Results From Free Cytosolic Calcium Dynamic Assays in PitNET Cells in Response to MF Alone or in Combination With Octreotide
| Treatment . | No. Samples . | Cells Analyzed . | % PRC . | % PRM ± SEM . | Time (s) ± SEM . |
|---|---|---|---|---|---|
| ACTHomas | |||||
| MF | 1/2 | 58 | 12.1% | 20 ± 1.77 | 51.43 ± 1.95 |
| Octreotide | 1/2 | 67 | 4.5% | 23.9 ± 3.62 | 110 ± 0 |
| MF + Octreotide | 1/2 | 66 | 4.5% | 28.9 ± 5.44 | 45 ± 4.08 |
| GHomas | |||||
| MF | 0/2 | 70 | 0 | — | — |
| Octreotide | 2/2 | 70 | 10% | 21.6 ± 0.8 | 89.4 ± 3.71 |
| MF + Octreotide | 1/2 | 68 | 27.9% | 37.6 ± 3.89 | 85 ± 0 |
| Treatment . | No. Samples . | Cells Analyzed . | % PRC . | % PRM ± SEM . | Time (s) ± SEM . |
|---|---|---|---|---|---|
| ACTHomas | |||||
| MF | 1/2 | 58 | 12.1% | 20 ± 1.77 | 51.43 ± 1.95 |
| Octreotide | 1/2 | 67 | 4.5% | 23.9 ± 3.62 | 110 ± 0 |
| MF + Octreotide | 1/2 | 66 | 4.5% | 28.9 ± 5.44 | 45 ± 4.08 |
| GHomas | |||||
| MF | 0/2 | 70 | 0 | — | — |
| Octreotide | 2/2 | 70 | 10% | 21.6 ± 0.8 | 89.4 ± 3.71 |
| MF + Octreotide | 1/2 | 68 | 27.9% | 37.6 ± 3.89 | 85 ± 0 |
No. samples is the number of responsive samples of the total of samples analyzed. Cells analyzed indicates the total number of individual cells analyzed. % PRC is the percentage of responsive cells in responsive samples. Time is the time of response to biguanide administration.
Results From Free Cytosolic Calcium Dynamic Assays in PitNET Cells in Response to MF Alone or in Combination With Octreotide
| Treatment . | No. Samples . | Cells Analyzed . | % PRC . | % PRM ± SEM . | Time (s) ± SEM . |
|---|---|---|---|---|---|
| ACTHomas | |||||
| MF | 1/2 | 58 | 12.1% | 20 ± 1.77 | 51.43 ± 1.95 |
| Octreotide | 1/2 | 67 | 4.5% | 23.9 ± 3.62 | 110 ± 0 |
| MF + Octreotide | 1/2 | 66 | 4.5% | 28.9 ± 5.44 | 45 ± 4.08 |
| GHomas | |||||
| MF | 0/2 | 70 | 0 | — | — |
| Octreotide | 2/2 | 70 | 10% | 21.6 ± 0.8 | 89.4 ± 3.71 |
| MF + Octreotide | 1/2 | 68 | 27.9% | 37.6 ± 3.89 | 85 ± 0 |
| Treatment . | No. Samples . | Cells Analyzed . | % PRC . | % PRM ± SEM . | Time (s) ± SEM . |
|---|---|---|---|---|---|
| ACTHomas | |||||
| MF | 1/2 | 58 | 12.1% | 20 ± 1.77 | 51.43 ± 1.95 |
| Octreotide | 1/2 | 67 | 4.5% | 23.9 ± 3.62 | 110 ± 0 |
| MF + Octreotide | 1/2 | 66 | 4.5% | 28.9 ± 5.44 | 45 ± 4.08 |
| GHomas | |||||
| MF | 0/2 | 70 | 0 | — | — |
| Octreotide | 2/2 | 70 | 10% | 21.6 ± 0.8 | 89.4 ± 3.71 |
| MF + Octreotide | 1/2 | 68 | 27.9% | 37.6 ± 3.89 | 85 ± 0 |
No. samples is the number of responsive samples of the total of samples analyzed. Cells analyzed indicates the total number of individual cells analyzed. % PRC is the percentage of responsive cells in responsive samples. Time is the time of response to biguanide administration.
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