Histological Findings in Samples From 61 Gonads Grouped According to Reason for Diagnosis and Including Ages at the Time of Biopsy/Gonadectomy and EMS Scores
| ID . | Biopsy or Gonadectomy: Age in Years (L/R) . | Overall Morphology . | Male Characteristics . | Female Characteristics . | Germ Cells . | Spermatogenesis/Follicles . | Internal Genitalia . | EMS . | Group (N/NG) . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Testicular Tubules . | Leydig Cells . | SCO, Y/N . | ||||||||||
| Female . | Male . | |||||||||||
| 1 | G: 15 (l) | Dysgenetic testis | Present, thick basal membrane, fibrosis; branched tubules, calcification. | Hyperplasia | Y | — | Absent | — | UT; FT | EP | 4 | G |
| G: 15 (r) | Müllerian derivatives | — | — | — | — | — | — | |||||
| 2 | G: 0.3 (l) | Dysgenetic testis | Prepubertal pattern | Absent | Y | — | Absent | NA due to age | UT | EP | 4 | G |
| G: 0.3 (r) | Dysgenetic testis | Prepubertal pattern | Absent | Y | — | Absent | NA due to age | |||||
| 3 | G: 4 (l) | Testis | Prepubertal pattern | — | — | NA | — | NA due to age | UT; FT UL | EP; VD UL | 1 | G |
| G: 4 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | |||||
| 4 | G: 2 (l) | Wolffian and Müllerian derivatives | — | — | — | — | — | NA due to age | FT | EP | 9.5 | G |
| 5 | B: 5 (l) | Dysgenetic testis | Prepubertal testis | Absent | N | Present | NA due to age | UT; FT BL | EP BL | 8 | G | |
| G: 5 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue with primitive sex cord structures | — | NA due to age | |||||
| 6 | B: 4.8 (l) | Dysgenetic testis | Normal | Present | Y | — | Absent | NA due to age | FT UL | VD, EP UL | 5.5 | G |
| G: 4.8 (r) | Ovarian-like tissue | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | |||||
| 7 | B: 0.1 (l) | Dysgenetic testis | Irregular, abnormal | — | N | — | Rare absent | NA due to age, absent | UT UL | VD, EP UL | 5.5 | G |
| B: 15 (l) | Dysgenetic testis | Irregular, abnormal | — | Y | — | |||||||
| G: 1.0 (r) | Ovarian-like tissue | NA | NA | NA | Ovarian-like tissue with germ cells present | Present, gonadoblastoma in situ | NA due to age | FT UL | ||||
| 8 | B: 1 (r) | Prepubertal testis; abnormal area with peripheral microlithiasis | Normal | Normal | N | — | — | NA due to age | — | Normal | — | G |
| 9 | G: childhood (l) | Prepubertal testis | — | — | — | — | — | NA due to age | — | Agenesis of SV | — | G |
| G: childhood (r) | Streak gonad | NA | NA | NA | Streak gonad | Absent | NA due to age | — | ||||
| 10 | B: 13.2 (l) | Fibrous tissue without testicular morphology | Absent | Absent | — | — | Absent | Absent | FT, UT UL | VD, EP UL | 3 | G |
| B: 13.2 (r) | Testis without spermatogenesis | Normal | Rare | Y | Fibrous ovarian-like tissue | Absent | Absent | |||||
| G: 13.9 (r) | ||||||||||||
| 11 | B: 0.75 (l) | Prepubertal testis | Normal | Absent | N | None | Normal | NA due to age | UT, FT UL | WR UL | 5.5 | G |
| B: 16 | Testis with partial atrophy and SCO; other parts with incomplete spermatogenesis | Mixed abnormal and normal | Normal | Y/N | None | Strongly reduced number, no malignancy | Incomplete spermatogenesis, round elongated spermatids, no mature sperm (sperm present in semen sample) | |||||
| G: 0.75 (r) | No gonadal tissue | NA | NA | NA | NA | NA | NA | UT, FT UL | WR | |||
| 12 | B: 3 (l) | Dysgenetic testis | Dichotomized seminiferous tubules predominantly with Sertoli cells | — | N | — | Few spermatogonia | NA due to age | UT-like structure | WR | 3 | G |
| G: 6 (l) | Hypoplastic TA | Prepubertal seminiferous tubules invading TA | Rare | N | — | — | NA due to age | |||||
| Dysgenetic testis; thickened TA | ||||||||||||
| B: 6 (r) | Prepubertal testis | Normal | Normal | N | — | — | NA due to age | |||||
| 13 | B: 2 (l) | Prepubertal testis | — | — | — | — | — | NA due to age | UT, FT | — | G | |
| 14 | B: 1.5 | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | UT, FT | — | G | |
| G: 6 | NA due to age | |||||||||||
| 15 | G: 1 (l) | Streak gonad | NA | NA | NA | Streak gonad | Absent | NA due to age | FT UL | VD UL | 2.5 | G |
| G: 2 (r) | Dysgenetic testis | — | — | — | — | — | NA due to age | |||||
| 16 | B:21 (l) | Hypotrophic testis | Hyalinized | Rare | — | NA | Absent | Absent | UT, FT UL | VD, EP UL | 2.5 | G |
| G:3 (r) | Atrophic testis | — | — | — | — | — | NA due to age | |||||
| 17 | G: 3 (l) | Dysgenetic testis and ovarian tissue | Seminiferous tubules without germ cells | — | Y | Ovarian tissue | Absent, no malignancy | NA due to age | — | — | 4 | G |
| B: 3 (r) | Dysgenetic testis | — | — | — | — | No malignancy | NA due to age | — | — | |||
| 18 | G: 1 (l) | Steak gonad | NA | NA | NA | Streak gonad | Absent, no malignancy | NA due to age | — | — | 8.5 | G |
| B: 1 (r) | Dysgenetic testis | — | — | — | — | No malignancy | NA due to age | — | — | |||
| B: 5 (r) | Dysgenetic testis | — | — | — | — | — | NA due to age | |||||
| 19 | G: 4 | Dysgenetic gonad | — | — | — | — | No malignancy | NA due to age | — | — | 5 | G |
| B: 11 | — | — | — | — | — | — | — | |||||
| 20 | B/G: 5 | Fibrous tissue | — | — | — | — | No malignancy | NA due to age | — | — | 6 | G |
| 21 | B: 3.3 (r) | Prepubertal testis | — | — | — | — | Presence of germ cells uncertain | NA due to age | — | EP | — | G |
| 22 | G: 1.9 (l) | Dysgenetic gonad | Few nests of sex cords | — | — | Ovarian- like tissue | Absent | NA due to age | FT | WR | — | G |
| 23 | G: 1.5 (l) | Dysgenetic gonad UGT | Abnormal | — | Y | Ovarian-like tissue with germ cells present | Present, presence of primordial follicles uncertain | NA due to age | Rudimentary UT, FT | — | — | G |
| B: 9.5 (r) | No gonadal tissue | NA | NA | NA | NA | NA | NA | Fimbriae with edema | — | |||
| 24 | G: 1.3 (l) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | FT | — | — | G |
| 25 | B: 14.0 (l) | No gonadal tissue | NA | NA | NA | NA | NA | Rudimentary UT, FT BL | VD BL | 8 | G | |
| B: 21.3 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | |||||
| G: 14.0 (r) | Ovotesticular remnant | Present | — | — | Ovotesticular remnant | Absent, no malignancy | Absent | |||||
| 26 | B: 1.9 (l) | Prepubertal testis | Normal | Presence uncertain, fibrosis | N | Absent | Present, no malignancy | NA due to age | Rudimentary UT, FL BL | VD UL | 4 | G |
| G: 14.5 (l) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y/N | Absent | Present, GCNIS | Overall spermatocytic arrest, some spermatids present | |||||
| G: 1.9 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent, no malignancy | Absent | |||||
| 27 | G: 2.2 (l) | Fibrotic ovarian-like tissue | NA | NA | NA | Ovarian-like tissue | Absent | NA | MR, rudimentary UT, FT BL | VD, EP BL | 1 | G |
| B: 2.2 (r) | Dysgenetic testis | Normal | Present | Y/N | Absent | Spermatogonia and gonocytes present | NA due to age | |||||
| G: 14.2 (r) | Prepubertal testis | Normal | Present | Y/N | Absent | Present, GCNIS | NA due to age | |||||
| 28 | B: 43.7 (l) | Dysgenetic testis | Present, some hyalinized, fibrosis | Hyperplasia | N | Absent | Absent, no malignancy | Absent | 9.5 | G | ||
| G: 42.8 (r) | Streak gonad | NA | NA | NA | Streak gonad | Absent, no malignancy | Absent | Rudimentary UT, FT UL | ||||
| 29 | B: 16.1 (l) | Dysgenetic testis | Present | — | Y | Absent | Absent, no malignancy | Absent | — | — | 7 | G |
| 30 | B: 1.5 (l) | Dysgenetic testis | Present | Unknown | Y | Absent | Absent, no malignancy | NA due to age | — | — | 4 | G |
| G: 12.0 (r) | Streak gonad | NA | NA | NA | Streak gonad | Absent, no malignancy | Absent | |||||
| 31 | G: 22 (r) | Dysgenetic testis | — | — | — | — | Present, GCNIS | — | — | — | — | G |
| 32 | G: 0.08 (l) | Streak gonad | NA | NA | NA | Streak gonad | Absent | NA due to age | — | VD UL | — | NG |
| B: 0.08 (r) | Dysgenetic testis | Few, abnormal, hyalinized | Rare | N | — | Absent | NA due to age | |||||
| 33 | B: 0.42 (l) | Dysgenetic testis | Few, abnormal, hyalinized | Rare | N | — | Absent | NA due to age | — | VD BL | 10 | NG |
| B: 0.42 (r) | Dysgenetic testis | Few, abnormal, hyalinized | Rare | N | — | Absent | NA due to age | |||||
| 34 | B: 34.4 (l) | Dysgenetic testis | Present, thick basal membrane | Present | Y | Absent | Absent, no malignancy | Absent | 12 | NG | ||
| B: 34.4 (r) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Present | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | |||||
| 35 | B: 28.2 (l) | Dysgenetic testis | Present, thick basal membrane | Normal | Y | Absent | Absent, no malignancy | Absent | 12 | NG | ||
| B: 28.2 (r) | Dysgenetic testis | Present, thick basal membrane | Normal | Y | Absent | Absent, no malignancy | Absent | |||||
| 36 | B: 30.1 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Normal | Y | Absent | Absent, no malignancy | Absent | 11 | NG | ||
| B: 30.1 (r) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | |||||
| 37 | B: 18.77 (l) | Dysgenetic testis | Present, thick basal membrane | Normal | N | Absent | Present, no malignancy | Overall spermatocytic arrest, few spermatids present | 12 | NG | ||
| B: 18.77 (r) | Dysgenetic testis | Present, thick basal membrane | Normal | N | Absent | Present, no malignancy | Spermatocytic arrest | |||||
| 38 | B: 36.3 (l) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y/N | Absent | Present, no malignancy | Only spermatogonia present | — | NG | ||
| B: 36.3 (r) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y/N | Absent | Present, no malignancy | Only spermatogonia present | |||||
| 39 | B: 49.4 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | 12 | NG | ||
| B: 49.4 (r) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y/N | Absent | Present, no malignancy | Only spermatogonia present | |||||
| 40 | B: 19.1 (l) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | — | — | 12 | NG |
| B: 19.1 (r) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | |||||
| 41 | B: 34.1 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Present, fibrosis | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | — | — | 11.5 | NG |
| B: 34.1 (r) | Dysgenetic testis | Present, thick basal membrane | Present | Y | Absent | Absent, no malignancy | Absent | |||||
| 42 | B: 17.1 (l) | Normal testis | — | — | — | — | Present, no malignancy | Normal spermatogenesis (small vol semen sample with conc of 114 mio/mL) | Rudimentary UT, FT BL | — | 11.5 | NG |
| G: 15.6 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent, no malignancy | Absent | |||||
| 43 | B: 28.6 (l) | Dysgenetic testis | Present, thick basal membrane, fibrosis | Present | N | Absent | Present, GCNIS | — | — | — | 12 | NG |
| B: 28.6 (r) | Slightly dysgenetic testis | Present, slightly thick basal membrane | Normal | N | Absent | Present, no malignancy | Preserved spermatogenesis (semen sample with conc of 0.06 mio/mL, few progressively motile) | |||||
| 44 | B: 47.5 (l) | Dysgenetic testis | Present, some atrophic and hyalinized | Hyperplasia | Y | Absent | Absent | Absent | — | EP BL | 10.5 | NG |
| B: 47.5 (r) | Dysgenetic testis | Present, some atrophic and hyalinized | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | |||||
| ID . | Biopsy or Gonadectomy: Age in Years (L/R) . | Overall Morphology . | Male Characteristics . | Female Characteristics . | Germ Cells . | Spermatogenesis/Follicles . | Internal Genitalia . | EMS . | Group (N/NG) . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Testicular Tubules . | Leydig Cells . | SCO, Y/N . | ||||||||||
| Female . | Male . | |||||||||||
| 1 | G: 15 (l) | Dysgenetic testis | Present, thick basal membrane, fibrosis; branched tubules, calcification. | Hyperplasia | Y | — | Absent | — | UT; FT | EP | 4 | G |
| G: 15 (r) | Müllerian derivatives | — | — | — | — | — | — | |||||
| 2 | G: 0.3 (l) | Dysgenetic testis | Prepubertal pattern | Absent | Y | — | Absent | NA due to age | UT | EP | 4 | G |
| G: 0.3 (r) | Dysgenetic testis | Prepubertal pattern | Absent | Y | — | Absent | NA due to age | |||||
| 3 | G: 4 (l) | Testis | Prepubertal pattern | — | — | NA | — | NA due to age | UT; FT UL | EP; VD UL | 1 | G |
| G: 4 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | |||||
| 4 | G: 2 (l) | Wolffian and Müllerian derivatives | — | — | — | — | — | NA due to age | FT | EP | 9.5 | G |
| 5 | B: 5 (l) | Dysgenetic testis | Prepubertal testis | Absent | N | Present | NA due to age | UT; FT BL | EP BL | 8 | G | |
| G: 5 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue with primitive sex cord structures | — | NA due to age | |||||
| 6 | B: 4.8 (l) | Dysgenetic testis | Normal | Present | Y | — | Absent | NA due to age | FT UL | VD, EP UL | 5.5 | G |
| G: 4.8 (r) | Ovarian-like tissue | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | |||||
| 7 | B: 0.1 (l) | Dysgenetic testis | Irregular, abnormal | — | N | — | Rare absent | NA due to age, absent | UT UL | VD, EP UL | 5.5 | G |
| B: 15 (l) | Dysgenetic testis | Irregular, abnormal | — | Y | — | |||||||
| G: 1.0 (r) | Ovarian-like tissue | NA | NA | NA | Ovarian-like tissue with germ cells present | Present, gonadoblastoma in situ | NA due to age | FT UL | ||||
| 8 | B: 1 (r) | Prepubertal testis; abnormal area with peripheral microlithiasis | Normal | Normal | N | — | — | NA due to age | — | Normal | — | G |
| 9 | G: childhood (l) | Prepubertal testis | — | — | — | — | — | NA due to age | — | Agenesis of SV | — | G |
| G: childhood (r) | Streak gonad | NA | NA | NA | Streak gonad | Absent | NA due to age | — | ||||
| 10 | B: 13.2 (l) | Fibrous tissue without testicular morphology | Absent | Absent | — | — | Absent | Absent | FT, UT UL | VD, EP UL | 3 | G |
| B: 13.2 (r) | Testis without spermatogenesis | Normal | Rare | Y | Fibrous ovarian-like tissue | Absent | Absent | |||||
| G: 13.9 (r) | ||||||||||||
| 11 | B: 0.75 (l) | Prepubertal testis | Normal | Absent | N | None | Normal | NA due to age | UT, FT UL | WR UL | 5.5 | G |
| B: 16 | Testis with partial atrophy and SCO; other parts with incomplete spermatogenesis | Mixed abnormal and normal | Normal | Y/N | None | Strongly reduced number, no malignancy | Incomplete spermatogenesis, round elongated spermatids, no mature sperm (sperm present in semen sample) | |||||
| G: 0.75 (r) | No gonadal tissue | NA | NA | NA | NA | NA | NA | UT, FT UL | WR | |||
| 12 | B: 3 (l) | Dysgenetic testis | Dichotomized seminiferous tubules predominantly with Sertoli cells | — | N | — | Few spermatogonia | NA due to age | UT-like structure | WR | 3 | G |
| G: 6 (l) | Hypoplastic TA | Prepubertal seminiferous tubules invading TA | Rare | N | — | — | NA due to age | |||||
| Dysgenetic testis; thickened TA | ||||||||||||
| B: 6 (r) | Prepubertal testis | Normal | Normal | N | — | — | NA due to age | |||||
| 13 | B: 2 (l) | Prepubertal testis | — | — | — | — | — | NA due to age | UT, FT | — | G | |
| 14 | B: 1.5 | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | UT, FT | — | G | |
| G: 6 | NA due to age | |||||||||||
| 15 | G: 1 (l) | Streak gonad | NA | NA | NA | Streak gonad | Absent | NA due to age | FT UL | VD UL | 2.5 | G |
| G: 2 (r) | Dysgenetic testis | — | — | — | — | — | NA due to age | |||||
| 16 | B:21 (l) | Hypotrophic testis | Hyalinized | Rare | — | NA | Absent | Absent | UT, FT UL | VD, EP UL | 2.5 | G |
| G:3 (r) | Atrophic testis | — | — | — | — | — | NA due to age | |||||
| 17 | G: 3 (l) | Dysgenetic testis and ovarian tissue | Seminiferous tubules without germ cells | — | Y | Ovarian tissue | Absent, no malignancy | NA due to age | — | — | 4 | G |
| B: 3 (r) | Dysgenetic testis | — | — | — | — | No malignancy | NA due to age | — | — | |||
| 18 | G: 1 (l) | Steak gonad | NA | NA | NA | Streak gonad | Absent, no malignancy | NA due to age | — | — | 8.5 | G |
| B: 1 (r) | Dysgenetic testis | — | — | — | — | No malignancy | NA due to age | — | — | |||
| B: 5 (r) | Dysgenetic testis | — | — | — | — | — | NA due to age | |||||
| 19 | G: 4 | Dysgenetic gonad | — | — | — | — | No malignancy | NA due to age | — | — | 5 | G |
| B: 11 | — | — | — | — | — | — | — | |||||
| 20 | B/G: 5 | Fibrous tissue | — | — | — | — | No malignancy | NA due to age | — | — | 6 | G |
| 21 | B: 3.3 (r) | Prepubertal testis | — | — | — | — | Presence of germ cells uncertain | NA due to age | — | EP | — | G |
| 22 | G: 1.9 (l) | Dysgenetic gonad | Few nests of sex cords | — | — | Ovarian- like tissue | Absent | NA due to age | FT | WR | — | G |
| 23 | G: 1.5 (l) | Dysgenetic gonad UGT | Abnormal | — | Y | Ovarian-like tissue with germ cells present | Present, presence of primordial follicles uncertain | NA due to age | Rudimentary UT, FT | — | — | G |
| B: 9.5 (r) | No gonadal tissue | NA | NA | NA | NA | NA | NA | Fimbriae with edema | — | |||
| 24 | G: 1.3 (l) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | FT | — | — | G |
| 25 | B: 14.0 (l) | No gonadal tissue | NA | NA | NA | NA | NA | Rudimentary UT, FT BL | VD BL | 8 | G | |
| B: 21.3 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | |||||
| G: 14.0 (r) | Ovotesticular remnant | Present | — | — | Ovotesticular remnant | Absent, no malignancy | Absent | |||||
| 26 | B: 1.9 (l) | Prepubertal testis | Normal | Presence uncertain, fibrosis | N | Absent | Present, no malignancy | NA due to age | Rudimentary UT, FL BL | VD UL | 4 | G |
| G: 14.5 (l) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y/N | Absent | Present, GCNIS | Overall spermatocytic arrest, some spermatids present | |||||
| G: 1.9 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent, no malignancy | Absent | |||||
| 27 | G: 2.2 (l) | Fibrotic ovarian-like tissue | NA | NA | NA | Ovarian-like tissue | Absent | NA | MR, rudimentary UT, FT BL | VD, EP BL | 1 | G |
| B: 2.2 (r) | Dysgenetic testis | Normal | Present | Y/N | Absent | Spermatogonia and gonocytes present | NA due to age | |||||
| G: 14.2 (r) | Prepubertal testis | Normal | Present | Y/N | Absent | Present, GCNIS | NA due to age | |||||
| 28 | B: 43.7 (l) | Dysgenetic testis | Present, some hyalinized, fibrosis | Hyperplasia | N | Absent | Absent, no malignancy | Absent | 9.5 | G | ||
| G: 42.8 (r) | Streak gonad | NA | NA | NA | Streak gonad | Absent, no malignancy | Absent | Rudimentary UT, FT UL | ||||
| 29 | B: 16.1 (l) | Dysgenetic testis | Present | — | Y | Absent | Absent, no malignancy | Absent | — | — | 7 | G |
| 30 | B: 1.5 (l) | Dysgenetic testis | Present | Unknown | Y | Absent | Absent, no malignancy | NA due to age | — | — | 4 | G |
| G: 12.0 (r) | Streak gonad | NA | NA | NA | Streak gonad | Absent, no malignancy | Absent | |||||
| 31 | G: 22 (r) | Dysgenetic testis | — | — | — | — | Present, GCNIS | — | — | — | — | G |
| 32 | G: 0.08 (l) | Streak gonad | NA | NA | NA | Streak gonad | Absent | NA due to age | — | VD UL | — | NG |
| B: 0.08 (r) | Dysgenetic testis | Few, abnormal, hyalinized | Rare | N | — | Absent | NA due to age | |||||
| 33 | B: 0.42 (l) | Dysgenetic testis | Few, abnormal, hyalinized | Rare | N | — | Absent | NA due to age | — | VD BL | 10 | NG |
| B: 0.42 (r) | Dysgenetic testis | Few, abnormal, hyalinized | Rare | N | — | Absent | NA due to age | |||||
| 34 | B: 34.4 (l) | Dysgenetic testis | Present, thick basal membrane | Present | Y | Absent | Absent, no malignancy | Absent | 12 | NG | ||
| B: 34.4 (r) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Present | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | |||||
| 35 | B: 28.2 (l) | Dysgenetic testis | Present, thick basal membrane | Normal | Y | Absent | Absent, no malignancy | Absent | 12 | NG | ||
| B: 28.2 (r) | Dysgenetic testis | Present, thick basal membrane | Normal | Y | Absent | Absent, no malignancy | Absent | |||||
| 36 | B: 30.1 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Normal | Y | Absent | Absent, no malignancy | Absent | 11 | NG | ||
| B: 30.1 (r) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | |||||
| 37 | B: 18.77 (l) | Dysgenetic testis | Present, thick basal membrane | Normal | N | Absent | Present, no malignancy | Overall spermatocytic arrest, few spermatids present | 12 | NG | ||
| B: 18.77 (r) | Dysgenetic testis | Present, thick basal membrane | Normal | N | Absent | Present, no malignancy | Spermatocytic arrest | |||||
| 38 | B: 36.3 (l) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y/N | Absent | Present, no malignancy | Only spermatogonia present | — | NG | ||
| B: 36.3 (r) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y/N | Absent | Present, no malignancy | Only spermatogonia present | |||||
| 39 | B: 49.4 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | 12 | NG | ||
| B: 49.4 (r) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y/N | Absent | Present, no malignancy | Only spermatogonia present | |||||
| 40 | B: 19.1 (l) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | — | — | 12 | NG |
| B: 19.1 (r) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | |||||
| 41 | B: 34.1 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Present, fibrosis | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | — | — | 11.5 | NG |
| B: 34.1 (r) | Dysgenetic testis | Present, thick basal membrane | Present | Y | Absent | Absent, no malignancy | Absent | |||||
| 42 | B: 17.1 (l) | Normal testis | — | — | — | — | Present, no malignancy | Normal spermatogenesis (small vol semen sample with conc of 114 mio/mL) | Rudimentary UT, FT BL | — | 11.5 | NG |
| G: 15.6 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent, no malignancy | Absent | |||||
| 43 | B: 28.6 (l) | Dysgenetic testis | Present, thick basal membrane, fibrosis | Present | N | Absent | Present, GCNIS | — | — | — | 12 | NG |
| B: 28.6 (r) | Slightly dysgenetic testis | Present, slightly thick basal membrane | Normal | N | Absent | Present, no malignancy | Preserved spermatogenesis (semen sample with conc of 0.06 mio/mL, few progressively motile) | |||||
| 44 | B: 47.5 (l) | Dysgenetic testis | Present, some atrophic and hyalinized | Hyperplasia | Y | Absent | Absent | Absent | — | EP BL | 10.5 | NG |
| B: 47.5 (r) | Dysgenetic testis | Present, some atrophic and hyalinized | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | |||||
Ovarian-like tissue does not contain follicles unless specifically indicated.
Abbreviations: —, information not available; B, biopsy; BL, bilateral; EP, epididymis; FT, fallopian tubes; G, genital (last column); G, gonadectomy (column 2); ID, identification; l, left; mio/mL, million per milliliter; MR, Müllerian remnants; N, no; NA, not applicable; NG, nongenital; r, right; SCO, Sertoli cell only; SV, seminal vesicle; TA, tunica albuginea; UGT, undifferentiated; UL, unilateral; UT, uterus; VD, vas deferens; vol, volume; WR, Wolffian duct remnants; Y, yes.
Histological Findings in Samples From 61 Gonads Grouped According to Reason for Diagnosis and Including Ages at the Time of Biopsy/Gonadectomy and EMS Scores
| ID . | Biopsy or Gonadectomy: Age in Years (L/R) . | Overall Morphology . | Male Characteristics . | Female Characteristics . | Germ Cells . | Spermatogenesis/Follicles . | Internal Genitalia . | EMS . | Group (N/NG) . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Testicular Tubules . | Leydig Cells . | SCO, Y/N . | ||||||||||
| Female . | Male . | |||||||||||
| 1 | G: 15 (l) | Dysgenetic testis | Present, thick basal membrane, fibrosis; branched tubules, calcification. | Hyperplasia | Y | — | Absent | — | UT; FT | EP | 4 | G |
| G: 15 (r) | Müllerian derivatives | — | — | — | — | — | — | |||||
| 2 | G: 0.3 (l) | Dysgenetic testis | Prepubertal pattern | Absent | Y | — | Absent | NA due to age | UT | EP | 4 | G |
| G: 0.3 (r) | Dysgenetic testis | Prepubertal pattern | Absent | Y | — | Absent | NA due to age | |||||
| 3 | G: 4 (l) | Testis | Prepubertal pattern | — | — | NA | — | NA due to age | UT; FT UL | EP; VD UL | 1 | G |
| G: 4 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | |||||
| 4 | G: 2 (l) | Wolffian and Müllerian derivatives | — | — | — | — | — | NA due to age | FT | EP | 9.5 | G |
| 5 | B: 5 (l) | Dysgenetic testis | Prepubertal testis | Absent | N | Present | NA due to age | UT; FT BL | EP BL | 8 | G | |
| G: 5 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue with primitive sex cord structures | — | NA due to age | |||||
| 6 | B: 4.8 (l) | Dysgenetic testis | Normal | Present | Y | — | Absent | NA due to age | FT UL | VD, EP UL | 5.5 | G |
| G: 4.8 (r) | Ovarian-like tissue | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | |||||
| 7 | B: 0.1 (l) | Dysgenetic testis | Irregular, abnormal | — | N | — | Rare absent | NA due to age, absent | UT UL | VD, EP UL | 5.5 | G |
| B: 15 (l) | Dysgenetic testis | Irregular, abnormal | — | Y | — | |||||||
| G: 1.0 (r) | Ovarian-like tissue | NA | NA | NA | Ovarian-like tissue with germ cells present | Present, gonadoblastoma in situ | NA due to age | FT UL | ||||
| 8 | B: 1 (r) | Prepubertal testis; abnormal area with peripheral microlithiasis | Normal | Normal | N | — | — | NA due to age | — | Normal | — | G |
| 9 | G: childhood (l) | Prepubertal testis | — | — | — | — | — | NA due to age | — | Agenesis of SV | — | G |
| G: childhood (r) | Streak gonad | NA | NA | NA | Streak gonad | Absent | NA due to age | — | ||||
| 10 | B: 13.2 (l) | Fibrous tissue without testicular morphology | Absent | Absent | — | — | Absent | Absent | FT, UT UL | VD, EP UL | 3 | G |
| B: 13.2 (r) | Testis without spermatogenesis | Normal | Rare | Y | Fibrous ovarian-like tissue | Absent | Absent | |||||
| G: 13.9 (r) | ||||||||||||
| 11 | B: 0.75 (l) | Prepubertal testis | Normal | Absent | N | None | Normal | NA due to age | UT, FT UL | WR UL | 5.5 | G |
| B: 16 | Testis with partial atrophy and SCO; other parts with incomplete spermatogenesis | Mixed abnormal and normal | Normal | Y/N | None | Strongly reduced number, no malignancy | Incomplete spermatogenesis, round elongated spermatids, no mature sperm (sperm present in semen sample) | |||||
| G: 0.75 (r) | No gonadal tissue | NA | NA | NA | NA | NA | NA | UT, FT UL | WR | |||
| 12 | B: 3 (l) | Dysgenetic testis | Dichotomized seminiferous tubules predominantly with Sertoli cells | — | N | — | Few spermatogonia | NA due to age | UT-like structure | WR | 3 | G |
| G: 6 (l) | Hypoplastic TA | Prepubertal seminiferous tubules invading TA | Rare | N | — | — | NA due to age | |||||
| Dysgenetic testis; thickened TA | ||||||||||||
| B: 6 (r) | Prepubertal testis | Normal | Normal | N | — | — | NA due to age | |||||
| 13 | B: 2 (l) | Prepubertal testis | — | — | — | — | — | NA due to age | UT, FT | — | G | |
| 14 | B: 1.5 | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | UT, FT | — | G | |
| G: 6 | NA due to age | |||||||||||
| 15 | G: 1 (l) | Streak gonad | NA | NA | NA | Streak gonad | Absent | NA due to age | FT UL | VD UL | 2.5 | G |
| G: 2 (r) | Dysgenetic testis | — | — | — | — | — | NA due to age | |||||
| 16 | B:21 (l) | Hypotrophic testis | Hyalinized | Rare | — | NA | Absent | Absent | UT, FT UL | VD, EP UL | 2.5 | G |
| G:3 (r) | Atrophic testis | — | — | — | — | — | NA due to age | |||||
| 17 | G: 3 (l) | Dysgenetic testis and ovarian tissue | Seminiferous tubules without germ cells | — | Y | Ovarian tissue | Absent, no malignancy | NA due to age | — | — | 4 | G |
| B: 3 (r) | Dysgenetic testis | — | — | — | — | No malignancy | NA due to age | — | — | |||
| 18 | G: 1 (l) | Steak gonad | NA | NA | NA | Streak gonad | Absent, no malignancy | NA due to age | — | — | 8.5 | G |
| B: 1 (r) | Dysgenetic testis | — | — | — | — | No malignancy | NA due to age | — | — | |||
| B: 5 (r) | Dysgenetic testis | — | — | — | — | — | NA due to age | |||||
| 19 | G: 4 | Dysgenetic gonad | — | — | — | — | No malignancy | NA due to age | — | — | 5 | G |
| B: 11 | — | — | — | — | — | — | — | |||||
| 20 | B/G: 5 | Fibrous tissue | — | — | — | — | No malignancy | NA due to age | — | — | 6 | G |
| 21 | B: 3.3 (r) | Prepubertal testis | — | — | — | — | Presence of germ cells uncertain | NA due to age | — | EP | — | G |
| 22 | G: 1.9 (l) | Dysgenetic gonad | Few nests of sex cords | — | — | Ovarian- like tissue | Absent | NA due to age | FT | WR | — | G |
| 23 | G: 1.5 (l) | Dysgenetic gonad UGT | Abnormal | — | Y | Ovarian-like tissue with germ cells present | Present, presence of primordial follicles uncertain | NA due to age | Rudimentary UT, FT | — | — | G |
| B: 9.5 (r) | No gonadal tissue | NA | NA | NA | NA | NA | NA | Fimbriae with edema | — | |||
| 24 | G: 1.3 (l) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | FT | — | — | G |
| 25 | B: 14.0 (l) | No gonadal tissue | NA | NA | NA | NA | NA | Rudimentary UT, FT BL | VD BL | 8 | G | |
| B: 21.3 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | |||||
| G: 14.0 (r) | Ovotesticular remnant | Present | — | — | Ovotesticular remnant | Absent, no malignancy | Absent | |||||
| 26 | B: 1.9 (l) | Prepubertal testis | Normal | Presence uncertain, fibrosis | N | Absent | Present, no malignancy | NA due to age | Rudimentary UT, FL BL | VD UL | 4 | G |
| G: 14.5 (l) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y/N | Absent | Present, GCNIS | Overall spermatocytic arrest, some spermatids present | |||||
| G: 1.9 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent, no malignancy | Absent | |||||
| 27 | G: 2.2 (l) | Fibrotic ovarian-like tissue | NA | NA | NA | Ovarian-like tissue | Absent | NA | MR, rudimentary UT, FT BL | VD, EP BL | 1 | G |
| B: 2.2 (r) | Dysgenetic testis | Normal | Present | Y/N | Absent | Spermatogonia and gonocytes present | NA due to age | |||||
| G: 14.2 (r) | Prepubertal testis | Normal | Present | Y/N | Absent | Present, GCNIS | NA due to age | |||||
| 28 | B: 43.7 (l) | Dysgenetic testis | Present, some hyalinized, fibrosis | Hyperplasia | N | Absent | Absent, no malignancy | Absent | 9.5 | G | ||
| G: 42.8 (r) | Streak gonad | NA | NA | NA | Streak gonad | Absent, no malignancy | Absent | Rudimentary UT, FT UL | ||||
| 29 | B: 16.1 (l) | Dysgenetic testis | Present | — | Y | Absent | Absent, no malignancy | Absent | — | — | 7 | G |
| 30 | B: 1.5 (l) | Dysgenetic testis | Present | Unknown | Y | Absent | Absent, no malignancy | NA due to age | — | — | 4 | G |
| G: 12.0 (r) | Streak gonad | NA | NA | NA | Streak gonad | Absent, no malignancy | Absent | |||||
| 31 | G: 22 (r) | Dysgenetic testis | — | — | — | — | Present, GCNIS | — | — | — | — | G |
| 32 | G: 0.08 (l) | Streak gonad | NA | NA | NA | Streak gonad | Absent | NA due to age | — | VD UL | — | NG |
| B: 0.08 (r) | Dysgenetic testis | Few, abnormal, hyalinized | Rare | N | — | Absent | NA due to age | |||||
| 33 | B: 0.42 (l) | Dysgenetic testis | Few, abnormal, hyalinized | Rare | N | — | Absent | NA due to age | — | VD BL | 10 | NG |
| B: 0.42 (r) | Dysgenetic testis | Few, abnormal, hyalinized | Rare | N | — | Absent | NA due to age | |||||
| 34 | B: 34.4 (l) | Dysgenetic testis | Present, thick basal membrane | Present | Y | Absent | Absent, no malignancy | Absent | 12 | NG | ||
| B: 34.4 (r) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Present | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | |||||
| 35 | B: 28.2 (l) | Dysgenetic testis | Present, thick basal membrane | Normal | Y | Absent | Absent, no malignancy | Absent | 12 | NG | ||
| B: 28.2 (r) | Dysgenetic testis | Present, thick basal membrane | Normal | Y | Absent | Absent, no malignancy | Absent | |||||
| 36 | B: 30.1 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Normal | Y | Absent | Absent, no malignancy | Absent | 11 | NG | ||
| B: 30.1 (r) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | |||||
| 37 | B: 18.77 (l) | Dysgenetic testis | Present, thick basal membrane | Normal | N | Absent | Present, no malignancy | Overall spermatocytic arrest, few spermatids present | 12 | NG | ||
| B: 18.77 (r) | Dysgenetic testis | Present, thick basal membrane | Normal | N | Absent | Present, no malignancy | Spermatocytic arrest | |||||
| 38 | B: 36.3 (l) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y/N | Absent | Present, no malignancy | Only spermatogonia present | — | NG | ||
| B: 36.3 (r) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y/N | Absent | Present, no malignancy | Only spermatogonia present | |||||
| 39 | B: 49.4 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | 12 | NG | ||
| B: 49.4 (r) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y/N | Absent | Present, no malignancy | Only spermatogonia present | |||||
| 40 | B: 19.1 (l) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | — | — | 12 | NG |
| B: 19.1 (r) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | |||||
| 41 | B: 34.1 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Present, fibrosis | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | — | — | 11.5 | NG |
| B: 34.1 (r) | Dysgenetic testis | Present, thick basal membrane | Present | Y | Absent | Absent, no malignancy | Absent | |||||
| 42 | B: 17.1 (l) | Normal testis | — | — | — | — | Present, no malignancy | Normal spermatogenesis (small vol semen sample with conc of 114 mio/mL) | Rudimentary UT, FT BL | — | 11.5 | NG |
| G: 15.6 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent, no malignancy | Absent | |||||
| 43 | B: 28.6 (l) | Dysgenetic testis | Present, thick basal membrane, fibrosis | Present | N | Absent | Present, GCNIS | — | — | — | 12 | NG |
| B: 28.6 (r) | Slightly dysgenetic testis | Present, slightly thick basal membrane | Normal | N | Absent | Present, no malignancy | Preserved spermatogenesis (semen sample with conc of 0.06 mio/mL, few progressively motile) | |||||
| 44 | B: 47.5 (l) | Dysgenetic testis | Present, some atrophic and hyalinized | Hyperplasia | Y | Absent | Absent | Absent | — | EP BL | 10.5 | NG |
| B: 47.5 (r) | Dysgenetic testis | Present, some atrophic and hyalinized | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | |||||
| ID . | Biopsy or Gonadectomy: Age in Years (L/R) . | Overall Morphology . | Male Characteristics . | Female Characteristics . | Germ Cells . | Spermatogenesis/Follicles . | Internal Genitalia . | EMS . | Group (N/NG) . | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Testicular Tubules . | Leydig Cells . | SCO, Y/N . | ||||||||||
| Female . | Male . | |||||||||||
| 1 | G: 15 (l) | Dysgenetic testis | Present, thick basal membrane, fibrosis; branched tubules, calcification. | Hyperplasia | Y | — | Absent | — | UT; FT | EP | 4 | G |
| G: 15 (r) | Müllerian derivatives | — | — | — | — | — | — | |||||
| 2 | G: 0.3 (l) | Dysgenetic testis | Prepubertal pattern | Absent | Y | — | Absent | NA due to age | UT | EP | 4 | G |
| G: 0.3 (r) | Dysgenetic testis | Prepubertal pattern | Absent | Y | — | Absent | NA due to age | |||||
| 3 | G: 4 (l) | Testis | Prepubertal pattern | — | — | NA | — | NA due to age | UT; FT UL | EP; VD UL | 1 | G |
| G: 4 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | |||||
| 4 | G: 2 (l) | Wolffian and Müllerian derivatives | — | — | — | — | — | NA due to age | FT | EP | 9.5 | G |
| 5 | B: 5 (l) | Dysgenetic testis | Prepubertal testis | Absent | N | Present | NA due to age | UT; FT BL | EP BL | 8 | G | |
| G: 5 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue with primitive sex cord structures | — | NA due to age | |||||
| 6 | B: 4.8 (l) | Dysgenetic testis | Normal | Present | Y | — | Absent | NA due to age | FT UL | VD, EP UL | 5.5 | G |
| G: 4.8 (r) | Ovarian-like tissue | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | |||||
| 7 | B: 0.1 (l) | Dysgenetic testis | Irregular, abnormal | — | N | — | Rare absent | NA due to age, absent | UT UL | VD, EP UL | 5.5 | G |
| B: 15 (l) | Dysgenetic testis | Irregular, abnormal | — | Y | — | |||||||
| G: 1.0 (r) | Ovarian-like tissue | NA | NA | NA | Ovarian-like tissue with germ cells present | Present, gonadoblastoma in situ | NA due to age | FT UL | ||||
| 8 | B: 1 (r) | Prepubertal testis; abnormal area with peripheral microlithiasis | Normal | Normal | N | — | — | NA due to age | — | Normal | — | G |
| 9 | G: childhood (l) | Prepubertal testis | — | — | — | — | — | NA due to age | — | Agenesis of SV | — | G |
| G: childhood (r) | Streak gonad | NA | NA | NA | Streak gonad | Absent | NA due to age | — | ||||
| 10 | B: 13.2 (l) | Fibrous tissue without testicular morphology | Absent | Absent | — | — | Absent | Absent | FT, UT UL | VD, EP UL | 3 | G |
| B: 13.2 (r) | Testis without spermatogenesis | Normal | Rare | Y | Fibrous ovarian-like tissue | Absent | Absent | |||||
| G: 13.9 (r) | ||||||||||||
| 11 | B: 0.75 (l) | Prepubertal testis | Normal | Absent | N | None | Normal | NA due to age | UT, FT UL | WR UL | 5.5 | G |
| B: 16 | Testis with partial atrophy and SCO; other parts with incomplete spermatogenesis | Mixed abnormal and normal | Normal | Y/N | None | Strongly reduced number, no malignancy | Incomplete spermatogenesis, round elongated spermatids, no mature sperm (sperm present in semen sample) | |||||
| G: 0.75 (r) | No gonadal tissue | NA | NA | NA | NA | NA | NA | UT, FT UL | WR | |||
| 12 | B: 3 (l) | Dysgenetic testis | Dichotomized seminiferous tubules predominantly with Sertoli cells | — | N | — | Few spermatogonia | NA due to age | UT-like structure | WR | 3 | G |
| G: 6 (l) | Hypoplastic TA | Prepubertal seminiferous tubules invading TA | Rare | N | — | — | NA due to age | |||||
| Dysgenetic testis; thickened TA | ||||||||||||
| B: 6 (r) | Prepubertal testis | Normal | Normal | N | — | — | NA due to age | |||||
| 13 | B: 2 (l) | Prepubertal testis | — | — | — | — | — | NA due to age | UT, FT | — | G | |
| 14 | B: 1.5 | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | UT, FT | — | G | |
| G: 6 | NA due to age | |||||||||||
| 15 | G: 1 (l) | Streak gonad | NA | NA | NA | Streak gonad | Absent | NA due to age | FT UL | VD UL | 2.5 | G |
| G: 2 (r) | Dysgenetic testis | — | — | — | — | — | NA due to age | |||||
| 16 | B:21 (l) | Hypotrophic testis | Hyalinized | Rare | — | NA | Absent | Absent | UT, FT UL | VD, EP UL | 2.5 | G |
| G:3 (r) | Atrophic testis | — | — | — | — | — | NA due to age | |||||
| 17 | G: 3 (l) | Dysgenetic testis and ovarian tissue | Seminiferous tubules without germ cells | — | Y | Ovarian tissue | Absent, no malignancy | NA due to age | — | — | 4 | G |
| B: 3 (r) | Dysgenetic testis | — | — | — | — | No malignancy | NA due to age | — | — | |||
| 18 | G: 1 (l) | Steak gonad | NA | NA | NA | Streak gonad | Absent, no malignancy | NA due to age | — | — | 8.5 | G |
| B: 1 (r) | Dysgenetic testis | — | — | — | — | No malignancy | NA due to age | — | — | |||
| B: 5 (r) | Dysgenetic testis | — | — | — | — | — | NA due to age | |||||
| 19 | G: 4 | Dysgenetic gonad | — | — | — | — | No malignancy | NA due to age | — | — | 5 | G |
| B: 11 | — | — | — | — | — | — | — | |||||
| 20 | B/G: 5 | Fibrous tissue | — | — | — | — | No malignancy | NA due to age | — | — | 6 | G |
| 21 | B: 3.3 (r) | Prepubertal testis | — | — | — | — | Presence of germ cells uncertain | NA due to age | — | EP | — | G |
| 22 | G: 1.9 (l) | Dysgenetic gonad | Few nests of sex cords | — | — | Ovarian- like tissue | Absent | NA due to age | FT | WR | — | G |
| 23 | G: 1.5 (l) | Dysgenetic gonad UGT | Abnormal | — | Y | Ovarian-like tissue with germ cells present | Present, presence of primordial follicles uncertain | NA due to age | Rudimentary UT, FT | — | — | G |
| B: 9.5 (r) | No gonadal tissue | NA | NA | NA | NA | NA | NA | Fimbriae with edema | — | |||
| 24 | G: 1.3 (l) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent | NA due to age | FT | — | — | G |
| 25 | B: 14.0 (l) | No gonadal tissue | NA | NA | NA | NA | NA | Rudimentary UT, FT BL | VD BL | 8 | G | |
| B: 21.3 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | |||||
| G: 14.0 (r) | Ovotesticular remnant | Present | — | — | Ovotesticular remnant | Absent, no malignancy | Absent | |||||
| 26 | B: 1.9 (l) | Prepubertal testis | Normal | Presence uncertain, fibrosis | N | Absent | Present, no malignancy | NA due to age | Rudimentary UT, FL BL | VD UL | 4 | G |
| G: 14.5 (l) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y/N | Absent | Present, GCNIS | Overall spermatocytic arrest, some spermatids present | |||||
| G: 1.9 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent, no malignancy | Absent | |||||
| 27 | G: 2.2 (l) | Fibrotic ovarian-like tissue | NA | NA | NA | Ovarian-like tissue | Absent | NA | MR, rudimentary UT, FT BL | VD, EP BL | 1 | G |
| B: 2.2 (r) | Dysgenetic testis | Normal | Present | Y/N | Absent | Spermatogonia and gonocytes present | NA due to age | |||||
| G: 14.2 (r) | Prepubertal testis | Normal | Present | Y/N | Absent | Present, GCNIS | NA due to age | |||||
| 28 | B: 43.7 (l) | Dysgenetic testis | Present, some hyalinized, fibrosis | Hyperplasia | N | Absent | Absent, no malignancy | Absent | 9.5 | G | ||
| G: 42.8 (r) | Streak gonad | NA | NA | NA | Streak gonad | Absent, no malignancy | Absent | Rudimentary UT, FT UL | ||||
| 29 | B: 16.1 (l) | Dysgenetic testis | Present | — | Y | Absent | Absent, no malignancy | Absent | — | — | 7 | G |
| 30 | B: 1.5 (l) | Dysgenetic testis | Present | Unknown | Y | Absent | Absent, no malignancy | NA due to age | — | — | 4 | G |
| G: 12.0 (r) | Streak gonad | NA | NA | NA | Streak gonad | Absent, no malignancy | Absent | |||||
| 31 | G: 22 (r) | Dysgenetic testis | — | — | — | — | Present, GCNIS | — | — | — | — | G |
| 32 | G: 0.08 (l) | Streak gonad | NA | NA | NA | Streak gonad | Absent | NA due to age | — | VD UL | — | NG |
| B: 0.08 (r) | Dysgenetic testis | Few, abnormal, hyalinized | Rare | N | — | Absent | NA due to age | |||||
| 33 | B: 0.42 (l) | Dysgenetic testis | Few, abnormal, hyalinized | Rare | N | — | Absent | NA due to age | — | VD BL | 10 | NG |
| B: 0.42 (r) | Dysgenetic testis | Few, abnormal, hyalinized | Rare | N | — | Absent | NA due to age | |||||
| 34 | B: 34.4 (l) | Dysgenetic testis | Present, thick basal membrane | Present | Y | Absent | Absent, no malignancy | Absent | 12 | NG | ||
| B: 34.4 (r) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Present | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | |||||
| 35 | B: 28.2 (l) | Dysgenetic testis | Present, thick basal membrane | Normal | Y | Absent | Absent, no malignancy | Absent | 12 | NG | ||
| B: 28.2 (r) | Dysgenetic testis | Present, thick basal membrane | Normal | Y | Absent | Absent, no malignancy | Absent | |||||
| 36 | B: 30.1 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Normal | Y | Absent | Absent, no malignancy | Absent | 11 | NG | ||
| B: 30.1 (r) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | |||||
| 37 | B: 18.77 (l) | Dysgenetic testis | Present, thick basal membrane | Normal | N | Absent | Present, no malignancy | Overall spermatocytic arrest, few spermatids present | 12 | NG | ||
| B: 18.77 (r) | Dysgenetic testis | Present, thick basal membrane | Normal | N | Absent | Present, no malignancy | Spermatocytic arrest | |||||
| 38 | B: 36.3 (l) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y/N | Absent | Present, no malignancy | Only spermatogonia present | — | NG | ||
| B: 36.3 (r) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y/N | Absent | Present, no malignancy | Only spermatogonia present | |||||
| 39 | B: 49.4 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | 12 | NG | ||
| B: 49.4 (r) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Hyperplasia | Y/N | Absent | Present, no malignancy | Only spermatogonia present | |||||
| 40 | B: 19.1 (l) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | — | — | 12 | NG |
| B: 19.1 (r) | Dysgenetic testis | Present, thick basal membrane | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | |||||
| 41 | B: 34.1 (l) | Dysgenetic testis | Present, thick basal membrane, some hyalinized | Present, fibrosis | Y/N | Absent | Present, no malignancy | Spermatocytic arrest | — | — | 11.5 | NG |
| B: 34.1 (r) | Dysgenetic testis | Present, thick basal membrane | Present | Y | Absent | Absent, no malignancy | Absent | |||||
| 42 | B: 17.1 (l) | Normal testis | — | — | — | — | Present, no malignancy | Normal spermatogenesis (small vol semen sample with conc of 114 mio/mL) | Rudimentary UT, FT BL | — | 11.5 | NG |
| G: 15.6 (r) | Streak gonad | NA | NA | NA | Ovarian-like tissue | Absent, no malignancy | Absent | |||||
| 43 | B: 28.6 (l) | Dysgenetic testis | Present, thick basal membrane, fibrosis | Present | N | Absent | Present, GCNIS | — | — | — | 12 | NG |
| B: 28.6 (r) | Slightly dysgenetic testis | Present, slightly thick basal membrane | Normal | N | Absent | Present, no malignancy | Preserved spermatogenesis (semen sample with conc of 0.06 mio/mL, few progressively motile) | |||||
| 44 | B: 47.5 (l) | Dysgenetic testis | Present, some atrophic and hyalinized | Hyperplasia | Y | Absent | Absent | Absent | — | EP BL | 10.5 | NG |
| B: 47.5 (r) | Dysgenetic testis | Present, some atrophic and hyalinized | Hyperplasia | Y | Absent | Absent, no malignancy | Absent | |||||
Ovarian-like tissue does not contain follicles unless specifically indicated.
Abbreviations: —, information not available; B, biopsy; BL, bilateral; EP, epididymis; FT, fallopian tubes; G, genital (last column); G, gonadectomy (column 2); ID, identification; l, left; mio/mL, million per milliliter; MR, Müllerian remnants; N, no; NA, not applicable; NG, nongenital; r, right; SCO, Sertoli cell only; SV, seminal vesicle; TA, tunica albuginea; UGT, undifferentiated; UL, unilateral; UT, uterus; VD, vas deferens; vol, volume; WR, Wolffian duct remnants; Y, yes.
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