Genetic variants included in the novel 5p15.33 instrumental variable and their associations with the telomere length Z-score in the combined dataset (n = 2051)
| Variant . | Gene . | Alleles . | EAF . | Per-allele estimate . | P-value . | ||
|---|---|---|---|---|---|---|---|
| Long TL . | Other . | βa,b . | (SE) . | ||||
| rs956942 | LINC01511 | A | G | 2.4 × 10–3 | 1.11 | (0.29) | 1.7 × 10–4 |
| Chr5: 1383486 | CLPTM1L-SLC6A3 | A | G | 4.9 × 10–4 | 2.09 | (0.65) | 1.4 × 10–3 |
| Chr5: 1404329 | SLC6A3 | T | C | 9.8 × 10–4 | 1.28 | (0.46) | 5.8 × 10–3 |
| Chr5: 1501109 | LPCAT1 | A | G | 7.4 × 10–4 | 1.46 | (0.53) | 6.1 × 10–3 |
| Chr5: 1297379 | TERT | A | C/G | 1.5 × 10–3 | 0.68 | (0.27) | 0.01 |
| rs80022192 | LINC01511 | G | A | 4.9 × 10–4 | 1.60 | (0.65) | 0.01 |
| rs35033501 | TERT | A | G | 0.03 | 0.22 | (0.09) | 0.01 |
| rs28363089 | SLC6A3 | A | G | 0.03 | 0.23 | (0.02) | 0.01 |
| Chr5: 1434327 | SLC6A3 | A | T | 0.99 | 0.89 | (0.38) | 0.02 |
| Chr5: 1402812 | SLC6A3 | T | C | 4.9 × 10–4 | 1.49 | (0.65) | 0.02 |
| rs79717857 | CLPTM1L | A | C | 0.02 | 0.21 | (0.09) | 0.02 |
| rs35334674 | TERT | G | A | 0.97 | 0.19 | (0.08) | 0.02 |
| rs7733853 | LPCAT1 | A | G | 0.24 | 0.08 | (0.03) | 0.02 |
| rs72715516 | SLC6A3 | G | A | 0.96 | 0.21 | (0.10) | 0.04 |
| Variant . | Gene . | Alleles . | EAF . | Per-allele estimate . | P-value . | ||
|---|---|---|---|---|---|---|---|
| Long TL . | Other . | βa,b . | (SE) . | ||||
| rs956942 | LINC01511 | A | G | 2.4 × 10–3 | 1.11 | (0.29) | 1.7 × 10–4 |
| Chr5: 1383486 | CLPTM1L-SLC6A3 | A | G | 4.9 × 10–4 | 2.09 | (0.65) | 1.4 × 10–3 |
| Chr5: 1404329 | SLC6A3 | T | C | 9.8 × 10–4 | 1.28 | (0.46) | 5.8 × 10–3 |
| Chr5: 1501109 | LPCAT1 | A | G | 7.4 × 10–4 | 1.46 | (0.53) | 6.1 × 10–3 |
| Chr5: 1297379 | TERT | A | C/G | 1.5 × 10–3 | 0.68 | (0.27) | 0.01 |
| rs80022192 | LINC01511 | G | A | 4.9 × 10–4 | 1.60 | (0.65) | 0.01 |
| rs35033501 | TERT | A | G | 0.03 | 0.22 | (0.09) | 0.01 |
| rs28363089 | SLC6A3 | A | G | 0.03 | 0.23 | (0.02) | 0.01 |
| Chr5: 1434327 | SLC6A3 | A | T | 0.99 | 0.89 | (0.38) | 0.02 |
| Chr5: 1402812 | SLC6A3 | T | C | 4.9 × 10–4 | 1.49 | (0.65) | 0.02 |
| rs79717857 | CLPTM1L | A | C | 0.02 | 0.21 | (0.09) | 0.02 |
| rs35334674 | TERT | G | A | 0.97 | 0.19 | (0.08) | 0.02 |
| rs7733853 | LPCAT1 | A | G | 0.24 | 0.08 | (0.03) | 0.02 |
| rs72715516 | SLC6A3 | G | A | 0.96 | 0.21 | (0.10) | 0.04 |
EAF, effect allele frequency, where the effect allele is the long telomere allele; SE, standard error; LINC01511, long intergenic non-protein coding RNA 151; CLPTM1L, cleft lip and palate associated transmembrane protein 1-like; SLC6A3, solute carrier family 6 member 3; LPCAT1, lysophosphatidylcholine acyltransferase 1; TERT, telomerase reverse transcriptase. aLinear regression models adjusted for age, sex, study and ethnicity principal components. bRegression coefficients are standardized and correspond to a 1 standard deviation (1 unit) change in the telomere length Z-score, approximately 1000 base pairs.
Genetic variants included in the novel 5p15.33 instrumental variable and their associations with the telomere length Z-score in the combined dataset (n = 2051)
| Variant . | Gene . | Alleles . | EAF . | Per-allele estimate . | P-value . | ||
|---|---|---|---|---|---|---|---|
| Long TL . | Other . | βa,b . | (SE) . | ||||
| rs956942 | LINC01511 | A | G | 2.4 × 10–3 | 1.11 | (0.29) | 1.7 × 10–4 |
| Chr5: 1383486 | CLPTM1L-SLC6A3 | A | G | 4.9 × 10–4 | 2.09 | (0.65) | 1.4 × 10–3 |
| Chr5: 1404329 | SLC6A3 | T | C | 9.8 × 10–4 | 1.28 | (0.46) | 5.8 × 10–3 |
| Chr5: 1501109 | LPCAT1 | A | G | 7.4 × 10–4 | 1.46 | (0.53) | 6.1 × 10–3 |
| Chr5: 1297379 | TERT | A | C/G | 1.5 × 10–3 | 0.68 | (0.27) | 0.01 |
| rs80022192 | LINC01511 | G | A | 4.9 × 10–4 | 1.60 | (0.65) | 0.01 |
| rs35033501 | TERT | A | G | 0.03 | 0.22 | (0.09) | 0.01 |
| rs28363089 | SLC6A3 | A | G | 0.03 | 0.23 | (0.02) | 0.01 |
| Chr5: 1434327 | SLC6A3 | A | T | 0.99 | 0.89 | (0.38) | 0.02 |
| Chr5: 1402812 | SLC6A3 | T | C | 4.9 × 10–4 | 1.49 | (0.65) | 0.02 |
| rs79717857 | CLPTM1L | A | C | 0.02 | 0.21 | (0.09) | 0.02 |
| rs35334674 | TERT | G | A | 0.97 | 0.19 | (0.08) | 0.02 |
| rs7733853 | LPCAT1 | A | G | 0.24 | 0.08 | (0.03) | 0.02 |
| rs72715516 | SLC6A3 | G | A | 0.96 | 0.21 | (0.10) | 0.04 |
| Variant . | Gene . | Alleles . | EAF . | Per-allele estimate . | P-value . | ||
|---|---|---|---|---|---|---|---|
| Long TL . | Other . | βa,b . | (SE) . | ||||
| rs956942 | LINC01511 | A | G | 2.4 × 10–3 | 1.11 | (0.29) | 1.7 × 10–4 |
| Chr5: 1383486 | CLPTM1L-SLC6A3 | A | G | 4.9 × 10–4 | 2.09 | (0.65) | 1.4 × 10–3 |
| Chr5: 1404329 | SLC6A3 | T | C | 9.8 × 10–4 | 1.28 | (0.46) | 5.8 × 10–3 |
| Chr5: 1501109 | LPCAT1 | A | G | 7.4 × 10–4 | 1.46 | (0.53) | 6.1 × 10–3 |
| Chr5: 1297379 | TERT | A | C/G | 1.5 × 10–3 | 0.68 | (0.27) | 0.01 |
| rs80022192 | LINC01511 | G | A | 4.9 × 10–4 | 1.60 | (0.65) | 0.01 |
| rs35033501 | TERT | A | G | 0.03 | 0.22 | (0.09) | 0.01 |
| rs28363089 | SLC6A3 | A | G | 0.03 | 0.23 | (0.02) | 0.01 |
| Chr5: 1434327 | SLC6A3 | A | T | 0.99 | 0.89 | (0.38) | 0.02 |
| Chr5: 1402812 | SLC6A3 | T | C | 4.9 × 10–4 | 1.49 | (0.65) | 0.02 |
| rs79717857 | CLPTM1L | A | C | 0.02 | 0.21 | (0.09) | 0.02 |
| rs35334674 | TERT | G | A | 0.97 | 0.19 | (0.08) | 0.02 |
| rs7733853 | LPCAT1 | A | G | 0.24 | 0.08 | (0.03) | 0.02 |
| rs72715516 | SLC6A3 | G | A | 0.96 | 0.21 | (0.10) | 0.04 |
EAF, effect allele frequency, where the effect allele is the long telomere allele; SE, standard error; LINC01511, long intergenic non-protein coding RNA 151; CLPTM1L, cleft lip and palate associated transmembrane protein 1-like; SLC6A3, solute carrier family 6 member 3; LPCAT1, lysophosphatidylcholine acyltransferase 1; TERT, telomerase reverse transcriptase. aLinear regression models adjusted for age, sex, study and ethnicity principal components. bRegression coefficients are standardized and correspond to a 1 standard deviation (1 unit) change in the telomere length Z-score, approximately 1000 base pairs.
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