Percentage Insulitis, Percentage β and α Cell Area, Percentage Pseudoatrophic Islets, and CD+ Cell Number in and Around the Islets in Case 1, Case 2, and Case 3
| . | Case 1 (n)a . | Case 2 (n)a . | Case 3 (n)a . | Mean ± SD . |
|---|---|---|---|---|
| Frequency of insulitis, % | 51.7 (29) | 66.7 (15) | 70.0 (20) | 62.8 ± 9.7 |
| β Cell area, % | 0.01 ± 0.009 (8) | 0.5 ± 0.6 (15) | 0 (3) | 0.2 ± 0.3 |
| α Cell area, % | 0.7 ± 0.1 (8) | 0.3 ± 0.4 (15) | 0.05 ± 0.02 (3) | 0.3 ± 0.3 |
| Frequency of pseudoatrophic islets, % | 95.7 (46) | 10 (30) | 100 (22) | 68.6 ± 50.8 |
| VP1+ islet, % | 100 (12) | 100 (10) | 77.0 (13) | 92.3 ± 13.3 |
| CD45+ cell number per islet | 24.4 ± 14.1 (11) | 78.6 ± 45.6 (11) | 46.4 ± 12.4 (12) | 49.8 ± 27.3 |
| CD3+ cell number per islet | 26.3 ± 15.8 (15) | 32.4 ± 16.8 (15) | 21.9 ± 12.4 (15) | 26.9 ± 5.3 |
| CD8+ cell number per islet | 17.2 ± 22.6 (19) | 24.0 ± 20.6 (28) | 30.4 ± 37.0 (11) | 23.9 ± 6.6 |
| CD4+ cell number per islet | 0.7 ± 1.0 (10) | 0.5 ± 0.7 (10) | 0.8 ± 1.2 (12) | 0.7 ± 0.2 |
| CD20+ cell number per islet | 1.4 ± 1.5 (12) | 3.3 ± 5.2 (12) | 3.1 ± 2.6 (13) | 2.6 ± 1.0 |
| CD68+ cell number per islet | 14.4 ± 11.8 (10) | 59.3 ± 22.3 (10) | 55.1 ± 24.6 (10) | 42.9 ± 24.8 |
| CD11c+ cell number per islet | 40.9 ± 28.5 (10) | 53.8 ± 35.3 (11) | 3.8 ± 3.9 (12) | 32.6 ± 26.0 |
| . | Case 1 (n)a . | Case 2 (n)a . | Case 3 (n)a . | Mean ± SD . |
|---|---|---|---|---|
| Frequency of insulitis, % | 51.7 (29) | 66.7 (15) | 70.0 (20) | 62.8 ± 9.7 |
| β Cell area, % | 0.01 ± 0.009 (8) | 0.5 ± 0.6 (15) | 0 (3) | 0.2 ± 0.3 |
| α Cell area, % | 0.7 ± 0.1 (8) | 0.3 ± 0.4 (15) | 0.05 ± 0.02 (3) | 0.3 ± 0.3 |
| Frequency of pseudoatrophic islets, % | 95.7 (46) | 10 (30) | 100 (22) | 68.6 ± 50.8 |
| VP1+ islet, % | 100 (12) | 100 (10) | 77.0 (13) | 92.3 ± 13.3 |
| CD45+ cell number per islet | 24.4 ± 14.1 (11) | 78.6 ± 45.6 (11) | 46.4 ± 12.4 (12) | 49.8 ± 27.3 |
| CD3+ cell number per islet | 26.3 ± 15.8 (15) | 32.4 ± 16.8 (15) | 21.9 ± 12.4 (15) | 26.9 ± 5.3 |
| CD8+ cell number per islet | 17.2 ± 22.6 (19) | 24.0 ± 20.6 (28) | 30.4 ± 37.0 (11) | 23.9 ± 6.6 |
| CD4+ cell number per islet | 0.7 ± 1.0 (10) | 0.5 ± 0.7 (10) | 0.8 ± 1.2 (12) | 0.7 ± 0.2 |
| CD20+ cell number per islet | 1.4 ± 1.5 (12) | 3.3 ± 5.2 (12) | 3.1 ± 2.6 (13) | 2.6 ± 1.0 |
| CD68+ cell number per islet | 14.4 ± 11.8 (10) | 59.3 ± 22.3 (10) | 55.1 ± 24.6 (10) | 42.9 ± 24.8 |
| CD11c+ cell number per islet | 40.9 ± 28.5 (10) | 53.8 ± 35.3 (11) | 3.8 ± 3.9 (12) | 32.6 ± 26.0 |
Counted islets.
Percentage Insulitis, Percentage β and α Cell Area, Percentage Pseudoatrophic Islets, and CD+ Cell Number in and Around the Islets in Case 1, Case 2, and Case 3
| . | Case 1 (n)a . | Case 2 (n)a . | Case 3 (n)a . | Mean ± SD . |
|---|---|---|---|---|
| Frequency of insulitis, % | 51.7 (29) | 66.7 (15) | 70.0 (20) | 62.8 ± 9.7 |
| β Cell area, % | 0.01 ± 0.009 (8) | 0.5 ± 0.6 (15) | 0 (3) | 0.2 ± 0.3 |
| α Cell area, % | 0.7 ± 0.1 (8) | 0.3 ± 0.4 (15) | 0.05 ± 0.02 (3) | 0.3 ± 0.3 |
| Frequency of pseudoatrophic islets, % | 95.7 (46) | 10 (30) | 100 (22) | 68.6 ± 50.8 |
| VP1+ islet, % | 100 (12) | 100 (10) | 77.0 (13) | 92.3 ± 13.3 |
| CD45+ cell number per islet | 24.4 ± 14.1 (11) | 78.6 ± 45.6 (11) | 46.4 ± 12.4 (12) | 49.8 ± 27.3 |
| CD3+ cell number per islet | 26.3 ± 15.8 (15) | 32.4 ± 16.8 (15) | 21.9 ± 12.4 (15) | 26.9 ± 5.3 |
| CD8+ cell number per islet | 17.2 ± 22.6 (19) | 24.0 ± 20.6 (28) | 30.4 ± 37.0 (11) | 23.9 ± 6.6 |
| CD4+ cell number per islet | 0.7 ± 1.0 (10) | 0.5 ± 0.7 (10) | 0.8 ± 1.2 (12) | 0.7 ± 0.2 |
| CD20+ cell number per islet | 1.4 ± 1.5 (12) | 3.3 ± 5.2 (12) | 3.1 ± 2.6 (13) | 2.6 ± 1.0 |
| CD68+ cell number per islet | 14.4 ± 11.8 (10) | 59.3 ± 22.3 (10) | 55.1 ± 24.6 (10) | 42.9 ± 24.8 |
| CD11c+ cell number per islet | 40.9 ± 28.5 (10) | 53.8 ± 35.3 (11) | 3.8 ± 3.9 (12) | 32.6 ± 26.0 |
| . | Case 1 (n)a . | Case 2 (n)a . | Case 3 (n)a . | Mean ± SD . |
|---|---|---|---|---|
| Frequency of insulitis, % | 51.7 (29) | 66.7 (15) | 70.0 (20) | 62.8 ± 9.7 |
| β Cell area, % | 0.01 ± 0.009 (8) | 0.5 ± 0.6 (15) | 0 (3) | 0.2 ± 0.3 |
| α Cell area, % | 0.7 ± 0.1 (8) | 0.3 ± 0.4 (15) | 0.05 ± 0.02 (3) | 0.3 ± 0.3 |
| Frequency of pseudoatrophic islets, % | 95.7 (46) | 10 (30) | 100 (22) | 68.6 ± 50.8 |
| VP1+ islet, % | 100 (12) | 100 (10) | 77.0 (13) | 92.3 ± 13.3 |
| CD45+ cell number per islet | 24.4 ± 14.1 (11) | 78.6 ± 45.6 (11) | 46.4 ± 12.4 (12) | 49.8 ± 27.3 |
| CD3+ cell number per islet | 26.3 ± 15.8 (15) | 32.4 ± 16.8 (15) | 21.9 ± 12.4 (15) | 26.9 ± 5.3 |
| CD8+ cell number per islet | 17.2 ± 22.6 (19) | 24.0 ± 20.6 (28) | 30.4 ± 37.0 (11) | 23.9 ± 6.6 |
| CD4+ cell number per islet | 0.7 ± 1.0 (10) | 0.5 ± 0.7 (10) | 0.8 ± 1.2 (12) | 0.7 ± 0.2 |
| CD20+ cell number per islet | 1.4 ± 1.5 (12) | 3.3 ± 5.2 (12) | 3.1 ± 2.6 (13) | 2.6 ± 1.0 |
| CD68+ cell number per islet | 14.4 ± 11.8 (10) | 59.3 ± 22.3 (10) | 55.1 ± 24.6 (10) | 42.9 ± 24.8 |
| CD11c+ cell number per islet | 40.9 ± 28.5 (10) | 53.8 ± 35.3 (11) | 3.8 ± 3.9 (12) | 32.6 ± 26.0 |
Counted islets.
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