Table 1. Open in new tab Differences...

	Diagnosed Due to:
Age
Age at presentation, y, median (range)	0.00 (0.0 to 42.7)	35	24.0 (0.0 to 49.00)	25	<0.001^a
Age at last evaluation, y, median (range)	18.9 (14.0 to 70.2)	34	30.6 (13.4 to 58.6)	27	0.039
Genital phenotype
EMS,^b median (range)	4.00 (1.0 to 9.5)	24	12 (10.0 to 12.0)	20	<0.001^a
Spontaneous pubertal onset, yes/no	22/10	32	25/2	27	0.023^a
T treatment, yes/no	17/15	32	4/17	21	0.013^a
Growth
Final height, cm, median (range)	156.7 (143.0 to 169.2)	31	164.5 (141.1 to 187.7)	21	0.001^a
Height, SDS, median (range)	−2.29 (−4.6 to −0.28)	29	−1.53 (−3.09 to 1.53)	18	0.016^a
H – TH, SDS,^c median (range)	−2.49 (−4.18 to −1.22)	23	−2.21 (−3.44 to −0.96)	13	0.296
GH treatment, yes/no	13/19	32	4/19	23	0.066
Comorbidity
Renal malformations, yes/no	5/27	32	2/23	25	0.450
Cardiac malformations, yes/no	9/24	33	4/21	25	0.308
Surgery
Hypospadias repair	29/4	33	2/23	25	<0.001^a
Orchidopexy, uni- or bilateral	14/16	30	3/22	25	0.006^a
Gonadectomy, uni- or bilateral	28/8	36	2/24	26	<0.001^a
Neoplasia
Gonadal neoplasia,^d yes/no	4/20	24	1/16	17	0.382

Diagnosed Due to:

Genital Anomalies

Nongenital Reasons

P Value

Median (Range) or Yes/No

Age

Age at presentation, y, median (range)

0.00 (0.0 to 42.7)

24.0 (0.0 to 49.00)

<0.001^a

Age at last evaluation, y, median (range)

18.9 (14.0 to 70.2)

30.6 (13.4 to 58.6)

0.039

Genital phenotype

EMS,^b median (range)

4.00 (1.0 to 9.5)

12 (10.0 to 12.0)

<0.001^a

Spontaneous pubertal onset, yes/no

22/10

25/2

0.023^a

T treatment, yes/no

17/15

4/17

0.013^a

Growth

Final height, cm, median (range)

156.7 (143.0 to 169.2)

164.5 (141.1 to 187.7)

0.001^a

Height, SDS, median (range)

−2.29 (−4.6 to −0.28)

−1.53 (−3.09 to 1.53)

0.016^a

H – TH, SDS,^c median (range)

−2.49 (−4.18 to −1.22)

−2.21 (−3.44 to −0.96)

0.296

GH treatment, yes/no

13/19

4/19

0.066

Comorbidity

Renal malformations, yes/no

5/27

2/23

0.450

Cardiac malformations, yes/no

9/24

4/21

0.308

Surgery

Hypospadias repair

29/4

2/23

<0.001^a

Orchidopexy, uni- or bilateral

14/16

3/22

0.006^a

Gonadectomy, uni- or bilateral

28/8

2/24

<0.001^a

Neoplasia

Gonadal neoplasia,^d yes/no

4/20

1/16

0.382

	Diagnosed Due to:
Age
Age at presentation, y, median (range)	0.00 (0.0 to 42.7)	35	24.0 (0.0 to 49.00)	25	<0.001^a
Age at last evaluation, y, median (range)	18.9 (14.0 to 70.2)	34	30.6 (13.4 to 58.6)	27	0.039
Genital phenotype
EMS,^b median (range)	4.00 (1.0 to 9.5)	24	12 (10.0 to 12.0)	20	<0.001^a
Spontaneous pubertal onset, yes/no	22/10	32	25/2	27	0.023^a
T treatment, yes/no	17/15	32	4/17	21	0.013^a
Growth
Final height, cm, median (range)	156.7 (143.0 to 169.2)	31	164.5 (141.1 to 187.7)	21	0.001^a
Height, SDS, median (range)	−2.29 (−4.6 to −0.28)	29	−1.53 (−3.09 to 1.53)	18	0.016^a
H – TH, SDS,^c median (range)	−2.49 (−4.18 to −1.22)	23	−2.21 (−3.44 to −0.96)	13	0.296
GH treatment, yes/no	13/19	32	4/19	23	0.066
Comorbidity
Renal malformations, yes/no	5/27	32	2/23	25	0.450
Cardiac malformations, yes/no	9/24	33	4/21	25	0.308
Surgery
Hypospadias repair	29/4	33	2/23	25	<0.001^a
Orchidopexy, uni- or bilateral	14/16	30	3/22	25	0.006^a
Gonadectomy, uni- or bilateral	28/8	36	2/24	26	<0.001^a
Neoplasia
Gonadal neoplasia,^d yes/no	4/20	24	1/16	17	0.382

Table 1.

Open in new tab

Differences Between the Genital and Nongenital Group in Terms of Age, Genital Phenotype, Growth, Comorbidities, Surgeries, and Gonadal Neoplasia

	Diagnosed Due to:
	Genital Anomalies		Nongenital Reasons		P Value
	Median (Range) or Yes/No	n	Median (Range) or Yes/No	n	P Value
Age
Age at presentation, y, median (range)	0.00 (0.0 to 42.7)	35	24.0 (0.0 to 49.00)	25	<0.001^a
Age at last evaluation, y, median (range)	18.9 (14.0 to 70.2)	34	30.6 (13.4 to 58.6)	27	0.039
Genital phenotype
EMS,^b median (range)	4.00 (1.0 to 9.5)	24	12 (10.0 to 12.0)	20	<0.001^a
Spontaneous pubertal onset, yes/no	22/10	32	25/2	27	0.023^a
T treatment, yes/no	17/15	32	4/17	21	0.013^a
Growth
Final height, cm, median (range)	156.7 (143.0 to 169.2)	31	164.5 (141.1 to 187.7)	21	0.001^a
Height, SDS, median (range)	−2.29 (−4.6 to −0.28)	29	−1.53 (−3.09 to 1.53)	18	0.016^a
H – TH, SDS,^c median (range)	−2.49 (−4.18 to −1.22)	23	−2.21 (−3.44 to −0.96)	13	0.296
GH treatment, yes/no	13/19	32	4/19	23	0.066
Comorbidity
Renal malformations, yes/no	5/27	32	2/23	25	0.450
Cardiac malformations, yes/no	9/24	33	4/21	25	0.308
Surgery
Hypospadias repair	29/4	33	2/23	25	<0.001^a
Orchidopexy, uni- or bilateral	14/16	30	3/22	25	0.006^a
Gonadectomy, uni- or bilateral	28/8	36	2/24	26	<0.001^a
Neoplasia
Gonadal neoplasia,^d yes/no	4/20	24	1/16	17	0.382

	Diagnosed Due to:
	Genital Anomalies		Nongenital Reasons		P Value
	Median (Range) or Yes/No	n	Median (Range) or Yes/No	n	P Value
Age
Age at presentation, y, median (range)	0.00 (0.0 to 42.7)	35	24.0 (0.0 to 49.00)	25	<0.001^a
Age at last evaluation, y, median (range)	18.9 (14.0 to 70.2)	34	30.6 (13.4 to 58.6)	27	0.039
Genital phenotype
EMS,^b median (range)	4.00 (1.0 to 9.5)	24	12 (10.0 to 12.0)	20	<0.001^a
Spontaneous pubertal onset, yes/no	22/10	32	25/2	27	0.023^a
T treatment, yes/no	17/15	32	4/17	21	0.013^a
Growth
Final height, cm, median (range)	156.7 (143.0 to 169.2)	31	164.5 (141.1 to 187.7)	21	0.001^a
Height, SDS, median (range)	−2.29 (−4.6 to −0.28)	29	−1.53 (−3.09 to 1.53)	18	0.016^a
H – TH, SDS,^c median (range)	−2.49 (−4.18 to −1.22)	23	−2.21 (−3.44 to −0.96)	13	0.296
GH treatment, yes/no	13/19	32	4/19	23	0.066
Comorbidity
Renal malformations, yes/no	5/27	32	2/23	25	0.450
Cardiac malformations, yes/no	9/24	33	4/21	25	0.308
Surgery
Hypospadias repair	29/4	33	2/23	25	<0.001^a
Orchidopexy, uni- or bilateral	14/16	30	3/22	25	0.006^a
Gonadectomy, uni- or bilateral	28/8	36	2/24	26	<0.001^a
Neoplasia
Gonadal neoplasia,^d yes/no	4/20	24	1/16	17	0.382

n, total count of individuals with available information.

Significance by a 0.05 level.

EMS (0 to 12 points).

Height (H) − target height (TH), SDS.

Gonadal neoplasia is defined as germ-cell neoplasia in situ (GCNIS), gonadoblastoma, and/or invasive gonadal tumors.

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