Table 1. Open in new tab Clinical and...

Subject	TV (mL)	BMI (kg/m²)	Testosterone (ng/dL)	Estradiol (pg/mL)	FSH (IU/L)	Inhibin B (pg/mL)	LH (IU/L)	Pulses (#)	Mean Amplitude	LH Pulse Pattern	Recovery	Sperm Count (×10⁶/mL)
1	23	17.7	19.9	53	473	15	5.0	n/a	9.3	3	6.1	Normal	Yes	n/a
2	20	18.8	19.3	191	247	13	4.2	n/a	5.3	6	3.0	Normal	Yes	n/a
3	20	18.9	19.3	122	133	<10	4.7	147.2	2.8	5	2.5	Normal	Yes	n/a
4	23	21.3	22.1	109	193	13	3.5	74.4	9.1	5	6.6	Normal	Yes	23
5	20	23.9	26.8	145	225	<10	2.7	n/a	4.9	3	4.0	Sleep-entrained	Yes	n/a
6	20	19.1	20.8	82	121	11	7.4	70.7	6.7	4	3.0	Sleep-entrained	n/a	n/a
7	25	20.5	26.8	144	187	12	2.5	n/a	5.7	3	5.3	Sleep-entrained	n/a	n/a
8	25	22.2	23.0	179	243	22	2.9	n/a	7.0	5	5.7	Normal	n/a	50
9	17	22.7	22.9	99	228	28	6.6	74.2	5.0	4	3.6	Normal	n/a	118
10	23	23	17.8	129	161	<10	2.3	n/a	1.5	0	n/a	Apulsatile	n/a	n/a
Men with FHH (n = 10)	20.3 ± 2.1	20.6 ± 2.1^a	125 ± 40	193 ± 47^a	14.4 ± 6.0^a	4.1 ± 1.8	91.6 ± 37.1^b	4.1 ± 1.8^a	3.9 ± 1.8	4.2 ± 1.5^c	—	—	—
Controls (n = 18)	—	24.1 ± 2.2	—	513 ± 93	38.2 ± 9.7	5.0 ± 1.7	176.8 ± 58.8	10.2 ± 2.8	5.0 ± 1.9	7.7 ± 2.9	Normal	—	—

Subject

TV (mL)

BMI (kg/m²)

Testosterone (ng/dL)

Estradiol (pg/mL)

FSH (IU/L)

Inhibin B (pg/mL)

LH (IU/L)

Pulses (#)

Mean Amplitude

LH Pulse Pattern

Recovery

Sperm Count (×10⁶/mL)

Present

NE Eval

Present

NE Eval

17.7

19.9

473

5.0

n/a

9.3

6.1

Normal

Yes

n/a

18.8

19.3

191

247

4.2

n/a

5.3

3.0

Normal

Yes

n/a

18.9

19.3

122

133

<10

4.7

147.2

2.8

2.5

Normal

Yes

n/a

21.3

22.1

109

193

3.5

74.4

9.1

6.6

Normal

Yes

23.9

26.8

145

225

<10

2.7

n/a

4.9

4.0

Sleep-entrained

Yes

n/a

19.1

20.8

121

7.4

70.7

6.7

3.0

Sleep-entrained

n/a

20.5

26.8

144

187

2.5

n/a

5.7

5.3

Sleep-entrained

n/a

22.2

23.0

179

243

2.9

n/a

7.0

5.7

Normal

n/a

22.7

22.9

228

6.6

74.2

5.0

3.6

Normal

n/a

118

17.8

129

161

<10

2.3

n/a

1.5

n/a

Apulsatile

n/a

Men with FHH (n = 10)

20.3 ± 2.1

20.6 ± 2.1^a

125 ± 40

193 ± 47^a

14.4 ± 6.0^a

4.1 ± 1.8

91.6 ± 37.1^b

4.1 ± 1.8^a

3.9 ± 1.8

4.2 ± 1.5^c

—

Controls (n = 18)

—

24.1 ± 2.2

—

513 ± 93

38.2 ± 9.7

5.0 ± 1.7

176.8 ± 58.8

10.2 ± 2.8

5.0 ± 1.9

7.7 ± 2.9

Normal

—

Subject	TV (mL)	BMI (kg/m²)	Testosterone (ng/dL)	Estradiol (pg/mL)	FSH (IU/L)	Inhibin B (pg/mL)	LH (IU/L)	Pulses (#)	Mean Amplitude	LH Pulse Pattern	Recovery	Sperm Count (×10⁶/mL)
1	23	17.7	19.9	53	473	15	5.0	n/a	9.3	3	6.1	Normal	Yes	n/a
2	20	18.8	19.3	191	247	13	4.2	n/a	5.3	6	3.0	Normal	Yes	n/a
3	20	18.9	19.3	122	133	<10	4.7	147.2	2.8	5	2.5	Normal	Yes	n/a
4	23	21.3	22.1	109	193	13	3.5	74.4	9.1	5	6.6	Normal	Yes	23
5	20	23.9	26.8	145	225	<10	2.7	n/a	4.9	3	4.0	Sleep-entrained	Yes	n/a
6	20	19.1	20.8	82	121	11	7.4	70.7	6.7	4	3.0	Sleep-entrained	n/a	n/a
7	25	20.5	26.8	144	187	12	2.5	n/a	5.7	3	5.3	Sleep-entrained	n/a	n/a
8	25	22.2	23.0	179	243	22	2.9	n/a	7.0	5	5.7	Normal	n/a	50
9	17	22.7	22.9	99	228	28	6.6	74.2	5.0	4	3.6	Normal	n/a	118
10	23	23	17.8	129	161	<10	2.3	n/a	1.5	0	n/a	Apulsatile	n/a	n/a
Men with FHH (n = 10)	20.3 ± 2.1	20.6 ± 2.1^a	125 ± 40	193 ± 47^a	14.4 ± 6.0^a	4.1 ± 1.8	91.6 ± 37.1^b	4.1 ± 1.8^a	3.9 ± 1.8	4.2 ± 1.5^c	—	—	—
Controls (n = 18)	—	24.1 ± 2.2	—	513 ± 93	38.2 ± 9.7	5.0 ± 1.7	176.8 ± 58.8	10.2 ± 2.8	5.0 ± 1.9	7.7 ± 2.9	Normal	—	—

Table 1.

Open in new tab

Clinical and Biochemical Characteristics of Men With FHH

Subject	TV (mL)	BMI (kg/m²)		Testosterone (ng/dL)		Estradiol (pg/mL)	FSH (IU/L)	Inhibin B (pg/mL)	LH (IU/L)	Pulses (#)	Mean Amplitude	LH Pulse Pattern	Recovery	Sperm Count (×10⁶/mL)
Subject	TV (mL)	Present	NE Eval	Present	NE Eval	Estradiol (pg/mL)	FSH (IU/L)	Inhibin B (pg/mL)	LH (IU/L)	Pulses (#)	Mean Amplitude	LH Pulse Pattern	Recovery	Sperm Count (×10⁶/mL)
1	23	17.7	19.9	53	473	15	5.0	n/a	9.3	3	6.1	Normal	Yes	n/a
2	20	18.8	19.3	191	247	13	4.2	n/a	5.3	6	3.0	Normal	Yes	n/a
3	20	18.9	19.3	122	133	<10	4.7	147.2	2.8	5	2.5	Normal	Yes	n/a
4	23	21.3	22.1	109	193	13	3.5	74.4	9.1	5	6.6	Normal	Yes	23
5	20	23.9	26.8	145	225	<10	2.7	n/a	4.9	3	4.0	Sleep-entrained	Yes	n/a
6	20	19.1	20.8	82	121	11	7.4	70.7	6.7	4	3.0	Sleep-entrained	n/a	n/a
7	25	20.5	26.8	144	187	12	2.5	n/a	5.7	3	5.3	Sleep-entrained	n/a	n/a
8	25	22.2	23.0	179	243	22	2.9	n/a	7.0	5	5.7	Normal	n/a	50
9	17	22.7	22.9	99	228	28	6.6	74.2	5.0	4	3.6	Normal	n/a	118
10	23	23	17.8	129	161	<10	2.3	n/a	1.5	0	n/a	Apulsatile	n/a	n/a
Men with FHH (n = 10)		20.3 ± 2.1	20.6 ± 2.1^a	125 ± 40	193 ± 47^a	14.4 ± 6.0^a	4.1 ± 1.8	91.6 ± 37.1^b	4.1 ± 1.8^a	3.9 ± 1.8	4.2 ± 1.5^c	—	—	—
Controls (n = 18)		—	24.1 ± 2.2	—	513 ± 93	38.2 ± 9.7	5.0 ± 1.7	176.8 ± 58.8	10.2 ± 2.8	5.0 ± 1.9	7.7 ± 2.9	Normal	—	—

Subject	TV (mL)	BMI (kg/m²)		Testosterone (ng/dL)		Estradiol (pg/mL)	FSH (IU/L)	Inhibin B (pg/mL)	LH (IU/L)	Pulses (#)	Mean Amplitude	LH Pulse Pattern	Recovery	Sperm Count (×10⁶/mL)
Subject	TV (mL)	Present	NE Eval	Present	NE Eval	Estradiol (pg/mL)	FSH (IU/L)	Inhibin B (pg/mL)	LH (IU/L)	Pulses (#)	Mean Amplitude	LH Pulse Pattern	Recovery	Sperm Count (×10⁶/mL)
1	23	17.7	19.9	53	473	15	5.0	n/a	9.3	3	6.1	Normal	Yes	n/a
2	20	18.8	19.3	191	247	13	4.2	n/a	5.3	6	3.0	Normal	Yes	n/a
3	20	18.9	19.3	122	133	<10	4.7	147.2	2.8	5	2.5	Normal	Yes	n/a
4	23	21.3	22.1	109	193	13	3.5	74.4	9.1	5	6.6	Normal	Yes	23
5	20	23.9	26.8	145	225	<10	2.7	n/a	4.9	3	4.0	Sleep-entrained	Yes	n/a
6	20	19.1	20.8	82	121	11	7.4	70.7	6.7	4	3.0	Sleep-entrained	n/a	n/a
7	25	20.5	26.8	144	187	12	2.5	n/a	5.7	3	5.3	Sleep-entrained	n/a	n/a
8	25	22.2	23.0	179	243	22	2.9	n/a	7.0	5	5.7	Normal	n/a	50
9	17	22.7	22.9	99	228	28	6.6	74.2	5.0	4	3.6	Normal	n/a	118
10	23	23	17.8	129	161	<10	2.3	n/a	1.5	0	n/a	Apulsatile	n/a	n/a
Men with FHH (n = 10)		20.3 ± 2.1	20.6 ± 2.1^a	125 ± 40	193 ± 47^a	14.4 ± 6.0^a	4.1 ± 1.8	91.6 ± 37.1^b	4.1 ± 1.8^a	3.9 ± 1.8	4.2 ± 1.5^c	—	—	—
Controls (n = 18)		—	24.1 ± 2.2	—	513 ± 93	38.2 ± 9.7	5.0 ± 1.7	176.8 ± 58.8	10.2 ± 2.8	5.0 ± 1.9	7.7 ± 2.9	Normal	—	—

Statistically significant differences noted in bold.

Abbreviations: n/a, not applicable; NE eval, at neuroendocrine evaluation; present; at presentation.

P < 0.001.

P = 0.015.

P = 0.004.

This Feature Is Available To Subscribers Only