Table 2. Open in new tab Time-Dependent...

Variables	Crude HR	Adjusted HR^a
ATD drug use, cDDD
<28	1.00	Reference		1.00	Reference
28–83	0.92	0.84	1.01	0.0818	0.91	0.83	1.00	0.0478
≥84	0.60	0.55	0.66	<0.0001	0.65	0.59	0.71	<0.0001
Sex
Female	1.00	Reference		1.00	Reference
Male	1.78	1.70	1.87	<0.0001	1.71	1.63	1.80	<0.0001
Age, y
18–44	1.00	Reference		1.00	Reference
45–64	1.82	1.66	2.00	<0.0001	1.58	1.44	1.74	<0.0001
≥65	5.34	4.88	5.84	<0.0001	3.44	3.13	3.78	<0.0001
Urbanization level
1 (City)	0.69	0.63	0.76	<0.0001	0.75	0.69	0.83	<0.0001
2	0.78	0.72	0.85	<0.0001	0.83	0.76	0.91	<0.0001
3	0.91	0.83	1.00	0.0536	0.90	0.82	0.99	0.0282
4 (Villages)	1.00	Reference		1.00	Reference
Income
0	1.00	Reference		1.00	Reference
1–15,840	1.09	1.02	1.17	0.0177	1.00	0.93	1.07	0.9265
15,841–25,000	0.77	0.73	0.82	<0.0001	0.87	0.81	0.93	<0.0001
>25,000	0.55	0.51	0.60	<0.0001	0.67	0.61	0.73	<0.0001
Comorbidities
Heart failure	2.52	2.40	2.65	<0.0001	1.45	1.37	1.52	<0.0001
ESRD	3.26	3.02	3.51	<0.0001	2.73	2.53	2.96	<0.0001
COPD	1.75	1.67	1.84	<0.0001	1.07	1.02	1.12	0.0105
Malignancy	3.93	3.75	4.12	<0.0001	3.16	3.01	3.32	<0.0001
Adapted DCSI	1.37	1.34	1.39	<0.0001	1.18	1.15	1.20	<0.0001

Variables

Crude HR

Adjusted HR^a

95% CI

P Value

95% CI

P Value

ATD drug use, cDDD

<28

1.00

Reference

1.00

Reference

28–83

0.92

0.84

1.01

0.0818

0.91

0.83

1.00

0.0478

≥84

0.60

0.55

0.66

<0.0001

0.65

0.59

0.71

<0.0001

Sex

Female

1.00

Reference

1.00

Reference

Male

1.78

1.70

1.87

<0.0001

1.71

1.63

1.80

<0.0001

Age, y

18–44

1.00

Reference

1.00

Reference

45–64

1.82

1.66

2.00

<0.0001

1.58

1.44

1.74

<0.0001

≥65

5.34

4.88

5.84

<0.0001

3.44

3.13

3.78

<0.0001

Urbanization level

1 (City)

0.69

0.63

0.76

<0.0001

0.75

0.69

0.83

<0.0001

0.78

0.72

0.85

<0.0001

0.83

0.76

0.91

<0.0001

0.91

0.83

1.00

0.0536

0.90

0.82

0.99

0.0282

4 (Villages)

1.00

Reference

1.00

Reference

Income

1.00

Reference

1.00

Reference

1–15,840

1.09

1.02

1.17

0.0177

1.00

0.93

1.07

0.9265

15,841–25,000

0.77

0.73

0.82

<0.0001

0.87

0.81

0.93

<0.0001

>25,000

0.55

0.51

0.60

<0.0001

0.67

0.61

0.73

<0.0001

Comorbidities

Heart failure

2.52

2.40

2.65

<0.0001

1.45

1.37

1.52

<0.0001

ESRD

3.26

3.02

3.51

<0.0001

2.73

2.53

2.96

<0.0001

COPD

1.75

1.67

1.84

<0.0001

1.07

1.02

1.12

0.0105

Malignancy

3.93

3.75

4.12

<0.0001

3.16

3.01

3.32

<0.0001

Adapted DCSI

1.37

1.34

1.39

<0.0001

1.18

1.15

1.20

<0.0001

Variables	Crude HR	Adjusted HR^a
ATD drug use, cDDD
<28	1.00	Reference		1.00	Reference
28–83	0.92	0.84	1.01	0.0818	0.91	0.83	1.00	0.0478
≥84	0.60	0.55	0.66	<0.0001	0.65	0.59	0.71	<0.0001
Sex
Female	1.00	Reference		1.00	Reference
Male	1.78	1.70	1.87	<0.0001	1.71	1.63	1.80	<0.0001
Age, y
18–44	1.00	Reference		1.00	Reference
45–64	1.82	1.66	2.00	<0.0001	1.58	1.44	1.74	<0.0001
≥65	5.34	4.88	5.84	<0.0001	3.44	3.13	3.78	<0.0001
Urbanization level
1 (City)	0.69	0.63	0.76	<0.0001	0.75	0.69	0.83	<0.0001
2	0.78	0.72	0.85	<0.0001	0.83	0.76	0.91	<0.0001
3	0.91	0.83	1.00	0.0536	0.90	0.82	0.99	0.0282
4 (Villages)	1.00	Reference		1.00	Reference
Income
0	1.00	Reference		1.00	Reference
1–15,840	1.09	1.02	1.17	0.0177	1.00	0.93	1.07	0.9265
15,841–25,000	0.77	0.73	0.82	<0.0001	0.87	0.81	0.93	<0.0001
>25,000	0.55	0.51	0.60	<0.0001	0.67	0.61	0.73	<0.0001
Comorbidities
Heart failure	2.52	2.40	2.65	<0.0001	1.45	1.37	1.52	<0.0001
ESRD	3.26	3.02	3.51	<0.0001	2.73	2.53	2.96	<0.0001
COPD	1.75	1.67	1.84	<0.0001	1.07	1.02	1.12	0.0105
Malignancy	3.93	3.75	4.12	<0.0001	3.16	3.01	3.32	<0.0001
Adapted DCSI	1.37	1.34	1.39	<0.0001	1.18	1.15	1.20	<0.0001

Table 2.

Open in new tab

Time-Dependent Cox Regression Analysis of Mortality in Patients With DM and Depressive Disorder

Variables	Crude HR				Adjusted HR^a
Variables	HR	95% CI		P Value	HR	95% CI		P Value
ATD drug use, cDDD
<28	1.00	Reference			1.00	Reference
28–83	0.92	0.84	1.01	0.0818	0.91	0.83	1.00	0.0478
≥84	0.60	0.55	0.66	<0.0001	0.65	0.59	0.71	<0.0001
Sex
Female	1.00	Reference			1.00	Reference
Male	1.78	1.70	1.87	<0.0001	1.71	1.63	1.80	<0.0001
Age, y
18–44	1.00	Reference			1.00	Reference
45–64	1.82	1.66	2.00	<0.0001	1.58	1.44	1.74	<0.0001
≥65	5.34	4.88	5.84	<0.0001	3.44	3.13	3.78	<0.0001
Urbanization level
1 (City)	0.69	0.63	0.76	<0.0001	0.75	0.69	0.83	<0.0001
2	0.78	0.72	0.85	<0.0001	0.83	0.76	0.91	<0.0001
3	0.91	0.83	1.00	0.0536	0.90	0.82	0.99	0.0282
4 (Villages)	1.00	Reference			1.00	Reference
Income
0	1.00	Reference			1.00	Reference
1–15,840	1.09	1.02	1.17	0.0177	1.00	0.93	1.07	0.9265
15,841–25,000	0.77	0.73	0.82	<0.0001	0.87	0.81	0.93	<0.0001
>25,000	0.55	0.51	0.60	<0.0001	0.67	0.61	0.73	<0.0001
Comorbidities
Heart failure	2.52	2.40	2.65	<0.0001	1.45	1.37	1.52	<0.0001
ESRD	3.26	3.02	3.51	<0.0001	2.73	2.53	2.96	<0.0001
COPD	1.75	1.67	1.84	<0.0001	1.07	1.02	1.12	0.0105
Malignancy	3.93	3.75	4.12	<0.0001	3.16	3.01	3.32	<0.0001
Adapted DCSI	1.37	1.34	1.39	<0.0001	1.18	1.15	1.20	<0.0001

Variables	Crude HR				Adjusted HR^a
Variables	HR	95% CI		P Value	HR	95% CI		P Value
ATD drug use, cDDD
<28	1.00	Reference			1.00	Reference
28–83	0.92	0.84	1.01	0.0818	0.91	0.83	1.00	0.0478
≥84	0.60	0.55	0.66	<0.0001	0.65	0.59	0.71	<0.0001
Sex
Female	1.00	Reference			1.00	Reference
Male	1.78	1.70	1.87	<0.0001	1.71	1.63	1.80	<0.0001
Age, y
18–44	1.00	Reference			1.00	Reference
45–64	1.82	1.66	2.00	<0.0001	1.58	1.44	1.74	<0.0001
≥65	5.34	4.88	5.84	<0.0001	3.44	3.13	3.78	<0.0001
Urbanization level
1 (City)	0.69	0.63	0.76	<0.0001	0.75	0.69	0.83	<0.0001
2	0.78	0.72	0.85	<0.0001	0.83	0.76	0.91	<0.0001
3	0.91	0.83	1.00	0.0536	0.90	0.82	0.99	0.0282
4 (Villages)	1.00	Reference			1.00	Reference
Income
0	1.00	Reference			1.00	Reference
1–15,840	1.09	1.02	1.17	0.0177	1.00	0.93	1.07	0.9265
15,841–25,000	0.77	0.73	0.82	<0.0001	0.87	0.81	0.93	<0.0001
>25,000	0.55	0.51	0.60	<0.0001	0.67	0.61	0.73	<0.0001
Comorbidities
Heart failure	2.52	2.40	2.65	<0.0001	1.45	1.37	1.52	<0.0001
ESRD	3.26	3.02	3.51	<0.0001	2.73	2.53	2.96	<0.0001
COPD	1.75	1.67	1.84	<0.0001	1.07	1.02	1.12	0.0105
Malignancy	3.93	3.75	4.12	<0.0001	3.16	3.01	3.32	<0.0001
Adapted DCSI	1.37	1.34	1.39	<0.0001	1.18	1.15	1.20	<0.0001

Abbreviation: DCSI, Diabetes Complications Severity Index.

Adjusted for sex, age, urbanization, income, comorbidities, and adapted DCSI.

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