Table 3.
Open in new tab

Clinicopathological Correlations of the Metabolic Gene Signature in the TCGA Cohort

VariablesNMetabolic Gene SignatureP Value
Low-Risk ScoreHigh-Risk Score
Age, y0.899
 <55336167 (49.7%)169 (50.3%)
 ≥5516583 (50.3%)82 (49.7%)
Sex0.379
 Male13563 (46.7%)72 (53.3%)
 Female366187 (51.1%)179 (48.9%)
Multifocality0.568
 Unifocal265128 (48.3%)137 (51.7%)
 Multifocal226115 (50.9%)111 (49.1%)
Coexistent HT0.412
 Yes6530 (46.2%)35 (53.8%)
 No397205 (51.6%)192 (48.4%)
T stage<0.001
 T1/T2308177 (57.5%)131 (42.5%)
 T3/T419173 (38.2%)118 (61.8%)
ETE<0.001
 Yes15247 (30.9%)105 (69.1%)
 No331192 (58.0%)139 (42.0%)
LNM<0.001
 N0227140 (61.7%)87 (38.3%)
 N122477 (34.4%)147 (65.6%)
TNM stage0.004
 I/II480246 (51.2%)234 (48.8%)
 III/IV214 (19.0%)17 (81.0%)
BRAFV600E<0.001
 Mutation23974 (31.0%)165 (69.0%)
 Wild-type254172 (67.7%)82 (32.3%)
TERT0.499
 Mutation20 (0.0%)2 (100.0%)
 Wild-type491246 (50.1%)245 (49.9%)
RAS<0.001
 Mutation5148 (94.1%)3 (5.9%)
 Wild-type442198 (44.8%)244 (55.2%)
EIF1AX0.122
 Mutation65 (83.3%)1 (16.7%)
 Wild-type487241 (49.5%)246 (50.5%)
ETV6_NTRK30.216
 Fusion54 (80.0%)1 (20.0%)
 Wild-type488242 (49.6%)246 (50.4%)
CCDC6_RET0.510
 Fusion219 (42.9%)12 (57.1%)
 Wild-type472237 (50.2%)235 (49.8%)
PAX8_PPARG0.123
 Fusion44 (100.0%)0 (0.0%)
 Wild-type489243 (49.6%)247 (50.4%)
VariablesNMetabolic Gene SignatureP Value
Low-Risk ScoreHigh-Risk Score
Age, y0.899
 <55336167 (49.7%)169 (50.3%)
 ≥5516583 (50.3%)82 (49.7%)
Sex0.379
 Male13563 (46.7%)72 (53.3%)
 Female366187 (51.1%)179 (48.9%)
Multifocality0.568
 Unifocal265128 (48.3%)137 (51.7%)
 Multifocal226115 (50.9%)111 (49.1%)
Coexistent HT0.412
 Yes6530 (46.2%)35 (53.8%)
 No397205 (51.6%)192 (48.4%)
T stage<0.001
 T1/T2308177 (57.5%)131 (42.5%)
 T3/T419173 (38.2%)118 (61.8%)
ETE<0.001
 Yes15247 (30.9%)105 (69.1%)
 No331192 (58.0%)139 (42.0%)
LNM<0.001
 N0227140 (61.7%)87 (38.3%)
 N122477 (34.4%)147 (65.6%)
TNM stage0.004
 I/II480246 (51.2%)234 (48.8%)
 III/IV214 (19.0%)17 (81.0%)
BRAFV600E<0.001
 Mutation23974 (31.0%)165 (69.0%)
 Wild-type254172 (67.7%)82 (32.3%)
TERT0.499
 Mutation20 (0.0%)2 (100.0%)
 Wild-type491246 (50.1%)245 (49.9%)
RAS<0.001
 Mutation5148 (94.1%)3 (5.9%)
 Wild-type442198 (44.8%)244 (55.2%)
EIF1AX0.122
 Mutation65 (83.3%)1 (16.7%)
 Wild-type487241 (49.5%)246 (50.5%)
ETV6_NTRK30.216
 Fusion54 (80.0%)1 (20.0%)
 Wild-type488242 (49.6%)246 (50.4%)
CCDC6_RET0.510
 Fusion219 (42.9%)12 (57.1%)
 Wild-type472237 (50.2%)235 (49.8%)
PAX8_PPARG0.123
 Fusion44 (100.0%)0 (0.0%)
 Wild-type489243 (49.6%)247 (50.4%)

Bold type indicates statistical significance.

Abbreviation: HT, Hashimoto thyroiditis.

Table 3.
Open in new tab

Clinicopathological Correlations of the Metabolic Gene Signature in the TCGA Cohort

VariablesNMetabolic Gene SignatureP Value
Low-Risk ScoreHigh-Risk Score
Age, y0.899
 <55336167 (49.7%)169 (50.3%)
 ≥5516583 (50.3%)82 (49.7%)
Sex0.379
 Male13563 (46.7%)72 (53.3%)
 Female366187 (51.1%)179 (48.9%)
Multifocality0.568
 Unifocal265128 (48.3%)137 (51.7%)
 Multifocal226115 (50.9%)111 (49.1%)
Coexistent HT0.412
 Yes6530 (46.2%)35 (53.8%)
 No397205 (51.6%)192 (48.4%)
T stage<0.001
 T1/T2308177 (57.5%)131 (42.5%)
 T3/T419173 (38.2%)118 (61.8%)
ETE<0.001
 Yes15247 (30.9%)105 (69.1%)
 No331192 (58.0%)139 (42.0%)
LNM<0.001
 N0227140 (61.7%)87 (38.3%)
 N122477 (34.4%)147 (65.6%)
TNM stage0.004
 I/II480246 (51.2%)234 (48.8%)
 III/IV214 (19.0%)17 (81.0%)
BRAFV600E<0.001
 Mutation23974 (31.0%)165 (69.0%)
 Wild-type254172 (67.7%)82 (32.3%)
TERT0.499
 Mutation20 (0.0%)2 (100.0%)
 Wild-type491246 (50.1%)245 (49.9%)
RAS<0.001
 Mutation5148 (94.1%)3 (5.9%)
 Wild-type442198 (44.8%)244 (55.2%)
EIF1AX0.122
 Mutation65 (83.3%)1 (16.7%)
 Wild-type487241 (49.5%)246 (50.5%)
ETV6_NTRK30.216
 Fusion54 (80.0%)1 (20.0%)
 Wild-type488242 (49.6%)246 (50.4%)
CCDC6_RET0.510
 Fusion219 (42.9%)12 (57.1%)
 Wild-type472237 (50.2%)235 (49.8%)
PAX8_PPARG0.123
 Fusion44 (100.0%)0 (0.0%)
 Wild-type489243 (49.6%)247 (50.4%)
VariablesNMetabolic Gene SignatureP Value
Low-Risk ScoreHigh-Risk Score
Age, y0.899
 <55336167 (49.7%)169 (50.3%)
 ≥5516583 (50.3%)82 (49.7%)
Sex0.379
 Male13563 (46.7%)72 (53.3%)
 Female366187 (51.1%)179 (48.9%)
Multifocality0.568
 Unifocal265128 (48.3%)137 (51.7%)
 Multifocal226115 (50.9%)111 (49.1%)
Coexistent HT0.412
 Yes6530 (46.2%)35 (53.8%)
 No397205 (51.6%)192 (48.4%)
T stage<0.001
 T1/T2308177 (57.5%)131 (42.5%)
 T3/T419173 (38.2%)118 (61.8%)
ETE<0.001
 Yes15247 (30.9%)105 (69.1%)
 No331192 (58.0%)139 (42.0%)
LNM<0.001
 N0227140 (61.7%)87 (38.3%)
 N122477 (34.4%)147 (65.6%)
TNM stage0.004
 I/II480246 (51.2%)234 (48.8%)
 III/IV214 (19.0%)17 (81.0%)
BRAFV600E<0.001
 Mutation23974 (31.0%)165 (69.0%)
 Wild-type254172 (67.7%)82 (32.3%)
TERT0.499
 Mutation20 (0.0%)2 (100.0%)
 Wild-type491246 (50.1%)245 (49.9%)
RAS<0.001
 Mutation5148 (94.1%)3 (5.9%)
 Wild-type442198 (44.8%)244 (55.2%)
EIF1AX0.122
 Mutation65 (83.3%)1 (16.7%)
 Wild-type487241 (49.5%)246 (50.5%)
ETV6_NTRK30.216
 Fusion54 (80.0%)1 (20.0%)
 Wild-type488242 (49.6%)246 (50.4%)
CCDC6_RET0.510
 Fusion219 (42.9%)12 (57.1%)
 Wild-type472237 (50.2%)235 (49.8%)
PAX8_PPARG0.123
 Fusion44 (100.0%)0 (0.0%)
 Wild-type489243 (49.6%)247 (50.4%)

Bold type indicates statistical significance.

Abbreviation: HT, Hashimoto thyroiditis.

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