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Table 1

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Disease	Disease subtype/classification	Gene	Protein	Ion channel type	Molecular defect	Reference
I_Ks disease	LQT1	KCNQ1	KvLQT1	I_Ks channel (α-subunit)	loss of function	[4]
	LQT5	KCNE1	MinK	I_Ks channel (β-subunit)	loss of function	[5]
	FAF	KCNQ1	KvLQT1	I_Ks channel (α-subunit)	gain of function	[6–8]
	SQT2	KCNQ1	KvLQT1	I_Ks channel (α-subunit)	gain of function	[9]
I_Kr disease	LQT2	KCNH2	HERG	I_Kr channel (α-subunit)	loss of function	[10]
	LQT6	KCNE2	MiRP1	I_Kr channel (β-subunit)	loss of function	[11]
	SQT1	KCNH2	HERG	I_Kr channel (α-subunit)	gain of function	[12]
I_Na disease	LQT3	SCN5A	Nav1.5	I_Na channel	gain of function	[13]
	Brugada syndrome	SCN5A	Nav1.5	I_Na channel	loss of function	[14,15]
	FCD	SCN5A	–	I_Na channel	loss of function	[16]
I_K1 disease	Andersen syndrome	KCNJ2	Kir2.1	I_K1 channel	–	[17]
	SQT3	KCNJ2	Kir2.1	I_K1 channel	gain of function	[18]
Ankyrin disease	LQT4	ANK2	Ankyrin B	Ankyrin	–	[19]

Disease	Disease subtype/classification	Gene	Protein	Ion channel type	Molecular defect	Reference
I_Ks disease	LQT1	KCNQ1	KvLQT1	I_Ks channel (α-subunit)	loss of function	[4]
	LQT5	KCNE1	MinK	I_Ks channel (β-subunit)	loss of function	[5]
	FAF	KCNQ1	KvLQT1	I_Ks channel (α-subunit)	gain of function	[6–8]
	SQT2	KCNQ1	KvLQT1	I_Ks channel (α-subunit)	gain of function	[9]
I_Kr disease	LQT2	KCNH2	HERG	I_Kr channel (α-subunit)	loss of function	[10]
	LQT6	KCNE2	MiRP1	I_Kr channel (β-subunit)	loss of function	[11]
	SQT1	KCNH2	HERG	I_Kr channel (α-subunit)	gain of function	[12]
I_Na disease	LQT3	SCN5A	Nav1.5	I_Na channel	gain of function	[13]
	Brugada syndrome	SCN5A	Nav1.5	I_Na channel	loss of function	[14,15]
	FCD	SCN5A	–	I_Na channel	loss of function	[16]
I_K1 disease	Andersen syndrome	KCNJ2	Kir2.1	I_K1 channel	–	[17]
	SQT3	KCNJ2	Kir2.1	I_K1 channel	gain of function	[18]
Ankyrin disease	LQT4	ANK2	Ankyrin B	Ankyrin	–	[19]

Summary of genetic findings in inherited arrhythmogenic diseases. LQT = Long QT syndrome, FAF = familial atrial fibrillation, SQT = short QT syndrome, FCD = familial conduction disease.

Table 1

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Disease	Disease subtype/classification	Gene	Protein	Ion channel type	Molecular defect	Reference
I_Ks disease	LQT1	KCNQ1	KvLQT1	I_Ks channel (α-subunit)	loss of function	[4]
	LQT5	KCNE1	MinK	I_Ks channel (β-subunit)	loss of function	[5]
	FAF	KCNQ1	KvLQT1	I_Ks channel (α-subunit)	gain of function	[6–8]
	SQT2	KCNQ1	KvLQT1	I_Ks channel (α-subunit)	gain of function	[9]
I_Kr disease	LQT2	KCNH2	HERG	I_Kr channel (α-subunit)	loss of function	[10]
	LQT6	KCNE2	MiRP1	I_Kr channel (β-subunit)	loss of function	[11]
	SQT1	KCNH2	HERG	I_Kr channel (α-subunit)	gain of function	[12]
I_Na disease	LQT3	SCN5A	Nav1.5	I_Na channel	gain of function	[13]
	Brugada syndrome	SCN5A	Nav1.5	I_Na channel	loss of function	[14,15]
	FCD	SCN5A	–	I_Na channel	loss of function	[16]
I_K1 disease	Andersen syndrome	KCNJ2	Kir2.1	I_K1 channel	–	[17]
	SQT3	KCNJ2	Kir2.1	I_K1 channel	gain of function	[18]
Ankyrin disease	LQT4	ANK2	Ankyrin B	Ankyrin	–	[19]

Disease	Disease subtype/classification	Gene	Protein	Ion channel type	Molecular defect	Reference
I_Ks disease	LQT1	KCNQ1	KvLQT1	I_Ks channel (α-subunit)	loss of function	[4]
	LQT5	KCNE1	MinK	I_Ks channel (β-subunit)	loss of function	[5]
	FAF	KCNQ1	KvLQT1	I_Ks channel (α-subunit)	gain of function	[6–8]
	SQT2	KCNQ1	KvLQT1	I_Ks channel (α-subunit)	gain of function	[9]
I_Kr disease	LQT2	KCNH2	HERG	I_Kr channel (α-subunit)	loss of function	[10]
	LQT6	KCNE2	MiRP1	I_Kr channel (β-subunit)	loss of function	[11]
	SQT1	KCNH2	HERG	I_Kr channel (α-subunit)	gain of function	[12]
I_Na disease	LQT3	SCN5A	Nav1.5	I_Na channel	gain of function	[13]
	Brugada syndrome	SCN5A	Nav1.5	I_Na channel	loss of function	[14,15]
	FCD	SCN5A	–	I_Na channel	loss of function	[16]
I_K1 disease	Andersen syndrome	KCNJ2	Kir2.1	I_K1 channel	–	[17]
	SQT3	KCNJ2	Kir2.1	I_K1 channel	gain of function	[18]
Ankyrin disease	LQT4	ANK2	Ankyrin B	Ankyrin	–	[19]

Summary of genetic findings in inherited arrhythmogenic diseases. LQT = Long QT syndrome, FAF = familial atrial fibrillation, SQT = short QT syndrome, FCD = familial conduction disease.