mo Mean; CV%	Age Group B 5 Children: 4 F, 1 M Age 2–3 y Mean; CV%	Age Group C 264 Adults: 153 F, 111 M Age 21–87 y Mean; CV%	P Value for A vs B^a	P Value for A vs C^a	P Value for B vs C^a
N-glycosylation
TSHdi, mIU/L	2.61; 54.3	2.25; 47.0	1.09;41.2	NS	^b	^b
TSHtri, mIU/L	0.92; 63.0	1.36; 46.0	1.05; 40.6	NS	NS	NS
Percentage TSHtri	26.1; 10.8	37.7; 4.70	49.2; 8.76	^c	^b	^b
Glycan modifications
SU per TSHdi molecule	2.94; 4.80	2.56; 9.87	2.67; 5.28	^c	^b	NS
SA per TSHdi molecule	0.76; 16.3	1.08; 18.7	1.13; 12.1	^c	^b	NS
SU per TSHtri molecule	3.20; 4.02	2.91; 8.53	2.91; 4.34	^c	^b	NS
SA per TSHtri molecule	1.92; 8.08	2.35; 10.8	2.37; 7.36	^b	^b	NS
Ratio SU/SA on TSHdi	4.01; 22.2	2.47; 27.7	2.40; 17.4	^c	^b	NS
Ratio SU/SA on TSHtri	1.68; 10.2	1.25; 18.4	1.24; 11.4	^c	^b	NS
AMS per glycan on TSHdi	1.85; 2.38	1.82; 1.97	1.90; 1.51	NS	^b	^d
AMS per glycan on TSHtri	1.71; 2.53	1.75; 1.67	1.76; 1.69	^d	^b	NS

Abbreviations: F, female; M, male; NS, not significant (P > 0.05).

^a

Nonparametric Mann-Whitney tests.

^b

P < 0.001.

^c

P < 0.01.

^d

P < 0.05.