Examples of anti-biofilm molecules and their mechanisms of action, according to different strategies.
| Anti-biofilm strategy . | Mechanism of action . | Molecules . | References . |
|---|---|---|---|
| Inhibition of bacterial attachment to surfaces | Anti-adhesive surface properties | Hydrophilic polymers and surfaces with micro- and nanoscale topography | Huang et al. 2002; Hsu et al. 2013; Kang et al. 2016 |
| Antimicrobial surface properties | Antimicrobial peptides, essential oils, metallic nanoparticles, bacteriophages | Agnihotri, Mukherji and Mukherji 2013; Wang, Sauvageau and Elias 2016; Zaltsman et al. 2017; He et al. 2018 | |
| Interference with signal molecules modulating biofilm formation | AI degradation | Lactonases, acylases and oxidoreductases | Wang et al. 2004; Lade, Paul and Kweon 2014; Chan, Liu and Chang 2015 |
| AI synthesis inhibition | Halogenated furanone compounds, quercetin, cycloleucine, nickel and cadmium | Kim et al. 2008; Vega et al. 2014; Yadav et al. 2014; Gopu, Meena and Shetty 2015 | |
| AI antagonization | AHL analogues (cyclic sulfur compounds, phenolic compounds), AI-2 analogues (ursolic acid, isobutyl-4,5-dihydroxy-2,3-pentanedione (isobutyl-DPD) and phenyl-DPD), AIP analogues (cyclic peptides, RNA III) | Brackman and Coenye 2015; Hossain et al. 2017 | |
| c-Di-GMP signaling system inhibition | LP 3134, LP 3145, LP 4010, LP 1062 | Bachovchin et al. 2009; Sambanthamoorthy et al. 2014 | |
| Disruption of biofilm architecture | EPS/matrix degradation | Polysaccharide-degrading enzymes (dispersin B, endolysins), nucleases (DNase I), proteases (proteinase K, trypsin) | Kaplan et al. 2003; Sugimoto et al. 2018 |
| Biofilm dispersion | Nitric oxide, cis-2-decenoic acid, ethylenediaminetetraacetic acid, lactoferrin | Banin, Vasil and Greenberg 2005; Banin, Brady and Greenberg 2006; Barraud et al. 2009; Kumar Shukla and Rao 2013; Marques, Davies and Sauer 2015 |
| Anti-biofilm strategy . | Mechanism of action . | Molecules . | References . |
|---|---|---|---|
| Inhibition of bacterial attachment to surfaces | Anti-adhesive surface properties | Hydrophilic polymers and surfaces with micro- and nanoscale topography | Huang et al. 2002; Hsu et al. 2013; Kang et al. 2016 |
| Antimicrobial surface properties | Antimicrobial peptides, essential oils, metallic nanoparticles, bacteriophages | Agnihotri, Mukherji and Mukherji 2013; Wang, Sauvageau and Elias 2016; Zaltsman et al. 2017; He et al. 2018 | |
| Interference with signal molecules modulating biofilm formation | AI degradation | Lactonases, acylases and oxidoreductases | Wang et al. 2004; Lade, Paul and Kweon 2014; Chan, Liu and Chang 2015 |
| AI synthesis inhibition | Halogenated furanone compounds, quercetin, cycloleucine, nickel and cadmium | Kim et al. 2008; Vega et al. 2014; Yadav et al. 2014; Gopu, Meena and Shetty 2015 | |
| AI antagonization | AHL analogues (cyclic sulfur compounds, phenolic compounds), AI-2 analogues (ursolic acid, isobutyl-4,5-dihydroxy-2,3-pentanedione (isobutyl-DPD) and phenyl-DPD), AIP analogues (cyclic peptides, RNA III) | Brackman and Coenye 2015; Hossain et al. 2017 | |
| c-Di-GMP signaling system inhibition | LP 3134, LP 3145, LP 4010, LP 1062 | Bachovchin et al. 2009; Sambanthamoorthy et al. 2014 | |
| Disruption of biofilm architecture | EPS/matrix degradation | Polysaccharide-degrading enzymes (dispersin B, endolysins), nucleases (DNase I), proteases (proteinase K, trypsin) | Kaplan et al. 2003; Sugimoto et al. 2018 |
| Biofilm dispersion | Nitric oxide, cis-2-decenoic acid, ethylenediaminetetraacetic acid, lactoferrin | Banin, Vasil and Greenberg 2005; Banin, Brady and Greenberg 2006; Barraud et al. 2009; Kumar Shukla and Rao 2013; Marques, Davies and Sauer 2015 |
Examples of anti-biofilm molecules and their mechanisms of action, according to different strategies.
| Anti-biofilm strategy . | Mechanism of action . | Molecules . | References . |
|---|---|---|---|
| Inhibition of bacterial attachment to surfaces | Anti-adhesive surface properties | Hydrophilic polymers and surfaces with micro- and nanoscale topography | Huang et al. 2002; Hsu et al. 2013; Kang et al. 2016 |
| Antimicrobial surface properties | Antimicrobial peptides, essential oils, metallic nanoparticles, bacteriophages | Agnihotri, Mukherji and Mukherji 2013; Wang, Sauvageau and Elias 2016; Zaltsman et al. 2017; He et al. 2018 | |
| Interference with signal molecules modulating biofilm formation | AI degradation | Lactonases, acylases and oxidoreductases | Wang et al. 2004; Lade, Paul and Kweon 2014; Chan, Liu and Chang 2015 |
| AI synthesis inhibition | Halogenated furanone compounds, quercetin, cycloleucine, nickel and cadmium | Kim et al. 2008; Vega et al. 2014; Yadav et al. 2014; Gopu, Meena and Shetty 2015 | |
| AI antagonization | AHL analogues (cyclic sulfur compounds, phenolic compounds), AI-2 analogues (ursolic acid, isobutyl-4,5-dihydroxy-2,3-pentanedione (isobutyl-DPD) and phenyl-DPD), AIP analogues (cyclic peptides, RNA III) | Brackman and Coenye 2015; Hossain et al. 2017 | |
| c-Di-GMP signaling system inhibition | LP 3134, LP 3145, LP 4010, LP 1062 | Bachovchin et al. 2009; Sambanthamoorthy et al. 2014 | |
| Disruption of biofilm architecture | EPS/matrix degradation | Polysaccharide-degrading enzymes (dispersin B, endolysins), nucleases (DNase I), proteases (proteinase K, trypsin) | Kaplan et al. 2003; Sugimoto et al. 2018 |
| Biofilm dispersion | Nitric oxide, cis-2-decenoic acid, ethylenediaminetetraacetic acid, lactoferrin | Banin, Vasil and Greenberg 2005; Banin, Brady and Greenberg 2006; Barraud et al. 2009; Kumar Shukla and Rao 2013; Marques, Davies and Sauer 2015 |
| Anti-biofilm strategy . | Mechanism of action . | Molecules . | References . |
|---|---|---|---|
| Inhibition of bacterial attachment to surfaces | Anti-adhesive surface properties | Hydrophilic polymers and surfaces with micro- and nanoscale topography | Huang et al. 2002; Hsu et al. 2013; Kang et al. 2016 |
| Antimicrobial surface properties | Antimicrobial peptides, essential oils, metallic nanoparticles, bacteriophages | Agnihotri, Mukherji and Mukherji 2013; Wang, Sauvageau and Elias 2016; Zaltsman et al. 2017; He et al. 2018 | |
| Interference with signal molecules modulating biofilm formation | AI degradation | Lactonases, acylases and oxidoreductases | Wang et al. 2004; Lade, Paul and Kweon 2014; Chan, Liu and Chang 2015 |
| AI synthesis inhibition | Halogenated furanone compounds, quercetin, cycloleucine, nickel and cadmium | Kim et al. 2008; Vega et al. 2014; Yadav et al. 2014; Gopu, Meena and Shetty 2015 | |
| AI antagonization | AHL analogues (cyclic sulfur compounds, phenolic compounds), AI-2 analogues (ursolic acid, isobutyl-4,5-dihydroxy-2,3-pentanedione (isobutyl-DPD) and phenyl-DPD), AIP analogues (cyclic peptides, RNA III) | Brackman and Coenye 2015; Hossain et al. 2017 | |
| c-Di-GMP signaling system inhibition | LP 3134, LP 3145, LP 4010, LP 1062 | Bachovchin et al. 2009; Sambanthamoorthy et al. 2014 | |
| Disruption of biofilm architecture | EPS/matrix degradation | Polysaccharide-degrading enzymes (dispersin B, endolysins), nucleases (DNase I), proteases (proteinase K, trypsin) | Kaplan et al. 2003; Sugimoto et al. 2018 |
| Biofilm dispersion | Nitric oxide, cis-2-decenoic acid, ethylenediaminetetraacetic acid, lactoferrin | Banin, Vasil and Greenberg 2005; Banin, Brady and Greenberg 2006; Barraud et al. 2009; Kumar Shukla and Rao 2013; Marques, Davies and Sauer 2015 |
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